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Entry: PS00177

General information about the entry

Entry name [info] TOPOISOMERASE_II
Accession [info] PS00177
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); DEC-2004 (DATA UPDATE); OCT-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00160

Name and characterization of the entry

Description [info] DNA topoisomerase II signature.
Pattern [info]
[LIVMA]-{R}-E-G-[DN]-S-A-{F}-[STAG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_11 which contains 553'231 sequence entries.


Total number of hits 181 in 181 different sequences
Number of true positive hits 168 in 168 different sequences
Number of 'unknown' hits 0
Number of false positive hits 13 in 13 different sequences
Number of false negative sequences 3
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 92.82 %
Recall (true positives / (true positives + false negatives)) 98.25 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
168 sequences

GYRB1_ACILW (Q44088    ), GYRB2_ACILW (Q44272    ), GYRBM_ARATH (Q94BZ7    ), 
GYRBP_ARATH (Q9SS38    ), GYRBR_STRNV (P50074    ), GYRBS_STRNV (P50075    ), 
GYRB_ACIBA  (Q43907    ), GYRB_ACIBZ  (Q44273    ), GYRB_ACICA  (Q43947    ), 
GYRB_ACIG6  (Q44271    ), GYRB_ACIGI  (Q44274    ), GYRB_ACIHA  (Q44065    ), 
GYRB_ACIJO  (Q44081    ), GYRB_ACIJU  (Q44080    ), GYRB_ACIPI  (Q44270    ), 
GYRB_ACIS8  (Q44275    ), GYRB_ACIS9  (Q44276    ), GYRB_ACIVR  (Q44277    ), 
GYRB_BACAN  (Q9X3Y6    ), GYRB_BACCE  (Q9X3Y3    ), GYRB_BACHD  (O50627    ), 
GYRB_BACMY  (Q9X3Y5    ), GYRB_BACSU  (P05652    ), GYRB_BORBU  (P33769    ), 
GYRB_BORHE  (Q9ZFK1    ), GYRB_BUCAI  (P57126    ), GYRB_BUCAP  (P29435    ), 
GYRB_BUCBP  (Q89B37    ), GYRB_CAMJE  (O87667    ), GYRB_CAUCN  (B8GXQ0    ), 
GYRB_CAUCR  (P0CAX1    ), GYRB_CHIJA  (Q9FAX2    ), GYRB_CHLMU  (Q9PKK3    ), 
GYRB_CHLPN  (Q9Z8R3    ), GYRB_CHLTR  (O84193    ), GYRB_CLOAB  (P94604    ), 
GYRB_CYTAU  (Q9LCK0    ), GYRB_CYTHU  (Q9LCK1    ), GYRB_ECO57  (P0AES7    ), 
GYRB_ECOLI  (P0AES6    ), GYRB_ENTFA  (Q839Z1    ), GYRB_FLEEL  (Q9FAX1    ), 
GYRB_HAEIN  (P43701    ), GYRB_HALL2  (P21558    ), GYRB_HALVD  (D4GZ01    ), 
GYRB_HELPJ  (Q9ZLX3    ), GYRB_HELPY  (P55992    ), GYRB_MICLC  (C5C7X8    ), 
GYRB_MYCAT  (Q9ZAQ6    ), GYRB_MYCBP  (A0A0G2Q9D6), GYRB_MYCGA  (P47720    ), 
GYRB_MYCGE  (P47249    ), GYRB_MYCHP  (P43053    ), GYRB_MYCLE  (Q59533    ), 
GYRB_MYCPA  (Q9L7L3    ), GYRB_MYCPN  (P22447    ), GYRB_MYCS2  (A0QNE0    ), 
GYRB_MYCSM  (P0C559    ), GYRB_MYCTA  (A5TY73    ), GYRB_MYCTO  (P9WG44    ), 
GYRB_MYCTU  (P9WG45    ), GYRB_MYXXA  (O33367    ), GYRB_NEIGO  (P22118    ), 
GYRB_NICBE  (Q5YLB4    ), GYRB_ORYSJ  (Q5NBJ3    ), GYRB_PSEAE  (Q9I7C2    ), 
GYRB_PSEPU  (P13364    ), GYRB_RICBR  (Q1RHT8    ), GYRB_RICCN  (Q92H87    ), 
GYRB_RICFE  (Q4UKX5    ), GYRB_RICPR  (Q9ZCX2    ), GYRB_RICTY  (Q68WF6    ), 
GYRB_SALTI  (P0A2I4    ), GYRB_SALTY  (P0A2I3    ), GYRB_SHIFL  (P0AES8    ), 
GYRB_SPICI  (P34031    ), GYRB_STAA3  (Q2FKQ1    ), GYRB_STAAC  (Q5HJZ1    ), 
GYRB_STAAM  (P66936    ), GYRB_STAAN  (P66937    ), GYRB_STAAR  (Q6GKU0    ), 
GYRB_STAAS  (Q6GD85    ), GYRB_STAAU  (P0A0K8    ), GYRB_STAAW  (P0A0K7    ), 
GYRB_STAEQ  (Q5HK03    ), GYRB_STAES  (Q8CQK4    ), GYRB_STRCO  (P35886    ), 
GYRB_STRP1  (Q9A0L0    ), GYRB_STRP3  (P0DG04    ), GYRB_STRP6  (Q5XD05    ), 
GYRB_STRP8  (Q8P1M4    ), GYRB_STRPN  (P0A4L9    ), GYRB_STRPQ  (P0DG05    ), 
GYRB_STRR6  (P0A4M0    ), GYRB_SYNY3  (P77966    ), GYRB_THEMA  (P77993    ), 
GYRB_THET8  (Q5SHZ4    ), GYRB_TREDE  (O87545    ), GYRB_TREPA  (O08399    ), 
GYRB_VIBCH  (Q9KVX3    ), GYRB_VIBPA  (O51859    ), PARE_BACSU  (Q59192    ), 
PARE_BARBK  (P94281    ), PARE_BORBU  (Q59189    ), PARE_CAUCR  (O54479    ), 
PARE_ECOLI  (P20083    ), PARE_ENTFA  (H7C794    ), PARE_FRATH  (A0A0J9WZF0), 
PARE_HAEIN  (P43703    ), PARE_MYCCT  (P50028    ), PARE_MYCGA  (Q59526    ), 
PARE_MYCGE  (P47445    ), PARE_MYCPN  (P78016    ), PARE_PSEAE  (Q9HUJ8    ), 
PARE_RICBR  (Q1RK03    ), PARE_RICCN  (Q92IW1    ), PARE_RICFE  (Q4UKT4    ), 
PARE_RICPR  (Q9ZDU7    ), PARE_RICTY  (Q68XE1    ), PARE_SALTI  (P0A2I6    ), 
PARE_SALTY  (P0A2I5    ), PARE_STAA8  (Q2FYS5    ), PARE_STAAC  (Q5HG65    ), 
PARE_STAAM  (P66938    ), PARE_STAAN  (P66939    ), PARE_STAAR  (Q6GH51    ), 
PARE_STAAS  (Q6G9K5    ), PARE_STAAU  (P0C1S7    ), PARE_STAAW  (P0A0K9    ), 
PARE_STAEQ  (Q5HPI6    ), PARE_STAES  (Q8CSN9    ), PARE_STRPN  (Q59961    ), 
TOP2A_CHICK (O42130    ), TOP2A_CRIGR (P41515    ), TOP2A_HUMAN (P11388    ), 
TOP2A_MOUSE (Q01320    ), TOP2A_PIG   (O46374    ), TOP2A_RAT   (P41516    ), 
TOP2B_CHICK (O42131    ), TOP2B_CRILO (Q64399    ), TOP2B_HUMAN (Q02880    ), 
TOP2B_MOUSE (Q64511    ), TOP2M_CAEEL (P34534    ), TOP2M_DICDI (P90520    ), 
TOP2_ARATH  (P30182    ), TOP2_ASFB7  (Q00942    ), TOP2_ASFK5  (P0C9C2    ), 
TOP2_ASFM2  (P34203    ), TOP2_ASFP4  (P0C9C0    ), TOP2_ASFWA  (P0C9C1    ), 
TOP2_BOMMO  (O16140    ), TOP2_CAEEL  (Q23670    ), TOP2_CANGA  (O93794    ), 
TOP2_CRIFA  (P27570    ), TOP2_DICDI  (Q55BP5    ), TOP2_DROME  (P15348    ), 
TOP2_LEICH  (O61078    ), TOP2_MIMIV  (Q5UQE6    ), TOP2_PEA    (O24308    ), 
TOP2_PENCH  (Q9Y8G8    ), TOP2_PLAFK  (P41001    ), TOP2_SCHPO  (P08096    ), 
TOP2_TRYBB  (P12531    ), TOP2_TRYCR  (P30190    ), TOP2_YEAST  (P06786    ), 
TOP4B_AQUAE (O67137    ), TOPL_BPT4   (P09176    ), TOPON_MYCS2 (A0QPN2    )
» more

UniProtKB/Swiss-Prot
False negative sequences
3 sequences

GYRB_ARCFU  (O29720    ), TOP2_CANAX  (P87078    ), TOP2_PICGU  (Q01879    )

		
UniProtKB/Swiss-Prot
'Partial' sequences
2 sequences

GYRB_PROMI  (P22840    ), GYRB_RHOCA  (P31860    )

		
UniProtKB/Swiss-Prot
False positive sequences
13 sequences

ASTD_BURXL  (Q141D3    ), CIPK6_ORYSJ (Q6Z9F4    ), DDL_CUPNH   (Q0K6M6    ), 
DOM_DROME   (Q9NDJ2    ), MIC60_DEBHA (Q6BXM9    ), NACA_DANRE  (Q8JIU7    ), 
RPOA_METCA  (Q605D7    ), SECA_HALHL  (A1WYM9    ), SEPT9_MOUSE (Q80UG5    ), 
SEPT9_RAT   (Q9QZR6    ), XTH9_ARATH  (Q8LDW9    ), Y1130_XYLFA (Q9PE98    ), 
Y419_XYLFT  (Q87E99    )
» more

PDB
[Detailed view]
54 PDB

1BGW; 1BJT; 2RGR; 2XCO; 2XCQ; 2XCR; 2XCS; 2XCT; 3FOE; 3FOF; 3K9F; 3KSA; 3KSB; 3L4J; 3L4K; 3LTN; 3NUH; 3QX3; 3RAD; 3RAE; 3RAF; 4BUL; 4FM9; 4G0U; 4G0V; 4G0W; 4GFH; 4J3N; 4JUO; 4KOE; 4KPE; 4KPF; 4PLB; 4Z3O; 4Z4Q; 4Z53; 5BS3; 5BS8; 5BTA; 5BTC; 5BTD; 5BTF; 5BTG; 5BTI; 5BTL; 5BTN; 5CDM; 5CDN; 5CDO; 5CDP; 5CDQ; 5CDR; 5IWI; 5IWM
» more

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