Entry: PS00280

General information about the entry

Entry name [info] BPTI_KUNITZ_1
Accession [info] PS00280
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED; 01-APR-2006 DATA UPDATE; 05-JUL-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC00252

Name and characterization of the entry

Description [info] Pancreatic trypsin inhibitor (Kunitz) family signature.
Pattern [info] 
F-x(2)-{I}-G-C-x(6)-[FY]-x(5)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_07 which contains 555'100 sequence entries.


Total number of hits 358 in 296 different sequences
Number of true positive hits 352 in 290 different sequences
Number of 'unknown' hits 0
Number of false positive hits 6 in 6 different sequences
Number of false negative sequences 60
Number of 'partial' sequences 20
Precision (true positives / (true positives + false positives)) 98.32 %
Recall (true positives / (true positives + false negatives)) 85.44 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 11
Site [info] disulfide at position 5
Site [info] disulfide at position 9
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 290 sequences 

A4_CAVPO    (Q60495    ), A4_HUMAN    (P05067    ), A4_MACFA    (P53601    ), 

A4_MACMU    (P29216    ), A4_MOUSE    (P12023    ), A4_PANTR    (Q5IS80    ), 
A4_PIG      (P79307    ), A4_RAT      (P08592    ), A4_SAISC    (Q95241    ), 
A4_TAKRU    (O93279    ), AMBP_BOVIN  (P00978    ), AMBP_HUMAN  (P02760    ), 
AMBP_MERUN  (Q62577    ), AMBP_MESAU  (Q60559    ), AMBP_MOUSE  (Q07456    ), 
AMBP_PIG    (P04366    ), AMBP_PLEPL  (P36992    ), AMBP_RAT    (Q64240    ), 
ANIS1_ANISI (Q7Z1K3    ), APLP2_HUMAN (Q06481    ), APLP2_RAT   (P15943    ), 
BMTI6_RHIMP (P83606    ), BMTIA_RHIMP (P83609    ), BOOG2_RHIMP (Q8WPI3    ), 
BOOH2_RHIMP (Q8WPI2    ), BPT1_BOVIN  (P00974    ), BPT2_BOVIN  (P04815    ), 
CO6A3_CHICK (P15989    ), CO6A3_HUMAN (P12111    ), CO7A1_HUMAN (Q02388    ), 
CO7A1_MOUSE (Q63870    ), COSA1_HUMAN (Q2UY09    ), COSA1_MOUSE (Q2UY11    ), 
CRPTI_RHIMP (P81162    ), CSTI_BOMMO  (P81902    ), ELAC_MACEU  (O62845    ), 
ELAC_TRIVU  (Q29143    ), EPPI_HUMAN  (O95925    ), EPPI_MACMU  (Q9BDL1    ), 
EPPI_MOUSE  (Q9DA01    ), EPPI_RAT    (D4A2Z2    ), HTIB_MANSE  (P26227    ), 
IATR_CAPHI  (P62756    ), IATR_HORSE  (P04365    ), IATR_SHEEP  (P62757    ), 
IBPC_BOVIN  (P00976    ), IBPI_TACTR  (P16044    ), IBPS_BOVIN  (P00975    ), 
IBP_CARCR   (P00993    ), IMAP_DROFU  (P11424    ), ISC1_BOMMO  (P10831    ), 
ISC2_BOMMO  (P10832    ), ISC3_BOMMO  (P07481    ), ISIK_HELPO  (P00994    ), 
ISPI2_GALME (P81906    ), IVBI3_HOPST (B5L5R6    ), IVBI4_NOTSC (B5L5R4    ), 
IVBI4_PSEPO (B5L5R0    ), IVBI5_PSEPO (B5L5R1    ), IVBI_AUSSU  (B5L5M7    ), 
IVBS5_OXYSC (B5L5Q3    ), KCP1_PINMA  (P86959    ), KCP1_PINMG  (H2A0M2    ), 
KCP2_PINMG  (H2A0N1    ), KCP3_PINMA  (P86964    ), KCP3_PINMG  (H2A0N5    ), 
KCP4_PINMG  (H2A0N9    ), KCP5_PINMG  (H2A0P0    ), KCP_HALAI   (P86733    ), 
