Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Entry: PS50166

General information about the entry

Entry name [info] IMPORTIN_B_NT
Accession [info] PS50166
Entry type [info] MATRIX
Date [info] 01-APR-2002 CREATED; 10-MAY-2017 DATA UPDATE; 20-DEC-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC50166
Associated ProRule [info] PRU00115

Name and characterization of the entry

Description [info] Importin-beta N-terminal domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=75;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=70;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.7352000; R2=0.0226132; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3855.5461426; R2=3.7153847; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=344; H_SCORE=5134; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=255; H_SCORE=4803; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-80; MD=-80; IM=-80; DM=-80;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='A'; M= 43, -8,-10,-17, -8,-20,  0,-18,-12,-10,-13,-12, -7,-10, -8,-18, 15,  3, -2,-23,-20, -8;
/M: SY='E'; M= -9,  7,-28, 12, 44,-31,-20,  1,-26,  8,-19,-14,  0, -3, 28,  2,  2, -5,-28,-27,-17, 36;
/M: SY='K'; M= -8, -3,-24, -5,  7,-23,-21, -7,-18, 15,-14, -6, -3,-12, 14, 12, -1,  5,-15,-23,-10, 10;
/M: SY='Q'; M=-10, -8,-24,-13, -7, -3,-15,  0, -9,-10,-10, -2, -2,-19,  5, -7, -5, -5,-11,-18, -1,  0;
/M: SY='L'; M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 50, 20,-30,-30,-20,-20,-30,-10, 10,-20,  0,-20;
/M: SY='R'; M=-12, -5,-26, -5, 10,-14,-22, -7,-20, 13,-12, -8, -4,-13,  7, 19, -5, -1,-16,-21, -8,  8;
/M: SY='Q'; M=-10,  7,-26,  7, 13,-30,-16,  0,-24, 14,-23,-11,  7,-11, 22, 14,  3, -2,-23,-26,-13, 17;
/M: SY='F'; M= -1,-25,-23,-29,-19, 14,-21,-20,  1,-20,  9,  1,-23,-24,-17,-18,-17,-10,  0, 13,  6,-16;
/I:         I=-8; MI=-5; MD=-15; IM=-5; DM=-15;
/M: SY='E'; M= -8,  7,-27, 14, 32,-27,-17,  2,-25,  4,-21,-15,  2, -7, 21, -1,  5, -5,-25,-26,-10, 26;
/M: SY='B'; M= -4, 15,-22, 10,  1,-24, -5, -8,-24,  7,-24,-16, 15,-13, -2,  0,  5,  6,-18,-30,-16, -1;
/M: SY='Q'; M= -7, -5,-23,-10, -4, -8,-19,  5, -7, -7, -5, -1, -1,-20,  9, -5, -6, -8,-12,-18,  2,  2;
/M: SY='P'; M= -5, -9,-31, -3,  1,-26,-17, -5,-18, -9,-20,-13,-10, 37, -2,-14, -4, -8,-22,-29,-19, -3;
/M: SY='D'; M= -7, 12,-25, 13,  0,-29, 12, -8,-29, -6,-24,-17, 10,-14,  2, -9,  5,  0,-24,-28,-19,  1;
/M: SY='F'; M= -7,-24,-18,-32,-25, 47,-25,-18,  0,-23,  5, -1,-18,-25,-30,-18,-12, -3,  3,  1, 20,-25;
/M: SY='W'; M= -1,-21,-25,-24,-17,  0,-13,-12, -7,-20,  3, -3,-19,-14,-16,-18,-14, -9, -9,  5, -1,-16;
/M:         M=  0,-14,-22,-14,-11,-14, -4,-14, -9,-10, -7, -5,-11,-11, -8,-11, -3, -5, -6,-21, -9,-10;
/M: SY='A'; M=  5,-11,-20,-13,  0, -9,-18,-14, -8, -3,  1, -2,-11,-15, -2, -7, -6, -3, -7,-20, -8, -1;
/M: SY='L'; M=  1,-24, -6,-26,-18,  1,-23,-20,  8,-25, 28,  9,-23,-26,-18,-20,-16, -6,  5,-24, -7,-18;
/M: SY='L'; M= -1,-11,-19,-12, -9, -7,-19,-12,  0,-16,  6,  0,-10,-19, -6,-14, -1,  2, -2,-23, -3, -8;
/M: SY='H'; M=-11, 13,-24, 13,  6,-26,-12, 16,-25,  1,-24,-13, 16,-14, 12,  6,  6, -1,-23,-32,-10,  7;
