Entry: PS01187

General information about the entry

Entry name [info] EGF_CA
Accession [info] PS01187
Entry type [info] PATTERN
Date [info] NOV-1997 (CREATED); DEC-2001 (DATA UPDATE); MAY-2015 (INFO UPDATE).
PROSITE Doc. [info] PDOC00913

Name and characterization of the entry

Description [info] Calcium-binding EGF-like domain signature.
Pattern [info]
[DEQN]-x-[DEQN](2)-C-x(3,14)-C-x(3,7)-C-x-[DN]-x(4)-[FY]-x-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2015_07 which contains 548'872 sequence entries.


Total number of hits 1'680 in 410 different sequences
Number of true positive hits 1'672 in 402 different sequences
Number of 'unknown' hits 8 in 8 different sequences
Number of false positive hits 0
Number of false negative sequences 6
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 99.64 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 43
Site [info] disulfide at position 4
Site [info] disulfide at position 6
Site [info] disulfide at position 8
Site [info] disulfide at position 14
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
402 sequences

AGRE1_HUMAN (Q14246), AGRE1_MOUSE (Q61549), AGRE1_RAT   (Q5Y4N8), 
AGRE2_CANFA (Q2Q421), AGRE2_HUMAN (Q9UHX3), AGRE2_MACMU (Q2Q426), 
AGRE3_HUMAN (Q9BY15), AGRE4_HUMAN (Q86SQ3), AGRE4_MOUSE (Q91ZE5), 
BMP1_HUMAN  (P13497), BMP1_MOUSE  (P98063), BMP1_XENLA  (P98070), 
BMPH_STRPU  (P98069), C1QR1_HUMAN (Q9NPY3), C1QR1_MOUSE (O89103), 
C1QR1_RAT   (Q9ET61), C1RA_MOUSE  (Q8CG16), C1RB_MOUSE  (Q8CFG9), 
C1R_HUMAN   (P00736), C1R_MACFA   (Q4R577), C1R_PANTR   (Q5R1W3), 
C1R_PONAB   (Q5R544), C1S_BOVIN   (Q0VCX1), C1S_HUMAN   (P09871), 
C1S_PIG     (Q69DK8), C1S_RAT     (Q6P6T1), CASP_MESAU  (P15156), 
CCBE1_DANRE (A8WGB1), CCBE1_HUMAN (Q6UXH8), CCBE1_MOUSE (Q3MI99), 
CD248_HUMAN (Q9HCU0), CD248_MOUSE (Q91V98), CD97_BOVIN  (Q8SQA4), 
CD97_HUMAN  (P48960), CD97_MOUSE  (Q9Z0M6), COMP_BOVIN  (P35445), 
COMP_HUMAN  (P49747), COMP_MOUSE  (Q9R0G6), COMP_RAT    (P35444), 
CRAC1_HUMAN (Q9NQ79), CRAC1_MOUSE (Q8R555), CRAC1_XENTR (Q0V9M0), 
CRB_DROME   (P10040), CRE2A_XENLA (Q5XH36), CRE2B_XENLA (Q4V7M2), 
CREL1_BOVIN (Q5EA46), CREL1_HUMAN (Q96HD1), CREL1_MOUSE (Q91XD7), 
CREL1_RAT   (Q4V7F2), CREL2_BOVIN (Q2KIT5), CREL2_CRIGR (Q60438), 
CREL2_DANRE (Q7SXF6), CREL2_HUMAN (Q6UXH1), CREL2_MOUSE (Q9CYA0), 
CREL2_RAT   (Q4G063), CRUM1_HUMAN (P82279), CRUM1_MOUSE (Q8VHS2), 
CRUM2_HUMAN (Q5IJ48), CRUM2_MOUSE (Q80YA8), CS1A_MOUSE  (Q8CG14), 
CS1B_MOUSE  (Q8CFG8), CSPG2_BOVIN (P81282), CSPG2_CHICK (Q90953), 
