To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Entry: PS50812

General information about the entry

Entry name [info] PWWP
Accession [info] PS50812
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED; 10-MAY-2017 DATA UPDATE; 22-NOV-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC50812
Associated ProRule [info] PRU00162

Name and characterization of the entry

Description [info] PWWP domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=62;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=57;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.9419000; R2=0.0123090; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3817.5488281; R2=4.8558640; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=615; H_SCORE=6804; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=452; H_SCORE=6012; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='F'; M=-10,-28,-25,-31,-23, 16,-30,-25, 15,-23,  3,  3,-22,  0,-26,-22,-15, -8, 13,-16, -1,-25;
/M: SY='G'; M= -7, -5,-30, -5, -4,-31, 24, 16,-32, -9,-25,-10,  2,-17,  9, -7, -2,-17,-30,-22,-13,  2;
/M: SY='D'; M=-15, 24,-32, 39, 25,-35,-15, -5,-33,  0,-28,-25,  6, 15,  3,-10, -2,-10,-30,-35,-22, 13;
/M: SY='L'; M=-10,-30,-23,-33,-23,  7,-33,-23, 28,-30, 42, 20,-27,-27,-20,-23,-27,-10, 16,-20,  0,-23;
/M: SY='V'; M= -3,-30,-16,-33,-30,  0,-33,-30, 36,-23, 13, 13,-27,-27,-27,-23,-13, -3, 44,-27, -7,-30;
/M: SY='W'; M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/M: SY='A'; M= 14,-13,-15,-16,-16,-17,  9,-20, -9,-15,-14, -9, -8,-18,-16,-18,  9,  0,  4,-28,-20,-16;
/M: SY='K'; M=-10,  0,-30,  0, 10,-30,-20,-10,-30, 50,-30,-10,  0,-10, 10, 30,-10,-10,-20,-20,-10, 10;
/M: SY='L'; M= -8,-30,-18,-30,-22,  8,-30,-22, 22,-28, 40, 18,-30,-30,-22,-20,-25, -8, 20,-22, -2,-22;
/M: SY='R'; M= -5, -5,-25, -5, -3,-25, 10,-10,-30, 11,-28,-15,  2,-15, -1, 16,  5, -6,-20,-25,-18, -3;
/M: SY='G'; M= -3,  4,-27, -2,-14,-27, 50,-12,-34,-14,-30,-20, 17,-20,-14,-14,  3,-14,-30,-26,-27,-14;
/M: SY='Y'; M=-20,-25,-25,-30,-25, 54,-30,  1,  0,-20,  5,  0,-20,-30,-24,-15,-20,-10, -5, 20, 56,-25;
/M: SY='P'; M= -8,-12,-30, -8,  0,-25,-15,-12,-23,  1,-27,-17, -7, 34, -2,  8,  2, -3,-22,-30,-22, -5;
/M: SY='W'; M=-20,-38,-43,-40,-30, 26,-22,-28,-15,-22,-13,-15,-35,-30,-25,-20,-35,-25,-23,118, 30,-22;
/M: SY='W'; M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/M: SY='P'; M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='A'; M= 23,-12, 17,-20,-17,-22, 10,-22,-22,-17,-17,-15,-10,-20,-17,-22,  3, -7,-10,-27,-25,-17;
/M: SY='R'; M=-12, -4,-28, -4, 14,-20,-20, -2,-18, 19,-13,  4, -5,-12, 10, 22,-10,-10,-16,-23,-10, 11;
