Entry: PS01187

General information about the entry

Entry name [info] EGF_CA
Accession [info] PS01187
Entry type [info] PATTERN
Date [info] NOV-1997 (CREATED); DEC-2001 (DATA UPDATE); JUN-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00913

Name and characterization of the entry

Description [info] Calcium-binding EGF-like domain signature.
Pattern [info]
[DEQN]-x-[DEQN](2)-C-x(3,14)-C-x(3,7)-C-x-[DN]-x(4)-[FY]-x-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_08 which contains 551'987 sequence entries.


Total number of hits 1'685 in 412 different sequences
Number of true positive hits 1'677 in 404 different sequences
Number of 'unknown' hits 8 in 8 different sequences
Number of false positive hits 0
Number of false negative sequences 6
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 99.64 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 43
Site [info] disulfide at position 4
Site [info] disulfide at position 6
Site [info] disulfide at position 8
Site [info] disulfide at position 14
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
404 sequences

AGRE1_HUMAN (Q14246    ), AGRE1_MOUSE (Q61549    ), AGRE1_RAT   (Q5Y4N8    ), 
AGRE2_CANLF (Q2Q421    ), AGRE2_HUMAN (Q9UHX3    ), AGRE2_MACMU (Q2Q426    ), 
AGRE3_HUMAN (Q9BY15    ), AGRE4_HUMAN (Q86SQ3    ), AGRE4_MOUSE (Q91ZE5    ), 
AGRL4_DANRE (Q7SY09    ), AGRL4_HUMAN (Q9HBW9    ), AGRL4_MOUSE (Q923X1    ), 
AGRL4_RAT   (Q9ESC1    ), BMP1_HUMAN  (P13497    ), BMP1_MOUSE  (P98063    ), 
BMP1_XENLA  (P98070    ), BMPH_STRPU  (P98069    ), C1QR1_HUMAN (Q9NPY3    ), 
C1QR1_MOUSE (O89103    ), C1QR1_RAT   (Q9ET61    ), C1RA_MOUSE  (Q8CG16    ), 
C1RB_MOUSE  (Q8CFG9    ), C1R_HUMAN   (P00736    ), C1R_MACFA   (Q4R577    ), 
C1R_PANTR   (Q5R1W3    ), C1R_PONAB   (Q5R544    ), C1S_BOVIN   (Q0VCX1    ), 
C1S_HUMAN   (P09871    ), C1S_PIG     (Q69DK8    ), C1S_RAT     (Q6P6T1    ), 
CASP_MESAU  (P15156    ), CCBE1_DANRE (A8WGB1    ), CCBE1_HUMAN (Q6UXH8    ), 
CCBE1_MOUSE (Q3MI99    ), CD248_HUMAN (Q9HCU0    ), CD248_MOUSE (Q91V98    ), 
CD97_BOVIN  (Q8SQA4    ), CD97_HUMAN  (P48960    ), CD97_MOUSE  (Q9Z0M6    ), 
COMP_BOVIN  (P35445    ), COMP_HUMAN  (P49747    ), COMP_MOUSE  (Q9R0G6    ), 
COMP_RAT    (P35444    ), CRAC1_HUMAN (Q9NQ79    ), CRAC1_MOUSE (Q8R555    ), 
CRAC1_XENTR (Q0V9M0    ), CRB_DROME   (P10040    ), CRE2A_XENLA (Q5XH36    ), 
