PROSITE entry PS50104
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General information about the entry
| Entry name [info] | TIR |
| Accession [info] | PS50104 |
| Entry type [info] | MATRIX |
| Date [info] |
01-JAN-2002 CREATED;
07-APR-2021 DATA UPDATE; 27-MAR-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC50104 |
| Associated ProRule [info] | PRU00204 |
Name and characterization of the entry
| Description [info] | TIR domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=142; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=137; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9004707; R2=0.0080595; TEXT='-LogE'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=21907.6386719; R2=3.2387173; PRIORITY=1; TEXT='Heuristic 0.1%'; /CUT_OFF: LEVEL=0; SCORE=1005; H_SCORE=25163; N_SCORE=10.0; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=571; H_SCORE=23757; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-24; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='K'; M= -45, -2, -21, 14, 8, -50, -61, -30, 53, -13, -60, -3, -7, -14, 33, -20, 4, -17, 49, 0; /M: SY='E'; M= -32, 20, 5, 37, 6, -1, -49, -41, 7, 4, 14, -26, -25, 23, 14, -7, 25, -36, -76, -61; /M: SY='Y'; M= -69, 3, -18, -28, 42, -75, 25, -25, 1, -36, -54, -18, 11, -60, -6, -44, -63, -45, -8, 103; /M: SY='D'; M= -39, -79, 99, 22, -85, -60, 14, -83, -12, -81, -76, 13, -49, 26, -48, -9, -43, -79, -94, -68; /M: SY='V'; M= 59, -23, -73, -28, -2, -67, -76, 15, -68, -49, -50, -69, -72, -35, -71, -54, -4, 66, -78, -62; /M: SY='F'; M= -71, -10, -82, -80, 100, -82, -61, 0, -75, 1, -47, -45, -84, -79, -73, -72, -64, 1, -43, 66; /M: SY='I'; M= -53, -72, -83, -77, 7, -85, -79, 71, -35, 27, -13, -77, 0, -74, -76, -70, -40, 53, -74, -55; /M: SY='S'; M= -41, 57, -64, -65, -32, -63, -65, 21, -28, 7, -54, 21, -72, -59, -45, 72, -46, 16, -80, -31; /M: SY='Y'; M= -72, -18, -72, -73, 74, -79, 74, -7, -68, -50, -50, -67, -81, -66, -65, -67, -66, -59, -40, 102; /M: SY='S'; M= 16, 43, -1, -9, -75, -26, 2, -72, -7, -55, -66, -34, 11, -51, 48, 59, -22, -33, -82, -67; /M: SY='G'; M= -12, 27, -20, 25, -75, 41, 28, -35, 23, -59, -66, -38, -1, -16, 33, 18, -23, -71, -77, -20; /M: SY='K'; M= 13, -29, 23, 24, -54, -65, 24, -44, 34, -40, -62, 14, -18, 33, -23, 2, -3, 5, 19, -32; /M: SY='D'; M= 0, -23, 94, 22, -47, -64, 9, -52, -55, -66, -72, 3, 4, -11, -62, -20, -20, -39, -90, -27; /I: I=-19; MI=0; MD=-49; IM=0; DM=-49; /M: SY='W'; M= -48, -92, -16, 12, -56, -62, -91, -5, -82, -16, -70, -85, -90, -80, -59, -25, -3, 35, 65, -51; D=-19; /I: I=-19; DM=-49; /M: SY='R'; M= -10, 34, 1, 25, -80, -23, -66, -75, -29, -36, -70, -39, -76, 7, 60, 10, -26, -11, -87, -73; D=-19; /I: I=-19; DM=-49; /M: SY='D'; M= -23, -78, 46, 40, -31, -53, 27, -23, 11, -11, -63, 27, -69, 11, 12, -15, -33, -56, -77, 16; D=-19; /I: I=-19; DM=-49; /M: SY='W'; M= -14, -78, -13, 8, -9, -4, 40, -44, -31, -62, -64, -1, -70, 31, -24, 13, 25, -55, 104, 32; D=-19; /I: I=-19; DM=-49; /M: SY='F'; M= -33, -71, -41, -77, 