Entry: PS00177
General information about the entry
Entry nameTOPOISOMERASE_II
Accession numberPS00177
Entry typePATTERN
DateAPR-1990 (CREATED); DEC-2004 (DATA UPDATE); DEC-2011 (INFO UPDATE).
PROSITE DocumentationPDOC00160
Name and characterization of the entry
DescriptionDNA topoisomerase II signature.
Pattern[LIVMA]-{R}-E-G-[DN]-S-A-{F}-[STAG].
Numerical results
  • UniProtKB/Swiss-Prot release number: 01, total number of sequence entries in that release: 534242.
  • Total number of hits in UniProtKB/Swiss-Prot: 174 hits in 174 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 161 hits in 161 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 13 hits in 13 different sequences
  • Number of known missed hits: 3
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 3
  • Precision (true hits / (true hits + false positives)): 92.53 %
  • Recall (true hits / (true hits + false negatives)): 98.17 %
Comments
  • Taxonomic range: Archaebacteria, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • VERSION: 1
Cross-references
UniProtKB/Swiss-ProtTrue positive hits:
GYRBM_ARATH (Q94BZ7), GYRBP_ARATH (Q9SS38), GYRBR_STRSH (P50074), 
GYRBS_STRSH (P50075), GYRB_ACIBA  (Q43907), GYRB_ACICA  (Q43947), 
GYRB_ACIG3  (Q44270), GYRB_ACIG6  (Q44271), GYRB_ACIG9  (Q44272), 
GYRB_ACIGA  (Q44273), GYRB_ACIGB  (Q44274), GYRB_ACIHA  (Q44065), 
GYRB_ACIJO  (Q44081), GYRB_ACIJU  (Q44080), GYRB_ACILW  (Q44088), 
GYRB_ACIS6  (Q44277), GYRB_ACIS8  (Q44275), GYRB_ACIS9  (Q44276), 
GYRB_AQUAE  (O67137), GYRB_BACAN  (Q9X3Y6), GYRB_BACCE  (Q9X3Y3), 
GYRB_BACHD  (O50627), GYRB_BACMY  (Q9X3Y5), GYRB_BACSU  (P05652), 
GYRB_BARBK  (P94281), GYRB_BORBU  (P33769), GYRB_BORHE  (Q9ZFK1), 
GYRB_BUCAI  (P57126), GYRB_BUCAP  (P29435), GYRB_BUCBP  (Q89B37), 
GYRB_CAMJE  (O87667), GYRB_CAUCN  (B8GXQ0), GYRB_CAUCR  (P0CAX1), 
GYRB_CHIJA  (Q9FAX2), GYRB_CHLMU  (Q9PKK3), GYRB_CHLPN  (Q9Z8R3), 
GYRB_CHLTR  (O84193), GYRB_CLOAB  (P94604), GYRB_CYTAU  (Q9LCK0), 
GYRB_CYTHU  (Q9LCK1), GYRB_ECO57  (P0AES7), GYRB_ECOLI  (P0AES6), 
GYRB_FLEEL  (Q9FAX1), GYRB_HAEIN  (P43701), GYRB_HALL2  (P21558), 
GYRB_HALVD  (D4GZ01), GYRB_HELPJ  (Q9ZLX3), GYRB_HELPY  (P55992), 
GYRB_MYCAT  (Q9ZAQ6), GYRB_MYCCT  (P50028), GYRB_MYCGA  (P47720), 
GYRB_MYCGE  (P47249), GYRB_MYCHP  (P43053), GYRB_MYCLE  (Q59533), 
GYRB_MYCPA  (Q9L7L3), GYRB_MYCPN  (P22447), GYRB_MYCS2  (A0QNE0), 
GYRB_MYCSM  (P0C559), GYRB_MYCTA  (A5TY73), GYRB_MYCTU  (P0C5C5), 
GYRB_MYXXA  (O33367), GYRB_NEIGO  (P22118), GYRB_NICBE  (Q5YLB4), 
GYRB_ORYSJ  (Q5NBJ3), GYRB_PSEAE  (Q9I7C2), GYRB_PSEPU  (P13364), 
GYRB_RICBR  (Q1RHT8), GYRB_RICCN  (Q92H87), GYRB_RICFE  (Q4UKX5), 
GYRB_RICPR  (Q9ZCX2), GYRB_RICTY  (Q68WF6), GYRB_SALTI  (P0A2I4), 
GYRB_SALTY  (P0A2I3), GYRB_SHIFL  (P0AES8), GYRB_SPICI  (P34031), 
GYRB_STAA3  (Q2FKQ1), GYRB_STAAC  (Q5HJZ1), GYRB_STAAM  (P66936), 
GYRB_STAAN  (P66937), GYRB_STAAR  (Q6GKU0), GYRB_STAAS  (Q6GD85), 
GYRB_STAAU  (P0A0K8), GYRB_STAAW  (P0A0K7), GYRB_STAEQ  (Q5HK03), 
GYRB_STAES  (Q8CQK4), GYRB_STRCO  (P35886), GYRB_STRP1  (Q9A0L0), 
GYRB_STRP3  (P0DG04), GYRB_STRP6  (Q5XD05), GYRB_STRP8  (Q8P1M4), 
GYRB_STRPN  (P0A4L9), GYRB_STRPQ  (P0DG05), GYRB_STRR6  (P0A4M0), 
GYRB_SYNY3  (P77966), GYRB_THEMA  (P77993), GYRB_TREDE  (O87545), 
GYRB_TREPA  (O08399), GYRB_VIBCH  (Q9KVX3), GYRB_VIBPA  (O51859), 
PARE_BACSU  (Q59192), PARE_BORBU  (Q59189), PARE_CAUCR  (O54479), 
PARE_ECOLI  (P20083), PARE_HAEIN  (P43703), PARE_MYCGA  (Q59526), 
PARE_MYCGE  (P47445), PARE_MYCPN  (P78016), PARE_PSEAE  (Q9HUJ8), 
PARE_RICBR  (Q1RK03), PARE_RICCN  (Q92IW1), PARE_RICFE  (Q4UKT4), 
PARE_RICPR  (Q9ZDU7), PARE_RICTY  (Q68XE1), PARE_SALTI  (P0A2I6), 
PARE_SALTY  (P0A2I5), PARE_STAA8  (Q2FYS5), PARE_STAAC  (Q5HG65), 
PARE_STAAM  (P66938), PARE_STAAN  (P66939), PARE_STAAR  (Q6GH51), 
PARE_STAAS  (Q6G9K5), PARE_STAAU  (P0C1S7), PARE_STAAW  (P0A0K9), 
PARE_STAEQ  (Q5HPI6), PARE_STAES  (Q8CSN9), PARE_STRPN  (Q59961), 
TOP2A_CHICK (O42130), TOP2A_CRIGR (P41515), TOP2A_HUMAN (P11388), 
TOP2A_MOUSE (Q01320), TOP2A_PIG   (O46374), TOP2A_RAT   (P41516), 
TOP2B_CHICK (O42131), TOP2B_CRILO (Q64399), TOP2B_HUMAN (Q02880), 
TOP2B_MOUSE (Q64511), TOP2M_CAEEL (P34534), TOP2M_DICDI (P90520), 
TOP2_ARATH  (P30182), TOP2_ASFB7  (Q00942), TOP2_ASFK5  (P0C9C2), 
TOP2_ASFM2  (P34203), TOP2_ASFP4  (P0C9C0), TOP2_ASFWA  (P0C9C1), 
TOP2_BOMMO  (O16140), TOP2_CAEEL  (Q23670), TOP2_CANGA  (O93794), 
TOP2_CRIFA  (P27570), TOP2_DICDI  (Q55BP5), TOP2_DROME  (P15348), 
TOP2_LEICH  (O61078), TOP2_MIMIV  (Q5UQE6), TOP2_PEA    (O24308), 
TOP2_PENCH  (Q9Y8G8), TOP2_PLAFK  (P41001), TOP2_SCHPO  (P08096), 
TOP2_TRYBB  (P12531), TOP2_TRYCR  (P30190), TOP2_YEAST  (P06786), 
TOPL_BPT4   (P09176), Y457_MYCS2  (A0QPN2)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
GYRB_ARCFU  (O29720), TOP2_CANAX  (P87078), TOP2_PICGU  (Q01879)
`Potential' hits (partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences):
GYRB_ACIS7  (Q44278), GYRB_PROMI  (P22840), GYRB_RHOCA  (P31860)
False positive hits (sequences which do not belong to the set under consideration):
ASTD_BURXL  (Q141D3), CIPK6_ORYSJ (Q6Z9F4), DDL_CUPNH   (Q0K6M6), 
DOM_DROME   (Q9NDJ2), FCJ1_DEBHA  (Q6BXM9), NACA_DANRE  (Q8JIU7), 
RPOA_METCA  (Q605D7), SECA_HALHL  (A1WYM9), SEPT9_MOUSE (Q80UG5), 
SEPT9_RAT   (Q9QZR6), XTH9_ARATH  (Q8LDW9), Y1130_XYLFA (Q9PE98), 
Y419_XYLFT  (Q87E99)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]
1BGW; 1BJT; 1LWZ; 2RGR; 2XCO; 2XCQ; 2XCR; 2XCS; 2XCT; 3FOE; 3FOF; 3K9F; 3KSA; 3KSB; 3L4J; 3L4K; 3LTN; 3NUH; 3QX3;

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission


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