CSPG2_HUMAN (P13611), CSPG2_MACNE (Q28858), CSPG2_MOUSE (Q62059), 
CSPG2_RAT   (Q9ERB4), CUBN_CAEEL  (Q20911), CUBN_CANFA  (Q9TU53), 
CUBN_HUMAN  (O60494), CUBN_MOUSE  (Q9JLB4), CUBN_RAT    (O70244), 
DEX1_CAEEL  (P41950), DIG1_CAEEL  (Q09165), DLK2_BOVIN  (A4FV93), 
DLK2_HUMAN  (Q6UY11), DLK2_MOUSE  (Q8K1E3), DLK2_PIG    (B2LW77), 
DLK2_RAT    (D3ZUK3), DLL1_HUMAN  (O00548), DLL1_MOUSE  (Q61483), 
DLL1_RAT    (P97677), DLLA_DANRE  (Q6DI48), DLLB_DANRE  (O57409), 
DLLC_DANRE  (Q9IAT6), DLLD_DANRE  (Q8UWJ4), DL_DROME    (P10041), 
DNER_HUMAN  (Q8NFT8), DNER_MOUSE  (Q8JZM4), EDIL3_HUMAN (O43854), 
EDIL3_MOUSE (O35474), EDIL3_PONAB (Q5R7K9), EGFEM_MOUSE (Q8C088), 
EGFL6_HUMAN (Q8IUX8), EGFL6_MOUSE (Q9JJZ5), EGFL6_XENLA (Q8AVH7), 
EGFL7_HUMAN (Q9UHF1), EGFL7_MOUSE (Q9QXT5), EGFL7_RAT   (Q6AZ60), 
EGFL8_HUMAN (Q99944), EGFL8_MOUSE (Q6GUQ1), EGFL8_PIG   (A5A8Y8), 
EGFL8_RAT   (Q6MG84), EGF_CANFA   (Q9BEA0), EGF_FELCA   (Q95ND4), 
EGF_HUMAN   (P01133), EGF_MOUSE   (P01132), EGF_PIG     (Q00968), 
EGF_RAT     (P07522), ELTD1_HUMAN (Q9HBW9), ELTD1_MOUSE (Q923X1), 
ELTD1_RAT   (Q9ESC1), EYS_DROME   (A0A1F4), EYS_HUMAN   (Q5T1H1), 
FA101_PSETE (Q1L659), FA102_PSETE (Q1L658), FA10_BOVIN  (P00743), 
FA10_CHICK  (P25155), FA10_HUMAN  (P00742), FA10_MOUSE  (O88947), 
FA10_RABIT  (O19045), FA10_RAT    (Q63207), FA10_TROCA  (Q4QXT9), 
FA7_BOVIN   (P22457), FA7_HUMAN   (P08709), FA7_MOUSE   (P70375), 
FA7_PANPA   (Q2F9P4), FA7_PANTR   (Q2F9P2), FA7_RABIT   (P98139), 
FA7_RAT     (Q8K3U6), FA9_BOVIN   (P00741), FA9_CANFA   (P19540), 
FA9_CHICK   (Q804X6), FA9_FELCA   (Q6SA95), FA9_HUMAN   (P00740), 
FA9_MOUSE   (P16294), FA9_PANTR   (Q95ND7), FA9_PIG     (P16293), 
FA9_RAT     (P16296), FAT1_HUMAN  (Q14517), FAT2_DROME  (Q9VW71), 
FAT3_HUMAN  (Q8TDW7), FAT3_MOUSE  (Q8BNA6), FAT3_RAT    (Q8R508), 
FAT4_HUMAN  (Q6V0I7), FAT4_MOUSE  (Q2PZL6), FAXC_OXYMI  (Q58L95), 
FAXC_OXYSU  (Q58L96), FAXC_PSETE  (Q56VR3), FAXD1_DEMVE (A6MFK7), 
FAXD1_NOTSC (P82807), FAXD2_DEMVE (A6MFK8), FAXD2_NOTSC (Q58L94), 
FAXD_HOPST  (P83370), FAXD_PSEPO  (Q58L93), FAXD_RHING  (B5G6G5), 
FAXD_TROCA  (P81428), FBLN1_CAEEL (O77469), FBLN1_CHICK (O73775), 
FBLN1_CHLAE (Q8MJJ9), FBLN1_DANRE (O42182), FBLN1_HUMAN (P23142), 
FBLN1_MOUSE (Q08879), FBLN2_HUMAN (P98095), FBLN2_MOUSE (P37889), 
FBLN3_HUMAN (Q12805), FBLN3_MACFA (Q7YQD7), FBLN3_MOUSE (Q8BPB5), 
FBLN3_RAT   (O35568), FBLN4_CRIGR (O55058), FBLN4_HUMAN (O95967), 
FBLN4_MOUSE (Q9WVJ9), FBLN5_BOVIN (Q5EA62), FBLN5_HUMAN (Q9UBX5), 
FBLN5_MOUSE (Q9WVH9), FBLN5_PONAB (Q5RC26), FBLN5_RAT   (Q9WVH8), 
