PROSITE entry PS50078
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General information about the entry
| Entry name [info] | POLO_BOX |
| Accession [info] | PS50078 |
| Entry type [info] | MATRIX |
| Date [info] |
01-DEC-2001 CREATED;
22-FEB-2023 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC50078 |
| Associated ProRule [info] | PRU00154 |
Name and characterization of the entry
| Description [info] | POLO box domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=83; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=78; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4037728; R2=0.0090278; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=953; N_SCORE=11.0; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=454; N_SCORE=6.5; MODE=1; TEXT='RR'; /DEFAULT: M0=-29; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='W'; M= -43, -82, -24, -70, 42, -75, 21, -22, -68, -3, -55, -73, 28, -26, -70, -68, -5, -38, 123, 70; /M: SY='V'; M= -39, -70, -83, -78, -49, -84, -78, 58, -76, 41, 22, -77, -78, -73, -76, -38, -56, 64, -78, -57; /M: SY='R'; M= -58, 2, -61, -52, -70, -68, -6, -69, 49, 3, -59, -53, -29, 9, 65, 44, 11, -66, -77, -63; /M: SY='K'; M= -62, -76, -60, -50, 22, -70, 13, -68, 68, -37, -60, -2, -69, 41, 33, 4, -11, -30, 39, 9; /M: SY='W'; M= -68, -11, -87, -77, -38, -76, -73, 9, -71, -4, 0, -82, -79, -69, -72, -15, -69, 7, 146, 67; /M: SY='F'; M= 5, -68, -71, -70, 56, -72, 19, 0, -66, -8, -49, 17, -75, -67, -14, 2, 7, 55, -71, -49; /I: I=-26; MD=-67; /M: SY='D'; M= -92,-101, 59, -74, 50, -95, -7, -19, -87, -63, -85, -75, 12, -89, -92, -86, -40, -85, -92, -69; D=-26; /I: I=-26; MD=-67; /M: SY='Y'; M= -94,-104, -16, -94, 0,-104, 11, -32, -47, -79, -78, -91,-105, -90, -90, -90, -21, -6, -72, 77; D=-26; /I: I=-26; MI=0; MD=-67; IM=0; DM=-67; /M: SY='S'; M= -30, -78, -13, -31, -78, -18, -68, -37, 22, -72, 10, -60, -5, -58, 39, 46, -1, 12, -87, -72; D=-26; /I: I=-26; DM=-67; /M: SY='D'; M= -37, -73, 57, 0, -22, -63, -57, -71, 0, -51, -68, 38, 45, -30, -60, 24, 47, -68, -81, -4; /M: SY='K'; M= -59, -75, 35, -1, -77, 20, -57, -74, 67, -41, -67, 40, -66, -48, 9, 5, -25, -26, -80, -68; /M: SY='Y'; M= -58, -6, -65, -62, -16, -70, 42, 5, -13, -56, -53, 4, -11, 26, -20, 36, -53, 42, -65, 65; /M: SY='G'; M= 57, -70, -67, -70, 12, 77, -69, -73, -67, -71, 10, -56, -69, -65, -73, -48, -61, -66, -71, -67; /M: SY='W'; M= -62, -72, -82, -76, 33, -80, -75, 49, -73, 26, 42, -74, -76, -72, -75, -19, 17, 38, 76, -48; /M: SY='G'; M= 36, -69, -71, -70, -61, 50, -68, -1, -68, 6, 48, -61, -71, -64, -71, -3, -6, 19, -73, -1; /M: SY='Y'; M= -64, -72, -73, -73, 56, -76, -52, -48, -68, 6, 55, -68, -77, -65, -67, -2, 30, -17, -46, 93; /M: SY='Q'; M= -61, -79, -55, 28, -70, -72, 71, -64, -45, 7, 12, -23, -69, 85, 35, -17, -61, -13, -79, -56; /M: SY='L'; M= -68, -70, -85, -78, 36, -86, -69, -1, -78, 85, -30, -83, -84, -73, -75, -77, -63, -40, -66, -48; /M: SY='S'; M= -46, 59, -56, -56, -74, -55, -59, -73, -22, -75, -68, 12, -66, 28, -59, 90, 23, -66, -84, -67; /M: SY='N'; M= -61, -73, 65, -20, -79, -59, 49, -78, -53, -79, -70, 79, 22, 2, -59, 18, 12, -76, -93, -66; /M: SY='G'; M= -53, -76, -57, 0, -79, 87, -1, -83, -8, -34, -70, 32, -68, -59, -25, -23, -63, -79, -76, -73; /M: SY='T'; M= 4, -44, -16, -10, -66, -26, -64, -3, -53, -60, -1, -54, -66, -56, 35, 32, 64, 19, -80, -13; /M: SY='V'; M= -55, -68, -78, -75, 27, -79, -75, 13, -72, -43, -46, -71, -77, -73, -74, 6, 6, 84, -73, 21; /M: SY='Q'; M= -30, -82, -61, -48, -80, 59, -58, -80, -51, -75, -64, -53, -68, 105, -53, -51, -66, -80, 76, -61; /M: SY='V'; M= -8, -68, -83, -77, 8, -82, -82, 36, -75, -25, 2, -77, -78, -76, -76, -66, -53, 88, -80, -57; /M: SY='N'; M= -62, -72, -56, -57, 23, -66, 18, -14, -56, 26, -12, 69, -73, 67, -58, -5, -5, -59, -71, 14; /I: I=-45; MI=0; MD=-115; IM=0; DM=-115; /M: SY='F'; M= -73, 18, -85, -82, 112, -82, -64, -48, -77, -23, -50, -76, -86, -84, -74, -72, -66, -18, -41, 49; /M: SY='N'; M= -24, -70, -51, -59, -2, -5, 18, -64, 0, -5, -59, 85, -72, 10, -30, 7, -2, -30, -73, 31; /M: SY='D'; M= -64, -77, 107, -37, -83, -5, -55, -78, -56, -80, -77, 33, -67, -56, -64, -53, 5, -25, -98, -70; /M: SY='H'; M= -57, -75, -27, -16, -73, 55, 98, -77, 1, -31, -62, 18, -68, -53, -23, 17, -33, -36, -84, -57; /I: I=-24; MI=0; MD=-60; IM=0; DM=-60; /M: SY='T'; M= 5, -65, -61, -61, -64, -62, 8, -36, -57, -61, 28, -51, -65, -56, -1, 57, 73, 4, -80, 1; /M: SY='K'; M= -61, -77, -6, 4, -75, -70, 56, -69, 64, -69, 3, -10, -66, 57, 27, -31, 7, -7, -79, -60; /M: SY='M'; M= -62, -71, -83, -77, -47, -83, -70, 56, -75, 57, 72, -76, -77, -69, -74, -15, -58, 18, -74, -55; /M: SY='I'; M= 14, -70, -74, -69, -58, -72, -71, 55, -29, -14, 45, -66, -72, -62, 11, 31, -52, 45, -78, -60; /M: SY='W'; M= -64, -71, -84, -76, 12, -84, -74, 26, -73, 59, 26, -79, -80, -71, -22, -72, -24, 41, 68, -50; /M: SY='C'; M= -59, 77, -19, -62, -58, -69, 1, 25, -24, 21, -52, 13, -75, 37, -33, 42, -54, -53, -74, 