87, -62, -72, -6, -39, 32, -44, -76, -82, -40, -74, -71, -62, 41, -58, -37; D=-19; /I: I=-19; DM=-49; /M: SY='V'; M= 25, -22, -43, -2, -58, -74, -70, 17, -22, 12, -28, -49, -73, 1, -5, -59, 8, 49, 24, -5; D=-19; /I: I=-19; DM=-49; /M: SY='S'; M= -22, -70, -6, 21, -27, -35, 18, -64, -13, 12, -59, 50, -68, 22, -40, 57, -28, -33, -80, -42; /M: SY='H'; M= -49, -78, -9, 51, 17, -75, 94, -28, 2, 17, -53, -28, -69, -16, -4, -49, -63, -46, 18, -22; /M: SY='L'; M= -66, -71, -82, -76, 45, -58, -69, 30, -73, 65, 42, -76, -80, -36, -28, -57, -18, -6, -66, -47; /M: SY='L'; M= -12, -71, -22, -4, -23, -53, -64, 6, -9, 36, 13, -66, -74, -23, 25, 9, -56, 36, -72, 11; /M: SY='P'; M= -3, -77, -16, 14, -17, -48, -22, -67, 36, -54, -64, -28, 71, 20, 5, 15, -28, -9, -75, -16; /M: SY='Q'; M= 21, -16, 15, 35, -71, -36, 26, -43, 9, -56, 18, 16, -32, 44, 2, -6, -36, -3, -78, -7; /I: I=-42; MI=0; MD=-106; IM=0; DM=-106; /M: SY='L'; M= -66, -69, -82, -30, 5, -85, -68, -22, -76, 82, 16, -81, -82, -70, -74, -75, -62, 9, -69, -14; /M: SY='E'; M= -47, -31, -3, 84, -79, -31, -21, -44, 3, -51, -67, -26, -62, 33, 36, -11, -44, -44, -79, -68; /M: SY='R'; M= -12, -75, -9, 19, -30, -7, -1, -73, 28, -17, -37, 33, -68, 29, 56, 8, -22, -70, -77, -33; /M: SY='Q'; M= -13, -52, 10, 37, -23, -12, 33, -74, 36, -27, -63, 18, -35, 38, 27, -16, -2, -71, -77, -29; /I: I=-33; MI=0; MD=-84; IM=0; DM=-84; /M: SY='G'; M= -20, -75, -1, -52, -62, 79, -2, -81, -10, -54, -70, 23, 19, -41, -29, -1, -14, -77, -78, -72; /M: SY='Y'; M= -66, -76, -80, -78, 41, -84, -64, 71, -71, 8, -33, -47, -79, -71, -18, -56, -61, 13, -54, 72; /I: I=-25; MI=0; MD=-63; IM=0; DM=-63; /M: SY='K'; M= -53, -88, -52, -62, -86, -20, -15, -56, 51, -51, -75, 30, -81, 15, 43, -10, -32, -83, -88, -35; D=-25; /I: I=-25; DM=-63; /M: SY='L'; M= -16, 5, -62, -50, 2, -62, -78, -9, -77, 49, -29, -33, -23, -76, -53, -35, 4, 33, -82, -63; D=-25; /I: I=-25; DM=-63; /M: SY='C'; M= -58, 108, -58, -81, 70, -39, -77, -67, -52, -48, -20, -32, -48, -83, -80, -36, 20, -50, -10, -33; D=-25; /I: I=-25; DM=-63; /M: SY='I'; M= -39, -76, -86, -81, 47, -86, -77, 54, -62, 42, -29, -36, -83, -57, -60, -23, -46, 4, -4, -33; D=-25; /I: I=-25; DM=-63; /M: SY='H'; M= -53, 27, 56, 23, 19, -62, 60, -8, -49, -24, -45, -25, 11, 4, -28, -40, -53, -33, -79, 12; D=-25; /I: I=-25; DM=-63; /M: SY='D'; M= -37, -79, 63, 57, -5, -10, -21, -71, -17, -48, -69, -14, -68, -26, -40, -14, -22, -1, -81, 6; D=-25; /I: I=-25; DM=-63; /M: SY='R'; M= -29, -5, 21, 17, -72, -61, 15, -51, -8, -44, -31, -2, -74, -18, 82, -53, -48, -25, -7, 1; D=-25; /I: I=-25; DM=-63; /M: SY='D'; M= -45, -78, 84, 35, 4, -16, -36, -60, 6, -24, -69, -5, -38, -26, 13, -42, -25, -59, -83, -48; /M: SY='W'; M= -35, -73, -15, 7, 47, -79, -68, 16, -53, 40, 29, -71, -27, 10, -54, -26, -61, 19, 54, -48; /M: SY='E'; M= -22, -74, 0, 29, -20, -27, -62, 10, -5, 17, 5, -14, 0, -9, 9, -35, -21, 24, -72, 19; /M: SY='P'; M= 4, -1, -65, -41, -77, 15, -24, -27, -45, -75, -66, -17, 96, -61, 