FBLN7_HUMAN (Q53RD9), FBLN7_MOUSE (Q501P1), FBN1_BOVIN  (P98133), 
FBN1_HUMAN  (P35555), FBN1_MOUSE  (Q61554), FBN1_PIG    (Q9TV36), 
FBN2_HUMAN  (P35556), FBN2_MOUSE  (Q61555), FBN3_HUMAN  (Q75N90), 
FBP1_STRPU  (P10079), FBP3_STRPU  (P49013), GAS6_HUMAN  (Q14393), 
GAS6_MOUSE  (Q61592), GAS6_RAT    (Q63772), GLP1_CAEEL  (P13508), 
HEG1_HUMAN  (Q9ULI3), HEG1_MOUSE  (E9Q7X6), HEG_DANRE   (Q6R8J2), 
HMCN1_HUMAN (Q96RW7), HMCN2_HUMAN (Q8NDA2), HMCN2_MOUSE (A2AJ76), 
JAG1A_DANRE (Q90Y57), JAG1B_DANRE (Q90Y54), JAG1_HUMAN  (P78504), 
JAG1_MOUSE  (Q9QXX0), JAG1_RAT    (Q63722), JAG2_HUMAN  (Q9Y219), 
JAG2_MOUSE  (Q9QYE5), JAG2_RAT    (P97607), LDLR1_XENLA (Q99087), 
LDLR2_XENLA (Q99088), LDLR_CRIGR  (P35950), LDLR_HUMAN  (P01130), 
LDLR_MOUSE  (P35951), LDLR_PIG    (Q28832), LDLR_RABIT  (P20063), 
LDLR_RAT    (P35952), LIN12_CAEEL (P14585), LRP1B_HUMAN (Q9NZR2), 
LRP1B_MOUSE (Q9JI18), LRP1_CHICK  (P98157), LRP1_HUMAN  (Q07954), 
LRP1_MOUSE  (Q91ZX7), LRP2_HUMAN  (P98164), LRP2_MOUSE  (A2ARV4), 
LRP2_RAT    (P98158), LRP4_HUMAN  (O75096), LRP4_MOUSE  (Q8VI56), 
LRP4_RAT    (Q9QYP1), LRP8_CHICK  (Q98931), LRP8_HUMAN  (Q14114), 
LRP8_MOUSE  (Q924X6), LRP_CAEEL   (Q04833), LTBP1_HUMAN (Q14766), 
LTBP1_MOUSE (Q8CG19), LTBP1_RAT   (Q00918), LTBP2_BOVIN (Q28019), 
LTBP2_HUMAN (Q14767), LTBP2_MOUSE (O08999), LTBP2_RAT   (O35806), 
LTBP3_HUMAN (Q9NS15), LTBP3_MOUSE (Q61810), LTBP4_HUMAN (Q8N2S1), 
LTBP4_MOUSE (Q8K4G1), MASP1_HUMAN (P48740), MASP1_MOUSE (P98064), 
MASP1_RAT   (Q8CHN8), MASP2_HUMAN (O00187), MASP2_MOUSE (Q91WP0), 
MASP2_RAT   (Q9JJS8), MEGF6_HUMAN (O75095), MEGF6_MOUSE (Q80V70), 
MEGF6_RAT   (O88281), MEGF8_HUMAN (Q7Z7M0), MEGF8_MOUSE (P60882), 
MEGF8_RAT   (Q9QYP0), MLP_ACRMI   (B3EWY9), MUA3_CAEEL  (P34576), 
MUP4_CAEEL  (Q21281), NAS39_CAEEL (Q20176), NCAN_HUMAN  (O14594), 
NCAN_MOUSE  (P55066), NCAN_PANTR  (Q5IS41), NCAN_RAT    (P55067), 
NELL1_HUMAN (Q92832), NELL1_MOUSE (Q2VWQ2), NELL1_RAT   (Q62919), 
NELL2_BOVIN (A6QR11), NELL2_DANRE (A1A5Y0), NELL2_HUMAN (Q99435), 
NELL2_MOUSE (Q61220), NELL2_PONAB (Q5R3Z7), NELL2_RAT   (Q62918), 
NELL2_XENLA (Q7ZXL5), NELL2_XENTR (A2VCU8), NEL_CHICK   (Q90827), 
NID1_HUMAN  (P14543), NID1_MOUSE  (P10493), NID2_HUMAN  (Q14112), 
NID2_MOUSE  (O88322), NID2_RAT    (B5DFC9), NOTC1_CRIGR (G3I6Z6), 
NOTC1_DANRE (P46530), NOTC1_HUMAN (P46531), NOTC1_MOUSE (Q01705), 
NOTC1_RAT   (Q07008), NOTC1_XENLA (P21783), NOTC1_XENTR (A2RUV0), 
NOTC2_HUMAN (Q04721), NOTC2_MOUSE (O35516), NOTC2_RAT   (Q9QW30), 
NOTC3_HUMAN (Q9UM47), NOTC3_MOUSE (Q61982), NOTC3_RAT   (Q9R172), 
NOTC4_HUMAN (Q99466), NOTC4_MOUSE (P31695), NOTCH_DROME (P07207), 
NPNT_HUMAN  (Q6UXI9), NPNT_MOUSE  (Q91V88), NPNT_PONAB  (Q5RBP1), 
NT2NL_HUMAN (Q7Z3S9), OIT3_BOVIN  (Q29RU2), OIT3_HUMAN  (Q8WWZ8), 
PERT_CANFA  (Q8HYB7), PERT_HUMAN  (P07202), PERT_MOUSE  (P35419), 
PERT_RAT    (P14650), PGCA_BOVIN  (P13608), PGCA_CANFA  (Q28343), 
PGCA_CHICK  (P07898), PROC_BOVIN  (P00745), PROC_CANFA  (Q28278), 
PROC_HUMAN  (P04070), PROC_MOUSE  (P33587), PROC_PIG    (Q9GLP2), 
PROC_RABIT  (Q28661), PROC_RAT    (P31394), PROS_BOVIN  (P07224), 
PROS_HUMAN  (P07225), PROS_MACMU  (Q28520), PROS_MOUSE  (Q08761), 
PROS_RABIT  (P98118), PROS_RAT    (P53813), SCUB1_HUMAN (Q8IWY4), 
SCUB1_MOUSE (Q6NZL8), SCUB2_DANRE (Q5G872), SCUB2_HUMAN (Q9NQ36), 
SCUB2_MOUSE (Q9JJS0), SCUB3_HUMAN (Q8IX30), SCUB3_MOUSE (Q66PY1), 
SERR_DROME  (P18168), SLIT1_CAEEL (G5EFX6), SLIT1_HUMAN (O75093), 
SLIT1_MOUSE (Q80TR4), SLIT1_RAT   (O88279), SLIT2_HUMAN (O94813), 
SLIT2_MOUSE (Q9R1B9), SLIT3_HUMAN (O75094), SLIT3_MOUSE (Q9WVB4), 
SLIT3_RAT   (O88280), SLIT_DROME  (P24014), SNED1_HUMAN (Q8TER0), 
SNED1_MOUSE (Q70E20), SNED1_RAT   (Q5ZQU0), SP63_STRPU  (Q07929), 
SUSD1_HUMAN (Q6UWL2), SVEP1_HUMAN (Q4LDE5), SVEP1_MOUSE (A2AVA0), 
SVEP1_RAT   (P0C6B8), TLD_DROME   (P25723), TLL1_CHICK  (Q9DER7), 
TLL1_DANRE  (O57460), TLL1_HUMAN  (O43897), TLL1_MOUSE  (Q62381), 
TLL1_XENLA  (Q8JI28), TLL2_HUMAN  (Q9Y6L7), TLL2_MOUSE  (Q9WVM6), 
TLL2_XENLA  (O57382), TRBM_BOVIN  (P06579), TRBM_CANFA  (Q5W7P8), 
TRBM_HUMAN  (P07204), TRBM_MOUSE  (P15306), TRBM_SAISC  (Q71U07), 
TSP3A_DANRE (Q8JHW2), TSP3B_DANRE (Q1L8P7), TSP3_HUMAN  (P49746), 
TSP3_MOUSE  (Q05895), TSP4B_DANRE (Q8JGW0), TSP4_BOVIN  (Q3SWW8), 
TSP4_HUMAN  (P35443), TSP4_MOUSE  (Q9Z1T2), TSP4_RAT    (P49744), 
TSP4_XENLA  (Q06441), UROL1_HUMAN (Q5DID0), UROL1_MOUSE (Q5DID3), 
UROM_BOVIN  (P48733), UROM_CANFA  (Q862Z3), UROM_HUMAN  (P07911), 
UROM_MOUSE  (Q91X17), UROM_PONAB  (Q5R5C1), UROM_RAT    (P27590), 
VGR_SOLIN   (Q6X0I2), VLDLR_CHICK (P98165), VLDLR_HUMAN (P98155), 
VLDLR_MOUSE (P98156), VLDLR_RABIT (P35953), VLDLR_RAT   (P98166), 
VSR1_ARATH  (P93026), VSR1_PEA    (P93484), VSR2_ARATH  (O22925), 
VSR3_ARATH  (O80977), VSR4_ARATH  (Q56ZQ3), VSR5_ARATH  (O64758), 
VSR6_ARATH  (Q9FYH7), VSR7_ARATH  (Q8L7E3), VWCE_HUMAN  (Q96DN2), 
VWCE_MOUSE  (Q3U515), WAK1_ARATH  (Q39191), WAK2_ARATH  (Q9LMP1), 
WAK3_ARATH  (Q9LMN8), WAK4_ARATH  (Q9LMN6), WAK5_ARATH  (Q9LMN7), 
WAKLD_ARATH (Q9S9M2), WAKLE_ARATH (Q9S9M1), YL_DROME    (P98163)
» More

