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Entry: PS00075
General information about the entry
Entry nameDHFR_1
Accession numberPS00075
Entry typePATTERN
DateAPR-1990 (CREATED); NOV-1997 (DATA UPDATE); DEC-2011 (INFO UPDATE).
PROSITE DocumentationPDOC00072
Name and characterization of the entry
DescriptionDihydrofolate reductase (DHFR) domain signature.
Pattern[LVAGC]-[LIF]-G-x(4)-[LIVMF]-P-W-x(4,5)-[DE]-x(3)-[FYIV]-x(3)-[STIQ].
Numerical results
  • UniProtKB/Swiss-Prot release number: 01, total number of sequence entries in that release: 534242.
  • Total number of hits in UniProtKB/Swiss-Prot: 88 hits in 88 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 86 hits in 86 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 2 hits in 2 different sequences
  • Number of known missed hits: 6
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0
  • Precision (true hits / (true hits + false positives)): 97.73 %
  • Recall (true hits / (true hits + false negatives)): 93.48 %
Comments
  • Taxonomic range: Archaebacteria, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • VERSION: 1
Cross-references
UniProtKB/Swiss-ProtTrue positive hits:
DRTS1_ARATH (Q05762), DRTS2_ARATH (Q05763), DRTS_DAUCA  (P45350), 
DRTS_LEIAM  (P16126), DRTS_LEIMA  (P07382), DRTS_MAIZE  (O81395), 
DRTS_ORYSJ  (Q2QRX6), DRTS_PARTE  (Q27828), DRTS_PLABA  (Q27713), 
DRTS_PLACH  (P20712), DRTS_PLAFK  (P13922), DRTS_PLAVI  (O02604), 
DRTS_PLAVN  (P46103), DRTS_SOYBN  (P51820), DRTS_TOXGO  (Q07422), 
DRTS_TRYBB  (Q27783), DRTS_TRYCR  (Q27793), DYR10_ECOLX (Q04515), 
DYR13_ECOLX (Q59408), DYR15_ECOLX (P78218), DYR1_ECOLX  (P00382), 
DYR1_HALMA  (Q5V3R2), DYR2_HALMA  (Q5V600), DYR3_SALTY  (P12833), 
DYR5_ECOLX  (P11731), DYR6_PROMI  (P95524), DYR7_ECOLX  (P27422), 
DYR8_ECOLX  (P0ABQ7), DYR8_SHISO  (P0ABQ8), DYR9_ECOLX  (Q59397), 
DYRA_STAAU  (P13955), DYR_AEDAL   (P28019), DYR_BACSU   (P11045), 
DYR_BOVIN   (P00376), DYR_BPT4    (P04382), DYR_BUCAI   (P57243), 
DYR_BUCAP   (Q8K9Z8), DYR_BUCBP   (Q89AV2), DYR_CAEEL   (Q93341), 
DYR_CANAX   (P22906), DYR_CHICK   (P00378), DYR_CITFR   (P31073), 
DYR_CRYNJ   (Q07801), DYR_DROME   (P17719), DYR_ECOL6   (P0ABQ5), 
DYR_ECOLI   (P0ABQ4), DYR_ENTAE   (P31074), DYR_ENTFC   (P00380), 
DYR_HAEIN   (P43791), DYR_HALVD   (P15093), DYR_HELVI   (Q9U8B8), 
DYR_HUMAN   (P00374), DYR_LACCA   (P00381), DYR_LACLA   (Q59487), 