/M: SY='V'; M=  9,-25,-15,-30,-25, -5,-26,-28, 26,-20,  8,  8,-23,-23,-23,-22, -8, -2, 34,-25,-10,-25;
/M: SY='C'; M= -3,-20, 24,-23,-20, -8,-23,-23, -1,-23,  1, -3,-17,-28,-20,-20, -2,  0,  9,-36,-16,-20;
/M: SY='H'; M=  4, -5,-20, -7, -2,-20,-10, 21,-23, -1,-20,-10,  3,-15,  3,  9,  7, -3,-16,-28, -6, -2;
/M: SY='D'; M=-17,  8,-38, 20,  2,-25,-15,-13,-29, -8,-28,-25, -6, 13, -8,-15,-13,-15,-30,  9,-11, -3;
/I:         I=-4; MD=-18;
/M: SY='W'; M=-10,-15,-30,-12, -5,-13,-15,-15,-18,  7,-21,-13,-15, 12, -5, -1,-15,-13,-20, 24, -3, -5; D=-4;
/I:         I=-4; MI=0; MD=-18; IM=0; DM=-18;
/M: SY='M'; M= -5,-21,-13,-23,-18,  2,-21,-13, 18,-15, 20, 22,-21,-21,-13,-13,-15, -5, 19,-18, -3,-16; D=-4;
/I:         I=-4; DM=-18;
/M: SY='P'; M= -5,-13,-19,-13, -7, -8,-18,-15, -3,-13,  1, -3,-13, 16,-10,-13, -5,  7, -6,-21,-11,-10; D=-4;
/I:         I=-4; DM=-18;
/M: SY='P'; M= -8, -8,-26, -5, -5,-21,  7, 14,-23,-10,-21,-11, -3, 16, -5,-11, -5,-13,-23,-21,-11, -8; D=-4;
/I:         I=-4; DM=-18;
/M: SY='N'; M= -5,  9,-15,  3,  0,-15, -5,  0,-18,  5,-21,-13, 19,-13,  2, 15, 10,  2,-16,-26,-13,  0; D=-4;
/I:         I=-4; DM=-18;
/M: SY='Y'; M= -5,-13,-18,-16,-13,  2,-19, -6,  9,-13, -2,  1, -8,-15, -8,-13, -1,  0,  4, -8, 15,-13; D=-4;
/I:         I=-4; DM=-18;
/M: SY='R'; M= -8, -2,-18, -5,  3,-19,-15, -2,-15,  8,-13, -5,  0,-10, 17, 18,  2,  7,-13,-18, -8,  9; D=-4;
/I:         I=-4; DM=-18;
/M: SY='K'; M=  7, -2,-18, -5,  3,-21,-10,-10,-18, 24,-18, -8, -2, -8,  3, 11, -3, -5,-10,-15,-10,  3; D=-4;
/I:         I=-4; DM=-18;
/M: SY='M'; M=  5,-15,-20,-21,-11, -9,-18,-12,  1, -1,  8, 17,-15,-18, -5, -6,-13, -8,  1,-20, -7, -8;
/M: SY='K'; M=-12, 14,-30, 21, 25,-32,-18, -5,-32, 29,-28,-17,  5, -8, 10, 13, -5,-10,-25,-27,-15, 17;
/M: SY='G'; M= -6, -7,-30, -7,-14,-27, 45, 14,-37,-17,-27,-14,  3,-20,-12,-14, -3,-20,-30,-23,-16,-14;
/M: SY='Q'; M= -8,  3,-25,  3, 24,-30,-20,  0,-20,  5,-18, -8,  0, -7, 32,  2,  5,  5,-23,-25,-13, 28;
/I:         I=-4; MD=-22;
/M: SY='I'; M= -5, -8,-16,-11, -6, -7,-16,-11,  7,  4, -2,  3, -6, -8, -3, -1, -8, -5,  4,-10, -2, -6; D=-4;
/I:         I=-4; MD=-22;
/M: SY='G'; M= -2, -3,-16, -3, -3,-16, 15, -8,-19,  6,-16, -8,  0, -8, -3,  2, -2, -8,-13,-10,-11, -3; D=-4;
/I:         I=-4; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='E'; M= -5,  3,-16,  6, 22,-18,-10,  2,-13,  5,-10, -6,  0, -2, 20,  2,  0, -5,-16,-13, -8, 21; D=-4;
/I:         I=-4; DM=-22;
/M: SY='F'; M=-15,-23,-23,-25,-20, 25,-28, -8,  0, -8,  0,  0,-17,-28,-18,  5,-15, -8,  4, -2, 23,-20;
/M: SY='W'; M=-17, -4,-38,  3, -3,-20,-18, 11,-27,-10,-25,-17, -8, 11, -5,-13,-15,-17,-30, 12, -1, -5;