30, -15, -59, -27, -78, -28; /M: SY='G'; M= -52, -75, 18, -15, -28, 82, -65, -81, -23, -38, -70, -12, -67, -27, -30, 13, -6, -76, -76, -71; /M: SY='K'; M= -3, -18, 3, 33, -48, 22, 9, -56, 34, -35, -63, -2, -31, 29, 22, -21, -13, -10, -78, -43; /I: I=-42; MD=-106; /M: SY='D'; M= 6, 22, 28, -23, -32, -18, -38, -34, -54, -21, -68, 0, 1, -27, -7, 24, 23, -46, 24, -12; D=-42; /I: I=-42; MI=-106; MD=-106; IM=-106; DM=-106; /M: SY='I'; M= -52, -81, -80, 1, 36, -49, 8, 58, -62, 1, -30, -77, -38, -73, -35, -74, -42, 17, 33, 11; D=-42; /I: I=-42; DM=-106; /M: SY='W'; M= 10, -72, -11, -21, 9, -15, -3, 22, -46, 28, -4, -64, -28, -62, -9, 24, -13, 4, 51, -55; /M: SY='E'; M= 5, -75, 35, 55, -28, -56, 5, -41, -11, -56, -67, -3, 23, 7, -12, 28, 1, -43, -80, -32; /M: SY='N'; M= -2, 23, 14, 43, -72, -42, -55, -14, -3, -59, -64, 68, -68, 4, -5, -2, -33, -2, -82, -9; /M: SY='L'; M= -39, -71, -23, -33, -49, -80, 7, 53, -72, 61, -15, -70, -76, -37, -73, -15, 11, -4, -76, -56; /M: SY='Q'; M= -44, -2, 13, -9, 21, -47, -22, 24, -18, 30, -1, -6, -73, 34, -51, -3, 1, 4, 22, -54; /M: SY='D'; M= -2, -74, 45, 41, -78, -64, -19, -74, 27, -57, -67, 20, -65, 40, 6, 26, -6, -39, 2, -66; /M: SY='A'; M= 50, 19, -61, -1, -18, -38, -1, -40, -26, -2, 7, 16, -29, -54, 19, 36, -41, -32, -77, -48; /M: SY='I'; M= -49, -74, -84, -81, -2, -45, -80, 87, -77, 21, 10, -76, -76, -74, -79, -71, -37, 33, -73, -55; /M: SY='E'; M= -36, -77, 17, 54, -13, -31, -32, -61, 22, -35, -29, 33, -40, 29, 31, -5, -25, -53, 13, -12; /M: SY='H'; M= -44, -76, 12, 34, -28, -6, 48, -73, 47, -27, -37, 22, -66, 16, 24, 3, -29, -42, -78, -32; /I: I=-42; MI=0; MD=-106; IM=0; DM=-106; /M: SY='S'; M= 16, 61, -36, -59, -71, -37, -61, -73, -59, -74, -68, -49, -67, -53, -26, 92, -26, -64, -80, -4; /M: SY='R'; M= 4, -79, -24, -30, -73, -31, 16, -79, 53, -74, -64, -53, -70, -33, 89, -47, -43, -73, -74, -5; /M: SY='R'; M= -48, 45, -69, -62, 19, -76, -35, 35, 43, -47, -31, -11, -74, -34, 49, -31, -42, 28, 22, -26; /M: SY='T'; M= 27, -67, -68, -65, 2, -17, -32, 14, -5, 11, 23, -60, -69, -33, -32, 27, 40, 10, -75, -40; /M: SY='I'; M= -46, -71, -84, -80, -27, -86, -80, 73, -77, 32, -3, -78, -78, -75, -78, -71, -57, 60, -77, -57; /M: SY='V'; M= -2, 31, -82, -77, 49, -80, -74, 27, -75, 29, 22, -76, -55, -75, -75, -52, -57, 56, -69, -22; /M: SY='V'; M= -59, -70, -84, -79, -38, -86, -80, 58, -76, 34, 15, -79, -78, -75, -77, -71, -56, 72, -79, -57; /M: SY='L'; M= -66, -70, -84, -78, 53, -85, -71, 30, -77, 65, 23, -79, -81, -74, -75, -73, -26, 19, -65, -45; /M: SY='S'; M= -13, -1, -44, -58, -72, -54, -62, -67, -58, -72, -67, -47, -13, -53, -63, 91, 54, -28, -84, -67; /M: SY='P'; M= 0, -78, 25, 36, -80, -7, 13, -77, 17, -77, -68, -2, 59, 13, 21, 10, -29, -60, -81, -69; /M: SY='N'; M= -41, -72, 38, 14, -78, -5, 45, -78, -5, -79, -69, 81, -67, -6, -17, 24, 6, -75, -89, -66; /M: SY='Y'; M= -17, -14, -25, -47, 67, -74, -52, -40, -21, 3, -2, -26, -79, -65, -41, -7, -36, -42, -44, 93; /M: SY='L'; M= 25, 24, 4, -45, -56, -43, -69, 8, -35, 41, -7, -65, -41, -55, -30, -13, 9, 30, -78, -29; /M: SY='Q'; M= -15, 37, 27, 7, -45, -22, 16, -68, 20, -22, -62, 4, -17, 41, 16, 32, -36, -15, -80, -36; /M: SY='S'; M= -51, -15, 32, -24, 17, -39, -19, -73, -25, -73, -68, 11, -67, -23, 19, 81, -11, -68, -78, -32; /I: I=-13; MI=0; MD=-33; IM=0; DM=-33; /M: SY='E'; M= -47, -36, 12, 31, -79, 7, -21, -76, 30, -41, -71, -59, 28, -56, 0, 9, 9, -21, 9, -41; D=-13; /I: I=-13; DM=-33; /M: SY='W'; M= -48, -89, -30, -6, -40, -18, -78, -68, -8, 0, -66, -34, -6, -2, -37, -27, -73, -47, 146, 4; D=-13; /I: I=-13; DM=-33; /M: SY='C'; M= -14, 127, -78, -77, 16, -73, -77, -33, -74, -39, -65, -26, -85, -76, -59, 27, -58, -8, 5, -68; D=-13; /I: I=-13; DM=-33; /M: SY='L'; M= -39, -76, -6, -61, -58, -76, 37, -2, 15, 51, -1, 0, -44, 20, 24, -21, -62, -36, -77, -29; D=-13; /I: I=-13; DM=-33; /M: SY='F'; M= -39, -24, 45, 8, 50, -72, 25, -54, -2, -13, -20, 22, -74, -17, 10, -20, -28, -67, -65, 43; D=-13; /I: I=-13; DM=-33; /M: SY='E'; M= -19, -80, 0, 87, -12, -73, -22, -51, -17, -29, -67, -57, -33, 49, -53, -7, -60, -72, -78, -67; D=-13; /I: I=-13; DM=-33; /M: SY='L'; M= -67, -73, -75, 0, 44, -83, -66, -2, -29, 61, 10, -74, -54, 0, -69, -70, 0, -16, -65, 15; D=-13; /I: I=-13; DM=-33; /M: SY='V'; M= -8, -75, -1, 14, -61, -39, -61, -13, 27, 1, -10, 13, -73, 11, 6, -44, -58, 39, -74, 28; D=-13; /I: I=-13; DM=-33; /M: SY='F'; M= 2, -36, -62, 28, 32, -73, 14, 23, 27, -7, 1, -61, -70, 25, -36, -6, 6, -14, -71, -15; D=-13; /I: I=-13; DM=-33; /M: SY='A'; M= 57, -69, -72, -67, -64, -4, -8, 47, -64, -16, 18, -64, -71, -62, 1, 15, -34, -7, -77, -64; D=-13; /I: I=-13; MI=0; MD=-33; IM=0; DM=-33; /M: SY='H'; M= -60, -97, -82, -48, -23, -65, 52, -80, -79, 10, -10, 15, -96, 28, -28, -19, -82, -68, -95, 1; D=-13; /I: I=-13; DM=-33; /M: SY='M'; M= -66, -3, -7, 3, -76, -73, 2, -49, 0, -8, 40, 38, -35, 13, 7, 28, -17, -59, -4, -70; D=-13; /I: I=-13; DM=-33; /M: SY='E'; M= 15, 9, -10, 33, -69, -78, -70, -60, -2, 25, 26, -54, -77, -22, -1, -39, -23, -10, 15, -69; D=-13; /I: I=-13; DM=-33; /M: SY='C'; M= -28, 70, -78, -74, 23, -21, -1, -14, -56, 38, -54, -17, -84, 18, -20, -16, -8, -59, -79, -40; D=-13; /I: I=-13; DM=-33; /M: SY='R'; M= -53, -83, -14, 5, -22, -79, 21, -8, 12, -34, 12, -47, 7, 25, 35, -19, -27, 8, 26, -2; D=-13; /I: I=-13; DM=-33; /M: SY='Q'; M= -39, -80, 31, 48, -55, -11, 10, -77, 16, -19, -67, 20, -41, 50, -6, -6, -31, -57, -84, -68; D=-13; /I: I=-13; DM=-33; /M: SY='N'; M= 9, -40, 3, 26, -74, 17, 37, -73, 7, -20, -40, 51, -43, 11, 15, 9, -25, -62, -81, -49; /M: SY='N'; M= -58, 21, -30, 2, -8, 26, -11, -49, 28, -6, -28, 33, -16, -33, 16, 24, -3, -56, 20, -18; /M: SY='D'; M= -42, -76, 50, -10, -72, 21, 8, 3, 7, -45, 3, -7, 19, 19, 8, 15, -6, -45, -79, -13; /M: SY='K'; M= 2, -31, 11, -36, -71, -37, 13, -53, 50, 9, -57, 8, 7, 45, 13, -9, -35, -23, -78, -43; /I: I=-42; MI=0; MD=-106; IM=0; DM=-106; /M: SY='V'; M= -10, 36, -70, -31, -8, -55, -69, 36, -35, 7, 6, 23, -36, -64, 12, -18, -13, 49, -79, -60; /M: SY='V'; M= -17, -70, -83, -78, -34, -84, -83, 71, -75, -4, -39, -76, -76, -75, -78, -67, -20, 73, -80, -59; /M: SY='I'; M= -63, -72, -85, -80, 9, -86, -76, 69, -77, 44, 36, -78, -78, -73, -77, -73, -59, 42, -72, -30; /M: SY='P'; M= -64, -81, -72, -64, -15, -75, -73, 48, -44, -17, -53, -71, 98, -68, -25, -45, 5, 6, -77, -67; /M: SY='I'; M= -61, -73, -71, 26, 18, -55, -73, 62, -43, 27, 3, -73, -74, -31, -71, -68, -34, 44, -73, -55; /M: SY='F'; M= -69, 6, -81, -48, 84, -83, -66, -10, -18, 50, -3, -75, -82, -72, -6, -72, -48, -24, -55, 12; /I: I=-36; MI=0; MD=-90; IM=0; DM=-90; /M: SY='Y'; M= -58, 44, -31, 50, -10, -7, -45, -64, -23, -7, -57, -63, 3, 3, -28, -27, -39, -53, -53, 88; /M: SY='K'; M= -33, -77, 6, 23, -40, 36, -17, -75, 45, -29, -40, 5, 39, -23, 1, -20, -1, -73, 18, -67; /I: I=-8; MD=-20; /M: SY='V'; M= -22, -4, -24, -74, -6, -81, -77, 40, -50, 15, 4, -22, -24, -34, -64, -23, -47, 63, -81, -61; D=-8; /I: I=-8; MD=-20; /M: SY='D'; M= -39, -25, 48, 25, -83, -57, -1, -62, 1, -44, -26, -2, 20, 22, 13, 32, -20, -76, -88, -72; D=-8; /I: I=-8; MD=-20; /M: SY='P'; M= -43, -90, 29, -28, -40, -75, -70, -82, 4, -31, -76, -3, 73, 25, -27, 11, -65, -83, -16, -78; D=-8; /I: I=-8; MD=-20; /M: SY='Y'; M= -12, -26, -54, -22, -29, -74, -10, -60, -27, -14, -52, -36, -49, -49, -39, 53, -16, -60, -5, 53; D=-8; /I: I=-8; MD=-20; /M: SY='D'; M= -17, -30, 47, 8, -94, -81, 25, -63, -12, -53, -82, -19, -22, 28, -71, -3, 0, -86,-102, -81; D=-8; /I: I=-8; MD=-20; /M: SY='V'; M= -83, -40,-104, -98, -27,-107, -99, 17, -45, 19, -31, -99,-102, -94, -34, -92, -50, 42,-100, -79; D=-8; /I: I=-8; MD=-20; /M: SY='R'; M= -87, -34, -41, -3,-100, -95, -84, -94, -7, -63, 25, -22, 30, -74, 34, -9, -83, -67,-105, -93; D=-8; /I: I=-8; MI=0; MD=-20; IM=0; DM=-20; /M: SY='R'; M= -34, -96, -76, -5, -95, -26, -76, -11, 19, -89, -81, -20, -40, 36, 38, -4, -76, -72, -95, -84; D=-8; /I: I=-8; DM=-20; /M: SY='W'; M= -88,-100, -55, -54, 39, -94, -14, -75, -83, -19, 15, -93, -96, -13, -32, -89, -89, -65, 117, 39; D=-8; /I: I=-8; DM=-20; /M: SY='C'; M= -16, 34, -76, -17, -50, -83, 23, -11, 25, -27, 6, -71, 6, -13, 29, -19, -70, -6, -90, -73; D=-8; /I: I=-8; DM=-20; /M: SY='E'; M= -13, -84, 4, 40, -83, -59, -13, -67, 28, -38, -72, -20, -73, 22, 38, -22, 5, -61, -87, -48; D=-8; /I: I=-8; DM=-20; /M: SY='A'; M= 51, -76, -14, -14, -40, -69, -68, -33, -11, 22, -27, -68, 18, 34, -23, -35, -62, -46, -79, -34; D=-8; /I: I=-8; DM=-20; /M: SY='L'; M= -47, -76, -80, -71, 32, -84, -67, -25, 6, 47, 19, -74, -82, -66, 36, -72, -28, 9, 7, 13; D=-8; /I: I=-8; DM=-20; /M: SY='H'; M= 4, -77, -6, 4, -74, 16, 38, -75, 28, -45, -43, -17, 22, 24, 2, -24, 27, -71, -14, -4; D=-8; /I: I=-8; DM=-20; /M: SY='S'; M= -34, -42, 23, -1, 2, -13, -20, -22, 9, -7, -1, 6, -5, -10, 24, 26, -34, -51, -24, 17; D=-8; /I: I=-8; DM=-20; /M: SY='I'; M= 15, -71, -77, -21, 18, -78, -73, 42, -48, 35, 24, -48, -50, -69, -73, -40, 2, 31, -74, -56; D=-8; /I: I=-8; DM=-20; /M: SY='C'; M= 18, 25, -27, -31, 13, -16, -66, 0, 