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Entry: PS50867

General information about the entry

Entry name [info] PRE_SET
Accession [info] PS50867
Entry type [info] MATRIX
Date [info] 01-NOV-2002 CREATED; 10-MAY-2017 DATA UPDATE; 25-OCT-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC50280
Associated ProRule [info] PRU00157

Name and characterization of the entry

Description [info] Pre-SET domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=63;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=58;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1057999; R2=0.0059308; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=4844.3583984; R2=3.3438256; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1079; H_SCORE=8452; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=741; H_SCORE=7322; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M:         M= -8, -9,-12,-12, -6, -8,-21,-13, -8, -6,-10, -6, -6,-13, -4, -7, -2, -1, -5,-25, -9, -5;
/M: SY='G'; M= -1,-10,-16,-11,-15,-24, 33,-13,-28,-18,-25,-15, -2,-15,-14,-18,  5,-10,-21,-26,-22,-15;
/M: SY='C'; M= -8,-19, 98,-29,-28,-17,-28,-27,-24,-28,-14,-13,-19,-36,-27,-27,-10, -8, -7,-45,-26,-27;
/M: SY='N'; M= -8, 13,-17, 13,  5,-25, -6,  2,-24, -2,-24,-17, 14,-15,  1, -3,  7, -2,-20,-34,-16,  3;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/I:         I=-2; MD=-9;
/M: SY='K'; M=  1, -6,-19, -8,  0,-17,-18,-13, -7,  2,-10, -5, -6,-13,  0, -2,  1,  2, -2,-24,-11, -1; D=-2;
/I:         I=-2; MD=-9;
/M: SY='D'; M= -3, 14,-23, 16,  7,-26, 11, -7,-28, -4,-24,-19, 11,-11, -3, -9,  5, -5,-23,-28,-20,  2; D=-2;
/I:         I=-2; MI=0; MD=-9; IM=0; DM=-9;
/M: SY='D'; M= -3,  5,-21,  8,  5,-22,  3, -7,-21, -4,-18,-14,  3, -4, -1, -6,  3, -5,-17,-24,-17,  1; D=-2;
/I:         I=-2; DM=-9;
/M: SY='C'; M= -9,-19,114,-28,-28,-19,-28,-28,-28,-28,-19,-19,-19,-38,-28,-28, -9, -9, -9,-47,-28,-28; D=-2;
/I:         I=-2; DM=-9;
/M: SY='T'; M= -3, -6,-17, -8, -5,-10, -9,-11, -9, -9, -6, -3, -2,-15, -4, -7,  6,  7, -7,-26,-11, -5; D=-2;
/I:         I=-2; DM=-9;
/M: SY='D'; M= -5,  4,-20,  7,  2,-19,-13, -5,-20, -7,-20,-16,  1,  5, -5,-11,  3, -2,-18,-27,-13, -3; D=-2;
/I:         I=-2; DM=-9;
/M: SY='S'; M=  7, -1,-17, -2, -2,-20,  5,-10,-18, -1,-19,-12,  2,-10, -1, -4,  9, -1,-12,-22,-15, -2; D=-2;
/I:         I=-2; DM=-9;
/M: SY='B'; M= -2,  6,-13,  6,  5,-13, -7, -4,-11,  1,-12, -9,  6, -4,  0, -3,  4,  2,-10,-19,-10,  2; D=-2;
/I:         I=-2; DM=-9;
/M: SY='N'; M= -6, 10,-22,  6,  0,-22, -4, -6,-22,  9,-25,-15, 16,-11, -1,  5,  5,  0,-18,-29,-16, -1; D=-2;
/I:         I=-2; DM=-9;
/M: SY='C'; M=-10,-17,105,-26,-24,-19,-28,-27,-28,-26,-19,-19,-18,-36,-26,-26, -9, -9,-10,-46,-28,-25; D=-2;
/I:         I=-2; DM=-9;
