Entry: PS00396

General information about the entry

Entry name [info] TOPOISOMERASE_I_PROK
Accession [info] PS00396
Entry type [info] PATTERN
Date [info] NOV-1990 (CREATED); DEC-2004 (DATA UPDATE); MAY-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00333
Associated ProRule [info] PRU10131

Name and characterization of the entry

Description [info] Prokaryotic DNA topoisomerase I active site.
Pattern [info]
[EQ]-x-L-Y-[DEQSTLM]-x(3,12)-[LIVST]-[ST]-Y-x-R-[ST]-[DEQSN].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_05 which contains 551'193 sequence entries.


Total number of hits 107 in 107 different sequences
Number of true positive hits 106 in 106 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 0
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 99.07 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
106 sequences

TOP1P_MIMIV (Q5UQB5    ), TOP1P_XYLFA (Q9PHK2    ), TOP1_AERPE  (Q9YB01    ), 
TOP1_AQUAE  (O66893    ), TOP1_ARCFU  (O28469    ), TOP1_BACAN  (P40114    ), 
TOP1_BACHD  (Q9KA23    ), TOP1_BACPE  (P34184    ), TOP1_BACSU  (P39814    ), 
TOP1_BORBU  (O51768    ), TOP1_BUCAI  (P57371    ), TOP1_BUCAP  (Q8K9P7    ), 
TOP1_CAMJE  (Q9PLZ2    ), TOP1_ECOLI  (P06612    ), TOP1_FERIS  (O34204    ), 
TOP1_HAEIN  (P43012    ), TOP1_HELPJ  (Q9ZMV7    ), TOP1_HELPY  (P55991    ), 
TOP1_LACLA  (Q9CG80    ), TOP1_METJA  (Q59046    ), TOP1_METTH  (O27661    ), 
TOP1_MYCBO  (P0A621    ), TOP1_MYCGA  (Q9JN65    ), TOP1_MYCGE  (P47368    ), 
TOP1_MYCLE  (O69548    ), TOP1_MYCPN  (P78032    ), TOP1_MYCS2  (A0R5D9    ), 
TOP1_MYCTO  (P9WG48    ), TOP1_MYCTU  (P9WG49    ), TOP1_PASMU  (Q9CN30    ), 
TOP1_PSEAE  (Q9HZJ5    ), TOP1_PYRAB  (Q9UYS8    ), TOP1_PYRHO  (O58356    ), 
TOP1_RICBR  (Q1RIM1    ), TOP1_RICCN  (Q92IH1    ), TOP1_RICFE  (Q4UM42    ), 
TOP1_RICPR  (Q9ZDK2    ), TOP1_RICTY  (Q68X45    ), TOP1_SALTI  (P0A2I2    ), 
TOP1_SALTY  (P0A2I1    ), TOP1_STAA3  (Q2FHI8    ), TOP1_STAA8  (Q2FZ32    ), 
TOP1_STAAB  (Q2YXL8    ), TOP1_STAAC  (Q5HGI2    ), TOP1_STAAM  (Q99UM1    ), 
TOP1_STAAN  (Q7A5Y5    ), TOP1_STAAR  (Q6GHI5    ), TOP1_STAAS  (Q6G9W3    ), 
TOP1_STAAU  (Q06AK7    ), TOP1_STAAW  (Q8NWZ9    ), TOP1_STAEQ  (Q5HPU2    ), 
TOP1_STAES  (Q8CSU3    ), TOP1_STAHJ  (Q4L5V2    ), TOP1_STAS1  (Q49X35    ), 
TOP1_STRCO  (Q9X909    ), TOP1_SYNE7  (P34185    ), TOP1_SYNY3  (P73810    ), 
TOP1_THEAC  (Q9HM08    ), TOP1_THEMA  (P46799    ), TOP1_TREPA  (O83409    ), 
TOP1_VIBCH  (Q9KRB2    ), TOP1_XYLFA  (Q9PEV8    ), TOP1_XYLFT  (Q87AQ6    ), 
TOP1_ZYMMO  (Q9X3X7    ), TOP3A_ARATH (Q9LVP1    ), TOP3A_DROME (Q9NG98    ), 
TOP3A_HUMAN (Q13472    ), TOP3A_MOUSE (O70157    ), TOP3A_ORYSJ (C7J0A2    ), 
TOP3B_ARATH (F4ISQ7    ), TOP3B_DROME (O96651    ), TOP3B_HUMAN (O95985    ), 
TOP3B_MOUSE (Q9Z321    ), TOP3B_ORYSJ (Q0J0S6    ), TOP3_BACAH  (A0R979    ), 
TOP3_BACAN  (Q81Z97    ), TOP3_BACC1  (Q73E74    ), TOP3_BACCR  (Q81IH1    ), 
TOP3_BACCZ  (Q63GK5    ), TOP3_BACHK  (Q6HP19    ), TOP3_BACLD  (Q65N90    ), 
TOP3_BACSK  (Q5WAX6    ), TOP3_BACSU  (P96583    ), TOP3_CAEEL  (O61660    ), 
TOP3_DICDI  (Q8T2T7    ), TOP3_ECOLI  (P14294    ), TOP3_HAEIN  (P43704    ), 
TOP3_PASMU  (Q9CP53    ), TOP3_SALTI  (Q8Z6F5    ), TOP3_SALTY  (P40687    ), 
TOP3_SCHPO  (O60126    ), TOP3_STAA3  (Q2FEN5    ), TOP3_STAA8  (Q2FW03    ), 
TOP3_STAAB  (P0C2W6    ), TOP3_STAAC  (Q5HDV4    ), TOP3_STAAM  (Q99S17    ), 
TOP3_STAAN  (Q7A455    ), TOP3_STAAR  (Q6GEH9    ), TOP3_STAAS  (Q6G767    ), 
TOP3_STAAW  (Q7A075    ), TOP3_STAEQ  (Q5HLZ4    ), TOP3_STAES  (Q8CRF7    ), 
TOP3_STAHJ  (Q4L8B8    ), TOP3_STAS1  (Q49ZH2    ), TOP3_VIBCH  (Q9KQF5    ), 
TOP3_YEAST  (P13099    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

TOP1_ENTAE  (P46155    )

		
UniProtKB/Swiss-Prot
False positive sequences
1 sequence

SYSM_SCHPO  (Q9UTB2    )

		
PDB
[Detailed view]
25 PDB

1CY0; 1CY1; 1CY2; 1CY4; 1CY6; 1CY7; 1CY8; 1CY9; 1CYY; 1D6M; 1ECL; 1MW8; 1MW9; 2GAI; 2GAJ; 2O19; 2O54; 2O59; 2O5C; 2O5E; 3PWT; 4CGY; 4CHT; 4RUL; 5D5H
» more

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