/M: SY='V'; M= 11,-25,-10,-28,-25, -5,-23,-28, 21,-18,  5,  5,-25,-25,-25,-20, -5,  0, 39,-28,-12,-25;
/M: SY='M'; M=-15,-16,-25,-21, -9,  8,-23, -3, -7, -2, -2, 12,-11,-20,  6, 10,-13,-10, -9,-12,  4, -1;
/M: SY='F'; M=-20,-32,-27,-40,-30, 63,-28,-22, -5,-28,  3, -5,-25,-30,-35,-20,-25,-15, -7, 44, 30,-28;
/M: SY='F'; M=-20,-30,-20,-40,-30, 80,-30,-20,  0,-30, 10,  0,-20,-30,-40,-20,-20,-10,  0, 10, 30,-30;
/M: SY='G'; M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='D'; M= -9, 24,-24, 34, 14,-34, -9, -1,-30, -1,-28,-20, 13,-10, 14, -5, 11, -2,-24,-35,-18, 14;
/M: SY='H'; M=  5, -5,-25, -7, -5,-25,  7, 10,-28,  4,-23,-10,  0,-15, -2, -1, -3,-12,-20,-22,-10, -5;
/I:         I=-6; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='D'; M=-15, 28,-30, 41, 27,-35,-15, -2,-35, 15,-28,-23, 10, -8,  7,  2, -2,-10,-28,-33,-18, 17;
/M: SY='R'; M=-20,-18,-28,-20,-13, 19,-25,  1,-14,  4, -7, -5,-11,-25, -8, 25,-15,-10,-12,  1, 25,-13;
/M: SY='A'; M= 20,-10,-16,-15,-10, -6, -8, -6,-10,-10,-12,-10, -8,-16, -8,-15,  9,  2, -5,-11,  8,-10;
/M: SY='W'; M=-15,-38,-40,-38,-30,  8,-22,-30, -8,-20,-13,-13,-38,-30,-22,-20,-33,-23,-10,106, 20,-22;
/M: SY='V'; M= -2,-22,-15,-27,-24, -3,-30,-27, 24,-20,  7,  7,-19,-22,-22,-20, -4, 12, 31,-28, -8,-24;
/I:         I=-6; MD=-32;
/M: SY='H'; M=-10,-10, 12,-10, -7,-17,-18, 16,-20,-12,-17,-10, -7,  5, -7,-12, -8,-10,-18,-28, -9,-10; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='I'; M=-10,-22,-23,-26,-16,  8,-29,-16, 13,-16,  4,  7,-17,-22, -5,-14,-12, -8, 11,-15,  2,-10;
/M: SY='E'; M=  7, 11,-22,  9, 26,-25,-10, -3,-22,  2,-19,-17, 11, -7,  7, -6,  5, -5,-22,-29,-20, 17;
/M: SY='R'; M=-13,  6,-28,  2,  5,-25,-15, -3,-28, 33,-27,-12, 14,-15,  8, 34, -5, -8,-22,-25,-12,  5;
/M: SY='C'; M= -2,-20, 17,-23,-20, -7,-23,-23,  2,-22,  3, -2,-18,-27,-20,-20, -3,  0, 12,-35,-15,-20;
/M: SY='F'; M=-15,-25,-22,-31,-23, 32,-28, -6, 10,-20, 20, 20,-22,-28,-18,-15,-22,-10,  3,  0, 27,-20;
/M: SY='P'; M= -8,-25,-28,-19,-12,-14,-25,-22,  1,-17, -2, -4,-25, 33,-17,-20,-15, -8, -1,-28,-18,-17;
/M: SY='Y'; M=  2,-20,-20,-25,-18,  6,-20, -4,  7,-15, 14, 16,-20,-23,-10,-15,-15, -8,  2, -6, 18,-15;
/M: SY='F'; M= -3,-13,-15,-18,-13, 10,-13,-10, -4,-15, -6,  7, -6,-18,-10,-12,  9,  4, -2,-22, -2,-10;
/M: SY='E'; M= -5,  5,-25, 10, 34,-28,-15, -5,-28, 14,-25,-18,  2, -5, 13,  4,  8, -3,-23,-30,-18, 23;
/M: SY='G'; M= -7,-10,-28,-10, -4, -3, 25,-15,-28,-16,-18,-15, -5,-18,-16,-15, -5,-15,-23,-15,-13, -9;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_11 which contains 556'196 sequence entries.