27; /I: I=-22; MD=-55; /M: SY='P'; M= 20, -76, -14, -59, -79, 3, -66, -32, -62, -75, -67, 6, 82, -6, -70, 44, -32, -12, -82, -75; D=-22; /I: I=-22; MD=-55; /M: SY='D'; M= -2, -77, 46, 32, -73, 9, -62, -19, -2, -1, -63, 16, -7, 15, -27, -25, -23, -17, 23, -67; D=-22; /I: I=-22; MD=-55; /M: SY='M'; M= 4, 14, 1, 9, -69, 31, -63, -26, -25, -13, 57, 9, -71, -23, 18, -12, -21, 4, -81, -67; D=-22; /I: I=-22; MD=-55; /M: SY='Q'; M= -7, -78, 12, 47, -80, -30, -56, -44, 33, -71, 29, -2, -16, 63, -17, 12, -34, -71, -80, -68; D=-22; /I: I=-22; MI=0; MD=-55; IM=0; DM=-55; /M: SY='Q'; M= 15, -11, -12, -36, -71, 19, 31, -68, -27, 7, -61, -26, -73, 49, -63, 30, -3, -41, -80, -6; D=-22; /I: I=-22; DM=-55; /M: SY='V'; M= -61, -73, -83, -77, -52, -87, -80, 60, -22, 31, -39, -78, -79, -73, -14, -72, -58, 65, -80, -60; D=-22; /I: I=-22; DM=-55; /M: SY='T'; M= -30, -69, -11, -33, -66, -70, 34, 10, -25, -62, -58, -52, -65, 10, -63, 15, 86, -13, -82, 3; D=-22; /I: I=-22; DM=-55; /M: SY='Y'; M= -71, -79, -76, -77, 61, -80, -47, -54, -70, -14, -50, -74, -85, -68, -68, -21, -65, -29, -35, 116; D=-22; /I: I=-22; DM=-55; /M: SY='I'; M= -39, -72, -20, -70, -55, -78, -71, 56, -68, -13, 28, -19, -73, 4, -72, -16, 45, 35, 24, 12; D=-22; /I: I=-22; DM=-55; /M: SY='D'; M= 4, -75, 60, 32, -77, -63, -56, -68, -53, -20, -5, 38, 33, 40, -60, 10, -54, -18, -85, -69; /M: SY='P'; M= -4, 10, 25, 44, -77, -68, -11, -77, 7, -76, -68, -54, 51, 19, 45, 9, -22, -73, -78, -12; /M: SY='N'; M= -60, -73, 36, 17, -32, -1, 0, -22, 7, -42, -65, 71, -28, -19, 10, 10, 8, -40, -84, -66; /M: SY='G'; M= -30, -76, -59, -15, -77, 67, 8, -31, 19, -75, -66, 9, -69, 0, 44, -14, -24, -19, -77, -68; /I: I=-21; MD=-53; /M: SY='Q'; M= -64, -80, 20, 22, -79, -73, -11, -11, 26, -43, -67, 13, 26, 36, -2, -3, 23, -26, -86, -71; D=-21; /I: I=-21; MD=-53; /M: SY='S'; M= 4, -78, -34, -7, 28, -15, 30, 16, -69, -65, 2, -64, -7, -66, -27, 40, -3, -15, -81, -62; D=-21; /I: I=-21; MD=-53; /M: SY='T'; M= -66, 1, -68, 16, -9, -36, -44, -29, -65, -22, -66, -65, 10, -47, 3, -19, 67, -12, -87, -36; D=-21; /I: I=-21; MI=0; MD=-53; IM=0; DM=-53; /M: SY='Y'; M= -89,-102, 16, 8, 21, -96, 13, -48, -82, -83, -81, -81, -95, -5, -84, -38, -33, -88, 30, 60; D=-21; /I: I=-21; DM=-53; /M: SY='T'; M= -73, -87, -15, -1, -80, -42, 23, -72, 2, -35, -73, -69, -24, -69, 15, -29, 41, 10, -94, -12; D=-21; /I: I=-21; DM=-53; /M: SY='L'; M= 4, 0, -84, -21, 4, -9, -24, -63, -31, 28, -25, -82, -35, -19, -30, -76, -75, -13, -79, 21; D=-21; /I: I=-21; DM=-53; /M: SY='S'; M= -37, -78, 1, -22, 1, -70, 42, -20, -17, -73, -67, -27, -19, -1, 40, 46, 19, -70, 6, -4; D=-21; /I: I=-21; DM=-53; /M: SY='Y'; M= -40, -73, -69, -26, 26, -77, 53, 17, -68, 22, -47, -9, -36, -64, -68, -16, 19, 13, -61, 66; /M: SY='L'; M= -64, -75, -40, -68, 30, 26, 2, 2, -23, 42, 8, -18, 7, 16, -68, -64, -25, -17, -66, 22; /M: SY='E'; M= -42, -75, -7, 45, -65, -69, -14, -65, -13, 5, 11, 30, -1, 9, 28, 14, 2, -37, -75, 22; /M: SY='N'; M= 5, -71, -8, 17, -19, -49, 5, 4, -60, 5, 22, 38, -71, 6, -36, 17, -11, 28, -81, -62; /M: SY='D'; M= -17, -74, 52, 11, -26, -10, 27, -75, -22, -42, -68, 33, -9, -18, -7, 39, 15, -71, -83, -10; /M: SY='D'; M= -5, -77, 53, 4, -84, 51, -59, -83, 21, -80, -72, -11, -67, 46, -19, 11, -59, -78, -81, -71; /M: SY='C'; M= 8, 82, -35, -71, 5, -35, -2, -9, -26, 28, -13, -70, -80, -17, -71, -64, -60, 33, -71, 35; /M: SY='P'; M= -32, 54, -22, -58, -77, -68, -4, -67, -64, -17, -64, -65, 101, -3, -72, 20, -19, -22, -83, -75; /M: SY='E'; M= -13, -76, -22, 47, 0, -45, -59, -51, 40, -7, -5, 16, 29, -48, 21, 10, -43, -67, -76, -64; /M: SY='E'; M= 19, -73, 21, 43, -69, -44, -1, -64, 7, -34, -63, 13, -1, -9, -58, 22, -5, 9, -78, 11; /I: I=-36; MI=0; MD=-90; IM=0; DM=-90; /M: SY='L'; M= -66, -72, -85, -79, 38, -87, -73, 42, -78, 65, -35, -80, -82, -75, -77, -74, -25, 19, -67, -13; /M: SY='R'; M= -2, -78, 2, -52, -68, -25, 2, -26, 29, -23, -10, -27, -71, 37, 67, 2, -33, -67, -72, 21; /M: SY='H'; M= -38, -77, 37, 47, -80, -66, 48, -80, 29, -77, -69, -6, -17, 28, 11, 39, -22, -75, -84, -65; /M: SY='K'; M= -33, -80, -61, -11, -78, -33, 6, -73, 72, -74, -65, -55, -70, 13, 62, -24, -61, 0, -78, -66; /M: SY='L'; M= -67, -74, -85, -78, -47, -87, -72, 41, -21, 65, 46, -81, -82, -71, -74, -76, -63, 15, -74, -7; /M: SY='T'; M= -27, -76, -57, 15, -12, 4, 20, -75, 21, -73, -66, -2, -68, 45, 30, 3, 50, -70, -80, -64; /M: SY='Y'; M= -66, 34, -75, -69, -46, -9, 11, -6, -68, 37, 2, -71, -8, 42, -68, -67, -65, 1, -61, 72; /M: SY='L'; M= 29, -71, -84, -77, -16, -79, -74, 39, -77, 58, 27, -79, -80, -72, -77, -69, -61, 6, -75, -59; /M: SY='Q'; M= -62, -80, -16, -6, -74, -70, -59, -72, 44, -15, 9, -45, 44, 48, 29, 33, -58, -72, -77, -11; /M: SY='Y'; M= -5, -18, -56, 23, -13, -32, 21, -69, -57, -32, -62, 41, -72, 16, -22, 23, 19, -68, -66, 65; /M: SY='F'; M= -67, -74, -78, -19, 72, -31, 18, 31, -18, -17, 56, -71, -78, -72, -71, -69, -3, 24, -65, -43; /M: SY='L'; M= -6, -78, -8, -65, -61, -80, -70, 18, 0, 46, -48, -70, -80, 36, 12, -30, -64, 7, -80, -64; /M: SY='N'; M= -64, -14, -19, 2, -73, -42, 0, -61, 25, 5, 29, 34, -74, 11, 31, 21, -7, -69, -85, -68; /M: SY='Y'; M= -69, -83, -20, 7, -55, -77, 37, -70, 31, -20, 7, -16, -75, 39, -4, -28, -2, -71, -63, 75; /M: SY='M'; M= -70, -77, -84, -76, 28, -84, -66, -12, -23, 42, 98, -21, -82, -38, 0, -76, -67, -51, 23, -52; /M: SY='S'; M= 13, 19, -19, 3, -72, -42, -65, -39, 17, 15, 0, 25, -74, -8, -10, 28, -23, -43, -84, -70; /M: SY='N'; M= -2, 26, -15, 26, -74, -41, -60, -78, -9, -78, -71, 43, 1, 4, -1, 18, 27, -73, -81, 19; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 71 in 48 different sequences |
| Number of true positive hits | 71 in 48 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 2 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | POLO box |
| Version [info] | 6 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
48 sequences
CCR1_MAIZE (P0C8M8), CDC5_ENCCU (Q8SWM6), CDC5_YEAST (P32562), PLK1_BOVIN (Q2TA25), PLK1_CAEEL (P34331), PLK1_HUMAN (P53350), PLK1_MOUSE (Q07832), PLK1_RAT(Q62673), PLK1_XENLA (P70032), PLK1_XENTR (P62205), PLK2_CAEEL (Q9N2L7), PLK2_HUMAN (Q9NYY3), PLK2_MOUSE (P53351), PLK2_PONAB (Q5R4L1), PLK2_RAT(Q9R012), PLK3_CAEEL (Q20845), PLK3_HUMAN (Q9H4B4), PLK3_MOUSE (Q60806), PLK3_RAT(Q9R011), PLK4_AEDAE (Q16W24), PLK4_BOVIN (A2VDZ4), PLK4_CULQU (B0WAU8), PLK4_DANRE (Q7ZVS3), PLK4_DROAN (B3M6I4), PLK4_DROER (B3NE99), PLK4_DROGR (B4J3F1), PLK4_DROME (O97143), PLK4_DROMO (B4KYX8), PLK4_DROPE (B4HBU3), PLK4_DROPS (Q2LYK3), PLK4_DROSE (B4IAQ8), PLK4_DROSI (B4QK53), PLK4_DROVI (B4LDJ6), PLK4_DROWI (B4MXR8), PLK4_DROYA (B4PDM5), PLK4_HUMAN (O00444), PLK4_MOUSE (Q64702), PLK4_NEMVE (A7SNN5), PLK4_PONAB (Q5R9Z7), PLK4_RAT(B2GUY1), PLK4_XENLA (Q6PAD2), PLK4_XENTR (B3DL84), PLK5_HUMAN (Q496M5), PLK5_MOUSE (Q4FZD7), PLK_DICDI (Q86HN7), PLK_GIAIC (A8BPK8), PLO1_SCHPO (P50528), POLO_DROME (P52304)» more
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| PDB [Detailed view] |
72 PDB
1MBY; 1Q4K; 1Q4O; 1UMW; 2N19; 2OGQ; 2OJX; 3BZI; 3C5L; 3FVH; 3HIH; 3HIK; 3P2W; 3P2Z; 3P34; 3P35; 3P36; 3P37; 3Q1I; 3RQ7; 4DFW; 4E67; 4E9C; 4E9D; 4H5X; 4H71; 4HAB; 4HCO; 4HY2; 4LKL; 4LKM; 4O56; 4O6W; 4O9W; 4RCP; 4RS6; 4WHH; 4WHK; 4WHL; 4X9R; 4X9V; 4X9W; 4XB0; 4YYP; 5DMS; 5DMV; 5DNJ; 5J19; 5LHX; 5LHY; 5LHZ; 5NEI; 5NFU; 5NJE; 5NMM; 5NN1; 5NN2; 5X3S; 6AX4; 6GY2; 6MF4; 6MF5; 6MF6; 7MSO; 7MX1; 7RL3; 8CRC; 8JOQ; 8JOY; 8S30; 8S31; 8XB9 » more |