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PROSITE entry PS01187


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General information about the entry

Entry name [info] EGF_CA
Accession [info] PS01187
Entry type [info] PATTERN
Date [info] 01-NOV-1997 CREATED;
01-DEC-2001 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00913

Name and characterization of the entry

Description [info] Calcium-binding EGF-like domain signature.
Pattern [info] 
[DEQN]-x-[DEQN](2)-C-x(3,14)-C-x(3,7)-C-x-[DN]-x(4)-[FY]-x-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 1'747 in 431 different sequences
Number of true positive hits 1'739 in 423 different sequences
Number of 'unknown' hits 8 in 8 different sequences
Number of false positive hits 0
Number of false negative sequences 6
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 99.66 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 43
Site [info] disulfide at position 4
Site [info] disulfide at position 6
Site [info] disulfide at position 8
Site [info] disulfide at position 14
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 423 sequences 

AGRE1_HUMAN (Q14246), AGRE1_MOUSE (Q61549), AGRE1_RAT   (Q5Y4N8), 

AGRE2_CANLF (Q2Q421), AGRE2_HUMAN (Q9UHX3), AGRE2_MACMU (Q2Q426), 
AGRE3_HUMAN (Q9BY15), AGRE4_HUMAN (Q86SQ3), AGRE4_MOUSE (Q91ZE5), 
AGRE5_BOVIN (Q8SQA4), AGRE5_HUMAN (P48960), AGRE5_MOUSE (Q9Z0M6), 
AGRL4_DANRE (Q7SY09), AGRL4_HUMAN (Q9HBW9), AGRL4_MOUSE (Q923X1), 
AGRL4_RAT   (Q9ESC1), BMP1_HUMAN  (P13497), BMP1_MOUSE  (P98063), 
BMP1_XENLA  (P98070), BMPH_STRPU  (P98069), C1QR1_HUMAN (Q9NPY3), 
C1QR1_MOUSE (O89103), C1QR1_RAT   (Q9ET61), C1RA_MOUSE  (Q8CG16), 
C1RB_MOUSE  (Q8CFG9), C1R_HUMAN   (P00736), C1R_MACFA   (Q4R577), 
C1R_PANTR   (Q5R1W3), C1R_PONAB   (Q5R544), C1S_BOVIN   (Q0VCX1), 
C1S_HUMAN   (P09871), C1S_PIG (Q69DK8), C1S_RAT (Q6P6T1), 
CASP_MESAU  (P15156), CCBE1_DANRE (A8WGB1), CCBE1_HUMAN (Q6UXH8), 
CCBE1_MOUSE (Q3MI99), CD248_HUMAN (Q9HCU0), CD248_MOUSE (Q91V98), 
COMP_BOVIN  (P35445), COMP_HUMAN  (P49747), COMP_MOUSE  (Q9R0G6), 
COMP_RAT(P35444), CRAC1_HUMAN (Q9NQ79), CRAC1_MOUSE (Q8R555), 
CRAC1_XENTR (Q0V9M0), CRB_DROME   (P10040), CRE2A_XENLA (Q5XH36), 
CRE2B_XENLA (Q4V7M2), CREL1_BOVIN (Q5EA46), CREL1_CAEEL (Q19267), 
CREL1_HUMAN (Q96HD1), CREL1_MOUSE (Q91XD7), CREL1_RAT   (Q4V7F2), 
CREL1_XENTR (A0A6I8RMG7), CREL2_BOVIN (Q2KIT5), CREL2_CRIGR (Q60438), 
CREL2_DANRE (Q7SXF6), CREL2_HUMAN (Q6UXH1), CREL2_MOUSE (Q9CYA0), 
CREL2_RAT   (Q4G063), CRUM1_HUMAN (P82279), CRUM1_MOUSE (Q8VHS2), 
CRUM2_HUMAN (Q5IJ48), CRUM2_MOUSE (Q80YA8), CS1A_MOUSE  (Q8CG14), 
CS1B_MOUSE  (Q8CFG8), CSPG2_BOVIN (P81282), CSPG2_CHICK (Q90953), 
CSPG2_HUMAN (P13611), CSPG2_MACNE (Q28858), CSPG2_MOUSE (Q62059), 
CSPG2_RAT   (Q9ERB4), CUBN_CAEEL  (Q20911), CUBN_CANLF  (Q9TU53), 
CUBN_DROME  (Q9W332), CUBN_HUMAN  (O60494), CUBN_MOUSE  (Q9JLB4), 
CUBN_PIG(F1RWC3), CUBN_RAT(O70244), DEX1_CAEEL  (P41950), 
DIG1_CAEEL  (Q09165), DLK2_BOVIN  (A4FV93), DLK2_HUMAN  (Q6UY11), 
DLK2_MOUSE  (Q8K1E3), DLK2_PIG(B2LW77), DLK2_RAT(D3ZUK3), 
DLL1_HUMAN  (O00548), DLL1_MOUSE  (Q61483), DLL1_RAT(P97677), 
DLLA_DANRE  (Q6DI48), DLLB_DANRE  (O57409), DLLC_DANRE  (Q9IAT6), 
DLLD_DANRE  (Q8UWJ4), DL_DROME(P10041), DNER_HUMAN  (Q8NFT8), 
DNER_MOUSE  (Q8JZM4), EDIL3_HUMAN (O43854), EDIL3_MOUSE (O35474), 
EDIL3_PONAB (Q5R7K9), EGFEM_MOUSE (Q8C088), EGFL6_HUMAN (Q8IUX8), 
EGFL6_MOUSE (Q9JJZ5), EGFL6_XENLA (Q8AVH7), EGFL7_HUMAN (Q9UHF1), 
EGFL7_MOUSE (Q9QXT5), EGFL7_RAT   (Q6AZ60), EGFL8_HUMAN (Q99944), 
EGFL8_MOUSE (Q6GUQ1), EGFL8_PIG   (A5A8Y8), EGFL8_RAT   (Q6MG84), 
EGF_CANLF   (Q9BEA0), EGF_FELCA   (Q95ND4), EGF_HUMAN   (P01133), 
EGF_MOUSE   (P01132), EGF_PIG (Q00968), EGF_RAT (P07522), 
EYS_DANRE   (B8JI71), EYS_DROME   (A0A1F4), EYS_HUMAN   (Q5T1H1), 
EYS_MACFA   (A0A2K5V015), EYS_PONAB   (Q5R6R1), FA101_PSETE (Q1L659), 
FA102_PSETE (Q1L658), FA10_BOVIN  (P00743), FA10_CHICK  (P25155), 
FA10_HUMAN  (P00742), FA10_MOUSE  (O88947), FA10_RABIT  (O19045), 
FA10_RAT(Q63207), FA10_TROCA  (Q4QXT9), FA7_BOVIN   (P22457), 
FA7_HUMAN   (P08709), FA7_MOUSE   (P70375), FA7_PANPA   (Q2F9P4), 
FA7_PANTR   (Q2F9P2), FA7_RABIT   (P98139), FA7_RAT (Q8K3U6), 