MCPI_MELCP  (P82968    ), PCPI_SABMA  (P84875    ), PPN1_CAEEL  (O76840    ), 
PPN_DROME   (Q868Z9    ), PPN_HUMAN   (O95428    ), PPN_MOUSE   (Q9EPX2    ), 
SBPI_NEOBL  (P26228    ), SPIT1_HUMAN (O43278    ), SPIT1_MOUSE (Q9R097    ), 
SPIT2_HUMAN (O43291    ), SPIT2_MOUSE (Q9WU03    ), SPIT3_HUMAN (P49223    ), 
SPIT4_MOUSE (Q9D263    ), TFPI1_HUMAN (P10646    ), TFPI1_MACMU (Q28864    ), 
TFPI1_MOUSE (O54819    ), TFPI1_RABIT (P19761    ), TFPI1_RAT   (Q02445    ), 
TFPI2_BOVIN (Q7YRQ8    ), TFPI2_HUMAN (P48307    ), TFPI2_MOUSE (O35536    ), 
TKDP1_BOVIN (Q28201    ), TKDP1_SHEEP (Q29428    ), UPTI_PIG    (Q29100    ), 
VKBH2_BUNCA (Q8AY45    ), VKT11_HADGE (P0C8W3    ), VKT11_HAPSC (B2ZBB6    ), 
VKT12_DENAN (P0DMJ6    ), VKT12_MESMA (P0DJ47    ), VKT16_DRYCN (F8J2F4    ), 
VKT17_HAPHA (P0DJ66    ), VKT18_DRYCN (F8J2F6    ), VKT19_ANOSM (Q589G4    ), 
VKT1A_ANEVI (P0DN06    ), VKT1A_HAPSC (P68425    ), VKT1L_BUNMU (B4ESA2    ), 
VKT1_ANESU  (Q9TWG0    ), VKT1_ANTAF  (P81547    ), VKT1_ANTEL  (P86862    ), 
VKT1_ARAVE  (Q8T3S7    ), VKT1_AUSSU  (B5KL38    ), VKT1_BITGA  (Q6T6T5    ), 
VKT1_CRYNI  (B5KF95    ), VKT1_DABRR  (Q2ES50    ), VKT1_DEMVE  (A6MFL1    ), 
VKT1_HETCR  (B2G331    ), VKT1_HOPST  (B5KF94    ), VKT1_NOTSC  (Q6ITB3    ), 
VKT1_OXYMI  (Q6ITB5    ), VKT1_OXYSC  (Q6ITB7    ), VKT1_PHIOL  (A7X3V7    ), 
VKT1_PSERS  (E7FL11    ), VKT1_PSETT  (Q90WA1    ), VKT1_STIHL  (P31713    ), 
VKT1_TELDH  (A7X3V4    ), VKT1_TRILK  (W4VSH9    ), VKT1_TROCA  (Q6ITB0    ), 
VKT1_VIPAA  (P00991    ), VKT1_WALAE  (C1IC50    ), VKT27_HAPSC (P0DJ82    ), 
VKT28_DRYCN (F8J2F3    ), VKT2L_BUNMU (B4ESA3    ), VKT2_ANESU  (Q9TWF9    ), 
VKT2_ANTAF  (P81548    ), VKT2_AUSSU  (B5KL39    ), VKT2_BITGA  (Q6T6S5    ), 
VKT2_CRYNI  (B5KF96    ), VKT2_DABSI  (P00990    ), VKT2_DEMVE  (A6MFL2    ), 
VKT2_HEMHA  (P00985    ), VKT2_HETCR  (C0HJF4    ), VKT2_HOPST  (B5L5R7    ), 
VKT2_NAJNI  (P00986    ), VKT2_NOTSC  (Q6ITB2    ), VKT2_OXYMI  (Q6ITB4    ), 
VKT2_OXYSC  (Q6ITB6    ), VKT2_PIMHY  (Q8T0W4    ), VKT2_PSEAU  (Q6ITC0    ), 
VKT2_PSEPO  (B5G6G6    ), VKT2_PSERS  (E7FL12    ), VKT2_PSETT  (Q90WA0    ), 
VKT2_STIHL  (P81129    ), VKT2_TROCA  (B5KL33    ), VKT2_WALAE  (C1IC52    ), 
VKT31_MESMA (P0DJ50    ), VKT39_HAPSC (P0DMJ1    ), VKT3A_ACTEQ (P0DMW6    ), 
VKT3B_ACTEQ (P0DMW7    ), VKT3C_ACTEQ (P0DMJ2    ), VKT3L_BUNMU (B4ESA4    ), 
VKT3_ANESU  (Q9TWF8    ), VKT3_ANTAF  (P0DMX0    ), VKT3_AUSSU  (B5KL40    ), 
VKT3_BITGA  (Q6T269    ), VKT3_CRYNI  (B5KL34    ), VKT3_DABRR  (Q2ES48    ), 
VKT3_DEMVE  (A6MFL3    ), VKT3_HETCR  (C0HJF3    ), VKT3_NOTSC  (B5KL32    ), 
VKT3_OXYMI  (B5KL27    ), VKT3_OXYSC  (B5KL29    ), VKT3_PSEAU  (Q6ITB9    ), 
VKT3_PSEPO  (B5KL31    ), VKT3_PSERS  (E7FL13    ), VKT3_PSETT  (Q90W99    ), 
VKT3_STIHA  (B1B5I8    ), VKT3_VIPAA  (P00992    ), VKT3_WALAE  (C1IC51    ), 
VKT4_ANEVI  (P0DN07    ), VKT4_AUSSU  (B5KL41    ), VKT4_CRYNI  (B5KL35    ), 