18, 24, -54, 2, 7, -12, -30, 4, -10, -41, -74, -33; D=-8; /I: I=-8; DM=-20; /M: SY='R'; M= -45, -9, 27, -50, -33, -28, -8, -76, 38, -63, -39, 43, -25, 21, 55, 10, 16, -63, -81, -65; D=-8; /I: I=-8; DM=-20; /M: SY='W'; M= -63, -76, -69, -20, 31, -56, 16, 35, 4, 18, -5, 1, -10, 15, -20, 12, -38, -15, 72, -50; D=-8; /I: I=-8; DM=-20; /M: SY='S'; M= 16, 3, -18, -59, -65, -47, 4, 1, -9, 15, 8, 14, -1, 22, -15, 32, 25, -45, -79, -31; D=-8; /I: I=-8; DM=-20; /M: SY='G'; M= -32, -30, -65, -49, -44, 58, -21, -17, -14, -63, -8, -8, -35, 8, 8, -54, 8, 20, -65, 56; /I: I=-18; MD=-45; /M: SY='H'; M= -67, -41, -22, -11, -24, -46, 6, -1, -23, -36, -47, -88,-100, -13, -90, -19, -49, -23, -31, -3; D=-18; /I: I=-18; MI=0; MD=-45; IM=0; DM=-45; /M: SY='W'; M= -68, -77, 7, -69, -45, -79, 43, 7, -35, 60, -43, -72, -79, -66, -70, -25, -66, -31, 111, 8; /I: I=-10; MI=0; MD=-25; IM=0; DM=-25; /M: SY='C'; M= -39, 41, -31, 24, -4, -77, 17, -80, 14, -24, -70, 32, -61, 19, 14, -22, -18, -78, 13, -24; D=-10; /I: I=-10; DM=-25; /M: SY='W'; M= -18, -91, 30, -19, -46, 3, -78, -58, 9, -79, -77, -39, -80, -49, -26, -70, -26, -31, 126, 9; D=-10; /I: I=-10; DM=-25; /M: SY='P'; M= -30, 3, 31, 29, -78, -40, -65, -60, -24, -27, 8, -52, 66, -18, 18, -22, -65, -76, -83, 1; D=-10; /I: I=-10; DM=-25; /M: SY='D'; M= -53, -79, 27, 5, -70, -27, 14, -8, 23, -40, -40, 19, -31, -7, -23, 18, 13, -11, -81, 19; D=-10; /I: I=-10; DM=-25; /M: SY='D'; M= -22, -36, 53, 44, -84, -49, -60, -25, -18, -78, -72, 13, 22, 40, -42, 28, -58, -52, -88, -73; D=-10; /I: I=-10; DM=-25; /M: SY='P'; M= 7, -73, 0, 12, -8, -39, -61, -66, 11, -36, -8, 12, 40, 15, 3, 28, 18, -15, -79, -66; D=-10; /I: I=-10; DM=-25; /M: SY='W'; M= -8, 31, 25, 41, -56, -53, 4, -24, 9, -27, -64, -24, -47, 7, 6, 23, 14, -57, 56, -9; /M: SY='M'; M= 6, 4, -10, -59, 9, 4, -51, -35, 1, 21, 43, -60, 2, 33, 22, -39, 10, -48, -70, 10; /M: SY='I'; M= -46, -5, 8, -14, -37, -60, -5, 41, 26, 1, -14, 4, -47, 41, 3, -21, -57, 28, -78, -60; /M: SY='E'; M= -11, -75, 20, 51, -78, 16, -5, -45, 7, -49, -67, 19, 17, 21, -17, 21, -5, -46, -81, -69; /M: SY='W'; M= 1, -77, -4, 37, -68, -18, -21, -23, 49, -20, -28, -44, -66, 36, 17, -11, -37, -53, 65, -3; /M: SY='F'; M= -66, -73, -8, -49, 85, -26, -72, 55, -47, -24, 13, -71, -78, -76, -75, -69, -27, 23, -11, -38; /M: SY='W'; M= 17, -79, -79, -49, -22, -70, -14, -16, -7, -31, -60, -73, -74, -17, -27, -14, -10, 21, 141, 3; /M: SY='K'; M= -2, -76, 13, -4, -47, -70, 13, -6, 61, -45, -61, -3, -68, 6, 58, -56, -6, -36, -76, -34; /M: SY='D'; M= 15, -21, 45, 9, -9, -63, 5, -74, 31, -44, -66, 42, -68, 25, 22, 8, -21, -70, -16, -63; /M: SY='L'; M= -36, -69, -82, -76, -46, -84, -74, 41, -75, 60, -19, -78, -79, -72, -76, -69, -4, 52, -75, -16; /M: SY='R'; M= -6, -75, -24, -33, -8, -37, -57, -23, 29, -22, -59, -54, -70, 30, 68, 34, -19, -42, -71, 3; /M: SY='Y'; M= -2, -74, -12, 42, -34, -5, -55, -57, 30, -18, -30, 28, -67, 8, 1, -19, 0, -20, -68, 47; /M: SY='A'; M= 49, -11, 9, -4, -72, -64, 17, -23, 28, -41, 25, -56, -41, 42, -7, -21, -15, 6, -79, -64; /M: SY='M'; M= -45, -70, -77, -71, 2, -56, -15, 28, -31, 57, 64, -70, -40, -44, -69, 22, -48, -1, -72, -53; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 208 in 206 different sequences |
| Number of true positive hits | 208 in 206 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 6 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 97.20 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Taxonomic range [info] | Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 2 |
| Feature key [info] | DOMAIN |
| Feature description [info] | TIR |
| Version [info] | 7 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
206 sequences
ABTIR_ACIB9 (A0A009IHW8), ADR2_ARATH (Q9C7X0), APTIR_ACTS5 (G8SD34), BANK1_HUMAN (Q8NDB2), BANK1_MOUSE (Q80VH0), BCAP_CHICK (Q9DDT2), BCAP_HUMAN (Q6ZUJ8), BCAP_MOUSE (Q9EQ32), BDTIR_BRADI (I1GTC2), BTTIR_BACT4 (A0A0P0FGV9), CHL1_ARATH (Q9LUJ8), CHS1_ARATH (F4I902), CSA1_ARATH (F4KIF3), DAR4_ARATH (Q9FKN7), DSC1_ARATH (Q9SZ66), DSC2_ARATH (F4JWM0), I18RA_HUMAN (O95256), I18RA_MOUSE (Q9Z2B1), IL18R_HUMAN (Q13478), IL18R_MOUSE (Q61098), IL1AP_HUMAN (Q9NPH3), IL1AP_MACMU (P59822), IL1AP_MOUSE (Q61730), IL1AP_RAT (Q63621), IL1R1_HUMAN (P14778), IL1R1_MOUSE (P13504), IL1R1_RAT (Q02955), ILRL1_HUMAN (Q01638), ILRL1_MOUSE (P14719), ILRL1_RAT (Q62611), ILRL2_HUMAN (Q9HB29), ILRL2_MOUSE (Q9ERS7), ILRL2_RAT (Q62929), IRL1A_DANRE (B6ZK76), IRL1B_DANRE (B6ZK77), IRPL1_HUMAN (Q9NZN1), IRPL1_MOUSE (P59823), IRPL1_PANTR (P60029), IRPL1_PONPY (Q7YQL9), IRPL1_RAT (P59824), IRPL2_HUMAN (Q9NP60), IRPL2_MOUSE (Q9ERS6), L6_LINUS(Q40253), LAZ5_ARATH (O48573), MY88A_XENLA (Q9DF60), MY88B_XENLA (Q5FWM2), MYD88_BOVIN (Q599T9), MYD88_CERAT (B6CJX2), MYD88_CHICK (A5HNF6), MYD88_DANRE (Q5XJ85), MYD88_GORGO (B3Y680), MYD88_HUMAN (Q99836), MYD88_MACFA (B3Y682), MYD88_MACMU (B3Y683), MYD88_MOUSE (P22366), MYD88_ONCMY (Q4LBC6), MYD88_PANPA (B3Y679), MYD88_PANTR (B3Y678), MYD88_PIG (A2TF48), MYD88_PONPY (B3Y681), MYD88_RAT (Q6Y1S1), MYD88_SALSA (B3SRQ2), MYD88_SHEEP (C8BKC7), MYD88_TAKRU (A8QMS7), MYD88_XENTR (Q28DJ2), P2A05_ARATH (Q9C5Q9), P2A06_ARATH (Q9FHE8), P2A07_ARATH (Q9FHE5), P2A08_ARATH (Q9FHE9), PDTIR_PARDP (A1AY86), RBA1_ARATH (F4HT77), RLM1A_ARATH (F4I594), RLM1B_ARATH (Q9CAK1), RLM3_ARATH (Q9FT77), ROQ1_NICBE (A0A290U7C4), RPP1_ARATH (F4J339), RPP2A_ARATH (F4JT78), RPP2B_ARATH (F4JT80), RPP2C_ARATH (F4JT82), RPP2D_ARATH (O49471), RPP4_ARATH (F4JNA9), RPP5_ARATH (F4JNB7), RPS4B_ARATH (Q9FHF0), RPS4L_ARATH (Q9SCX6), RPS4R_ARATH (Q9SCX7), RPS4W_ARATH (C4B7M7), RPS4_ARATH (Q9XGM3), RPS6C_ARATH (F4KHH8), RPS6R_ARATH (P0DKH6), RPV1_VITRO (V9M2S5), RRS1B_ARATH (Q9FL92), RUN1_VITRO (V9M398), SARM1_CAEEL (Q86DA5), SARM1_DANRE (F1QWA8), SARM1_DROME (Q6IDD9), SARM1_HUMAN (Q6SZW1), SARM1_MOUSE (Q6PDS3), SARM1_PIG (I3L5V6), SARM1_RAT (D3ZUM2), SIGIR_HUMAN (Q6IA17), SIGIR_MOUSE (Q9JLZ8), SIGIR_RAT (Q4V892), SNC1_ARATH (O23530), STING_CRAGI (P0DUE1), TAO1_ARATH (Q9FI14), TCAM1_BOVIN (Q4JF29), TCAM1_HUMAN (Q8IUC6), TCAM1_MOUSE (Q80UF7), TCAM2_BOVIN (Q2LGB7), TCAM2_HUMAN (Q86XR7), TCAM2_MOUSE (Q8BJQ4), TCPA_THEAD (A0A151EH88), TCPB_BRUA2 (Q2YPC4), TCPB_BRUMB (C0RGW8), TCPB_BRUME (Q8YF53), TCPC_ECOL6 (A0A0H2V8B5), TCPF_ENTFA (Q833J1), TCPO_METOL (A0A1I4KS07), THSB2_BACDA (A0A5B8Z260), TIK_ARATH (Q0WSX8), TIRAP_HUMAN (P58753), TIRAP_MOUSE (Q99JY1), TIRA_DICDI (Q54HT1), TIRC_DICDI (Q54F65), TIRS_STAAS (P0DTS9), TIR_ARATH (Q9SSN3), TLR10_BOVIN (Q6GV17), TLR10_HUMAN (Q9BXR5), TLR11_MOUSE (Q6R5P0), TLR12_MOUSE (Q6QNU9), TLR13_MOUSE (Q6R5N8), TLR1_HUMAN (Q15399), TLR1_MOUSE (Q9EPQ1), TLR21_CHICK (Q9DD78), TLR22_CHICK (Q9DGB6), TLR2_BISBI (B2LT61), TLR2_BOSIN (B5T267), TLR2_BOSTR (Q2V897), TLR2_BOVIN (Q95LA9), TLR2_BUBBU (Q2PZH4), TLR2_CANLF (Q689D1), TLR2_CAPHI (Q0GC71), TLR2_CAPIB (B2LT62), TLR2_CRIGR (Q9R1F8), TLR2_GIRCA (B2LT64), TLR2_GORGO (B3Y615), TLR2_HORSE (Q6T752), TLR2_HUMAN (O60603), TLR2_MACFA (Q95M53), TLR2_MACMU (B3Y618), TLR2_MOUSE (Q9QUN7), TLR2_PANPA (B3Y614), TLR2_PANTR (B3Y613), TLR2_SHEEP (B2LT65), TLR3_BOSTR (Q0PV50), TLR3_BOVIN (Q5TJ59), TLR3_HUMAN (O15455), TLR3_MOUSE (Q99MB1), TLR4_BOSTR (Q2V898), TLR4_BOVIN (Q9GL65), TLR4_CRIGR (Q9WV82), TLR4_FELCA (P58727), TLR4_GORGO (Q8SPE8), TLR4_HORSE (Q9MYW3), TLR4_HUMAN (O00206), TLR4_MOUSE (Q9QUK6), TLR4_PANPA (Q9TTN0), TLR4_PAPAN (Q9TSP2), TLR4_PIG(Q68Y56), TLR4_PINIB (V5NAL9), TLR4_PONPY (Q8SPE9), TLR4_RAT(Q9QX05), TLR5_HUMAN (O60602), TLR5_MOUSE (Q9JLF7), TLR6_BOVIN (Q704V6), TLR6_DASNO (Q0ZUL9), TLR6_HUMAN (Q9Y2C9), TLR6_MOUSE (Q9EPW9), TLR7_HUMAN (Q9NYK1), TLR7_MOUSE (P58681), TLR8_HUMAN (Q9NR97), TLR8_MOUSE (P58682), TLR9_BOVIN (Q5I2M5), TLR9_CANLF (Q5I2M8), TLR9_FELCA (Q5I2M7), TLR9_HORSE (Q2EEY0), TLR9_HUMAN (Q9NR96), TLR9_MOUSE (Q9EQU3), TLR9_PIG(Q5I2M3), TLR9_SHEEP (Q5I2M4), TMVRN_NICGU (Q40392), TOLL6_DROME (Q9VUN0), TOLL7_DROME (Q7KIN0), TOLL8_DROME (Q9V477), TOLL_DROME (P08953), VAP14_ARATH (Q9SYC9), VICTR_ARATH (F4KHI3), WR52N_ARATH (E1B328), WR52R_ARATH (C4B7M6), WR52W_ARATH (C4B7M5), WRK19_ARATH (Q9SZ67), WRK52_ARATH (P0DKH5), Y4117_ARATH (O82500), Y4CD_SINFN (P55386), Y4LF_SINFN (P55546), YDDK_BACSU (P96648)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
6 sequences
CAP12_AGGAC (A0A5D0EMF2), CAP12_CAPGB (A0A381HAP5), CAP12_FLADA (P0DUD9), CAP12_LACSX (P0DUE0), CAP12_NIADE (A0A1G6LGU2), CAP12_SPHFK (A0A2T5Y4G4)» more |
| PDB [Detailed view] |
97 PDB
1FYV; 1FYW; 1FYX; 1O77; 1T3G; 2J67; 2JS7; 2M1W; 2M1X; 2NDH; 2Y92; 2Z5V; 3H16; 3J0A; 3JRN; 3OZI; 3UB2; 3UB3; 3UB4; 4C6R; 4C6S; 4C6T; 4C7M; 4DOM; 4EO7; 4FZ5; 4LQC; 4LQD; 4LZP; 4OM7; 5FOR; 5H3C; 5KU7; 5TEC; 5UZB; 6O0Q; 6O0R; 6O0U; 6O0V; 6O0W; 6O1B; 6WPK; 6WT6; 6WT7; 6ZFX; 6ZG0; 7ANW; 7BEQ; 7BER; 7C76; 7C77; 7CM5; 7CM6; 7CM7; 7CYN; 7DJT; 7FCC; 7FCH; 7FD3; 7JLU; 7JLV; 7JLX; 7KNQ; 7L6W; 7LD0; 7NAG; 7NAH; 7NAI; 7NAJ; 7NAK; 7NAL; 7NT7; 7NUW; 7NUX; 7QG0; 7RTS; 7RX1; 7S2Z; 7SZL; 7UWG; 7UXR; 7UXU; 7WV3; 8D0C; 8D0D; 8D0E; 8D0F; 8D0G; 8D0H; 8D0I; 8D0J; 8G83; 8GNI; 8GNJ; 8GQ5; 8P2L; 8P2M » more |