/M: SY='A'; M=  9, -4,-13, -7,  1,-13, -9, -6, -8, -6, -6, -5, -3,-10,  0, -8,  5,  3, -5,-21,-10,  0; D=-2;
/I:         I=-2; DM=-9;
/M: SY='C'; M= -9,-19,114,-28,-28,-19,-28,-28,-28,-28,-19,-19,-19,-38,-28,-28, -9, -9, -9,-47,-28,-28; D=-2;
/I:         I=-2; DM=-9;
/M: SY='A'; M=  6,-14,-21,-18,-12,-13, -7,-14, -2,-15, -2, -2,-11,-11,-10,-17, -5, -6, -2,-18,-12,-12; D=-2;
/I:         I=-2; DM=-9;
/M: SY='Q'; M= -8, -3,-25, -3,  5,-24,-12,  3,-18,  7,-16, -6, -1,-13, 15, 13, -3, -9,-16,-21,-10,  8; D=-2;
/I:         I=-2; DM=-9;
/M: SY='K'; M= -5, -7,-23, -8,  0,-14, -8,-10,-13,  1, -3, -2, -6,-16, -1,  1, -8, -9,-12,-20,-10, -1; D=-2;
/I:         I=-2; DM=-9;
/M: SY='N'; M=  0,  7,-16, -1, -5,-16, -5, -7,-12, -5,-17,-10, 15,-10, -4, -7, 10,  7,-11,-30,-16, -5; D=-2;
/I:         I=-2; DM=-9;
/M: SY='G'; M=  0, -7,-21, -7, -8,-16,  5,-11,-10,-10,-11, -6, -4,-11, -9,-12, -2, -7, -8,-20,-12, -9; D=-2;
/I:         I=-2; DM=-9;
/M: SY='G'; M= -6,  1,-24,  0, -1,-22,  7, -2,-20, -4,-18,-10,  4,-14, -1, -2, -2, -9,-17,-22,-14, -2; D=-2;
/I:         I=-2; DM=-9;
/M: SY='N'; M= -6,  0,-18, -1, -1,-18, -5, -7,-20, -5,-14,-11,  2,-11, -4, -3, -5, -9,-18,-26,-15, -3; D=-2;
/I:         I=-2; DM=-9;
/M: SY='F'; M=-14,-26,-24,-31,-23, 39,-27,-13,  3,-22, 10,  3,-22,-27,-24,-17,-20, -9, -1, 15, 27,-22;
/I:         I=-6; MD=-32;
/M: SY='P'; M= 11, -6,-20, -8, -1,-21, -7,-14,-16, -3,-18,-13, -4, 15, -5, -9,  2, -1,-14,-23,-19, -5; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='Y'; M=-18,-19,-23,-21,-18, 27,-29, 10, -3,-11, -1, -2,-18,-28,-13, -9,-17, -8, -8, 17, 59,-19;
/M: SY='D'; M= -9, 15,-17, 17,  1,-20,-12, -5,-20, -7,-16,-15,  8,-15, -6,-10,  5,  7,-14,-32,-12, -3;
/M: SY='G'; M= -1,  3,-26,  3, -1,-25,  6,-11,-25, -1,-23,-16,  4, -4, -6, -6,  0, -8,-20,-26,-19, -4;
/M: SY='B'; M= -6,  9,-25,  8,  5,-24, -8, -1,-22,  3,-18,-12,  9,-11,  4,  1,  0, -5,-20,-29,-15,  4;
/I:         I=-4; MD=-19;
/M: SY='G'; M= -2, -3,-21, -4, -8,-23, 26,-11,-24, -7,-22,-13,  4,-12, -4, -8,  4, -7,-19,-21,-19, -6; D=-4;
/I:         I=-4; MD=-19;
/M: SY='R'; M= -7, -4,-14, -4,  2,-14,-13, -4,-14,  5, -8, -5, -3,-13,  6, 16, -3, -4,-11,-18, -8,  2; D=-4;
/I:         I=-4; MI=0; MD=-19; IM=0; DM=-19;
/M: SY='I'; M= -5,-15,-19,-19,-14, -6,-18,-15, 11,-10,  6,  7,-11,-15, -9, -8,-11, -6,  8,-18, -6,-13; D=-4;
/I:         I=-4; DM=-19;
/M: SY='R'; M=-12, -4,-23, -5,  0,-13,-19, -4, -8,  4, -5, -3, -1,-16,  0, 13, -9, -8, -8,-21, -8, -2; D=-4;
/I:         I=-4; DM=-19;
/M: SY='L'; M=-10,-28,-21,-31,-23, 12,-30,-22, 20,-25, 28, 15,-25,-23,-22,-17,-22, -9, 15,-18,  1,-23;
/M: SY='N'; M= -6, -1,-17, -6, -4,-16,-14, -6, -8, -5,-11, -6,  6,-18, -2, -3, -1, -4, -7,-30,-13, -4;
/M: SY='E'; M= -4, -6,-20, -4,  8,-21,-12, -8,-21,  4,-21,-12, -4,  1,  2,  2,  2, -4,-18,-26,-13,  3;
/M: SY='G'; M=  0, -6,-26, -7, -2,-24, 11, -9,-23, -4,-21,-12, -2,-15, -1, -5,  1,-10,-19,-18,-16, -2;
/M: SY='K'; M= -8, -2,-21, -2,  1,-18,-16, -9,-17,  5,-18,-11, -2, -5, -2,  1, -2, -1,-14,-23, -7, -2;
/M: SY='P'; M= -7,-11,-32, -5,  0,-26,-17,-13,-17, -7,-21,-12,-13, 45, -5,-15, -7, -7,-21,-29,-22, -6;
/I:         I=-4; MD=-22;
/M: SY='I'; M= -1,-11,-11,-13,-10, -1,-14,-10,  5,-11,  5,  1,-11, -7, -9,-10, -4,  2,  5,-12,  0,-10; D=-4;
/I:         I=-4; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='I'; M= -7,-30,-23,-36,-29,  1,-36,-29, 41,-27, 20, 17,-24,-24,-23,-26,-18, -7, 34,-23, -3,-29;
/M: SY='Y'; M=-19,-20,-28,-23,-19, 29,-29,  9, -1,-10,  0,  0,-16,-27,-14, -7,-18,-10, -7, 14, 52,-19;
/M: SY='E'; M=-10, 10,-30, 20, 60,-30,-20,  0,-30, 10,-20,-20,  0,  0, 20,  0,  0,-10,-30,-30,-20, 40;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='N'; M= -7, 17,-24,  6, -7,-20, 15,  0,-25, -8,-29,-19, 32,-20, -6, -7,  6, -6,-28,-22,-18, -6;
/M: SY='D'; M= -8,  2,-27,  7,  7,-24,-12, -7,-24,  3,-23,-15,  0,  5,  2, -2,  2, -4,-20,-29,-16,  3;
/M: SY='R'; M= -3,-12,-22,-15, -8, -5,-16, -3,-12, -2, -6, -1, -8,-19, -2,  4, -5, -5, -8,-18, -2, -6;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='K'; M= -1, -3,-22, -5, -2,-26,  3,-12,-26,  6,-27,-15,  2, -3, -1,  2,  5, -3,-20,-27,-19, -3;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='S'; M= -4,  0,-20,  1, -5,-23,  0, -6,-24,-10,-25,-18,  2,  0, -7,-13,  5, -4,-20,-22,-17, -7;
/M: SY='R'; M= -9, -7,-28, -5,  0,-20,-18, -6,-19,  5,-17, -8, -6,  8,  1,  9, -4, -5,-17,-25,-12, -2;
/I:         I=-5; MD=-27;
/M: SY='N'; M= -8, 12,-22, 10,  4,-21,-11,  4,-21,  1,-20,-14, 16,-15,  4,  0,  5,  0,-20,-26,-11,  4; D=-5;
/I:         I=-5; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='R'; M= -9, -9,-24, -9, -3,-20,-10, -8,-21,  6,-20,-11, -5, -2,  1, 10, -4, -6,-17,-21, -9, -3;
/M: SY='N'; M= -9, 33,-19, 15, -2,-18, -2,  7,-17, -2,-25,-16, 51,-20, -1, -2,  9,  2,-26,-38,-18, -1;
/M: SY='R'; M=-19, -9,-30, -9,  1,-21,-20, -1,-30, 31,-21,-10,  0,-19, 10, 68,-10,-10,-20,-20,-10,  1;
/M: SY='V'; M= -2,-29,-12,-30,-27,  1,-30,-27, 27,-21, 16, 12,-28,-29,-27,-20,-12,  0, 40,-28, -8,-27;
/M: SY='V'; M=  2,-23,-11,-25,-24, -3,-25,-26, 19,-18,  6,  5,-22,-25,-23,-18, -2,  7, 34,-30,-10,-24;
/M: SY='Q'; M=-10, -1,-30,  0, 19,-37,-20, 10,-19,  9,-19, -1, -1,-11, 56,  9, -1,-10,-29,-18, -6, 37;
/M: SY='R'; M=-10,  3,-19, -2, -1,-18,-13, 10,-23, 10,-22, -9, 10,-17,  2, 12,  0, -2,-19,-28, -7, -1;
/M: SY='G'; M= -1, -8,-29, -9,-18,-29, 62,-18,-38,-17,-30,-20,  3,-20,-17,-15,  1,-18,-29,-21,-29,-18;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_10 which contains 556'006 sequence entries.


Total number of hits 51 in 51 different sequences
Number of true positive hits 51 in 51 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 5
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 91.07 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20_shuffled
Author [info] N_Hulo
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] Pre-SET
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
51 sequences

CLR4_SCHPO  (O60016    ), DIM5_NEUCR  (Q8X225    ), EHMT1_HUMAN (Q9H9B1    ), 
EHMT1_MOUSE (Q5DW34    ), EHMT2_HUMAN (Q96KQ7    ), EHMT2_MOUSE (Q9Z148    ), 
MET2_CAEEL  (P34544    ), SET23_CAEBR (A8XI75    ), SET23_CAEEL (Q95Y12    ), 
SETB1_DROME (Q32KD2    ), SETB1_DROPS (Q28Z18    ), SETB1_HUMAN (Q15047    ), 
SETB1_MOUSE (O88974    ), SETB1_XENLA (Q6INA9    ), SETB2_DANRE (Q06ZW3    ), 
SETB2_HUMAN (Q96T68    ), SETB2_MOUSE (Q8C267    ), SETB2_XENLA (Q6YI93    ), 
SETB2_XENTR (A4IGY9    ), SETMR_BOVIN (Q0VD24    ), SETMR_HUMAN (Q53H47    ), 
SETMR_MOUSE (Q80UJ9    ), SETMR_RAT   (Q5I0M0    ), STB1A_DANRE (Q1L8U8    ), 
STB1B_DANRE (Q08BR4    ), SUV39_DROME (P45975    ), SUV39_DROPS (Q294B9    ), 
SUV91_BOVIN (Q2NL30    ), SUV91_HUMAN (O43463    ), SUV91_MOUSE (O54864    ), 
SUV91_PONAB (Q5RB81    ), SUV91_XENLA (Q6NRE8    ), SUV92_BOVIN (Q32PH7    ), 
SUV92_CHICK (Q5F3W5    ), SUV92_HUMAN (Q9H5I1    ), SUV92_MACFA (Q4R3E0    ), 
SUV92_MOUSE (Q9EQQ0    ), SUV92_XENTR (Q28CQ7    ), SUVH1_ARATH (Q9FF80    ), 
SUVH1_TOBAC (Q93YF5    ), SUVH2_ARATH (O22781    ), SUVH3_ARATH (Q9C5P4    ), 
SUVH4_ARATH (Q8GZB6    ), SUVH5_ARATH (O82175    ), SUVH6_ARATH (Q8VZ17    ), 
SUVH7_ARATH (Q9C5P1    ), SUVH9_ARATH (Q9T0G7    ), SUVR1_ARATH (Q946J2    ), 
SUVR4_ARATH (Q8W595    ), SUVR5_ARATH (O64827    ), SV91A_DANRE (Q6DGD3    )
» more

UniProtKB/Swiss-Prot
False negative sequences
5 sequences

SUVH3_CHLRE (Q5QD03    ), SUVH8_ARATH (Q9C5P0    ), SUVHA_ARATH (Q3EC60    ), 
SUVR2_ARATH (Q9FNC7    ), SUVR3_ARATH (Q9SRV2    )
» more

PDB
[Detailed view]
30 PDB

1ML9; 1MVH; 1MVX; 1PEG; 2IGQ; 2O8J; 2R3A; 2RFI; 3BO5; 3FPD; 3HNA; 3K5K; 3MO0; 3MO2; 3MO5; 3RJW; 3SW9; 3SWC; 4I51; 4NJ5; 4NVQ; 4QEN; 4QEO; 4QEP; 5JHN; 5JIN; 5JIY; 5JJ0; 5T0K; 5T0M
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission