Entry: PS00177

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General information about the entry

Entry name [info] TOPOISOMERASE_II
Accession [info] PS00177
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); DEC-2004 (DATA UPDATE); MAR-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00160

Name and characterization of the entry

Description [info] DNA topoisomerase II signature.
Pattern [info]
[LIVMA]-{R}-E-G-[DN]-S-A-{F}-[STAG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_04 which contains 544'996 sequence entries.


Total number of hits 175 in 175 different sequences
Number of true positive hits 162 in 162 different sequences
Number of 'unknown' hits
Number of false positive hits 13 in 13 different sequences
Number of false negative sequences 3
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 92.57 %
Recall (true positives / (true positives + false negatives)) 98.18 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
162 sequences

GYRB1_ACILW (Q44088), GYRB2_ACILW (Q44272), GYRBM_ARATH (Q94BZ7), 
GYRBP_ARATH (Q9SS38), GYRBR_STRNV (P50074), GYRBS_STRNV (P50075), 
GYRB_ACIBA  (Q43907), GYRB_ACIBZ  (Q44273), GYRB_ACICA  (Q43947), 
GYRB_ACIG6  (Q44271), GYRB_ACIGI  (Q44274), GYRB_ACIHA  (Q44065), 
GYRB_ACIJO  (Q44081), GYRB_ACIJU  (Q44080), GYRB_ACIPI  (Q44270), 
GYRB_ACIS6  (Q44277), GYRB_ACIS8  (Q44275), GYRB_ACIS9  (Q44276), 
GYRB_AQUAE  (O67137), GYRB_BACAN  (Q9X3Y6), GYRB_BACCE  (Q9X3Y3), 
GYRB_BACHD  (O50627), GYRB_BACMY  (Q9X3Y5), GYRB_BACSU  (P05652), 
GYRB_BORBU  (P33769), GYRB_BORHE  (Q9ZFK1), GYRB_BUCAI  (P57126), 
GYRB_BUCAP  (P29435), GYRB_BUCBP  (Q89B37), GYRB_CAMJE  (O87667), 
GYRB_CAUCN  (B8GXQ0), GYRB_CAUCR  (P0CAX1), GYRB_CHIJA  (Q9FAX2), 
GYRB_CHLMU  (Q9PKK3), GYRB_CHLPN  (Q9Z8R3), GYRB_CHLTR  (O84193), 
GYRB_CLOAB  (P94604), GYRB_CYTAU  (Q9LCK0), GYRB_CYTHU  (Q9LCK1), 
GYRB_ECO57  (P0AES7), GYRB_ECOLI  (P0AES6), GYRB_FLEEL  (Q9FAX1), 
GYRB_HAEIN  (P43701), GYRB_HALL2  (P21558), GYRB_HALVD  (D4GZ01), 
GYRB_HELPJ  (Q9ZLX3), GYRB_HELPY  (P55992), GYRB_MYCAT  (Q9ZAQ6), 
GYRB_MYCCT  (P50028), GYRB_MYCGA  (P47720), GYRB_MYCGE  (P47249), 
GYRB_MYCHP  (P43053), GYRB_MYCLE  (Q59533), GYRB_MYCPA  (Q9L7L3), 
GYRB_MYCPN  (P22447), GYRB_MYCS2  (A0QNE0), GYRB_MYCSM  (P0C559), 
GYRB_MYCTA  (A5TY73), GYRB_MYCTO  (P9WG44), GYRB_MYCTU  (P9WG45), 
GYRB_MYXXA  (O33367), GYRB_NEIGO  (P22118), GYRB_NICBE  (Q5YLB4), 
GYRB_ORYSJ  (Q5NBJ3), GYRB_PSEAE  (Q9I7C2), GYRB_PSEPU  (P13364), 
GYRB_RICBR  (Q1RHT8), GYRB_RICCN  (Q92H87), GYRB_RICFE  (Q4UKX5), 
GYRB_RICPR  (Q9ZCX2), GYRB_RICTY  (Q68WF6), GYRB_SALTI  (P0A2I4), 
GYRB_SALTY  (P0A2I3), GYRB_SHIFL  (P0AES8), GYRB_SPICI  (P34031), 
GYRB_STAA3  (Q2FKQ1), GYRB_STAAC  (Q5HJZ1), GYRB_STAAM  (P66936), 
GYRB_STAAN  (P66937), GYRB_STAAR  (Q6GKU0), GYRB_STAAS  (Q6GD85), 
GYRB_STAAU  (P0A0K8), GYRB_STAAW  (P0A0K7), GYRB_STAEQ  (Q5HK03), 
GYRB_STAES  (Q8CQK4), GYRB_STRCO  (P35886), GYRB_STRP1  (Q9A0L0), 
GYRB_STRP3  (P0DG04), GYRB_STRP6  (Q5XD05), GYRB_STRP8  (Q8P1M4), 
GYRB_STRPN  (P0A4L9), GYRB_STRPQ  (P0DG05), GYRB_STRR6  (P0A4M0), 
GYRB_SYNY3  (P77966), GYRB_THEMA  (P77993), GYRB_TREDE  (O87545), 
GYRB_TREPA  (O08399), GYRB_VIBCH  (Q9KVX3), GYRB_VIBPA  (O51859), 
PARE_BACSU  (Q59192), PARE_BARBK  (P94281), PARE_BORBU  (Q59189), 
PARE_CAUCR  (O54479), PARE_ECOLI  (P20083), PARE_HAEIN  (P43703), 
PARE_MYCGA  (Q59526), PARE_MYCGE  (P47445), PARE_MYCPN  (P78016), 
PARE_PSEAE  (Q9HUJ8), PARE_RICBR  (Q1RK03), PARE_RICCN  (Q92IW1), 
PARE_RICFE  (Q4UKT4), PARE_RICPR  (Q9ZDU7), PARE_RICTY  (Q68XE1), 
PARE_SALTI  (P0A2I6), PARE_SALTY  (P0A2I5), PARE_STAA8  (Q2FYS5), 
PARE_STAAC  (Q5HG65), PARE_STAAM  (P66938), PARE_STAAN  (P66939), 
PARE_STAAR  (Q6GH51), PARE_STAAS  (Q6G9K5), PARE_STAAU  (P0C1S7), 
PARE_STAAW  (P0A0K9), PARE_STAEQ  (Q5HPI6), PARE_STAES  (Q8CSN9), 
PARE_STRPN  (Q59961), TOP2A_CHICK (O42130), TOP2A_CRIGR (P41515), 
TOP2A_HUMAN (P11388), TOP2A_MOUSE (Q01320), TOP2A_PIG   (O46374), 
TOP2A_RAT   (P41516), TOP2B_CHICK (O42131), TOP2B_CRILO (Q64399), 
TOP2B_HUMAN (Q02880), TOP2B_MOUSE (Q64511), TOP2M_CAEEL (P34534), 
TOP2M_DICDI (P90520), TOP2_ARATH  (P30182), TOP2_ASFB7  (Q00942), 
TOP2_ASFK5  (P0C9C2), TOP2_ASFM2  (P34203), TOP2_ASFP4  (P0C9C0), 
TOP2_ASFWA  (P0C9C1), TOP2_BOMMO  (O16140), TOP2_CAEEL  (Q23670), 
TOP2_CANGA  (O93794), TOP2_CRIFA  (P27570), TOP2_DICDI  (Q55BP5), 
TOP2_DROME  (P15348), TOP2_LEICH  (O61078), TOP2_MIMIV  (Q5UQE6), 
TOP2_PEA    (O24308), TOP2_PENCH  (Q9Y8G8), TOP2_PLAFK  (P41001), 
TOP2_SCHPO  (P08096), TOP2_TRYBB  (P12531), TOP2_TRYCR  (P30190), 
TOP2_YEAST  (P06786), TOPL_BPT4   (P09176), Y457_MYCS2  (A0QPN2)
» More

UniProtKB/Swiss-Prot
False negative sequences
3 sequences

GYRB_ARCFU  (O29720), TOP2_CANAX  (P87078), TOP2_PICGU  (Q01879)

		
UniProtKB/Swiss-Prot
'Partial' sequences
3 sequences

GYRB_ACIS7  (Q44278), GYRB_PROMI  (P22840), GYRB_RHOCA  (P31860)

		
UniProtKB/Swiss-Prot
False positive sequences
13 sequences

ASTD_BURXL  (Q141D3), CIPK6_ORYSJ (Q6Z9F4), DDL_CUPNH   (Q0K6M6), 
DOM_DROME   (Q9NDJ2), FCJ1_DEBHA  (Q6BXM9), NACA_DANRE  (Q8JIU7), 
RPOA_METCA  (Q605D7), SECA_HALHL  (A1WYM9), SEPT9_MOUSE (Q80UG5), 
SEPT9_RAT   (Q9QZR6), XTH9_ARATH  (Q8LDW9), Y1130_XYLFA (Q9PE98), 
Y419_XYLFT  (Q87E99)
» More

PDB
[Detailed view]
29 PDB

1BGW; 1BJT; 2RGR; 2XCO; 2XCQ; 2XCR; 2XCS; 2XCT; 3FOE; 3FOF; 3K9F; 3KSA; 3KSB; 3L4J; 3L4K; 3LTN; 3NUH; 3QX3; 3RAD; 3RAE; 3RAF; 4BUL; 4FM9; 4G0U; 4G0V; 4G0W; 4GFH; 4J3N; 4JUO
» More

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