Entry: PS00146

General information about the entry
Entry name BETA_LACTAMASE_A
Accession number PS00146
Entry type PATTERN
Date APR-1990 (CREATED); APR-2006 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation PDOC00134
Associated ProRule PRU10101
Name and characterization of the entry
DescriptionBeta-lactamase class-A active site.
Pattern [FY]-x-[LIVMFY]-{E}-S-[TV]-x-K-x(3)-{T}-[AGLM]-{D}-{KA}-[LC].
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052.
  • Total number of hits in UniProtKB/Swiss-Prot: 96 hits in 96 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 75 hits in 75 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 2 hits in 2 different sequences
  • Number of false hits (on unrelated proteins): 19 hits in 19 different sequences
  • Number of known missed hits: 6
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 1
  • Precision (true hits / (true hits + false positives)): 79.79 %
  • Recall (true hits / (true hits + false negatives)): 92.59 %
Comments
  • Taxonomic range: Prokaryotes (Bacteria)
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • `Interesting' site in the pattern: 5,active_site
  • VERSION: 2
Cross-references
UniProtKB/Swiss-Prot True positive hits:
BLA13_KLEPN (Q9S424), BLA1_ACTPL  (P67920), BLA1_AERHY  (Q44056), 
BLA1_BACCE  (P10424), BLA1_BACMY  (P28018), BLA1_ECOLX  (P0AD63), 
BLA1_ENTCL  (P18251), BLA1_HAEIF  (P67918), BLA1_KLEPN  (P0AD64), 
BLA1_PASHA  (P67919), BLA1_STRCI  (Q03680), BLA24_ECOLX (Q9S169), 
BLA29_KLEPN (Q9AHN9), BLA2_ECOLX  (P0A9Z7), BLA2_KLEPN  (P0A9Z8), 
BLA2_KLEPO  (P0A9Z9), BLA2_SALTM  (P0AA00), BLA2_STEMA  (P96465), 
BLA2_STRCI  (P14560), BLA34_ECOLX (Q93LM8), BLA3_BACCE  (P06548), 
BLA3_KLEPN  (P30896), BLA46_KLEOX (Q848S4), BLA4_KLEPN  (P37323), 
BLA5_KLEPN  (P0A3M1), BLA5_PSEAI  (P0A3M2), BLA6_KLEPN  (P96348), 
BLA8_ECOLX  (O08337), BLAB_PROVU  (P52664), BLAC_BACAM  (Q44674), 
BLAC_BACCE  (P00809), BLAC_BACLI  (P00808), BLAC_BACSU  (P39824), 
BLAC_BACTU  (Q45726), BLAC_BACUN  (P30898), BLAC_BACVU  (P30899), 
BLAC_CITDI  (P22390), BLAC_KLEPN  (P05192), BLAC_MYCBO  (P0A5I7), 
BLAC_MYCTA  (A5U493), BLAC_MYCTU  (P0C5C1), BLAC_NOCAS  (Q9EZQ7), 
BLAC_NOCFA  (Q5YXD6), BLAC_NOCLA  (Q06316), BLAC_PROMI  (P30897), 
BLAC_PROVU  (P80298), BLAC_RHOCA  (P14171), BLAC_STAAU  (P00807), 
BLAC_STRAL  (P14559), BLAC_STRAU  (P10509), BLAC_STRBA  (P35391), 
BLAC_STRCE  (Q06650), BLAC_STRLA  (P35393), BLAC_YEREN  (Q01166), 
BLAF_MYCFO  (Q59517), BLAT_ECOLX  (P62593), BLAT_KLEOX  (Q48406), 
BLAT_SALTI  (P62594), BLC1_ECOLX  (P28585), BLC2_SALTM  (P74841), 
BLC3_PSEAI  (P37322), BLC4_PSEAI  (Q51355), BLC4_SALTM  (O33807), 
BLC5_SALTM  (O65975), BLC6_SALTM  (O65976), BLC6_VIBCL  (P81781), 
BLC97_ECOLX (E1ANH6), BLE1_PSEAI  (P37321), BLO1_KLEOX  (P22391), 
BLO2_KLEOX  (P23954), BLP1_PSEAI  (Q03170), BLP4_PSEAI  (P16897), 
BLT1_ECOLX  (Q47066), BLT2_ECOLX  (O69395), ESTB_BURGA  (Q9KX40)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
BLAC_SERFO  (P80545), BLAC_STRFR  (P35392), BLAN_ENTCL  (P52663), 
BLAN_SERMA  (P52682), BLKPC_KLEOX (Q848S6), BLKPC_KLEPN (Q9F663)
`Potential' hits (partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences):
BLAC_STRGR  (P81173)
Sequences which could potentially belong to the set under consideration:
FIMDD_DICNO (P17420), FIMDH_DICNO (P17421)
False positive hits (sequences which do not belong to the set under consideration):
GLSA2_YERPE (Q9ZC49), GLSA_SYNY3  (P73903), MYO7B_MOUSE (Q99MZ6), 
NRT25_ARATH (Q9LPV5), PH11A_MOUSE (Q8BVM9), PH11L_RAT   (Q5I0J8), 
PHF11_MOUSE (A6H5X4), PHF11_RAT   (Q5I0E2), PHF1_ARATH  (Q8GYE0), 
PORA_BACPM  (B5CY96), PP244_ARATH (Q9LT48), PP448_ARATH (Q9FJY9), 
PPR83_ARATH (Q9FXA9), RR2_EUGGR   (P30389), RSMH_MESFL  (Q6F170), 
SRP72_DICDI (Q54EP7), UTP17_SCHPO (O13878), Y0701_DICDI (Q559T8), 
Y2899_ARATH (O81069)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]		 1ALQ; 1AXB; 1BLC; 1BLH; 1BLP; 1BSG; 1BT5; 1BTL; 1BZA; 1CI8; 1CI9; 1CK3; 1E25; 1ERM; 1ERO; 1ERQ; 1ESU; 1FQG; 1G68; 1G6A; 1GHI; 1GHM; 1GHP; 1HZO; 1I2S; 1I2W; 1IYO; 1IYP; 1IYQ; 1IYS; 1JTD; 1JTG; 1JVJ; 1JWP; 1JWV; 1JWZ; 1KGE; 1KGF; 1KGG; 1LHY; 1LI0; 1LI9; 1M40; 1MBL; 1N9B; 1NXY; 1NY0; 1NYM; 1NYY; 1OME; 1ONG; 1PIO; 1PZO; 1PZP; 1Q2P; 1RCJ; 1S0W; 1SHV; 1TDG; 1TDL; 1TEM; 1VM1; 1W7F; 1WE4; 1XPB; 1XXM; 1YT4; 1ZG4; 2A3U; 2A49; 2B5R; 2BLM; 2CC1; 2CN9; 2G2U; 2G2W; 2GDN; 2H0T; 2H0Y; 2H10; 2H5S; 2V1Z; 2V20; 2WK0; 2WYX; 2XQZ; 2XR0; 2ZD8; 2ZQ7; 2ZQ8; 2ZQ9; 2ZQA; 2ZQC; 2ZQD; 3B3X; 3BLM; 3BYD; 3C4O; 3C4P; 3C7U; 3C7V; 3CG5; 3CMZ; 3D4F; 3DTM; 3DWZ; 3IQA; 3JYI; 3LY3; 3LY4; 3M2J; 3M2K; 3M6B; 3M6H; 3MKE; 3MKF; 3MXR; 3MXS; 3N4I; 3N6I; 3N7W; 3N8L; 3N8R; 3N8S; 3NBL; 3NC8; 3NCK; 3NDE; 3NDG; 3OPH; 3OPL; 3OPP; 3OPR; 3SH7; 3SH8; 3SH9; 3SOI; 3TOI; 3V50; 3V5M; 3VFF; 3VFH; 4BD0; 4BD1; 4BLM; 4DF6; 4DXB; 4DXC; 4FCF; 4FH4; 4GKU;

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