CRE2B_XENLA (Q4V7M2    ), CREL1_BOVIN (Q5EA46    ), CREL1_HUMAN (Q96HD1    ), 
CREL1_MOUSE (Q91XD7    ), CREL1_RAT   (Q4V7F2    ), CREL2_BOVIN (Q2KIT5    ), 
CREL2_CRIGR (Q60438    ), CREL2_DANRE (Q7SXF6    ), CREL2_HUMAN (Q6UXH1    ), 
CREL2_MOUSE (Q9CYA0    ), CREL2_RAT   (Q4G063    ), CRUM1_HUMAN (P82279    ), 
CRUM1_MOUSE (Q8VHS2    ), CRUM2_HUMAN (Q5IJ48    ), CRUM2_MOUSE (Q80YA8    ), 
CS1A_MOUSE  (Q8CG14    ), CS1B_MOUSE  (Q8CFG8    ), CSPG2_BOVIN (P81282    ), 
CSPG2_CHICK (Q90953    ), CSPG2_HUMAN (P13611    ), CSPG2_MACNE (Q28858    ), 
CSPG2_MOUSE (Q62059    ), CSPG2_RAT   (Q9ERB4    ), CUBN_CAEEL  (Q20911    ), 
CUBN_CANLF  (Q9TU53    ), CUBN_DROME  (Q9W332    ), CUBN_HUMAN  (O60494    ), 
CUBN_MOUSE  (Q9JLB4    ), CUBN_RAT    (O70244    ), DEX1_CAEEL  (P41950    ), 
DIG1_CAEEL  (Q09165    ), DLK2_BOVIN  (A4FV93    ), DLK2_HUMAN  (Q6UY11    ), 
DLK2_MOUSE  (Q8K1E3    ), DLK2_PIG    (B2LW77    ), DLK2_RAT    (D3ZUK3    ), 
DLL1_HUMAN  (O00548    ), DLL1_MOUSE  (Q61483    ), DLL1_RAT    (P97677    ), 
DLLA_DANRE  (Q6DI48    ), DLLB_DANRE  (O57409    ), DLLC_DANRE  (Q9IAT6    ), 
DLLD_DANRE  (Q8UWJ4    ), DL_DROME    (P10041    ), DNER_HUMAN  (Q8NFT8    ), 
DNER_MOUSE  (Q8JZM4    ), EDIL3_HUMAN (O43854    ), EDIL3_MOUSE (O35474    ), 
EDIL3_PONAB (Q5R7K9    ), EGFEM_MOUSE (Q8C088    ), EGFL6_HUMAN (Q8IUX8    ), 
EGFL6_MOUSE (Q9JJZ5    ), EGFL6_XENLA (Q8AVH7    ), EGFL7_HUMAN (Q9UHF1    ), 
EGFL7_MOUSE (Q9QXT5    ), EGFL7_RAT   (Q6AZ60    ), EGFL8_HUMAN (Q99944    ), 
EGFL8_MOUSE (Q6GUQ1    ), EGFL8_PIG   (A5A8Y8    ), EGFL8_RAT   (Q6MG84    ), 
EGF_CANLF   (Q9BEA0    ), EGF_FELCA   (Q95ND4    ), EGF_HUMAN   (P01133    ), 
EGF_MOUSE   (P01132    ), EGF_PIG     (Q00968    ), EGF_RAT     (P07522    ), 
EYS_DROME   (A0A1F4    ), EYS_HUMAN   (Q5T1H1    ), FA101_PSETE (Q1L659    ), 
FA102_PSETE (Q1L658    ), FA10_BOVIN  (P00743    ), FA10_CHICK  (P25155    ), 
FA10_HUMAN  (P00742    ), FA10_MOUSE  (O88947    ), FA10_RABIT  (O19045    ), 
FA10_RAT    (Q63207    ), FA10_TROCA  (Q4QXT9    ), FA7_BOVIN   (P22457    ), 
FA7_HUMAN   (P08709    ), FA7_MOUSE   (P70375    ), FA7_PANPA   (Q2F9P4    ), 
FA7_PANTR   (Q2F9P2    ), FA7_RABIT   (P98139    ), FA7_RAT     (Q8K3U6    ), 
FA9_BOVIN   (P00741    ), FA9_CANLF   (P19540    ), FA9_CHICK   (Q804X6    ), 
FA9_FELCA   (Q6SA95    ), FA9_HUMAN   (P00740    ), FA9_MOUSE   (P16294    ), 
FA9_PANTR   (Q95ND7    ), FA9_PIG     (P16293    ), FA9_RAT     (P16296    ), 
FAT1_HUMAN  (Q14517    ), FAT2_DROME  (Q9VW71    ), FAT3_HUMAN  (Q8TDW7    ), 
FAT3_MOUSE  (Q8BNA6    ), FAT3_RAT    (Q8R508    ), FAT4_HUMAN  (Q6V0I7    ), 
FAT4_MOUSE  (Q2PZL6    ), FAXC_OXYMI  (Q58L95    ), FAXC_OXYSU  (Q58L96    ), 
FAXC_PSETE  (Q56VR3    ), FAXD1_DEMVE (A6MFK7    ), FAXD1_NOTSC (P82807    ), 
FAXD2_DEMVE (A6MFK8    ), FAXD2_NOTSC (Q58L94    ), FAXD_CRYNI  (B5G6G5    ), 
FAXD_HOPST  (P83370    ), FAXD_PSEPO  (Q58L93    ), FAXD_TROCA  (P81428    ), 
FBLN1_CAEEL (O77469    ), FBLN1_CHICK (O73775    ), FBLN1_CHLAE (Q8MJJ9    ), 
FBLN1_DANRE (O42182    ), FBLN1_HUMAN (P23142    ), FBLN1_MOUSE (Q08879    ), 
FBLN2_HUMAN (P98095    ), FBLN2_MOUSE (P37889    ), FBLN3_HUMAN (Q12805    ), 
FBLN3_MACFA (Q7YQD7    ), FBLN3_MOUSE (Q8BPB5    ), FBLN3_RAT   (O35568    ), 
FBLN4_CRIGR (O55058    ), FBLN4_HUMAN (O95967    ), FBLN4_MOUSE (Q9WVJ9    ), 
FBLN5_BOVIN (Q5EA62    ), FBLN5_HUMAN (Q9UBX5    ), FBLN5_MOUSE (Q9WVH9    ), 
FBLN5_PONAB (Q5RC26    ), FBLN5_RAT   (Q9WVH8    ), FBLN7_HUMAN (Q53RD9    ), 
FBLN7_MOUSE (Q501P1    ), FBN1_BOVIN  (P98133    ), FBN1_HUMAN  (P35555    ), 
FBN1_MOUSE  (Q61554    ), FBN1_PIG    (Q9TV36    ), FBN2_HUMAN  (P35556    ), 
FBN2_MOUSE  (Q61555    ), FBN3_HUMAN  (Q75N90    ), FBP1_STRPU  (P10079    ), 
FBP3_STRPU  (P49013    ), GAS6_HUMAN  (Q14393    ), GAS6_MOUSE  (Q61592    ), 
GAS6_RAT    (Q63772    ), GLP1_CAEEL  (P13508    ), HEG1_HUMAN  (Q9ULI3    ), 
HEG1_MOUSE  (E9Q7X6    ), HEG_DANRE   (Q6R8J2    ), HMCN1_HUMAN (Q96RW7    ), 
HMCN2_HUMAN (Q8NDA2    ), HMCN2_MOUSE (A2AJ76    ), JAG1A_DANRE (Q90Y57    ), 
JAG1B_DANRE (Q90Y54    ), JAG1_HUMAN  (P78504    ), JAG1_MOUSE  (Q9QXX0    ), 
JAG1_RAT    (Q63722    ), JAG2_HUMAN  (Q9Y219    ), JAG2_MOUSE  (Q9QYE5    ), 
JAG2_RAT    (P97607    ), LDLR1_XENLA (Q99087    ), LDLR2_XENLA (Q99088    ), 
LDLR_CRIGR  (P35950    ), LDLR_HUMAN  (P01130    ), LDLR_MOUSE  (P35951    ), 
LDLR_PIG    (Q28832    ), LDLR_RABIT  (P20063    ), LDLR_RAT    (P35952    ), 
LIN12_CAEEL (P14585    ), LRP1B_HUMAN (Q9NZR2    ), LRP1B_MOUSE (Q9JI18    ), 
LRP1_CHICK  (P98157    ), LRP1_HUMAN  (Q07954    ), LRP1_MOUSE  (Q91ZX7    ), 
LRP2_HUMAN  (P98164    ), LRP2_MOUSE  (A2ARV4    ), LRP2_RAT    (P98158    ), 
LRP4_HUMAN  (O75096    ), LRP4_MOUSE  (Q8VI56    ), LRP4_RAT    (Q9QYP1    ), 
LRP8_CHICK  (Q98931    ), LRP8_HUMAN  (Q14114    ), LRP8_MOUSE  (Q924X6    ), 
LRP_CAEEL   (Q04833    ), LTBP1_HUMAN (Q14766    ), LTBP1_MOUSE (Q8CG19    ), 
LTBP1_RAT   (Q00918    ), LTBP2_BOVIN (Q28019    ), LTBP2_HUMAN (Q14767    ), 
LTBP2_MOUSE (O08999    ), LTBP2_RAT   (O35806    ), LTBP3_HUMAN (Q9NS15    ), 
LTBP3_MOUSE (Q61810    ), LTBP4_HUMAN (Q8N2S1    ), LTBP4_MOUSE (Q8K4G1    ), 
MASP1_HUMAN (P48740    ), MASP1_MOUSE (P98064    ), MASP1_RAT   (Q8CHN8    ), 
MASP2_HUMAN (O00187    ), MASP2_MOUSE (Q91WP0    ), MASP2_RAT   (Q9JJS8    ), 
MEGF6_HUMAN (O75095    ), MEGF6_MOUSE (Q80V70    ), MEGF6_RAT   (O88281    ), 
MEGF8_HUMAN (Q7Z7M0    ), MEGF8_MOUSE (P60882    ), MEGF8_RAT   (Q9QYP0    ), 
MLP_ACRMI   (B3EWY9    ), MUA3_CAEEL  (P34576    ), MUP4_CAEEL  (Q21281    ), 
NAS39_CAEEL (Q20176    ), NCAN_HUMAN  (O14594    ), NCAN_MOUSE  (P55066    ), 
NCAN_PANTR  (Q5IS41    ), NCAN_RAT    (P55067    ), NELL1_HUMAN (Q92832    ), 
NELL1_MOUSE (Q2VWQ2    ), NELL1_RAT   (Q62919    ), NELL2_BOVIN (A6QR11    ), 
NELL2_DANRE (A1A5Y0    ), NELL2_HUMAN (Q99435    ), NELL2_MOUSE (Q61220    ), 
NELL2_PONAB (Q5R3Z7    ), NELL2_RAT   (Q62918    ), NELL2_XENLA (Q7ZXL5    ), 
NELL2_XENTR (A2VCU8    ), NEL_CHICK   (Q90827    ), NID1_HUMAN  (P14543    ), 
NID1_MOUSE  (P10493    ), NID2_HUMAN  (Q14112    ), NID2_MOUSE  (O88322    ), 
NID2_RAT    (B5DFC9    ), NOTC1_CRIGR (G3I6Z6    ), NOTC1_DANRE (P46530    ), 
NOTC1_HUMAN (P46531    ), NOTC1_MOUSE (Q01705    ), NOTC1_RAT   (Q07008    ), 
NOTC1_XENLA (P21783    ), NOTC1_XENTR (A2RUV0    ), NOTC2_HUMAN (Q04721    ), 
NOTC2_MOUSE (O35516    ), NOTC2_RAT   (Q9QW30    ), NOTC3_HUMAN (Q9UM47    ), 
NOTC3_MOUSE (Q61982    ), NOTC3_RAT   (Q9R172    ), NOTC4_HUMAN (Q99466    ), 
NOTC4_MOUSE (P31695    ), NOTCH_DROME (P07207    ), NPNT_HUMAN  (Q6UXI9    ), 
NPNT_MOUSE  (Q91V88    ), NPNT_PONAB  (Q5RBP1    ), NT2NL_HUMAN (Q7Z3S9    ), 
OIT3_BOVIN  (Q29RU2    ), OIT3_HUMAN  (Q8WWZ8    ), PERT_CANLF  (Q8HYB7    ), 
PERT_HUMAN  (P07202    ), PERT_MOUSE  (P35419    ), PERT_RAT    (P14650    ), 
PGCA_BOVIN  (P13608    ), PGCA_CANLF  (Q28343    ), PGCA_CHICK  (P07898    ), 
PROC_BOVIN  (P00745    ), PROC_CANLF  (Q28278    ), PROC_HUMAN  (P04070    ), 
PROC_MOUSE  (P33587    ), PROC_PIG    (Q9GLP2    ), PROC_RABIT  (Q28661    ), 
PROC_RAT    (P31394    ), PROS_BOVIN  (P07224    ), PROS_HUMAN  (P07225    ), 
PROS_MACMU  (Q28520    ), PROS_MOUSE  (Q08761    ), PROS_RABIT  (P98118    ), 
PROS_RAT    (P53813    ), SCUB1_HUMAN (Q8IWY4    ), SCUB1_MOUSE (Q6NZL8    ), 
SCUB2_DANRE (Q5G872    ), SCUB2_HUMAN (Q9NQ36    ), SCUB2_MOUSE (Q9JJS0    ), 
SCUB3_HUMAN (Q8IX30    ), SCUB3_MOUSE (Q66PY1    ), SERR_DROME  (P18168    ), 
SLIT1_CAEEL (G5EFX6    ), SLIT1_HUMAN (O75093    ), SLIT1_MOUSE (Q80TR4    ), 
SLIT1_RAT   (O88279    ), SLIT2_HUMAN (O94813    ), SLIT2_MOUSE (Q9R1B9    ), 
SLIT3_HUMAN (O75094    ), SLIT3_MOUSE (Q9WVB4    ), SLIT3_RAT   (O88280    ), 
SLIT_DROME  (P24014    ), SNED1_HUMAN (Q8TER0    ), SNED1_MOUSE (Q70E20    ), 
SNED1_RAT   (Q5ZQU0    ), SP63_STRPU  (Q07929    ), SUSD1_HUMAN (Q6UWL2    ), 
SVEP1_HUMAN (Q4LDE5    ), SVEP1_MOUSE (A2AVA0    ), SVEP1_RAT   (P0C6B8    ), 
TLD_DROME   (P25723    ), TLL1_CHICK  (Q9DER7    ), TLL1_DANRE  (O57460    ), 
TLL1_HUMAN  (O43897    ), TLL1_MOUSE  (Q62381    ), TLL1_XENLA  (Q8JI28    ), 
TLL2_HUMAN  (Q9Y6L7    ), TLL2_MOUSE  (Q9WVM6    ), TLL2_XENLA  (O57382    ), 
TRBM_BOVIN  (P06579    ), TRBM_CANLF  (Q5W7P8    ), TRBM_HUMAN  (P07204    ), 
TRBM_MOUSE  (P15306    ), TRBM_SAISC  (Q71U07    ), TSP3A_DANRE (Q8JHW2    ), 
TSP3B_DANRE (Q1L8P7    ), TSP3_HUMAN  (P49746    ), TSP3_MOUSE  (Q05895    ), 
TSP4B_DANRE (Q8JGW0    ), TSP4_BOVIN  (Q3SWW8    ), TSP4_HUMAN  (P35443    ), 
TSP4_MOUSE  (Q9Z1T2    ), TSP4_RAT    (P49744    ), TSP4_XENLA  (Q06441    ), 
UROL1_HUMAN (Q5DID0    ), UROL1_MOUSE (Q5DID3    ), UROM_BOVIN  (P48733    ), 
UROM_CANLF  (Q862Z3    ), UROM_HUMAN  (P07911    ), UROM_MOUSE  (Q91X17    ), 
UROM_PONAB  (Q5R5C1    ), UROM_RAT    (P27590    ), VGR_SOLIN   (Q6X0I2    ), 
VLDLR_CHICK (P98165    ), VLDLR_HUMAN (P98155    ), VLDLR_MOUSE (P98156    ), 
VLDLR_RABIT (P35953    ), VLDLR_RAT   (P98166    ), VSR1_ARATH  (P93026    ), 
VSR1_PEA    (P93484    ), VSR2_ARATH  (O22925    ), VSR3_ARATH  (O80977    ), 
VSR4_ARATH  (Q56ZQ3    ), VSR5_ARATH  (O64758    ), VSR6_ARATH  (Q9FYH7    ), 
VSR7_ARATH  (Q8L7E3    ), VWCE_HUMAN  (Q96DN2    ), VWCE_MOUSE  (Q3U515    ), 
WAK1_ARATH  (Q39191    ), WAK2_ARATH  (Q9LMP1    ), WAK3_ARATH  (Q9LMN8    ), 
WAK4_ARATH  (Q9LMN6    ), WAK5_ARATH  (Q9LMN7    ), WAKLD_ARATH (Q9S9M2    ), 
WAKLE_ARATH (Q9S9M1    ), YL_DROME    (P98163    )
» more

UniProtKB/Swiss-Prot
False negative sequences
6 sequences

CADN2_DROME (Q9VJB6    ), LRP5_HUMAN  (O75197    ), LRP5_MOUSE  (Q91VN0    ), 
OIT3_MOUSE  (Q8R4V5    ), OIT3_RAT    (Q6V0K7    ), PERT_PIG    (P09933    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

FAXD_NOTSN  (P0CY52    )

		
UniProtKB/Swiss-Prot
'Unknown' sequences
8 sequences

WAKLB_ARATH (Q7X8C5    ), WAKLC_ARATH (Q9S9M3    ), WAKLG_ARATH (Q9SA25    ), 
WAKLH_ARATH (Q9C9L5    ), WAKLJ_ARATH (Q8VYA3    ), WAKLK_ARATH (Q9LN59    ), 
WAKLM_ARATH (Q9M092    ), WAKLN_ARATH (Q0WNY5    )
» more

PDB
[Detailed view]
79 PDB

1APO; 1APQ; 1BF9; 1DAN; 1DVA; 1DX5; 1EDM; 1EMN; 1EMO; 1F7E; 1F7M; 1FAK; 1FF7; 1FFM; 1HJ7; 1HZ8; 1I0U; 1IXA; 1LMJ; 1N7D; 1NZI; 1SZB; 1TOZ; 1UZJ; 1UZK; 1UZP; 1UZQ; 1W0Y; 1W2K; 1WQV; 1WSS; 1WTG; 1WUN; 1WV7; 1Z6C; 1Z6J; 2A2Q; 2AEI; 2AER; 2B8O; 2BO2; 2BOU; 2BOX; 2C4F; 2EC9; 2FIR; 2KL7; 2RQZ; 2RR0; 2RR2; 2VJ3; 2W86; 2ZP0; 2ZWL; 2ZZU; 3DEM; 3GIS; 3M0C; 3P5B; 3P5C; 3TH2; 3TH4; 3V65; 4AQB; 4CUD; 4CUE; 4CUF; 4D0E; 4D0F; 4D90; 4IBL; 4LMF; 4LOR; 4XL1; 4XLW; 4YLQ; 4ZMA; 5FM9; 5FMA
» more

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