Entry: PS01248

General information about the entry
Entry name EGF_LAM_1
Accession number PS01248
Entry type PATTERN
Date NOV-1997 (CREATED); NOV-1997 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation PDOC00961
Name and characterization of the entry
DescriptionLaminin-type EGF-like (LE) domain signature.
Pattern C-x(1,2)-C-x(5)-G-x(2)-C-x(2)-C-x(3,4)-[FYW]-x(3,15)-C.
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052.
  • Total number of hits in UniProtKB/Swiss-Prot: 562 hits in 132 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 522 hits in 92 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 40 hits in 40 different sequences
  • Number of known missed hits: 1
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 1
  • Precision (true hits / (true hits + false positives)): 92.88 %
  • Recall (true hits / (true hits + false negatives)): 99.81 %
Comments
  • Taxonomic range: Eukaryotes
  • Maximum known number of repetitions of the pattern in a single protein: 21
  • `Interesting' site in the pattern: 1,disulfide
  • `Interesting' site in the pattern: 3,disulfide
  • `Interesting' site in the pattern: 7,disulfide
  • `Interesting' site in the pattern: 9,disulfide
  • `Interesting' site in the pattern: 13,disulfide
  • VERSION: 1
Cross-references
UniProtKB/Swiss-Prot True positive hits:
AGRIN_CHICK (P31696), AGRIN_DIPOM (Q90404), AGRIN_HUMAN (O00468), 
AGRIN_MOUSE (A2ASQ1), AGRIN_RAT   (P25304), ATRN1_HUMAN (Q5VV63), 
ATRN1_MOUSE (Q6A051), ATRN_HUMAN  (O75882), ATRN_MOUSE  (Q9WU60), 
ATRN_RAT    (Q99J86), CELR1_HUMAN (Q9NYQ6), CELR1_MOUSE (O35161), 
CELR2_HUMAN (Q9HCU4), CELR2_MOUSE (Q9R0M0), CELR2_RAT   (Q9QYP2), 
CELR3_HUMAN (Q9NYQ7), CELR3_MOUSE (Q91ZI0), CELR3_RAT   (O88278), 
EPI1_CAEEL  (Q21313), LAM2_CAEEL  (Q18823), LAMA1_HUMAN (P25391), 
LAMA1_MOUSE (P19137), LAMA2_HUMAN (P24043), LAMA2_MOUSE (Q60675), 
LAMA3_HUMAN (Q16787), LAMA3_MOUSE (Q61789), LAMA4_HUMAN (Q16363), 
LAMA4_MOUSE (P97927), LAMA5_HUMAN (O15230), LAMA5_MOUSE (Q61001), 
LAMA_DROME  (Q00174), LAMB1_CHICK (Q01635), LAMB1_DROME (P11046), 
LAMB1_HUMAN (P07942), LAMB1_HYDVU (Q27262), LAMB1_MOUSE (P02469), 
LAMB2_HUMAN (P55268), LAMB2_MOUSE (Q61292), LAMB2_RAT   (P15800), 
LAMB3_HUMAN (Q13751), LAMB3_MOUSE (Q61087), LAMB4_DANRE (Q8JHV6), 
LAMB4_HUMAN (A4D0S4), LAMB_HIRME  (Q25092), LAMC1_DANRE (Q1LVF0), 
LAMC1_DROME (P15215), LAMC1_HUMAN (P11047), LAMC1_MOUSE (P02468), 
LAMC1_XENTR (A0JP86), LAMC2_HORSE (Q8HZI9), LAMC2_HUMAN (Q13753), 
LAMC2_MOUSE (Q61092), LAMC3_HUMAN (Q9Y6N6), LAMC3_MOUSE (Q9R0B6), 
MEGF8_HUMAN (Q7Z7M0), MEGF8_MOUSE (P60882), MEGF8_RAT   (Q9QYP0), 
MEGF9_HUMAN (Q9H1U4), MEGF9_MOUSE (Q8BH27), NET1_CHICK  (Q90922), 
NET1_HUMAN  (O95631), NET1_MOUSE  (O09118), NET1_PIG    (Q2HXW4), 
NET1_RAT    (Q924Z9), NET3_CHICK  (Q90923), NET3_HUMAN  (O00634), 
NET3_MOUSE  (Q9R1A3), NET4_HUMAN  (Q9HB63), NET4_MOUSE  (Q9JI33), 
NET4_PONAB  (Q5RB89), NET5_HUMAN  (Q8WTR8), NET5_MOUSE  (Q3UQ22), 
NETA_DROME  (Q24567), NETB_DROME  (Q24568), NTNG1_HUMAN (Q9Y2I2), 
NTNG1_MOUSE (Q8R4G0), NTNG2_HUMAN (Q96CW9), NTNG2_MOUSE (Q8R4F1), 
PGBM_HUMAN  (P98160), PGBM_MOUSE  (Q05793), STAB1_HUMAN (Q9NY15), 
STAB1_MOUSE (Q8R4Y4), STAB2_HUMAN (Q8WWQ8), STAB2_MOUSE (Q8R4U0), 
STAB2_RAT   (Q8CFM6), STAN_DROME  (Q9V5N8), TAG53_CAEEL (Q19981), 
UNC52_CAEEL (Q06561), UNC6_CAEEL  (P34710), USH2A_HUMAN (O75445), 
USH2A_MOUSE (Q2QI47), USH2A_RAT   (Q8K3K1)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
SIGK_DICDI  (Q6TMJ6)
`Potential' hits (partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences):
LAMBV_CHICK (Q01636)
False positive hits (sequences which do not belong to the set under consideration):
ADP1_YEAST  (P25371), CRE2A_XENLA (Q5XH36), CRE2B_XENLA (Q4V7M2), 
CREL1_BOVIN (Q5EA46), CREL1_HUMAN (Q96HD1), CREL1_MOUSE (Q91XD7), 
CREL1_RAT   (Q4V7F2), CREL2_BOVIN (Q2KIT5), CREL2_CRIGR (Q60438), 
CREL2_DANRE (Q7SXF6), CREL2_HUMAN (Q6UXH1), CREL2_MOUSE (Q9CYA0), 
CREL2_RAT   (Q4G063), POL_COYMV   (P19199), SRCH_HUMAN  (P23327), 
SRCH_RABIT  (P16230), TYRO_BOVIN  (Q8MIU0), TYRO_CANFA  (P54834), 
TYRO_CHICK  (P55024), TYRO_COTJA  (Q08410), TYRO_GORGO  (Q9BDE0), 
TYRO_HUMAN  (P14679), TYRO_MOUSE  (P11344), TYRO_ORYLA  (P55025), 
TYRO_PELNI  (Q04604), TYRO_PELSI  (P55026), TYRP1_AMBME (P55027), 
TYRP1_BOVIN (Q8WN57), TYRP1_CARAU (P55028), TYRP1_CHICK (O57405), 
TYRP1_HUMAN (P17643), TYRP1_MOUSE (P07147), TYRP2_BOVIN (Q95119), 
TYRP2_CHICK (O93505), TYRP2_HUMAN (P40126), TYRP2_MOUSE (P29812), 
TYRP2_PIG   (Q4R1H1), WDR59_CHICK (Q5ZLG9), WDR59_HUMAN (Q6PJI9), 
WDR59_MOUSE (Q8C0M0)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]		 1KLO; 1NPE; 1TLE; 2Y38; 4AQS; 4AQT;

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