UniProtKB/Swiss-Prot
False negative sequences
6 sequences

CADN2_DROME (Q9VJB6), LRP5_HUMAN  (O75197), LRP5_MOUSE  (Q91VN0), 
OIT3_MOUSE  (Q8R4V5), OIT3_RAT    (Q6V0K7), PERT_PIG    (P09933)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

FAXD_NOTSN  (P0CY52)

		
UniProtKB/Swiss-Prot
'Unknown' sequences
8 sequences

WAKLB_ARATH (Q7X8C5), WAKLC_ARATH (Q9S9M3), WAKLG_ARATH (Q9SA25), 
WAKLH_ARATH (Q9C9L5), WAKLJ_ARATH (Q8VYA3), WAKLK_ARATH (Q9LN59), 
WAKLM_ARATH (Q9M092), WAKLN_ARATH (Q0WNY5)
» More

PDB
[Detailed view]
75 PDB

1APO; 1APQ; 1BF9; 1DAN; 1DVA; 1DX5; 1EDM; 1EMN; 1EMO; 1F7E; 1F7M; 1FAK; 1FF7; 1FFM; 1HJ7; 1HZ8; 1I0U; 1IXA; 1LMJ; 1N7D; 1NZI; 1SZB; 1TOZ; 1UZJ; 1UZK; 1UZP; 1UZQ; 1W0Y; 1W2K; 1WQV; 1WSS; 1WTG; 1WUN; 1WV7; 1Z6C; 1Z6J; 2A2Q; 2AEI; 2AER; 2B8O; 2BO2; 2BOU; 2BOX; 2C4F; 2EC9; 2FIR; 2KL7; 2RQZ; 2RR0; 2RR2; 2VJ3; 2W86; 2ZP0; 2ZWL; 2ZZU; 3DEM; 3GIS; 3M0C; 3P5B; 3P5C; 3TH2; 3TH4; 3V65; 4AQB; 4CUD; 4CUE; 4CUF; 4D0E; 4D0F; 4D90; 4IBL; 4LMF; 4LOR; 4XL1; 4XLW
» More

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