/M: SY='I'; M= -6,-30,-22,-35,-29,  1,-35,-29, 40,-26, 19, 16,-25,-25,-24,-25,-17, -6, 36,-24, -4,-29;
/M: SY='L'; M=  0,-26,-20,-29,-21,  4,-27,-19, 19,-24, 28, 13,-24,-25,-18,-21,-19, -8, 13,-17,  2,-21;
/M: SY='A'; M= 10, -9,-20,-11,  4,-18,-15,-12, -6, -9, -4, -4, -8,-13,  4,-12,  3, -2, -7,-25,-14,  4;
/M: SY='N'; M= -4, 16,-21, 12,  3,-19, -9, -3,-23,  4,-25,-16, 19,-14,  3, -1,  7, -1,-20,-30,-14,  4;
/M: SY='D'; M= -5,  2,-24,  6,  3,-24,  0, -3,-24,-10,-21,-16,  1, -1, -4,-12,  6, -1,-20,-31,-17, -2;
/M: SY='N'; M=  0, 10,-21,  6, 12,-25,  1, -4,-23, -2,-24,-17, 15,-11,  6, -6, 11,  1,-22,-31,-20,  9;
/M: SY='N'; M= -5, 10,-19,  5, -6, -8,-13, -6,-11,-10,-12,-11, 12,-19, -9,-10,  3,  2,-10,-26, -6, -8;
/M: SY='P'; M=  0, -2,-23,  0, -1,-24,-11,-13,-17, -4,-25,-17,  0, 18, -5,-10,  8,  1,-14,-33,-21, -5;
/M: SY='L'; M= -8,-15,-24,-14,  0,-13,-23,-10, -1,-12,  9,  4,-15,-10,  6, -9,-11, -7, -6,-24, -9,  3;
/I:         I=-6; MI=-32; MD=-32; IM=-32;
/M: SY='E'; M= -3,  4,-13,  3,  8,-13, -9, -2, -8, -1,-11, -7,  6, -8,  4, -3,  4, -1, -7,-20,-10,  6; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='I'; M=  4,-16,-18,-22,-17, -8,-13,-22,  8,-20,  4,  1,-12,-18,-15,-19,  0,  5,  8,-25,-11,-17;
/M: SY='R'; M=-16, -6,-30, -6,  4,-24,-20, -4,-30, 38,-24,-10,  0,-16, 10, 54,-10,-10,-20,-20,-10,  4;
/M: SY='L'; M=-10,-22,-24,-24,-14,  1,-28,-13,  9,-16, 10,  7,-21,-24, -3,-13,-17, -9,  5, -3,  6, -9;
/M: SY='A'; M=  5,-19, -7,-24,-18, -2,-12,-21,  1,-22,  5, -1,-14,-21,-17,-21, -5, -4,  2,-23,-10,-18;
/M: SY='A'; M= 40, -8,-12,-16, -9,-21,  6,-18,-14,-11,-15,-12, -6,-11, -9,-18, 14,  1, -4,-23,-21, -9;
/M: SY='A'; M= 11,-16,-17,-19,-15,-11,  3,-19, -5,-19,  3, -3,-13,-20,-15,-18, -1, -4, -1,-24,-15,-15;
/M: SY='L'; M= -5,-26,-19,-28,-21,  2,-28,-22, 23,-25, 25, 13,-22,-25,-19,-21,-14, -4, 18,-25, -5,-21;
/M: SY='Y'; M= -9,-11,-23,-13, -5,  0,-24, -4, -4, -8, -7, -3, -9,-18,  3, -8, -2,  4, -6,-11, 14, -2;
/M: SY='F'; M= -8,-28,-20,-34,-24, 29,-29,-21, 15,-28, 29, 11,-24,-27,-26,-21,-22, -9,  8,-10,  8,-24;
/M: SY='K'; M=-14,  5,-30,  8, 10,-30,-19, -5,-31, 35,-27,-12,  3,-12, 13, 31, -8,-10,-22,-23,-11, 10;
/I:         I=-6; MI=-32; MD=-32; IM=-32;
/M: SY='N'; M=-10, 21,-23, 10,  3,-22, -8,  2,-23, 18,-28,-15, 33,-16,  4, 15,  2, -4,-24,-30,-15,  3; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='Y'; M=-10,-17,-24,-17, -8,  4,-18, -9, -4, -9,  8,  1,-15,-22,-10, -8,-15, -9, -7,-11,  9,-10;
/M: SY='I'; M= -8,-30,-25,-36,-28,  2,-36,-28, 40,-28, 25, 18,-24,-24,-22,-26,-21, -8, 29,-22, -2,-28;
/M: SY='T'; M= -4, -2,-16, -4, -6,-15,-19, -9,-11, -1,-14, -8, -2,-14, -7, -4,  8, 20,  0,-30, -9, -7;
/M: SY='R'; M=-10, -6,-23, -8, -2,-15,-17,  5,-20, 12,-18, -5,  0,-16,  4, 21,  1,  0,-14,-22, -1, -2;
/M: SY='H'; M=-12, -1,-28, -3, -1,-17,-11, 15,-25, 15,-23, -9,  4,-17,  3, 12, -6,-10,-21,-17,  6, -1;
/M: SY='W'; M=-20,-21,-46,-17,-19, -1,-18,-24,-24,-16,-22,-22,-27,-26,-16,-18,-31,-26,-30,109, 19,-14;
/M: SY='S'; M= -5,  0,-22,  1,  0,-22,-12, -9,-20,  6,-25,-15,  5, -2, -1,  7,  9,  2,-14,-32,-17, -2;