DYR_MESAU   (P04753), DYR_MOUSE   (P00375), DYR_MYCBO   (P0A547), 
DYR_MYCGE   (P47470), DYR_MYCLE   (Q9CBW1), DYR_MYCPN   (P78028), 
DYR_MYCPU   (Q98Q32), DYR_MYCTU   (P0A546), DYR_NEIGO   (P04174), 
DYR_NEIMA   (Q9JSQ9), DYR_NEIMB   (Q9K168), DYR_PIG     (P00377), 
DYR_PNECA   (P16184), DYR_RAT     (Q920D2), DYR_SCHPO   (P36591), 
DYR_SHIFL   (P0ABQ6), DYR_SHV21   (P09503), DYR_SHV24   (P27421), 
DYR_SHV2C   (P22573), DYR_STAAC   (Q5HFZ7), DYR_STAAM   (P0A016), 
DYR_STAAN   (P99079), DYR_STAAR   (Q6GGY1), DYR_STAAS   (Q6G9D5), 
DYR_STAAU   (P0A017), DYR_STAAW   (Q8NWQ9), DYR_STAEP   (P0C0P0), 
DYR_STAEQ   (Q5HPB1), DYR_STAES   (P0C0P1), DYR_STAHA   (Q54277), 
DYR_STRPN   (Q54801), DYR_YEAST   (P07807)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
DRTS_CRIFA  (Q23695), DRTS_MIMIV  (Q5UQG3), DYRL1_HUMAN (Q86XF0), 
DYR_ENCCU   (O62583), DYR_THEMA   (Q60034), DYR_UREPA   (Q9PR30)
False positive hits (sequences which do not belong to the set under consideration):
Y2900_MYCTU (P65408), Y2924_MYCBO (P65409)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]		1AI9; 1AO8; 1AOE; 1BOZ; 1BZF; 1CD2; 1DAJ; 1DDR; 1DDS; 1DF7; 1DG5; 1DG7; 1DG8; 1DHF; 1DIS; 1DIU; 1DLR; 1DR1; 1DR2; 1DR3; 1DR4; 1DR5; 1DR6; 1DR7; 1DRA; 1DRE; 1DRF; 1DRH; 1DYH; 1DYI; 1DYJ; 1DYR; 1E26; 1HFP; 1HFQ; 1HFR; 1IA1; 1IA2; 1IA3; 1IA4; 1J3I; 1J3J; 1J3K; 1JOL; 1JOM; 1JUV; 1KLK; 1KMS; 1KMV; 1LUD; 1LY3; 1LY4; 1M78; 1M79; 1M7A; 1MVS; 1MVT; 1OHJ; 1OHK; 1PD8; 1PD9; 1PDB; 1RA1; 1RA2; 1RA3; 1RA8; 1RA9; 1RB2; 1RB3; 1RC4; 1RD7; 1RE7; 1RF7; 1RG7; 1RH3; 1RX1; 1RX2; 1RX3; 1RX4; 1RX5; 1RX6; 1RX7; 1RX8; 1RX9; 1S3U; 1S3V; 1S3W; 1S3Y; 1TDR; 1U72; 1VDR; 1VJ3; 1YHO; 2ANO; 2ANQ; 2BL9; 2BLA; 2BLB; 2BLC; 2C2S; 2C2T; 2CD2; 2CIG; 2D0K; 2DHF; 2FZH; 2FZI; 2FZJ; 2H2Q; 2HM9; 2HQP; 2INQ; 2L28; 2W3A; 2W3B; 2W3M; 2W9G; 2W9H; 2W9S; 2W9T; 3CD2; 3CL9; 3CLB; 3D80; 3D84; 3DAU; 3DFR; 3DG8; 3DGA; 3DRC; 3EIG; 3F8Y; 3F8Z; 3F91; 3FRA; 3FRB; 3FRD; 3FRE; 3FRF; 3FS6; 3FY8; 3FY9; 3FYV; 3FYW; 3GHC; 3GHV; 3GHW; 3GI2; 3GYF; 3HBB; 3I8A; 3INV; 3IRM; 3IRN; 3IRO; 3IX9; 3K45; 3K47; 3K74; 3KFY; 3L3R; 3LG4; 3M08; 3M09; 3N0H; 3NTZ; 3NU0; 3NXO; 3NXR; 3NXT; 3NXV; 3NXX; 3NXY; 3NZ6; 3NZ9; 3NZA; 3NZB; 3NZC; 3NZD; 3OAF; 3OCH; 3QFX; 3QL3; 3QLR; 3QLS; 3QLW; 3RG9; 3S3V; 3S7A; 3SQY; 3SR5; 3SRQ; 3SRR; 3SRS; 3SRU; 3SRW; 4CD2; 4DFR; 7DFR; 8DFR;

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