FA9_BOVIN   (P00741), FA9_CANLF   (P19540), FA9_CHICK   (Q804X6), 
FA9_FELCA   (Q6SA95), FA9_HUMAN   (P00740), FA9_MOUSE   (P16294), 
FA9_PANTR   (Q95ND7), FA9_PIG (P16293), FA9_RAT (P16296), 
FAT1_HUMAN  (Q14517), FAT2_DROME  (Q9VW71), FAT3_HUMAN  (Q8TDW7), 
FAT3_MOUSE  (Q8BNA6), FAT3_RAT(Q8R508), FAT4_HUMAN  (Q6V0I7), 
FAT4_MOUSE  (Q2PZL6), FAXC_OXYMI  (Q58L95), FAXC_OXYSU  (Q58L96), 
FAXC_PSETE  (Q56VR3), FAXD1_DEMVE (A6MFK7), FAXD1_NOTSC (P82807), 
FAXD2_DEMVE (A6MFK8), FAXD2_NOTSC (Q58L94), FAXD_CRYNI  (B5G6G5), 
FAXD_HOPST  (P83370), FAXD_PSEPO  (Q58L93), FAXD_TROCA  (P81428), 
FBLN1_CAEEL (O77469), FBLN1_CHICK (O73775), FBLN1_CHLAE (Q8MJJ9), 
FBLN1_DANRE (O42182), FBLN1_HUMAN (P23142), FBLN1_MOUSE (Q08879), 
FBLN2_HUMAN (P98095), FBLN2_MOUSE (P37889), FBLN3_HUMAN (Q12805), 
FBLN3_MACFA (Q7YQD7), FBLN3_MOUSE (Q8BPB5), FBLN3_RAT   (O35568), 
FBLN4_CRIGR (O55058), FBLN4_HUMAN (O95967), FBLN4_MOUSE (Q9WVJ9), 
FBLN5_BOVIN (Q5EA62), FBLN5_HUMAN (Q9UBX5), FBLN5_MOUSE (Q9WVH9), 
FBLN5_PONAB (Q5RC26), FBLN5_RAT   (Q9WVH8), FBLN7_HUMAN (Q53RD9), 
FBLN7_MOUSE (Q501P1), FBN1_BOVIN  (P98133), FBN1_HUMAN  (P35555), 
FBN1_MOUSE  (Q61554), FBN1_PIG(Q9TV36), FBN2_HUMAN  (P35556), 
FBN2_MOUSE  (Q61555), FBN3_HUMAN  (Q75N90), FBP1_STRPU  (P10079), 
FBP3_STRPU  (P49013), GAS6_HUMAN  (Q14393), GAS6_MOUSE  (Q61592), 
GAS6_RAT(Q63772), GLP1_CAEEL  (P13508), GLTX_GLYTI  (A0A1U9VX91), 
HEG1_HUMAN  (Q9ULI3), HEG1_MOUSE  (E9Q7X6), HEG_DANRE   (Q6R8J2), 
HMCN1_HUMAN (Q96RW7), HMCN1_MOUSE (D3YXG0), HMCN2_HUMAN (Q8NDA2), 
HMCN2_MOUSE (A2AJ76), JAG1A_DANRE (Q90Y57), JAG1B_DANRE (Q90Y54), 
JAG1_HUMAN  (P78504), JAG1_MOUSE  (Q9QXX0), JAG1_RAT(Q63722), 
JAG2_HUMAN  (Q9Y219), JAG2_MOUSE  (Q9QYE5), JAG2_RAT(P97607), 
LDLR1_XENLA (Q99087), LDLR2_XENLA (Q99088), LDLR_BOVIN  (P01131), 
LDLR_CRIGR  (P35950), LDLR_HUMAN  (P01130), LDLR_MOUSE  (P35951), 
LDLR_PIG(Q28832), LDLR_RABIT  (P20063), LDLR_RAT(P35952), 
LIN12_CAEEL (P14585), LRP1B_HUMAN (Q9NZR2), LRP1B_MOUSE (Q9JI18), 
LRP1_CHICK  (P98157), LRP1_HUMAN  (Q07954), LRP1_MOUSE  (Q91ZX7), 
LRP1_RAT(G3V928), LRP2_HUMAN  (P98164), LRP2_MOUSE  (A2ARV4), 