/M: SY='P'; M=  1, -3,-22, -2, -6,-18,-16,-15, -6,-12, -8, -5, -8,  2,-10,-17, -2, -1, -4,-29,-16, -9;
/I:         MD=-15;
/M:         M= -5,-10,-19,-11, -5,-12, -5,-14, -4, -3, -5, -2, -8,-13, -7, -6, -6, -4, -2,-18,-10, -7; D=-3;
/I:         MD=-15;
/M: SY='R'; M= -5, -3,-17, -7, -1,  0,-14, -7,-14,  5,-11, -8,  1,-13, -4,  8, -3, -1,-10,-14, -3, -2; D=-3;
/I:         MD=-15;
/M: SY='E'; M= -1,  1,-21,  3, 13,-21, -6, -5,-15,  1,-13, -9, -1, -8,  7, -1, -1, -7,-14,-20,-13,  9; D=-3;
/I:         MD=-15;
/M: SY='Q'; M= -7, 11,-20, 10, 14,-25,-10,  5,-18,  4,-19, -9, 12, -9, 25,  2,  5, -4,-22,-23,-12, 19; D=-3;
/I:         MD=-15;
/M: SY='Y'; M= -6,-13,-21,-15,-13, 10, -4,  3,-11,-13, -8, -5, -9,-10,-13,-12, -9, -9,-12, -1, 15,-14; D=-3;
/I:         MD=-15;
/M: SY='Q'; M=  0, -1,-14, -3,  2,-14, -8, -1, -9,  0, -8, -3,  2,-10, 11,  4,  2, -2,-10,-16, -8,  6; D=-3;
/I:         MD=-15;
/M: SY='Q'; M= -5,  8,-14,  8,  7,-18, -7,  1,-13,  5,-14, -7,  7, -6, 14,  3,  3, -2,-14,-16, -8, 10; D=-3;
/I:         I=-3; MI=0; IM=0; DM=-15;
/M: SY='I'; M= -7,-29,-23,-33,-25,  0,-33,-27, 32,-26, 20, 14,-25,-15,-22,-24,-19, -7, 25,-23, -5,-26;
/M: SY='D'; M=-12, 12,-19, 22, 11,-32,-15,-10,-30, -2,-28,-23,  1, 19, -3,-11, -1, -7,-26,-36,-23,  2;
/M: SY='E'; M=  7, -3,-25, -4, 11,-24,-15,-12,-15,  3,-18,-12, -4,  8,  0, -7, -1, -7,-15,-26,-19,  4;
/M: SY='D'; M= -7, 32,-24, 34, 17,-29, -7,  0,-28,  0,-27,-23, 25,-11,  2, -6,  7, -4,-26,-37,-20, 10;
/M: SY='E'; M=  4,  2,-20,  2,  9,-21,-15, -2,-13, -4,-14,-10,  0,-13,  2, -9,  2, -1, -8,-29,-14,  5;
/M: SY='R'; M=-13, -7,-28, -7,  2,-23,-21, -7,-25, 36,-22, -8, -2,-16,  7, 43,-10, -9,-14,-21,-10,  2;
/M:         M= -2, -5,-24, -5, -2,-17,-18,-12, -8, -2, -6, -6, -4, -8, -5, -1, -7, -7, -7,-26,-14, -5;
/M: SY='S'; M=  0, -8,-21, -9, -1,-12, -3, -3,-15,-11,-12, -8, -4,-16, -2,-11,  4, -4,-11,-25,-10, -2;
/M: SY='I'; M= -7,-30,-24,-37,-30,  0,-37,-30, 44,-27, 17, 17,-23,-23,-23,-27,-17, -7, 36,-23, -3,-30;
/M: SY='R'; M=-14, -4,-30, -4,  6,-26,-20, -6,-30, 42,-26,-10,  0,-14, 10, 46,-10,-10,-20,-20,-10,  6;
/M: SY='N'; M= -3, 16,-22, 12, 13,-24, -5, -5,-24,  3,-23,-17, 17,-11,  2, -3,  6,  3,-22,-31,-18,  7;
/M: SY='Y'; M=-11, -4,-22, -9, -6,  0,-19, -1, -9, -3,-10, -3,  2,-20, -5,  3, -3,  0, -8,-16,  8, -7;
/M: SY='L'; M= -3,-28,-20,-31,-23,  3,-30,-24, 26,-26, 30, 15,-26,-26,-21,-22,-20, -7, 22,-22, -4,-23;
/M: SY='L'; M= -8,-30,-18,-32,-25, 11,-32,-25, 26,-27, 30, 15,-28,-28,-25,-22,-22, -7, 25,-21, -1,-25;
/M: SY='H'; M= -6, -2,-28, -1, 11,-27,-12, 14,-25,  5,-22, -9,  0, -3, 13,  1, -2, -7,-23,-25, -9, 10;
/M: SY='L'; M=  0,-16,-15,-22,-16, -2,-22,-18,  7,-17, 16, 12,-16,-20,-13,-15, -6, 13,  9,-24, -6,-15;
/M: SY='M'; M= -5,-24, -9,-31,-22,  0,-26,-16, 18,-22, 25, 27,-23,-25,-14,-19,-20, -9, 10,-23, -4,-18;
/M: SY='V'; M= -7,-21,-21,-23,-23,  1,-18,-24, 17,-23, 11,  6,-19,-25,-23,-22,-14, -8, 19,-22, -6,-24;
/M: SY='S'; M=  3,  4,-15,  2,  5,-21, -7, -9,-21,  1,-27,-17, 11,-10,  2, -3, 25, 15,-13,-35,-17,  3;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_12 which contains 556'388 sequence entries.


Total number of hits 81 in 81 different sequences
Number of true positive hits 79 in 79 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 9
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 97.53 %
Recall (true positives / (true positives + false negatives)) 89.77 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] Importin N-terminal
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
79 sequences

CSE1_SCHPO  (O13671    ), CSE1_YEAST  (P33307    ), IMA3_SCHPO  (O59809    ), 
IMB1_ARATH  (Q9FJD4    ), IMB1_HUMAN  (Q14974    ), IMB1_MOUSE  (P70168    ), 
IMB1_RAT    (P52296    ), IMB1_SCHPO  (O13864    ), IMB1_YEAST  (Q06142    ), 
IMB4_SCHPO  (O60100    ), IMB4_YEAST  (P40069    ), IMB5_SCHPO  (Q10297    ), 
IMB5_YEAST  (P53067    ), IMB_DROME   (O18388    ), IMB_XENLA   (P52297    ), 
IMPO_ENCCU  (Q8SR54    ), IPO11_HUMAN (Q9UI26    ), IPO11_MOUSE (Q8K2V6    ), 
IPO13_BOVIN (A7YWD2    ), IPO13_HUMAN (O94829    ), IPO13_MOUSE (Q8K0C1    ), 
IPO13_RAT   (Q9JM04    ), IPO4_HUMAN  (Q8TEX9    ), IPO4_MOUSE  (Q8VI75    ), 
IPO5_HUMAN  (O00410    ), IPO5_MOUSE  (Q8BKC5    ), IPO7_DICDI  (Q55CX9    ), 
IPO7_HUMAN  (O95373    ), IPO7_MOUSE  (Q9EPL8    ), IPO8_HUMAN  (O15397    ), 
IPO8_MOUSE  (Q7TMY7    ), IPO9_HUMAN  (Q96P70    ), IPO9_MOUSE  (Q91YE6    ), 
KA113_SCHPO (O94545    ), KA120_YEAST (Q02932    ), NMD5_YEAST  (P46970    ), 
SAD2H_ARATH (F4J738    ), SAD2_ARATH  (F4IRR2    ), SXM1_YEAST  (Q04175    ), 
TNPO1_ARATH (Q8H0U4    ), TNPO1_BOVIN (Q3SYU7    ), TNPO1_HUMAN (Q92973    ), 
TNPO1_MOUSE (Q8BFY9    ), TNPO1_ORYSI (B8ARW2    ), TNPO1_ORYSJ (B9FDR3    ), 
TNPO_DICDI  (Q55CQ7    ), XPO1A_ARATH (Q9SMV6    ), XPO1B_ARATH (F4IZR5    ), 
XPO1_DICDI  (Q54EV7    ), XPO1_DROME  (Q9TVM2    ), XPO1_HUMAN  (O14980    ), 
XPO1_MOUSE  (Q6P5F9    ), XPO1_RAT    (Q80U96    ), XPO1_SCHPO  (P14068    ), 
XPO1_YEAST  (P30822    ), XPO2_ARATH  (Q9ZPY7    ), XPO2_BOVIN  (A5D785    ), 
XPO2_DANRE  (Q7SZC2    ), XPO2_DICDI  (Q54E36    ), XPO2_DROME  (Q9XZU1    ), 
XPO2_HUMAN  (P55060    ), XPO2_MOUSE  (Q9ERK4    ), XPO2_ORENI  (Q8AY73    ), 
XPO2_PAGMA  (Q9PTU3    ), XPO2_PONAB  (Q5R9J2    ), XPO2_XENLA  (Q6GMY9    ), 
XPO5_DICDI  (Q54PQ8    ), XPO6A_XENLA (Q53I77    ), XPO6B_XENLA (Q6NTZ5    ), 
XPO6_DANRE  (Q8QHJ8    ), XPO6_HUMAN  (Q96QU8    ), XPO6_MOUSE  (Q924Z6    ), 
XPO7A_XENLA (Q704U0    ), XPO7B_XENLA (Q569Z2    ), XPO7_CHICK  (Q5ZLT0    ), 
XPO7_HUMAN  (Q9UIA9    ), XPO7_MOUSE  (Q9EPK7    ), XPO7_PONAB  (Q5R9G4    ), 
YNR7_SCHPO  (Q9USZ2    )
» more

UniProtKB/Swiss-Prot
False negative sequences
9 sequences

IMB2_SCHPO  (O14089    ), IP13A_DICDI (Q54C85    ), IP13B_DICDI (Q54WT9    ), 
IPO13_CHICK (Q5ZIC8    ), IPO13_PONAB (Q5R974    ), MOS14_ARATH (Q8GUL2    ), 
TNPO2_HUMAN (O14787    ), TNPO2_MOUSE (Q99LG2    ), XPO6_DICDI  (Q54CB2    )
» more

UniProtKB/Swiss-Prot
False positive sequences
2 sequences

ATM_CRYNB   (P0CP61    ), ATM_CRYNJ   (P0CP60    )

		
PDB
[Detailed view]
79 PDB

1F59; 1GCJ; 1IBR; 1M5N; 1O6O; 1O6P; 1QBK; 1QGK; 1QGR; 1UKL; 1WA5; 1Z3H; 2BKU; 2P8Q; 2Q5D; 2QMR; 2X19; 2XWU; 2Z5J; 2Z5K; 2Z5M; 2Z5N; 2Z5O; 3EA5; 3GB8; 3GJX; 3LWW; 3M1I; 3NBY; 3NBZ; 3NC0; 3NC1; 3ND2; 3VYC; 3W5K; 3WYF; 3WYG; 3ZJY; 4BSM; 4BSN; 4FDD; 4FQ3; 4GMX; 4GPT; 4HAT; 4HAU; 4HAV; 4HAW; 4HAX; 4HAY; 4HAZ; 4HB0; 4HB2; 4HB3; 4HB4; 4JLQ; 4OO6; 5DH9; 5DHA; 5DHF; 5DI9; 5DIF; 5DIS; 5J3V; 5JLJ; 5OWU; 5TQC; 5UWH; 5UWI; 5UWJ; 5UWO; 5UWP; 5UWQ; 5UWR; 5UWS; 5UWT; 5UWU; 5UWW; 5XOJ
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission