Entry: PS00720

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General information about the entry

Entry name [info] RASGEF
Accession [info] PS00720
Entry type [info] PATTERN
Date [info] DEC-1992 (CREATED); APR-2003 (DATA UPDATE); JUL-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00594

Name and characterization of the entry

Description [info] Ras Guanine-nucleotide exchange factors domain signature.
Pattern [info]
[VI]-P-[FYWVI]-x-[GPSV]-x(2)-[LIVMFYK]-x-[DNE]-[LIVM]-x(13,35)-[IVL]-N-
[FYME]-x-K.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_08 which contains 546'238 sequence entries.


Total number of hits 67 in 67 different sequences
Number of true positive hits 67 in 67 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 66
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 50.38 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
67 sequences

BUD5_YEAST  (P25300), C3G_DROME   (O77086), CDC25_CANAL (P43069), 
CDC25_LACKL (Q02342), CDC25_YEAST (P04821), GEFB_DICDI  (Q8IS21), 
GEFC_DICDI  (Q8IS20), GEFK_DICDI  (Q54FF3), GEFS_DICDI  (Q8SSW7), 
GEFV_DICDI  (Q55FD8), GEFW_DICDI  (Q55GH9), GNDS_HUMAN  (Q12967), 
GNDS_MOUSE  (Q03385), GNDS_RAT    (Q03386), LTE1_ASHGO  (Q75BH9), 
LTE1_CANGA  (Q6FT12), LTE1_KLULA  (Q6CY10), LTE1_YEAST  (P07866), 
RG1BA_DANRE (Q6DHR3), RG1BB_DANRE (Q6DBW1), RGF1B_BOVIN (A4IFE4), 
RGF1B_HUMAN (Q0VAM2), RGF1B_MOUSE (Q8JZL7), RGF1B_PONAB (Q5RC04), 
RGF1B_XENTR (Q28EC1), RGF1C_HUMAN (Q8N431), RGF1C_MACFA (Q95KH6), 
RGF1C_MOUSE (Q9D300), RGL1_DANRE  (Q6P112), RGL1_HUMAN  (Q9NZL6), 
RGL1_MOUSE  (Q60695), RGL2_CANFA  (Q5TJE5), RGL2_HUMAN  (O15211), 
RGL2_MOUSE  (Q61193), RGL3_HUMAN  (Q3MIN7), RGL3_MOUSE  (Q3UYI5), 
RGRF1_HUMAN (Q13972), RGRF1_MOUSE (P27671), RGRF1_RAT   (P28818), 
RGRF2_DANRE (A2CEA7), RGRF2_HUMAN (O14827), RGRF2_MOUSE (P70392), 
RGRF2_RAT   (Q99JE4), RPGF1_CAEEL (P34578), RPGF1_HUMAN (Q13905), 
RPGF3_HUMAN (O95398), RPGF3_MOUSE (Q8VCC8), RPGF3_RAT   (Q9Z1C8), 
RPGF4_HUMAN (Q8WZA2), RPGF4_MOUSE (Q9EQZ6), RPGF4_RAT   (Q9Z1C7), 
RPGF5_HUMAN (Q92565), RPGF5_MOUSE (Q8C0Q9), RPGF5_RAT   (P83900), 
RPGF_CAEEL  (G5EDB9), SDC25_YEAS1 (B3LTF3), SDC25_YEAS6 (B5VMS9), 
SDC25_YEAS7 (A7A0P0), SDC25_YEAS8 (C8ZCV7), SDC25_YEASX (P0CF32), 
SOS1_HUMAN  (Q07889), SOS1_MOUSE  (Q62245), SOS2_HUMAN  (Q07890), 
SOS2_MOUSE  (Q02384), SOS_DROME   (P26675), STE6_SCHPO  (P26674), 
YL016_YEAST (P0CF34)
» More

UniProtKB/Swiss-Prot
False negative sequences
66 sequences

BCAR3_BOVIN (Q58DL5), BCAR3_HUMAN (O75815), BCAR3_MACFA (Q4R8R1), 
BCAR3_MOUSE (Q9QZK2), BCAR3_XENLA (Q6INP9), BEM2_YEAST  (P39960), 
EFC25_SCHPO (Q9USU1), GBPC_DICDI  (Q8MVR1), GBPD_DICDI  (Q54S40), 
GEFA_DICDI  (Q54PQ4), GEFD_DICDI  (Q8IS19), GEFE_DICDI  (Q8IS18), 
GEFF_DICDI  (Q54C94), GEFG_DICDI  (Q8ST25), GEFH_DICDI  (Q8IS16), 
GEFI_DICDI  (Q8IS15), GEFJ_DICDI  (Q8IS14), GEFL_DICDI  (B0M0P8), 
GEFM_DICDI  (Q8SSQ3), GEFN_DICDI  (Q8IS12), GEFO_DICDI  (Q8IS11), 
GEFP_DICDI  (Q54TK8), GEFQ_DICDI  (Q86G47), GEFR_DICDI  (Q8SSQ0), 
GEFX_DICDI  (Q55EC7), GEFY_DICDI  (Q552M5), GRP1_HUMAN  (O95267), 
GRP1_MOUSE  (Q9Z1S3), GRP1_RAT    (Q9R1K8), GRP1_XENLA  (Q6NTL4), 
GRP1_XENTR  (A4IJ06), GRP2A_XENLA (Q32N25), GRP2B_XENLA (Q6DCK3), 
GRP2_BOVIN  (A6N9I4), GRP2_HUMAN  (Q7LDG7), GRP2_MOUSE  (Q9QUG9), 
GRP2_RAT    (P0C643), GRP4_BOVIN  (Q1LZ97), GRP4_HUMAN  (Q8TDF6), 
GRP4_MOUSE  (Q8BTM9), GRP4_RAT    (Q8R5I4), PLCE1_HUMAN (Q9P212), 
PLCE1_MOUSE (Q8K4S1), PLCE1_RAT   (Q99P84), RGDSR_HUMAN (Q8IZJ4), 
RGF1A_HUMAN (Q8N9B8), RGF1A_XENTR (A0JM95), RGPS1_CHICK (Q5ZJK0), 
RGPS1_DANRE (B0UXH6), RGPS1_HUMAN (Q5JS13), RGPS1_MOUSE (A2AR50), 
RGPS2_HUMAN (Q86X27), RGPS2_MACFA (Q4R7W3), RGPS2_MOUSE (Q9ERD6), 
RPGF2_BOVIN (F1MSG6), RPGF2_CANFA (F1PBJ0), RPGF2_HUMAN (Q9Y4G8), 
RPGF2_MOUSE (Q8CHG7), RPGF2_RAT   (F1M386), RPGFL_HUMAN (Q9UHV5), 
RPGFL_MOUSE (Q68EF8), RPGFL_PONPY (Q5R9B2), SH2D3_HUMAN (Q8N5H7), 
SH2D3_MOUSE (Q9QZS8), VKIND_HUMAN (Q76NI1), VKIND_MOUSE (Q0KK55)
» More

PDB
[Detailed view]
18 PDB

1BKD; 1NVU; 1NVV; 1NVW; 1NVX; 1XD2; 1XD4; 1XDV; 2BYV; 2II0; 2IJE; 3CF6; 3KSY; 4F7Z; 4JGW; 4NYI; 4NYJ; 4NYM
» More

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