ID   TOPO_IB_1; PATTERN.
AC   PS00176;
DT   01-APR-1990 CREATED; 01-NOV-1997 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
DE   Topoisomerase (Topo) IB-type active site signature.
PA   [DEN]-x(6)-[GS]-[IT]-S-K-x(2)-Y-[LIVM]-x(3)-[LIVM].
NR   /RELEASE=2024_02,571282;
NR   /TOTAL=27(27); /POSITIVE=25(25); /UNKNOWN=0(0); /FALSE_POS=2(2);
NR   /FALSE_NEG=3; /PARTIAL=0;
CC   /TAXO-RANGE=??E?V; /MAX-REPEAT=1;
CC   /SITE=8,active_site;
CC   /VERSION=1;
DR   P30181    , TOP1A_ARATH, T; Q9FJ79    , TOP1B_ARATH, T;
DR   Q969P6    , TOP1M_HUMAN, T; A9Q1D5    , TOP1M_PANTR, T;
DR   O17966    , TOP1_CAEEL , T; A0A0L0P4F8, TOP1_CANAR , T;
DR   Q00313    , TOP1_CANAX , T; Q7YR26    , TOP1_CHLAE , T;
DR   Q07050    , TOP1_CRIGR , T; P93119    , TOP1_DAUCA , T;
DR   Q54RC3    , TOP1_DICDI , T; P30189    , TOP1_DROME , T;
DR   P11387    , TOP1_HUMAN , T; A0A7H0DN83, TOP1_MONPV , T;
DR   Q04750    , TOP1_MOUSE , T; Q9WUL0    , TOP1_RAT   , T;
DR   P16472    , TOP1_RFVKA , T; P07799    , TOP1_SCHPO , T;
DR   P41511    , TOP1_USTMA , T; Q76ZS7    , TOP1_VACCA , T;
DR   P68697    , TOP1_VACCC , T; P68698    , TOP1_VACCW , T;
DR   P32989    , TOP1_VAR67 , T; P41512    , TOP1_XENLA , T;
DR   P04786    , TOP1_YEAST , T;
DR   Q7T6X9    , TOP1E_MIMIV, N; Q8R4U6    , TOP1M_MOUSE, N;
DR   Q6IM78    , TOP1M_RAT  , N;
DR   Q66431    , L_DUGBA    , F; O14304    , YE88_SCHPO , F;
3D   1A31; 1A41; 1K4S; 1K4T; 1NH3; 1RR8; 1RRJ; 1SC7; 1SEU; 1T8I; 1TL8; 2H7F;
3D   2H7G; 3IGC;
PR   PRU10130;
DO   PDOC00159;
//