VKT4_DABRR  (Q2ES47    ), VKT4_DEMVE  (A6MFL4    ), VKT4_HAPSC  (P0DJ76    ), 
VKT4_OXYMI  (B5KL28    ), VKT4_OXYSC  (B5KL30    ), VKT4_PSEAU  (Q6ITB8    ), 
VKT4_PSETT  (Q90W98    ), VKT4_WALAE  (C1IC53    ), VKT52_ANESU (P10280    ), 
VKT53_ANEVI (P0DN08    ), VKT5_ANEVI  (P0DN09    ), VKT5_CRYNI  (B5KL36    ), 
VKT5_DABRR  (Q2ES46    ), VKT5_DEMVE  (A6MGX9    ), VKT5_HAPSC  (P0DJ77    ), 
VKT5_HETCR  (C0HJU6    ), VKT5_OXYMI  (B5L5Q6    ), VKT5_PSEAU  (B5L5Q8    ), 
VKT5_PSETT  (Q90W97    ), VKT6_ANEVI  (P0DN10    ), VKT6_CRYNI  (B5KL37    ), 
VKT6_HETCR  (C0HJU7    ), VKT6_PSETT  (Q90W96    ), VKT7_ANEVI  (P0DN11    ), 
VKT7_DEMVE  (A6MGY1    ), VKT7_PSETT  (B5L5Q1    ), VKT87_DRYCN (F8J2F5    ), 
VKT8_ANEVI  (P0DN12    ), VKT9_ANEVI  (P0DN13    ), VKT9_BUNFA  (P25660    ), 
VKTA_ANEVI  (P0DN14    ), VKTA_BUNCA  (Q8AY43    ), VKTB1_DABSI (A8Y7P1    ), 
VKTB2_DABSI (A8Y7P2    ), VKTB3_DABSI (A8Y7P3    ), VKTB4_DABSI (A8Y7P4    ), 
VKTB5_DABSI (A8Y7P5    ), VKTB6_DABSI (A8Y7P6    ), VKTB7_DABSI (A8Y7P0    ), 
VKTB_ANEVI  (P0DN15    ), VKTB_BUNCA  (Q8AY42    ), VKTC1_DABSI (A8Y7N4    ), 
VKTC2_DABSI (A8Y7N5    ), VKTC3_DABSI (A8Y7N6    ), VKTC4_DABSI (A8Y7N7    ), 
VKTC5_DABSI (A8Y7N8    ), VKTC6_DABSI (A8Y7N9    ), VKTCI_NAJNA (P19859    ), 
VKTCI_OPHHA (P82966    ), VKTCT_OPHHA (B6RLX2    ), VKTC_ANEVI  (P0DN16    ), 
VKTC_BUNCA  (Q8AY41    ), VKTD_ANEVI  (P0DN17    ), VKTE_ANEVI  (P0DN18    ), 
VKTE_DENPO  (P00984    ), VKTF_ANEVI  (P0DN19    ), VKTG_ANEVI  (P0DN20    ), 
VKTH1_BUNFA (B2KTG2    ), VKTH1_BUNMU (P00987    ), VKTH1_DENPO (P00979    ), 
VKTH1_PSEAU (Q6ITC1    ), VKTH2_BUNFA (B2KTG3    ), VKTH2_BUNMU (P00989    ), 
VKTH3_BUNCA (Q75S50    ), VKTH3_BUNMU (Q9W728    ), VKTH4_BUNCA (Q75S49    ), 
VKTH4_BUNMU (Q1RPT0    ), VKTH5_BUNMU (Q1RPS9    ), VKTH6_BUNMU (Q1RPS8    ), 
VKTH7_BUNCA (Q8AY44    ), VKTH7_BUNMU (Q0PL65    ), VKTHA_DENAN (P00980    ), 
VKTHB_BUNCA (Q8AY46    ), VKTHB_BUNFL (Q7T2Q6    ), VKTHB_DENPO (P00983    ), 
VKTHC_DENAN (P81658    ), VKTHD_DENAN (P00982    ), VKTHE_DENAN (Q7LZE3    ), 
VKTHK_DENPO (P00981    ), VKTI1_ANTFU (P0DMJ3    ), VKTI3_ANTFU (P0DMJ4    ), 
VKTK1_DABRR (H6VC05    ), VKTK2_DABRR (H6VC06    ), VKTRE_DENAN (Q7LZS8    ), 
VKTTI_NAJNA (P20229    ), VKT_AUSLA   (B2BS84    ), VKT_BOMIG   (G3LH89    ), 
VKT_BOMTE   (D8KY58    ), VKT_BUNFA   (B2KTG1    ), VKT_ERIMA   (P24541    ), 
VKT_HETCR   (P0DMJ5    ), VKT_MACLN   (I2G9B4    ), VKT_NAJAT   (Q5ZPJ7    ), 
VKT_OXYSC   (B7S4N9    ), VKT_PSEPO   (Q6ITB1    ), VKT_SISCA   (A5X2X1    ), 
VKT_VIPNI   (E5AJX3    ), VKT_VIPRE   (P0DKL8    ), WFC6A_MOUSE (Q3UW55    ), 
WFC6B_MOUSE (F6ULY1    ), WFDC8_HUMAN (Q8IUA0    ), WFDC8_MOUSE (Q4KUS1    ), 
WFKN1_HUMAN (Q96NZ8    ), WFKN1_MOUSE (Q8R0S6    ), WFKN1_RAT   (P0C5J5    ), 
WFKN2_BOVIN (Q08E66    ), WFKN2_HUMAN (Q8TEU8    ), WFKN2_MOUSE (Q7TQN3    ), 
WFKN_DANRE  (Q6NUX0    ), YN81_CAEEL  (Q03610    )
» more

UniProtKB/Swiss-Prot
False negative sequences		 60 sequences 

A4_TETFL    (O73683    ), BLI5_CAEEL  (O62247    ), BLI5_HAECO  (D3GGZ8    ), 

ORNT_ORNMO  (P56409    ), SPIT4_HUMAN (Q6UDR6    ), TAP_ORNMO   (P17726    ), 
VKT13_HAPSC (P0DJ79    ), VKT1A_CONCL (D2Y488    ), VKT1B_CONCL (D2Y489    ), 
VKT1C_CONCL (D2Y490    ), VKT1D_CONCL (D2Y491    ), VKT21_LYCMC (P0DJ46    ), 
VKT22_HAPSC (P0DJ80    ), VKT22_LYCMC (P0DJ45    ), VKT23_LYCMC (P0DJ48    ), 
VKT24_HAPSC (P0DJ81    ), VKT24_MESMA (P0DJ49    ), VKT2_DABRR  (Q2ES49    ), 
VKT2_HAPHA  (D2Y2F3    ), VKT2_HAPSC  (P0DJ75    ), VKT31_HAPHA (P0DJ64    ), 
VKT33_HAPSC (B2ZBB8    ), VKT34_HAPHA (P0DJ67    ), VKT35_HAPHA (P0DJ71    ), 
VKT40_HAPSC (P0DJ84    ), VKT45_HAPHA (P0DJ68    ), VKT45_HAPSC (P0DJ85    ), 
VKT4_HAPHA  (D2Y2F5    ), VKT4_HETCR  (P16344    ), VKT52_HAPHA (P0DJ69    ), 
VKT53_HAPHA (P0DJ70    ), VKT68_HAPHA (P0DJ72    ), VKT6_HAPSC  (P0DJ78    ), 
VKT74_HAPHA (P0DJ73    ), VKT76_HAPHA (P0DJ74    ), VKT7_HAPHA  (P0DJ65    ), 
VKTA1_HAPHA (D2Y2C2    ), VKTA_MICTN  (G9I929    ), VKTB1_CONBU (P0CY85    ), 
VKTC1_HAPHA (D2Y2F4    ), VKTE1_HAPHA (D2Y2F6    ), VKTF1_HAPHA (D2Y2F7    ), 
VKTG1_HAPHA (D2Y2F8    ), VKTG6_HAPSC (B2ZBB9    ), VKTG9_HAPSC (B2ZBC0    ), 
VKTH1_HAPHA (D2Y2F9    ), VKTI1_HAPHA (D2Y2G0    ), VKTJ1_HAPHA (D2Y2G1    ), 
VKTK1_HAPHA (D2Y2G2    ), VKTL1_HAPHA (D2Y2Q1    ), VKTM1_HAPHA (D2Y2Q2    ), 
VKTN1_HAPHA (D2Y2Q5    ), VKTO1_HAPHA (D2Y2Q6    ), VKTP1_HAPHA (D2Y2Q7    ), 
VKTQ1_HAPHA (D2Y2Q8    ), VKTR1_HAPHA (D2Y2Q9    ), VKTS1_CONST (P0C1X2    ), 
VKT_VESBI   (C0LNR2    ), WFDC6_HUMAN (Q9BQY6    ), YL15_CAEEL  (Q11101    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 20 sequences 

BMTI2_RHIMP (P83603    ), BMTI3_RHIMP (P83604    ), BMTI4_RHIMP (P83605    ), 

BMTID_RHIMP (P83607    ), HTIA_MANSE  (P26226    ), TIQ2_RHISA  (P84554    ), 
TIQ7_RHISA  (P84555    ), TIS5_RHISA  (P84556    ), VKT10_DABSI (P85041    ), 
VKT25_HAPHA (P0CH75    ), VKT33_ACTEQ (P0DMW8    ), VKT34_ACTEQ (P0DMW9    ), 
VKTC8_DABSI (P85039    ), VKTC9_DABSI (P85040    ), VKTG1_MICPY (P0CAR0    ), 
VKTH1_BUNCA (P84471    ), VKTH2_BUNCA (P84473    ), VKTH8_BUNCA (P84470    ), 
VKT_MICAT   (P0DM47    ), VKT_OXYMI   (P0DJ63    )
» more

UniProtKB/Swiss-Prot
False positive sequences		 6 sequences 

AB41G_ORYSJ (Q8GU83    ), LRIT2_HUMAN (A6NDA9    ), SSPO_HUMAN  (A2VEC9    ), 

TGB3_BNYVS  (Q65676    ), TNFA_TUPTA  (Q539C2    ), WAKLN_ARATH (Q0WNY5    )
» more

PDB
[Detailed view]		 139 PDB

1AAP; 1ADZ; 1B0C; 1BF0; 1BHC; 1BIK; 1BPI; 1BPT; 1BRB; 1BRC; 1BTH; 1BTI; 1BUN; 1BZ5; 1BZX; 1CA0; 1CBW; 1CO7; 1D0D; 1DEM; 1DEN; 1DTK; 1DTX; 1EAW; 1EJM; 1F5R; 1F7Z; 1FAK; 1FY8; 1G6X; 1IRH; 1JC6; 1K6U; 1KNT; 1KTH; 1KUN; 1LD5; 1MTN; 1NAG; 1OA5; 1OA6; 1P2I; 1P2J; 1P2K; 1P2M; 1P2N; 1P2O; 1P2Q; 1PIT; 1QLQ; 1SHP; 1T7C; 1T8L; 1T8M; 1T8N; 1T8O; 1TAW; 1TFX; 1TPA; 1UUA; 1UUB; 1YC0; 1YKT; 1ZJD; 1ZR0; 2DDI; 2DDJ; 2FI4; 2FTL; 2FTM; 2HEX; 2IJO; 2JOT; 2KAI; 2KNT; 2M99; 2ODY; 2PTC; 2R9P; 2RA3; 2TGP; 2TPI; 3BTD; 3BTE; 3BTF; 3BTG; 3BTH; 3BTK; 3BTM; 3BTQ; 3BTT; 3BTW; 3BYB; 3D65; 3FP6; 3FP7; 3FP8; 3GYM; 3L33; 3LDI; 3LDJ; 3LDM; 3M7Q; 3OFW; 3OTJ; 3P92; 3P95; 3T62; 3TGI; 3TGJ; 3TGK; 3TPI; 3U1J; 3UIR; 3UOU; 4BD9; 4BNR; 4BQD; 4DG4; 4DTG; 4ISL; 4ISN; 4ISO; 4PTI; 4TPI; 4U30; 4U32; 4WWY; 4WXV; 4Y0Y; 4Y0Z; 4Y10; 4Y11; 5C67; 5EZD; 5PTI; 6PTI; 8PTI; 9PTI
» more

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