LRP2_PIG(C0HL13), LRP2_RAT(P98158), LRP4_HUMAN  (O75096), 
LRP4_MOUSE  (Q8VI56), LRP4_RAT(Q9QYP1), LRP8_CHICK  (Q98931), 
LRP8_HUMAN  (Q14114), LRP8_MOUSE  (Q924X6), LRP_CAEEL   (Q04833), 
LTBP1_HUMAN (Q14766), LTBP1_MOUSE (Q8CG19), LTBP1_RAT   (Q00918), 
LTBP2_BOVIN (Q28019), LTBP2_HUMAN (Q14767), LTBP2_MOUSE (O08999), 
LTBP2_RAT   (O35806), LTBP3_HUMAN (Q9NS15), LTBP3_MOUSE (Q61810), 
LTBP4_HUMAN (Q8N2S1), LTBP4_MOUSE (Q8K4G1), MASP1_HUMAN (P48740), 
MASP1_MOUSE (P98064), MASP1_RAT   (Q8CHN8), MASP2_HUMAN (O00187), 
MASP2_MOUSE (Q91WP0), MASP2_RAT   (Q9JJS8), MEGF6_HUMAN (O75095), 
MEGF6_MOUSE (Q80V70), MEGF6_RAT   (O88281), MEGF8_HUMAN (Q7Z7M0), 
MEGF8_MOUSE (P60882), MEGF8_RAT   (Q9QYP0), MLP_ACRMI   (B3EWY9), 
MUA3_CAEEL  (P34576), MUP4_CAEEL  (Q21281), NAS39_CAEEL (Q20176), 
NBPFP_HUMAN (B4DH59), NCAN_HUMAN  (O14594), NCAN_MOUSE  (P55066), 
NCAN_PANTR  (Q5IS41), NCAN_RAT(P55067), NDG_DROME   (A1Z877), 
NELL1_HUMAN (Q92832), NELL1_MOUSE (Q2VWQ2), NELL1_RAT   (Q62919), 
NELL2_BOVIN (A6QR11), NELL2_DANRE (A1A5Y0), NELL2_HUMAN (Q99435), 
NELL2_MOUSE (Q61220), NELL2_PONAB (Q5R3Z7), NELL2_RAT   (Q62918), 
NELL2_XENLA (Q7ZXL5), NELL2_XENTR (A2VCU8), NEL_CHICK   (Q90827), 
NID1_HUMAN  (P14543), NID1_MOUSE  (P10493), NID2_HUMAN  (Q14112), 
NID2_MOUSE  (O88322), NID2_RAT(B5DFC9), NOTC1_CRIGR (G3I6Z6), 
NOTC1_DANRE (P46530), NOTC1_HUMAN (P46531), NOTC1_MOUSE (Q01705), 
NOTC1_RAT   (Q07008), NOTC1_XENLA (P21783), NOTC1_XENTR (A2RUV0), 
NOTC2_HUMAN (Q04721), NOTC2_MOUSE (O35516), NOTC2_RAT   (Q9QW30), 
NOTC3_HUMAN (Q9UM47), NOTC3_MOUSE (Q61982), NOTC3_RAT   (Q9R172), 
NOTC4_HUMAN (Q99466), NOTC4_MOUSE (P31695), NOTCH_DROME (P07207), 
NPNT_HUMAN  (Q6UXI9), NPNT_MOUSE  (Q91V88), NPNT_PONAB  (Q5RBP1), 
NT2NA_HUMAN (Q7Z3S9), NT2NB_HUMAN (P0DPK3), NT2NC_HUMAN (P0DPK4), 
NT2NR_HUMAN (A0A096LNW5), OIT3_BOVIN  (Q29RU2), OIT3_HUMAN  (Q8WWZ8), 
PERT_CANLF  (Q8HYB7), PERT_HUMAN  (P07202), PERT_MOUSE  (P35419), 
PERT_RAT(P14650), PGCA_BOVIN  (P13608), PGCA_CANLF  (Q28343), 
PGCA_CHICK  (P07898), PROC_BOVIN  (P00745), PROC_CANLF  (Q28278), 
PROC_HUMAN  (P04070), PROC_MOUSE  (P33587), PROC_PIG(Q9GLP2), 
PROC_RABIT  (Q28661), PROC_RAT(P31394), PROS_BOVIN  (P07224), 
PROS_HUMAN  (P07225), PROS_MACMU  (Q28520), PROS_MOUSE  (Q08761), 
PROS_RABIT  (P98118), PROS_RAT(P53813), SCUB1_HUMAN (Q8IWY4), 
SCUB1_MOUSE (Q6NZL8), SCUB2_DANRE (Q5G872), SCUB2_HUMAN (Q9NQ36), 
SCUB2_MOUSE (Q9JJS0), SCUB3_HUMAN (Q8IX30), SCUB3_MOUSE (Q66PY1), 
SERR_DROME  (P18168), SLIT1_CAEEL (G5EFX6), SLIT1_HUMAN (O75093), 
SLIT1_MOUSE (Q80TR4), SLIT1_RAT   (O88279), SLIT2_HUMAN (O94813), 
SLIT2_MOUSE (Q9R1B9), SLIT3_HUMAN (O75094), SLIT3_MOUSE (Q9WVB4), 
SLIT3_RAT   (O88280), SLIT_DROME  (P24014), SNED1_HUMAN (Q8TER0), 
SNED1_MOUSE (Q70E20), SNED1_RAT   (Q5ZQU0), SP63_STRPU  (Q07929), 
SUSD1_HUMAN (Q6UWL2), SVEP1_DANRE (A0A1D5NSM8), SVEP1_HUMAN (Q4LDE5), 
SVEP1_MOUSE (A2AVA0), SVEP1_RAT   (P0C6B8), TLD_DROME   (P25723), 
TLL1_CHICK  (Q9DER7), TLL1_DANRE  (O57460), TLL1_HUMAN  (O43897), 
TLL1_MOUSE  (Q62381), TLL1_XENLA  (Q8JI28), TLL2_HUMAN  (Q9Y6L7), 
TLL2_MOUSE  (Q9WVM6), TLL2_XENLA  (O57382), TOK_DROME   (Q9VC47), 
TRBM_BOVIN  (P06579), TRBM_CANLF  (Q5W7P8), TRBM_HUMAN  (P07204), 
TRBM_MOUSE  (P15306), TRBM_SAISC  (Q71U07), TSP3A_DANRE (Q8JHW2), 
TSP3B_DANRE (Q1L8P7), TSP3_HUMAN  (P49746), TSP3_MOUSE  (Q05895), 
TSP4B_DANRE (Q8JGW0), TSP4_BOVIN  (Q3SWW8), TSP4_HUMAN  (P35443), 
TSP4_MOUSE  (Q9Z1T2), TSP4_RAT(P49744), TSP4_XENLA  (Q06441), 
UROL1_HUMAN (Q5DID0), UROL1_MOUSE (Q5DID3), UROM_BOVIN  (P48733), 
UROM_CANLF  (Q862Z3), UROM_HUMAN  (P07911), UROM_MOUSE  (Q91X17), 
UROM_PONAB  (Q5R5C1), UROM_RAT(P27590), VGR_SOLIN   (Q6X0I2), 
VLDLR_CHICK (P98165), VLDLR_HUMAN (P98155), VLDLR_MOUSE (P98156), 
VLDLR_RABIT (P35953), VLDLR_RAT   (P98166), VSR1_ARATH  (P93026), 
VSR1_PEA(P93484), VSR2_ARATH  (O22925), VSR3_ARATH  (O80977), 
VSR4_ARATH  (Q56ZQ3), VSR5_ARATH  (O64758), VSR6_ARATH  (Q9FYH7), 
VSR7_ARATH  (Q8L7E3), VWCE_HUMAN  (Q96DN2), VWCE_MOUSE  (Q3U515), 
WAK17_MAIZE (A0A1D6E0S8), WAK1_ARATH  (Q39191), WAK2_ARATH  (Q9LMP1), 
WAK3_ARATH  (Q9LMN8), WAK4_ARATH  (Q9LMN6), WAK5_ARATH  (Q9LMN7), 
WAKLD_ARATH (Q9S9M2), WAKLE_ARATH (Q9S9M1), YL_DROME(P98163)
» more

