Entry: PS00075

General information about the entry

Entry name [info] DHFR_1
Accession [info] PS00075
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); NOV-1997 (DATA UPDATE); JUN-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00072

Name and characterization of the entry

Description [info] Dihydrofolate reductase (DHFR) domain signature.
Pattern [info]
[LVAGC]-[LIF]-G-x(4)-[LIVMF]-P-W-x(4,5)-[DE]-x(3)-[FYIV]-x(3)-[STIQ].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_07 which contains 551'705 sequence entries.


Total number of hits 92 in 92 different sequences
Number of true positive hits 89 in 89 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 6
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 96.74 %
Recall (true positives / (true positives + false negatives)) 93.68 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
89 sequences

DRTS1_ARATH (Q05762    ), DRTS2_ARATH (Q05763    ), DRTS_DAUCA  (P45350    ), 
DRTS_LEIAM  (P16126    ), DRTS_LEIMA  (P07382    ), DRTS_MAIZE  (O81395    ), 
DRTS_ORYSJ  (Q2QRX6    ), DRTS_PARTE  (Q27828    ), DRTS_PLABA  (Q27713    ), 
DRTS_PLACH  (P20712    ), DRTS_PLAFK  (P13922    ), DRTS_PLAVI  (O02604    ), 
DRTS_PLAVN  (P46103    ), DRTS_SOYBN  (P51820    ), DRTS_TOXGO  (Q07422    ), 
DRTS_TRYBB  (Q27783    ), DRTS_TRYCR  (Q27793    ), DYR10_ECOLX (Q04515    ), 
DYR13_ECOLX (Q59408    ), DYR15_ECOLX (P78218    ), DYR1_ECOLX  (P00382    ), 
DYR1_HALMA  (Q5V3R2    ), DYR2_HALMA  (Q5V600    ), DYR3_SALTM  (P12833    ), 
DYR5_ECOLX  (P11731    ), DYR6_PROMI  (P95524    ), DYR7_ECOLX  (P27422    ), 
DYR8_ECOLX  (P0ABQ7    ), DYR8_SHISO  (P0ABQ8    ), DYR9_ECOLX  (Q59397    ), 
DYRA_HALVD  (P15093    ), DYRA_STAAU  (P13955    ), DYRB_HALVO  (Q9UWQ4    ), 
DYR_AEDAL   (P28019    ), DYR_BACSU   (P11045    ), DYR_BOVIN   (P00376    ), 
DYR_BPT4    (P04382    ), DYR_BUCAI   (P57243    ), DYR_BUCAP   (Q8K9Z8    ), 
DYR_BUCBP   (Q89AV2    ), DYR_CAEEL   (Q93341    ), DYR_CANAX   (P22906    ), 
DYR_CHICK   (P00378    ), DYR_CITFR   (P31073    ), DYR_CRYNJ   (Q07801    ), 
DYR_DROME   (P17719    ), DYR_ECOL6   (P0ABQ5    ), DYR_ECOLI   (P0ABQ4    ), 
DYR_ENTAE   (P31074    ), DYR_ENTFC   (P00380    ), DYR_HAEIN   (P43791    ), 
DYR_HELVI   (Q9U8B8    ), DYR_HHV8P   (Q2HRC6    ), DYR_HUMAN   (P00374    ), 
DYR_LACCA   (P00381    ), DYR_LACLA   (Q59487    ), DYR_MESAU   (P04753    ), 
DYR_MOUSE   (P00375    ), DYR_MYCBO   (P0A547    ), DYR_MYCGE   (P47470    ), 
DYR_MYCLE   (Q9CBW1    ), DYR_MYCPN   (P78028    ), DYR_MYCPU   (Q98Q32    ), 
DYR_MYCTO   (P9WNX0    ), DYR_MYCTU   (P9WNX1    ), DYR_NEIGO   (P04174    ), 
DYR_NEIMA   (Q9JSQ9    ), DYR_NEIMB   (Q9K168    ), DYR_PIG     (P00377    ), 
DYR_PNECA   (P16184    ), DYR_RAT     (Q920D2    ), DYR_SCHPO   (P36591    ), 
DYR_SHIFL   (P0ABQ6    ), DYR_SHV21   (P09503    ), DYR_SHV24   (P27421    ), 
DYR_SHV2C   (P22573    ), DYR_STAAC   (Q5HFZ7    ), DYR_STAAM   (P0A016    ), 
DYR_STAAN   (P99079    ), DYR_STAAR   (Q6GGY1    ), DYR_STAAS   (Q6G9D5    ), 
DYR_STAAU   (P0A017    ), DYR_STAAW   (Q8NWQ9    ), DYR_STAEP   (P0C0P0    ), 
DYR_STAEQ   (Q5HPB1    ), DYR_STAES   (P0C0P1    ), DYR_STAHA   (Q54277    ), 
DYR_STRPN   (Q54801    ), DYR_YEAST   (P07807    )
» more

UniProtKB/Swiss-Prot
False negative sequences
6 sequences

DRTS_CRIFA  (Q23695    ), DRTS_MIMIV  (Q5UQG3    ), DYRL1_HUMAN (Q86XF0    ), 
DYR_ENCCU   (O62583    ), DYR_THEMA   (Q60034    ), DYR_UREPA   (Q9PR30    )
» more

UniProtKB/Swiss-Prot
False positive sequences
3 sequences

Y2900_MYCTO (P9WJP8    ), Y2900_MYCTU (P9WJP9    ), Y2924_MYCBO (P65409    )

		
PDB
[Detailed view]
267 PDB

1AI9; 1AO8; 1AOE; 1BOZ; 1BZF; 1CD2; 1DAJ; 1DDR; 1DDS; 1DF7; 1DG5; 1DG7; 1DG8; 1DHF; 1DIS; 1DIU; 1DLR; 1DR1; 1DR2; 1DR3; 1DR4; 1DR5; 1DR6; 1DR7; 1DRA; 1DRE; 1DRF; 1DRH; 1DYH; 1DYI; 1DYJ; 1DYR; 1E26; 1HFP; 1HFQ; 1HFR; 1IA1; 1IA2; 1IA3; 1IA4; 1J3I; 1J3J; 1J3K; 1JOL; 1JOM; 1JUV; 1KLK; 1KMS; 1KMV; 1LUD; 1LY3; 1LY4; 1M78; 1M79; 1M7A; 1MVS; 1MVT; 1OHJ; 1OHK; 1PD8; 1PD9; 1PDB; 1RA1; 1RA2; 1RA3; 1RA8; 1RA9; 1RB2; 1RB3; 1RC4; 1RD7; 1RE7; 1RF7; 1RG7; 1RH3; 1RX1; 1RX2; 1RX3; 1RX4; 1RX5; 1RX6; 1RX7; 1RX8; 1RX9; 1S3U; 1S3V; 1S3W; 1S3Y; 1TDR; 1U72; 1VDR; 1VJ3; 1YHO; 2ANO; 2ANQ; 2BL9; 2BLA; 2BLB; 2BLC; 2C2S; 2C2T; 2CD2; 2CIG; 2D0K; 2DHF; 2FZH; 2FZI; 2FZJ; 2H2Q; 2HM9; 2HQP; 2INQ; 2L28; 2LF1; 2W3A; 2W3B; 2W3M; 2W9G; 2W9H; 2W9S; 2W9T; 3CD2; 3CL9; 3CLB; 3D80; 3D84; 3DAU; 3DFR; 3DG8; 3DGA; 3DRC; 3EIG; 3F8Y; 3F8Z; 3F91; 3FRA; 3FRB; 3FRD; 3FRE; 3FRF; 3FS6; 3FY8; 3FY9; 3FYV; 3FYW; 3GHC; 3GHV; 3GHW; 3GI2; 3GYF; 3HBB; 3I8A; 3INV; 3IRM; 3IRN; 3IRO; 3IX9; 3K45; 3K47; 3K74; 3KFY; 3L3R; 3LG4; 3M08; 3M09; 3N0H; 3NTZ; 3NU0; 3NXO; 3NXR; 3NXT; 3NXV; 3NXX; 3NXY; 3NZ6; 3NZ9; 3NZA; 3NZB; 3NZC; 3NZD; 3OAF; 3OCH; 3QFX; 3QL3; 3QLR; 3QLS; 3QLW; 3QYL; 3QYO; 3R33; 3RG9; 3S3V; 3S7A; 3SGY; 3SH2; 3SQY; 3SR5; 3SRQ; 3SRR; 3SRS; 3SRU; 3SRW; 3TD8; 4CD2; 4DDR; 4DFR; 4ECK; 4EIG; 4EIL; 4EIZ; 4EJ1; 4FGG; 4FGH; 4FHB; 4G8Z; 4G95; 4GH8; 4H95; 4H96; 4H97; 4HOE; 4HOF; 4I13; 4I1N; 4IXE; 4IXF; 4IXG; 4KAK; 4KBN; 4KD7; 4KEB; 4KFJ; 4KJJ; 4KJK; 4KJL; 4KL9; 4KLX; 4KM0; 4KM2; 4KNE; 4KY4; 4KYA; 4LAE; 4LAG; 4LAH; 4LEK; 4M2X; 4M6J; 4M6K; 4M6L; 4NX6; 4NX7; 4PDJ; 4QHV; 4QJC; 4QJZ; 4X5F; 4X5G; 4X5H; 4X5I; 4X5J; 4XE6; 4XEC; 5CC9; 5CCC; 7DFR; 8DFR
» more

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