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Entry: PS50058

General information about the entry

Entry name [info] G_PROTEIN_GAMMA
Accession [info] PS50058
Entry type [info] MATRIX
Date [info] 01-NOV-1997 CREATED; 01-OCT-2013 DATA UPDATE; 27-SEP-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC01002
Associated ProRule [info] PRU00592

Name and characterization of the entry

Description [info] G-protein gamma subunit domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=66;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=61;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-.1439; R2=.01493742; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=579; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=445; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='N'; M=  0,  6,-19,  0, -6,-19,  7,  5,-19, -9,-23, -9, 18,-16, -3, -8, 13,  0,-18,-33,-16, -5;
/M: SY='T'; M=  5, -9,-16,-16,-13,-12,-10,-18, -1,-15, -8, -2, -4,-14,-10,-16, 11, 16,  2,-28,-12,-13;
/M: SY='S'; M=  8,  4,-18,  0, 10,-22, -9, -6,-17, -3,-18,-10,  7,-10,  7, -7, 13,  5,-15,-30,-17,  8;
/M: SY='S'; M= -2, 16,-19, 18, 11,-26, -6, -4,-26,  0,-29,-21, 17,-10,  3, -4, 20,  6,-19,-37,-19,  7;
/M: SY='I'; M= -3,-28,-21,-33,-24,  2,-31,-25, 30,-27, 28, 16,-25,-25,-21,-24,-20, -8, 22,-21, -3,-24;
/M: SY='A'; M= 19, -6,-16,-10, -4,-23, -2,-14,-16, -8,-19,-13, -3, -2,  0,-13, 16,  8,-10,-27,-19, -2;
/M: SY='Q'; M=  1,  2,-26,  4, 29,-32,-16,  1,-22,  6,-18, -9, -2, -6, 32,  1,  2, -8,-24,-24,-16, 31;
/I:         I=-5; MI=-5; IM=-5; B1=0;
/M: SY='L'; M= 11,-19,-19,-24,-13, -8,-19,-16,  9,-17, 15, 11,-18,-19, -6,-17,-11, -6,  5,-20, -8,-10;
/M: SY='R'; M=-15, -5,-30, -5,  6,-26,-20, -4,-29, 38,-25, -9,  0,-15, 14, 47, -9,-10,-21,-20,-10,  8;
/M: SY='K'; M= -4,-11,-23,-15, -6,-17,-19, -9, -8, 18, -9, 10, -9,-16,  1, 14,-10, -8, -3,-21, -9, -3;
/M: SY='T'; M=  0,-10,-18,-10,  3,-11,-20,-15, -2,-10,  1, -1,-12,-15, -6,-12, -1,  4,  3,-28,-12, -2;
/M: SY='V'; M=  0,-27,-10,-28,-28, -1,-29,-29, 26,-19,  8,  8,-27,-28,-28,-19, -7,  6, 44,-30,-10,-28;
/M: SY='E'; M=-11, 12,-30, 22, 50,-32,-19,  1,-30,  9,-21,-18,  2, -2, 24,  0,  0,-10,-30,-30,-19, 37;
/M: SY='Q'; M=-10,  0,-30,  0, 20,-40,-20, 10,-20, 10,-20,  0,  0,-10, 60, 10,  0,-10,-30,-20,-10, 40;
/M: SY='L'; M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 50, 20,-30,-30,-20,-20,-30,-10, 10,-20,  0,-20;
/M: SY='R'; M=-14, -6,-13, -7,  2,-25,-21, -8,-30, 33,-25,-11, -2,-17,  6, 39,-10,-10,-19,-23,-12,  2;
/M: SY='M'; M= -4,-16,-24,-20,-10,-10,-22,-13,  2,  3,  7, 12,-14,-19, -5,  3,-15, -9,  0,-20, -6, -8;
/M: SY='E'; M=-10, 10,-30, 20, 60,-30,-20,  0,-30, 10,-20,-20,  0,  0, 20,  0,  0,-10,-30,-30,-20, 40;
/M: SY='A'; M= 33,-17,-10,-23,-17,-13,-10,-23,  3,-13, -3, -3,-17,-17,-17,-20,  3,  0, 17,-23,-17,-17;
/M: SY='N'; M=  2,  4,-11, -3, -7,-23,  9,-11,-25, -2,-25,-16, 12,-17, -7, -6,  7,  0,-19,-30,-20, -7;
/M: SY='I'; M= -9,-23,-24,-30,-23,  1,-31,-21, 31,-25, 24, 18,-17,-24,-18,-22,-20, -8, 18,-23, -3,-23;
/M: SY='E'; M=-13, 18,-22, 25, 26,-33,-16, -1,-29,  2,-25,-19,  8,  0, 15, -4,  0, -9,-29,-33,-20, 20;
/M: SY='R'; M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='M'; M= -3,-18,-23,-23,-13,-12,-26,-15, 15, -7,  3, 16,-15,-18,  0,-10,-11, -8, 11,-22, -6, -8;
/M: SY='K'; M= -9, -6,-26, -7,  3,-21,-22,-11,-18, 26,-12, -4, -6,-14,  6, 15,-10, -4,-13,-21, -8,  4;
/M: SY='V'; M= -2,-30,-14,-32,-30,  0,-32,-30, 34,-22, 12, 12,-28,-28,-28,-22,-12, -2, 46,-28, -8,-30;
/M: SY='S'; M= 10,  0,-10,  0,  0,-20,  0,-10,-20,-10,-30,-20, 10,-10,  0,-10, 40, 20,-10,-40,-20,  0;
/M: SY='K'; M=-10,  2,-30,  4, 24,-33,-20, -2,-27, 29,-25, -9,  0, -8, 28, 17, -5,-10,-25,-22,-12, 26;
/M: SY='A'; M= 25,-12, 12,-20,-15,-17,-10,-22,-10,-15,-12,-11,-11,-17,-15,-20,  8,  5,  3,-29,-20,-15;
/M: SY='A'; M= 21, -9, 15,-15,-12,-21,  0,-19,-20,-15,-20,-16, -5,-17,-12,-19, 14,  2, -8,-32,-23,-12;
/M: SY='A'; M= 23, -4,-17, -7,  7,-24, -7,-14,-19,  6,-18,-13, -4, -8,  0, -5,  7, -2,-10,-24,-18,  4;
/M: SY='E'; M=-13, 21,-30, 33, 43,-33,-17, -1,-33, 11,-24,-22,  6, -4, 13,  0, -1,-10,-29,-32,-19, 28;
/M: SY='L'; M=-10,-29,-21,-32,-23, 10,-31,-20, 24,-27, 38, 23,-27,-27,-19,-21,-26,-10, 15,-19,  1,-22;
/M: SY='M'; M=-11,-15,-24,-18, -7,-10,-23, -7, -1,  6,  8, 21,-14,-19,  3,  7,-17,-10, -4,-20, -4, -3;
/M: SY='D'; M=  1, 16,-22, 18,  8,-30, -9, -4,-25,  3,-24,-16, 10,-11,  9, -4,  7, -1,-20,-30,-17,  8;
/M: SY='Y'; M=-20,-23,-27,-26,-23, 44,-30,  9,  0,-16,  3,  0,-20,-30,-18,-13,-20,-10, -7, 24, 66,-23;
/M: SY='C'; M= -8,-24, 69,-32,-30,-13,-32,-30, -5,-28, -7, -7,-22,-35,-28,-28,-12, -8,  8,-41,-21,-30;
/M: SY='E'; M= -9,  5,-26, 11, 37,-22,-20, -4,-20,  2,-10,-10, -3, -6, 11, -4, -2, -4,-20,-29,-16, 24;
/M: SY='E'; M=  6,  1,-24,  1, 23,-28,-15, -5,-21,  8,-18,-11, -2, -7, 19,  0,  3, -3,-19,-24,-16, 21;
/M: SY='H'; M=-16, 10,-27,  6,  5,-21,-14, 49,-27,  1,-23, -9, 21,-18,  8, 12, -3,-12,-28,-31,  0,  4;
/M: SY='A'; M= 27, -6,-14,-11,  0,-21, -6,-16,-13, -2,-15,-11, -6,-10, -4,-11, 10,  1, -4,-25,-18, -2;
/M: SY='R'; M= -8, -7, -9, -9, -5,-27,  2,-10,-28,  3,-23,-12, -3,-18,  5,  9, -2, -6,-21,-25,-18, -1;
/M: SY='E'; M=-12, 21,-27, 20, 28,-27,-13, 12,-27,  7,-25,-18, 22,-10, 10,  2,  2, -8,-29,-33,-16, 19;
/M: SY='D'; M=-20, 50,-30, 70, 20,-40,-10,  0,-40,  0,-30,-30, 20,-10,  0,-10,  0,-10,-30,-40,-20, 10;
/M: SY='P'; M= -6,-19,-34,-14, -5,-20,-20,-14,-13,-10,-20, -8,-19, 57, -9,-18,-11, -9,-21,-22,-14,-11;
/M: SY='L'; M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 50, 20,-30,-30,-20,-20,-30,-10, 10,-20,  0,-20;
/M: SY='L'; M= -6,-30,-18,-31,-25,  5,-31,-25, 27,-26, 32, 16,-29,-29,-24,-21,-22, -6, 27,-24, -4,-25;
/M: SY='T'; M= -3, -7,-17,-12, -8,-14,-21,-17, -5,  3,-11, -2, -6,-14, -7, -2,  5, 16,  3,-27,-10, -8;
/M: SY='G'; M= -2,-12,-32,-10,-15,-30, 49,-20,-35,-18,-30,-20, -5,  5,-18,-20, -2,-18,-30,-22,-30,-18;
/M: SY='V'; M= -6,-29,-21,-32,-27,  5,-32,-28, 28,-23,  9,  9,-25,-13,-26,-23,-14, -5, 29,-23, -5,-28;
/M: SY='P'; M= -6,-14,-31, -9, -2,-25,-18,-19,-18,-10,-26,-18,-13, 59, -9,-17,  1,  6,-22,-31,-25, -9;
/M: SY='E'; M= 13,  5,-17,  6, 14,-24, -9,-11,-21, -4,-19,-17,  1, -7,  1,-11, 13,  6,-13,-30,-19,  7;
/M: SY='D'; M=  0, 12,-21, 16,  7,-30, -2, -5,-26, -4,-26,-18,  8,-11, 11, -7, 16,  1,-20,-33,-19,  9;
/I:         I=-6; MI=-5; IM=-5; DM=-15; MD=-15;
/M: SY='E'; M= -8,  0,-25,  3, 20,-23,-20,  3,-21, 12,-19,-11, -1,-10,  7,  4,  0, -2,-15,-28,-11, 13;
/M: SY='N'; M=-10, 40,-20, 20,  0,-20,  0, 10,-20,  0,-30,-20, 60,-20,  0,  0, 10,  0,-30,-40,-20,  0;
/M: SY='P'; M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='F'; M=-20,-30,-20,-40,-30, 80,-30,-20,  0,-30, 10,  0,-20,-30,-40,-20,-20,-10,  0, 10, 30,-30;
/M: SY='R'; M=-15, -5,-30, -5,  6,-26,-20, -3,-29, 35,-24, -9,  0,-15, 16, 48, -9,-10,-21,-20,-10,  8;
/M: SY='E'; M=-12, 15,-31, 27, 47,-32,-18, -2,-31,  6,-23,-22,  2,  6, 13, -4, -1,-10,-30,-32,-21, 30;
/M: SY='K'; M=-10, -5,-30, -4,  7,-27,-21,-10,-23, 34,-21, -7, -5, -4, 10, 19,-11,-10,-19,-21,-11,  8;
/M: SY='K'; M= -8, -3,-28, -3,  3,-27, -3,-10,-31, 29,-28,-13,  1,-13,  4, 24, -3, -8,-21,-22,-14,  3;
/I:         I=-6; MI=-5; IM=-5;  DM=-15; MD=-15; E1=0;
/M: SY='S'; M= -2,-13,-18,-15,-14,  3,  1,-17,-14,-17,-16,-12, -5,-12,-17,-16, 10,  3, -7,-23,-10,-15;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='T'; M=  9,-11,-13,-18,-15,-10,-17,-21,  4,-15, -6, -4, -8,-15,-13,-16, 11, 18, 11,-29,-12,-15;
/M: SY='I'; M= -9,-30,-23,-36,-28,  9,-35,-27, 35,-28, 23, 16,-24,-25,-24,-25,-20, -8, 28,-19,  1,-28;
/M: SY='L'; M= -5,-22,-17,-22,-15,  2,-22,-17, 10,-25, 29, 10,-20,-25,-15,-17,-12, -2,  5,-25, -5,-15;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_09 which contains 555'594 sequence entries.


Total number of hits 50 in 50 different sequences
Number of true positive hits 50 in 50 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 22
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 69.44 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
50 sequences

EGL10_CAEEL (P49809    ), GBG10_HUMAN (P50151    ), GBG10_MOUSE (Q9CXP8    ), 
GBG11_BOVIN (Q5E9F0    ), GBG11_HUMAN (P61952    ), GBG11_MOUSE (P61953    ), 
GBG11_RAT   (P61954    ), GBG12_BOVIN (Q28024    ), GBG12_HUMAN (Q9UBI6    ), 
GBG12_MOUSE (Q9DAS9    ), GBG12_PONAB (Q5RBQ0    ), GBG13_HUMAN (Q9P2W3    ), 
GBG13_MOUSE (Q9JMF3    ), GBG14_HUMAN (A0A1W2PPG7), GBG1_BOVIN  (P02698    ), 
GBG1_CANLF  (P63210    ), GBG1_DROME  (P38040    ), GBG1_HUMAN  (P63211    ), 
GBG1_MOUSE  (Q61012    ), GBG2_BOVIN  (P63212    ), GBG2_HUMAN  (P59768    ), 
GBG2_MOUSE  (P63213    ), GBG2_PONAB  (Q5R7U4    ), GBG3_BOVIN  (P63214    ), 
GBG3_HUMAN  (P63215    ), GBG3_MOUSE  (P63216    ), GBG4_HUMAN  (P50150    ), 
GBG4_MOUSE  (P50153    ), GBG4_PONAB  (Q5R639    ), GBG5_BOVIN  (P63217    ), 
GBG5_HUMAN  (P63218    ), GBG5_MOUSE  (Q80SZ7    ), GBG5_PONAB  (Q5REH7    ), 
GBG5_RAT    (P63219    ), GBG7_BOVIN  (P30671    ), GBG7_HUMAN  (O60262    ), 
GBG7_MOUSE  (Q61016    ), GBG7_RAT    (P43425    ), GBG8_HUMAN  (Q9UK08    ), 
GBG8_MOUSE  (P63078    ), GBG8_RAT    (P63077    ), GBGE_CALVI  (Q9NFZ2    ), 
GBGE_DROME  (Q9NFZ3    ), GBGT2_BOVIN (P50154    ), GBGT2_CANLF (O97564    ), 
GBGT2_HUMAN (O14610    ), GBGT2_MOUSE (Q61017    ), GBG_CAEBR   (Q4VT26    ), 
GBG_CAEEL   (P54406    ), GBG_NEUCR   (Q7RWT0    )
» more

UniProtKB/Swiss-Prot
False negative sequences
22 sequences

GBG_LOLFO   (Q01821    ), GBG_YEAST   (P18852    ), GG1_ARATH   (Q9FDX9    ), 
GG1_ORYSI   (B8AN27    ), GG1_ORYSJ   (Q75WU1    ), GG2_ARATH   (Q93V47    ), 
GG2_ORYSI   (A2X0N9    ), GG2_ORYSJ   (Q6YXX9    ), GG3_ARATH   (Q6AWT8    ), 
RGS11_HUMAN (O94810    ), RGS11_MOUSE (Q9Z2H1    ), RGS6_HUMAN  (P49758    ), 
RGS6_MOUSE  (Q9Z2H2    ), RGS7_BOVIN  (O46470    ), RGS7_HUMAN  (P49802    ), 
RGS7_MOUSE  (O54829    ), RGS7_RAT    (P49803    ), RGS9_BOVIN  (O46469    ), 
RGS9_HUMAN  (O75916    ), RGS9_MOUSE  (O54828    ), RGS9_RAT    (P49805    ), 
RGS9_TAMST  (Q80ZD1    )
» more

PDB
[Detailed view]
29 PDB

1A0R; 1B9X; 1B9Y; 1GG2; 1GOT; 1GP2; 1OMW; 1TBG; 1XHM; 2BCJ; 2TRC; 3AH8; 3CIK; 3KRW; 3KRX; 3PSC; 3PVU; 3PVW; 3SN6; 3UZS; 3V5W; 4KFM; 4MK0; 4PNK; 5HE0; 5HE1; 5HE2; 5HE3; 5KDO
» more

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