Total number of hits 86 in 80 different sequences
Number of true positive hits 86 in 80 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 7
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 92.47 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Feature key [info] DOMAIN
Feature description [info] PWWP
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
80 sequences

ATM_ARATH   (Q9M3G7    ), ATX1_ARATH  (Q9C5X4    ), ATX2_ARATH  (P0CB22    ), 
ATX3_ARATH  (Q9M364    ), ATX4_ARATH  (Q9SUE7    ), ATX5_ARATH  (Q8GZ42    ), 
BRD1_HUMAN  (O95696    ), BRPF1_HUMAN (P55201    ), BRPF1_MOUSE (B2RRD7    ), 
BRPF3_HUMAN (Q9ULD4    ), DNM3A_CHICK (Q4W5Z4    ), DNM3A_HUMAN (Q9Y6K1    ), 
DNM3A_MOUSE (O88508    ), DNM3A_RAT   (Q1LZ53    ), DNM3B_HUMAN (Q9UBC3    ), 
DNM3B_MOUSE (O88509    ), GLYR1_AEDAE (Q175F8    ), GLYR1_ANOGA (Q7Q161    ), 
GLYR1_BOVIN (A4FUF0    ), GLYR1_CHICK (Q5ZLS7    ), GLYR1_DANRE (Q5RKN4    ), 
GLYR1_DROME (Q8T079    ), GLYR1_DROPS (Q29NG1    ), GLYR1_HUMAN (Q49A26    ), 
GLYR1_MOUSE (Q922P9    ), GLYR1_PONAB (Q5R7T2    ), GLYR1_RAT   (Q5RKH0    ), 
GLYR1_XENTR (Q562D5    ), HDGF_BOVIN  (Q9XSK7    ), HDGF_HUMAN  (P51858    ), 
HDGF_MOUSE  (P51859    ), HDGF_RAT    (Q8VHK7    ), HDGL1_HUMAN (Q5TGJ6    ), 
HDGR2_DANRE (Q5XXA7    ), HDGR2_HUMAN (Q7Z4V5    ), HDGR2_MOUSE (Q3UMU9    ), 
HDGR2_RAT   (Q925G1    ), HDGR2_XENLA (Q32N87    ), HDGR2_XENTR (Q6P4K1    ), 
HDGR3_HUMAN (Q9Y3E1    ), HDGR3_MOUSE (Q9JMG7    ), HDGR3_RAT   (Q923W4    ), 
HUA2_ARATH  (Q9XER9    ), HUAL1_ARATH (Q9LEY4    ), HUAL2_ARATH (F4IN78    ), 
HUAL3_ARATH (F4IZM8    ), MBD5_HUMAN  (Q9P267    ), MES4_DROME  (Q8MT36    ), 
MSH6_CHICK  (E1BYJ2    ), MSH6_HUMAN  (P52701    ), MSH6_MOUSE  (P54276    ), 
NSD1_HUMAN  (Q96L73    ), NSD1_MOUSE  (O88491    ), NSD2_HUMAN  (O96028    ), 
NSD2_MOUSE  (Q8BVE8    ), NSD3_HUMAN  (Q9BZ95    ), NSD3_MOUSE  (Q6P2L6    ), 
PDP1_SCHPO  (O59676    ), PDP2_SCHPO  (O94312    ), PDP3_SCHPO  (Q09842    ), 
PKCB1_HUMAN (Q9ULU4    ), PSIP1_BOVIN (Q8MJG1    ), PSIP1_CHICK (Q5XXA9    ), 
PSIP1_FELCA (Q66T72    ), PSIP1_HUMAN (O75475    ), PSIP1_MOUSE (Q99JF8    ), 
PSIP1_RAT   (Q812D1    ), PWP2A_HUMAN (Q96N64    ), PWP2A_MOUSE (Q69Z61    ), 
PWP2A_XENLA (A0A1L8GR68), PWP2A_XENTR (F7AQ22    ), PWP2B_HUMAN (Q6NUJ5    ), 
TRX1_ORYSJ  (Q6K431    ), Y1745_ARATH (P59278    ), YL455_YEAST (Q06188    ), 
ZCPW1_HUMAN (Q9H0M4    ), ZCPW1_MOUSE (Q6IR42    ), ZCPW2_HUMAN (Q504Y3    ), 
ZMY11_HUMAN (Q15326    ), ZMY11_MOUSE (Q8R5C8    )
» more

UniProtKB/Swiss-Prot
False negative sequences
7 sequences

MBD5_MOUSE  (B1AYB6    ), MUM1_BOVIN  (Q08DK9    ), MUM1_HUMAN  (Q2TAK8    ), 
MUM1_MOUSE  (Q6DID5    ), MUM1_RAT    (B1H224    ), MUML1_HUMAN (Q5H9M0    ), 
MUML1_MOUSE (Q4VA55    )
» more

PDB
[Detailed view]
36 PDB

1H3Z; 1KHC; 1N27; 1RI0; 2B8A; 2DAQ; 2GFU; 2L89; 2M16; 2NLU; 2X35; 2X4W; 2X4X; 2X4Y; 3EAE; 3FLG; 3L42; 3LLR; 3LYI; 3MO8; 3PFS; 3QBY; 3QJ6; 3QKJ; 3ZEH; 4COS; 4FU6; 4LD6; 4N4G; 4N4H; 4N4I; 4NS5; 4RXJ; 4Z02; 5C6S; 5CIU
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission