Entry: PS00177

General information about the entry

Entry name [info] TOPOISOMERASE_II
Accession [info] PS00177
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); DEC-2004 (DATA UPDATE); MAR-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00160

Name and characterization of the entry

Description [info] DNA topoisomerase II signature.
Pattern [info]
[LIVMA]-{R}-E-G-[DN]-S-A-{F}-[STAG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_04 which contains 550'960 sequence entries.


Total number of hits 181 in 181 different sequences
Number of true positive hits 168 in 168 different sequences
Number of 'unknown' hits 0
Number of false positive hits 13 in 13 different sequences
Number of false negative sequences 3
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 92.82 %
Recall (true positives / (true positives + false negatives)) 98.25 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
168 sequences

GYRB1_ACILW (Q44088), GYRB2_ACILW (Q44272), GYRBM_ARATH (Q94BZ7), 
GYRBP_ARATH (Q9SS38), GYRBR_STRNV (P50074), GYRBS_STRNV (P50075), 
GYRB_ACIBA  (Q43907), GYRB_ACIBZ  (Q44273), GYRB_ACICA  (Q43947), 
GYRB_ACIG6  (Q44271), GYRB_ACIGI  (Q44274), GYRB_ACIHA  (Q44065), 
GYRB_ACIJO  (Q44081), GYRB_ACIJU  (Q44080), GYRB_ACIPI  (Q44270), 
GYRB_ACIS8  (Q44275), GYRB_ACIS9  (Q44276), GYRB_ACIVR  (Q44277), 
GYRB_BACAN  (Q9X3Y6), GYRB_BACCE  (Q9X3Y3), GYRB_BACHD  (O50627), 
GYRB_BACMY  (Q9X3Y5), GYRB_BACSU  (P05652), GYRB_BORBU  (P33769), 
GYRB_BORHE  (Q9ZFK1), GYRB_BUCAI  (P57126), GYRB_BUCAP  (P29435), 
GYRB_BUCBP  (Q89B37), GYRB_CAMJE  (O87667), GYRB_CAUCN  (B8GXQ0), 
GYRB_CAUCR  (P0CAX1), GYRB_CHIJA  (Q9FAX2), GYRB_CHLMU  (Q9PKK3), 
GYRB_CHLPN  (Q9Z8R3), GYRB_CHLTR  (O84193), GYRB_CLOAB  (P94604), 
GYRB_CYTAU  (Q9LCK0), GYRB_CYTHU  (Q9LCK1), GYRB_ECO57  (P0AES7), 
GYRB_ECOLI  (P0AES6), GYRB_ENTFA  (Q839Z1), GYRB_FLEEL  (Q9FAX1), 
GYRB_HAEIN  (P43701), GYRB_HALL2  (P21558), GYRB_HALVD  (D4GZ01), 
GYRB_HELPJ  (Q9ZLX3), GYRB_HELPY  (P55992), GYRB_MICLC  (C5C7X8), 
GYRB_MYCAT  (Q9ZAQ6), GYRB_MYCBP  (A0A0G2Q9D6), GYRB_MYCGA  (P47720), 
GYRB_MYCGE  (P47249), GYRB_MYCHP  (P43053), GYRB_MYCLE  (Q59533), 
GYRB_MYCPA  (Q9L7L3), GYRB_MYCPN  (P22447), GYRB_MYCS2  (A0QNE0), 
GYRB_MYCSM  (P0C559), GYRB_MYCTA  (A5TY73), GYRB_MYCTO  (P9WG44), 
GYRB_MYCTU  (P9WG45), GYRB_MYXXA  (O33367), GYRB_NEIGO  (P22118), 
GYRB_NICBE  (Q5YLB4), GYRB_ORYSJ  (Q5NBJ3), GYRB_PSEAE  (Q9I7C2), 
GYRB_PSEPU  (P13364), GYRB_RICBR  (Q1RHT8), GYRB_RICCN  (Q92H87), 
GYRB_RICFE  (Q4UKX5), GYRB_RICPR  (Q9ZCX2), GYRB_RICTY  (Q68WF6), 
GYRB_SALTI  (P0A2I4), GYRB_SALTY  (P0A2I3), GYRB_SHIFL  (P0AES8), 
GYRB_SPICI  (P34031), GYRB_STAA3  (Q2FKQ1), GYRB_STAAC  (Q5HJZ1), 
GYRB_STAAM  (P66936), GYRB_STAAN  (P66937), GYRB_STAAR  (Q6GKU0), 
GYRB_STAAS  (Q6GD85), GYRB_STAAU  (P0A0K8), GYRB_STAAW  (P0A0K7), 
GYRB_STAEQ  (Q5HK03), GYRB_STAES  (Q8CQK4), GYRB_STRCO  (P35886), 
GYRB_STRP1  (Q9A0L0), GYRB_STRP3  (P0DG04), GYRB_STRP6  (Q5XD05), 
GYRB_STRP8  (Q8P1M4), GYRB_STRPN  (P0A4L9), GYRB_STRPQ  (P0DG05), 
GYRB_STRR6  (P0A4M0), GYRB_SYNY3  (P77966), GYRB_THEMA  (P77993), 
GYRB_THET8  (Q5SHZ4), GYRB_TREDE  (O87545), GYRB_TREPA  (O08399), 
GYRB_VIBCH  (Q9KVX3), GYRB_VIBPA  (O51859), PARE_BACSU  (Q59192), 
PARE_BARBK  (P94281), PARE_BORBU  (Q59189), PARE_CAUCR  (O54479), 
PARE_ECOLI  (P20083), PARE_ENTFA  (H7C794), PARE_FRATH  (A0A0J9WZF0), 
PARE_HAEIN  (P43703), PARE_MYCCT  (P50028), PARE_MYCGA  (Q59526), 
PARE_MYCGE  (P47445), PARE_MYCPN  (P78016), PARE_PSEAE  (Q9HUJ8), 
PARE_RICBR  (Q1RK03), PARE_RICCN  (Q92IW1), PARE_RICFE  (Q4UKT4), 
PARE_RICPR  (Q9ZDU7), PARE_RICTY  (Q68XE1), PARE_SALTI  (P0A2I6), 
PARE_SALTY  (P0A2I5), PARE_STAA8  (Q2FYS5), PARE_STAAC  (Q5HG65), 
PARE_STAAM  (P66938), PARE_STAAN  (P66939), PARE_STAAR  (Q6GH51), 
PARE_STAAS  (Q6G9K5), PARE_STAAU  (P0C1S7), PARE_STAAW  (P0A0K9), 
PARE_STAEQ  (Q5HPI6), PARE_STAES  (Q8CSN9), PARE_STRPN  (Q59961), 
TOP2A_CHICK (O42130), TOP2A_CRIGR (P41515), TOP2A_HUMAN (P11388), 
TOP2A_MOUSE (Q01320), TOP2A_PIG   (O46374), TOP2A_RAT   (P41516), 
TOP2B_CHICK (O42131), TOP2B_CRILO (Q64399), TOP2B_HUMAN (Q02880), 
TOP2B_MOUSE (Q64511), TOP2M_CAEEL (P34534), TOP2M_DICDI (P90520), 
TOP2_ARATH  (P30182), TOP2_ASFB7  (Q00942), TOP2_ASFK5  (P0C9C2), 
TOP2_ASFM2  (P34203), TOP2_ASFP4  (P0C9C0), TOP2_ASFWA  (P0C9C1), 
TOP2_BOMMO  (O16140), TOP2_CAEEL  (Q23670), TOP2_CANGA  (O93794), 
TOP2_CRIFA  (P27570), TOP2_DICDI  (Q55BP5), TOP2_DROME  (P15348), 
TOP2_LEICH  (O61078), TOP2_MIMIV  (Q5UQE6), TOP2_PEA    (O24308), 
TOP2_PENCH  (Q9Y8G8), TOP2_PLAFK  (P41001), TOP2_SCHPO  (P08096), 
TOP2_TRYBB  (P12531), TOP2_TRYCR  (P30190), TOP2_YEAST  (P06786), 
TOP4B_AQUAE (O67137), TOPL_BPT4   (P09176), TOPON_MYCS2 (A0QPN2)
» more

UniProtKB/Swiss-Prot
False negative sequences
3 sequences

GYRB_ARCFU  (O29720), TOP2_CANAX  (P87078), TOP2_PICGU  (Q01879)

		
UniProtKB/Swiss-Prot
'Partial' sequences
2 sequences

GYRB_PROMI  (P22840), GYRB_RHOCA  (P31860)

		
UniProtKB/Swiss-Prot
False positive sequences
13 sequences

ASTD_BURXL  (Q141D3), CIPK6_ORYSJ (Q6Z9F4), DDL_CUPNH   (Q0K6M6), 
DOM_DROME   (Q9NDJ2), MIC60_DEBHA (Q6BXM9), NACA_DANRE  (Q8JIU7), 
RPOA_METCA  (Q605D7), SECA_HALHL  (A1WYM9), SEPT9_MOUSE (Q80UG5), 
SEPT9_RAT   (Q9QZR6), XTH9_ARATH  (Q8LDW9), Y1130_XYLFA (Q9PE98), 
Y419_XYLFT  (Q87E99)
» more

PDB
[Detailed view]
48 PDB

1BGW; 1BJT; 2RGR; 2XCO; 2XCQ; 2XCR; 2XCS; 2XCT; 3FOE; 3FOF; 3K9F; 3KSA; 3KSB; 3L4J; 3L4K; 3LTN; 3NUH; 3QX3; 3RAD; 3RAE; 3RAF; 4BUL; 4FM9; 4G0U; 4G0V; 4G0W; 4GFH; 4J3N; 4JUO; 4KOE; 4KPE; 4KPF; 4PLB; 5BS3; 5BS8; 5BTA; 5BTC; 5BTD; 5BTF; 5BTG; 5BTI; 5BTN; 5CDM; 5CDN; 5CDO; 5CDP; 5CDQ; 5CDR
» more

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