Entry: PS00177

General information about the entry

Entry name [info] TOPOISOMERASE_II
Accession [info] PS00177
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); DEC-2004 (DATA UPDATE); MAY-2015 (INFO UPDATE).
PROSITE Doc. [info] PDOC00160

Name and characterization of the entry

Description [info] DNA topoisomerase II signature.
Pattern [info]
[LIVMA]-{R}-E-G-[DN]-S-A-{F}-[STAG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2015_07 which contains 548'872 sequence entries.


Total number of hits 175 in 175 different sequences
Number of true positive hits 162 in 162 different sequences
Number of 'unknown' hits 0
Number of false positive hits 13 in 13 different sequences
Number of false negative sequences 3
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 92.57 %
Recall (true positives / (true positives + false negatives)) 98.18 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
162 sequences

GYRB1_ACILW (Q44088), GYRB2_ACILW (Q44272), GYRBM_ARATH (Q94BZ7), 
GYRBP_ARATH (Q9SS38), GYRBR_STRNV (P50074), GYRBS_STRNV (P50075), 
GYRB_ACIBA  (Q43907), GYRB_ACIBZ  (Q44273), GYRB_ACICA  (Q43947), 
GYRB_ACIG6  (Q44271), GYRB_ACIGI  (Q44274), GYRB_ACIHA  (Q44065), 
GYRB_ACIJO  (Q44081), GYRB_ACIJU  (Q44080), GYRB_ACIPI  (Q44270), 
GYRB_ACIS6  (Q44277), GYRB_ACIS8  (Q44275), GYRB_ACIS9  (Q44276), 
GYRB_AQUAE  (O67137), GYRB_BACAN  (Q9X3Y6), GYRB_BACCE  (Q9X3Y3), 
GYRB_BACHD  (O50627), GYRB_BACMY  (Q9X3Y5), GYRB_BACSU  (P05652), 
GYRB_BORBU  (P33769), GYRB_BORHE  (Q9ZFK1), GYRB_BUCAI  (P57126), 
GYRB_BUCAP  (P29435), GYRB_BUCBP  (Q89B37), GYRB_CAMJE  (O87667), 
GYRB_CAUCN  (B8GXQ0), GYRB_CAUCR  (P0CAX1), GYRB_CHIJA  (Q9FAX2), 
GYRB_CHLMU  (Q9PKK3), GYRB_CHLPN  (Q9Z8R3), GYRB_CHLTR  (O84193), 
GYRB_CLOAB  (P94604), GYRB_CYTAU  (Q9LCK0), GYRB_CYTHU  (Q9LCK1), 
GYRB_ECO57  (P0AES7), GYRB_ECOLI  (P0AES6), GYRB_FLEEL  (Q9FAX1), 
GYRB_HAEIN  (P43701), GYRB_HALL2  (P21558), GYRB_HALVD  (D4GZ01), 
GYRB_HELPJ  (Q9ZLX3), GYRB_HELPY  (P55992), GYRB_MYCAT  (Q9ZAQ6), 
GYRB_MYCCT  (P50028), GYRB_MYCGA  (P47720), GYRB_MYCGE  (P47249), 
GYRB_MYCHP  (P43053), GYRB_MYCLE  (Q59533), GYRB_MYCPA  (Q9L7L3), 
GYRB_MYCPN  (P22447), GYRB_MYCS2  (A0QNE0), GYRB_MYCSM  (P0C559), 
GYRB_MYCTA  (A5TY73), GYRB_MYCTO  (P9WG44), GYRB_MYCTU  (P9WG45), 
GYRB_MYXXA  (O33367), GYRB_NEIGO  (P22118), GYRB_NICBE  (Q5YLB4), 
GYRB_ORYSJ  (Q5NBJ3), GYRB_PSEAE  (Q9I7C2), GYRB_PSEPU  (P13364), 
GYRB_RICBR  (Q1RHT8), GYRB_RICCN  (Q92H87), GYRB_RICFE  (Q4UKX5), 
GYRB_RICPR  (Q9ZCX2), GYRB_RICTY  (Q68WF6), GYRB_SALTI  (P0A2I4), 
GYRB_SALTY  (P0A2I3), GYRB_SHIFL  (P0AES8), GYRB_SPICI  (P34031), 
GYRB_STAA3  (Q2FKQ1), GYRB_STAAC  (Q5HJZ1), GYRB_STAAM  (P66936), 
GYRB_STAAN  (P66937), GYRB_STAAR  (Q6GKU0), GYRB_STAAS  (Q6GD85), 
GYRB_STAAU  (P0A0K8), GYRB_STAAW  (P0A0K7), GYRB_STAEQ  (Q5HK03), 
GYRB_STAES  (Q8CQK4), GYRB_STRCO  (P35886), GYRB_STRP1  (Q9A0L0), 
GYRB_STRP3  (P0DG04), GYRB_STRP6  (Q5XD05), GYRB_STRP8  (Q8P1M4), 
GYRB_STRPN  (P0A4L9), GYRB_STRPQ  (P0DG05), GYRB_STRR6  (P0A4M0), 
GYRB_SYNY3  (P77966), GYRB_THEMA  (P77993), GYRB_TREDE  (O87545), 
GYRB_TREPA  (O08399), GYRB_VIBCH  (Q9KVX3), GYRB_VIBPA  (O51859), 
PARE_BACSU  (Q59192), PARE_BARBK  (P94281), PARE_BORBU  (Q59189), 
PARE_CAUCR  (O54479), PARE_ECOLI  (P20083), PARE_HAEIN  (P43703), 
PARE_MYCGA  (Q59526), PARE_MYCGE  (P47445), PARE_MYCPN  (P78016), 
PARE_PSEAE  (Q9HUJ8), PARE_RICBR  (Q1RK03), PARE_RICCN  (Q92IW1), 
PARE_RICFE  (Q4UKT4), PARE_RICPR  (Q9ZDU7), PARE_RICTY  (Q68XE1), 
PARE_SALTI  (P0A2I6), PARE_SALTY  (P0A2I5), PARE_STAA8  (Q2FYS5), 
PARE_STAAC  (Q5HG65), PARE_STAAM  (P66938), PARE_STAAN  (P66939), 
PARE_STAAR  (Q6GH51), PARE_STAAS  (Q6G9K5), PARE_STAAU  (P0C1S7), 
PARE_STAAW  (P0A0K9), PARE_STAEQ  (Q5HPI6), PARE_STAES  (Q8CSN9), 
PARE_STRPN  (Q59961), TOP2A_CHICK (O42130), TOP2A_CRIGR (P41515), 
TOP2A_HUMAN (P11388), TOP2A_MOUSE (Q01320), TOP2A_PIG   (O46374), 
TOP2A_RAT   (P41516), TOP2B_CHICK (O42131), TOP2B_CRILO (Q64399), 
TOP2B_HUMAN (Q02880), TOP2B_MOUSE (Q64511), TOP2M_CAEEL (P34534), 
TOP2M_DICDI (P90520), TOP2_ARATH  (P30182), TOP2_ASFB7  (Q00942), 
TOP2_ASFK5  (P0C9C2), TOP2_ASFM2  (P34203), TOP2_ASFP4  (P0C9C0), 
TOP2_ASFWA  (P0C9C1), TOP2_BOMMO  (O16140), TOP2_CAEEL  (Q23670), 
TOP2_CANGA  (O93794), TOP2_CRIFA  (P27570), TOP2_DICDI  (Q55BP5), 
TOP2_DROME  (P15348), TOP2_LEICH  (O61078), TOP2_MIMIV  (Q5UQE6), 
TOP2_PEA    (O24308), TOP2_PENCH  (Q9Y8G8), TOP2_PLAFK  (P41001), 
TOP2_SCHPO  (P08096), TOP2_TRYBB  (P12531), TOP2_TRYCR  (P30190), 
TOP2_YEAST  (P06786), TOPL_BPT4   (P09176), Y457_MYCS2  (A0QPN2)
» More

UniProtKB/Swiss-Prot
False negative sequences
3 sequences

GYRB_ARCFU  (O29720), TOP2_CANAX  (P87078), TOP2_PICGU  (Q01879)

		
UniProtKB/Swiss-Prot
'Partial' sequences
3 sequences

GYRB_ACIS7  (Q44278), GYRB_PROMI  (P22840), GYRB_RHOCA  (P31860)

		
UniProtKB/Swiss-Prot
False positive sequences
13 sequences

ASTD_BURXL  (Q141D3), CIPK6_ORYSJ (Q6Z9F4), DDL_CUPNH   (Q0K6M6), 
DOM_DROME   (Q9NDJ2), MIC60_DEBHA (Q6BXM9), NACA_DANRE  (Q8JIU7), 
RPOA_METCA  (Q605D7), SECA_HALHL  (A1WYM9), SEPT9_MOUSE (Q80UG5), 
SEPT9_RAT   (Q9QZR6), XTH9_ARATH  (Q8LDW9), Y1130_XYLFA (Q9PE98), 
Y419_XYLFT  (Q87E99)
» More

PDB
[Detailed view]
33 PDB

1BGW; 1BJT; 2RGR; 2XCO; 2XCQ; 2XCR; 2XCS; 2XCT; 3FOE; 3FOF; 3K9F; 3KSA; 3KSB; 3L4J; 3L4K; 3LTN; 3NUH; 3QX3; 3RAD; 3RAE; 3RAF; 4BUL; 4FM9; 4G0U; 4G0V; 4G0W; 4GFH; 4J3N; 4JUO; 4KOE; 4KPE; 4KPF; 4PLB
» More

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