Entry: PS50073

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General information about the entry

Entry name [info] COPPER_FIST_2
Accession [info] PS50073
Entry type [info] MATRIX
Date [info] NOV-1997 (CREATED); OCT-2013 (DATA UPDATE); JUL-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00863
Associated ProRule [info] PRU00055

Name and characterization of the entry

Description [info] Copper-fist DNA-binding domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=40;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=36;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.2387; R2=0.01269227; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=-2484.17905; R2=20.71115; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=650; N_SCORE=8.5; H_SCORE=9363; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=493; N_SCORE=6.5; H_SCORE=7726; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-40; E1=-40; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='M'; M=-10,-20,-20,-30,-20,  0,-20,  0, 20,-10, 20, 60,-20,-20,  0,-10,-20,-10, 10,-20,  0,-10;
/M: SY='V'; M= -3,-28,-19,-28,-25, -5,-30,-28, 24,-20,  4,  6,-27, -7,-25,-22,-12, -3, 32,-28,-12,-26;
/M: SY='V'; M= -4,-30,-18,-33,-29,  1,-33,-29, 36,-24, 18, 14,-27,-27,-26,-23,-15, -4, 39,-26, -6,-29;
/M: SY='I'; M=-12,-30,-28,-40,-30, 13,-38,-28, 42,-30, 18, 17,-20,-22,-23,-28,-20,-10, 25,-15,  5,-30;
/M: SY='N'; M=-10, 36,-21, 20,  8,-21, -3,  9,-21,  1,-29,-20, 52,-17,  3,  0,  9, -1,-30,-39,-20,  5;
/M: SY='G'; M= -1, -3,-29, -6,-17,-29, 61,-16,-37,-17,-30,-20,  8,-20,-17,-17,  1,-17,-30,-23,-29,-17;
/M: SY='I'; M= -6,-13,-20,-19,-16,-10,-26,-16, 18,-14,  1,  6, -8,-22, -7,-14, -7, -4, 18,-27, -9,-13;
/M: SY='K'; M=-10,  0,-30,  0, 10,-30,-20,-10,-30, 50,-30,-10,  0,-10, 10, 30,-10,-10,-20,-20,-10, 10;
/M: SY='Y'; M=-17,-20,-27,-23,-20, 21,-27, 14,  6,-10,  6, 19,-20,-27, -7,-10,-20,-10, -4, 14, 55,-17;
/M: SY='A'; M= 50,-10,-10,-20,-10,-20,  0,-20,-10,-10,-10,-10,-10,-10,-10,-20, 10,  0,  0,-20,-20,-10;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E'; M= -1,  7,-26, 11, 17,-26,  1, -7,-24, -3,-17,-10, -1,-10,  2,-10, -1,-10,-20,-27,-19,  9;
/M: SY='R'; M= -4, -6,-23, -5,  0,-22,-13,-10,-23,  7,-25,-15,  0,  6,  1, 13, 10,  7,-16,-30,-17, -2;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='I'; M=-10,-30,-30,-40,-30,  0,-40,-30, 50,-30, 20, 20,-20,-20,-20,-30,-20,-10, 30,-20,  0,-30;
/M: SY='R'; M=-18, -8,-30, -8,  2,-22,-20, -2,-30, 34,-22,-10,  0,-18, 10, 63,-10,-10,-20,-20,-10,  2;
/M: SY='G'; M=  2, -8,-26, -8,-16,-28, 57,-18,-36,-18,-30,-20,  2,-18,-16,-18,  7,-13,-26,-24,-28,-16;
/M: SY='H'; M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='R'; M=-18, -8,-30, -8,  2,-22,-20, -2,-30, 34,-22,-10,  0,-18, 10, 63,-10,-10,-20,-20,-10,  2;
/M: SY='A'; M= 19,-10,-10,-13,-10,-15, -7,-18, -5,-12,-15,-10, -5,-15,-10,-15, 19,  9,  7,-32,-18,-10;
/M: SY='S'; M= 19, -3,-10, -9, -6,-17, -6,-16,-14,-10,-18,-14,  1,-10, -6,-13, 26, 23, -4,-31,-17, -6;
/M: SY='T'; M= -3,  0,-19, -4,  4,-24,-17, -8,-18,  7,-19, -8,  1,-10, 15,  3, 11, 18,-14,-27,-11,  9;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='N'; M= -9, 12,-22,  5, 10,-21,-14, -3,-22, 11,-22,-15, 17,-13,  4, 13,  5,  7,-20,-30,-15,  6;
/M: SY='H'; M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='T'; M= -5,  9,-17, -1, -7, -8,-12, -2,-13, -7,-18,-13, 17,-17, -5, -7, 13, 19,-13,-24,  1, -7;
/I:         I=-6; MI=-6; IM=-6; DM=-15; MD=-15;
/M: SY='D'; M=-17, 28,-30, 40, 24,-35,-15, 17,-34,  2,-25,-19, 12,-10, 13, -4, -2,-12,-30,-34,-12, 18;
/M: SY='R'; M=-15, -8,-30, -8,  3,-26,-10,  0,-29, 20,-21, -9,  0,-18, 19, 46, -7,-11,-23,-20,-12,  7;
/M: SY='P'; M= -8,-18,-30,-13, -1,-20,-22,-16, -6, -9,-14, -2,-19, 39, -8,-16,-10, -8, -9,-28,-20, -7;
/M: SY='L'; M=-10,-28,-20,-30,-20,  8,-28,-16, 20,-26, 45, 27,-28,-28,-16,-18,-28,-10, 10,-20,  0,-18;
/M: SY='I'; M=-10,-20,-24,-26,-16,  1,-29,-18, 15, -7,  3, 12,-16,-20, -8, -9,-14, -8, 12,-18, -1,-13;
/M: SY='P'; M=-11,-17,-31,-18, -8,-17,-24,-13, -2,  1, -9,  7,-14, 16, -4,  0,-14,-10, -8,-23,-12, -9;
/M: SY='I'; M= -7,-30,-21,-35,-28,  2,-35,-28, 38,-27, 22, 17,-25,-25,-23,-25,-18, -7, 33,-23, -3,-28;
/M: SY='R'; M=-16, -6,-30, -6,  4,-24,-20, -4,-30, 38,-24,-10,  0,-16, 10, 53,-10,-10,-20,-20,-10,  4;
/M: SY='P'; M= -9,-12,-32, -8,  0,-26,-20,-16,-21,  5,-26,-16,-11, 44, -4,  0, -5,  0,-22,-27,-21, -5;
/M: SY='R'; M=-13, -7,-32, -5,  5,-27,-20, -8,-28, 32,-27,-12, -4,  5,  6, 35,-10,-10,-22,-22,-14,  3;
/M: SY='G'; M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='R'; M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='P'; M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='S'; M=  5,-14,-20,-15, -9,-14,-14,-18, -2,-16, -6, -6, -9,  4, -9,-18,  6,  2, -3,-29,-16,-11;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_08 which contains 546'238 sequence entries.


Total number of hits 9 in 9 different sequences
Number of true positive hits 9 in 9 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DNA_BIND
Feature description [info] Copper-fist
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
9 sequences

AMT1_CANGA  (P41772), CRF1_YARLI  (P45815), CUF1_SCHPO  (Q09728), 
CUF2_SCHPO  (O94588), CUP2_YEAST  (P15315), GRISA_PODAS (Q92258), 
HAA1_YEAST  (Q12753), MAC1_CANAL  (Q5AFK0), MAC1_YEAST  (P35192)
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PDB
[Detailed view]
1 PDB

1CO4

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