UniProtKB/Swiss-Prot
False negative sequences		 6 sequences 

CADN2_DROME (Q9VJB6), LRP5_HUMAN  (O75197), LRP5_MOUSE  (Q91VN0), 

OIT3_MOUSE  (Q8R4V5), OIT3_RAT(Q6V0K7), PERT_PIG(P09933)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

FAXD_NOTSN  (P0CY52)


				
	

	

		UniProtKB/Swiss-Prot
'Unknown' sequences		
		
			8 sequences
			


			
WAKLB_ARATH (Q7X8C5), WAKLC_ARATH (Q9S9M3), WAKLG_ARATH (Q9SA25), 

			
WAKLH_ARATH (Q9C9L5), WAKLJ_ARATH (Q8VYA3), WAKLK_ARATH (Q9LN59), 
WAKLM_ARATH (Q9M092), WAKLN_ARATH (Q0WNY5)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			242 PDB
			


			1APO; 1APQ; 1AUT; 1BF9; 1C5M; 1CCF; 1DAN; 1DVA; 1DX5; 1EDM; 1EMN; 1EMO; 
			
				1EZQ; 1F0R; 1F0S; 1F7E; 1F7M; 1FAK; 1FAX; 1FF7; 1FFM; 1G2L; 1G2M; 1HJ7; 
				1HZ8; 1I0U; 1IOE; 1IQE; 1IQF; 1IQG; 1IQH; 1IQI; 1IQJ; 1IQK; 1IQL; 1IQM; 
				1IQN; 1IXA; 1KSN; 1LMJ; 1LPG; 1LPK; 1LPZ; 1LQD; 1N7D; 1NFU; 1NFW; 1NFX; 
				1NFY; 1NT0; 1NZI; 1O5D; 1P0S; 1PFX; 1SZB; 1TOZ; 1UZJ; 1UZK; 1UZP; 1UZQ; 
				1W0Y; 1W2K; 1WHE; 1WHF; 1WQV; 1WSS; 1WTG; 1WU1; 1WUN; 1WV7; 1X7A; 1XKA; 
				1XKB; 1Z6C; 1Z6J; 2A2Q; 2AEI; 2AER; 2B7D; 2B8O; 2BO2; 2BOH; 2BOU; 2BOX; 
				2C4F; 2CJI; 2EC9; 2F9B; 2FIR; 2FLB; 2FLR; 2H9E; 2J2U; 2J34; 2J38; 2J4I; 
				2J94; 2J95; 2KL7; 2RQZ; 2RR0; 2RR2; 2UWL; 2UWO; 2UWP; 2VH0; 2VH6; 2VJ3; 
				2W2M; 2W2N; 2W2O; 2W2P; 2W2Q; 2W86; 2WYG; 2WYJ; 2Y7X; 2Y7Z; 2Y80; 2Y81; 
				2Y82; 2ZP0; 2ZWL; 2ZZU; 3BPS; 3DEM; 3ELA; 3ENS; 3GCW; 3GCX; 3GIS; 3HPT; 
				3K9X; 3M0C; 3P5B; 3P5C; 3SW2; 3TH2; 3TH3; 3TH4; 3V65; 4A7I; 4AQB; 4BTI; 
				4BTT; 4BTU; 4BXS; 4BXW; 4CUD; 4CUE; 4CUF; 4D0E; 4D0F; 4D90; 4IBL; 4LMF; 
				4LOR; 4WM0; 4WMA; 4WMB; 4WMI; 4WMK; 4WN2; 4WNH; 4XBM; 4XL1; 4XLW; 4Y6D; 
				4Y71; 4Y76; 4Y79; 4Y7A; 4Y7B; 4YLQ; 4ZH8; 4ZHA; 4ZMA; 5B4X; 5CIS; 5CKM; 
				5CKN; 5CKQ; 5F84; 5F85; 5F86; 5FM9; 5FMA; 5JZ8; 5JZU; 5KXH; 5KY0; 5KY2; 
				5KY3; 5KY8; 5KY9; 5L0R; 5L0S; 5MS9; 5MWB; 5TO3; 5UB5; 5UK5; 5VYG; 6F1C; 
				6F1H; 6F39; 6M3B; 6M3C; 6POG; 6POL; 6TQK; 6ZS5; 6ZYA; 7ALJ; 7DO4; 7PFP; 
				7Q3N; 7T4R; 7TPP; 8EM4; 8EM7; 8EOK; 8EPH; 8JUT; 8JUU; 8JX8; 8JX9; 8JXA; 
				8JXB; 8JXC; 8JXD; 8JXE; 8JXF; 8JXG; 8JXH; 8JXI; 8JXJ; 8S9P; 8UFB; 9B1R; 
				9CTH; 9ETN
			
			

			» more