To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Entry: PS50877

General information about the entry

Entry name [info] GOLOCO
Accession [info] PS50877
Entry type [info] MATRIX
Date [info] 01-APR-2003 CREATED; 10-MAY-2017 DATA UPDATE; 25-OCT-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC50877
Associated ProRule [info] PRU00097

Name and characterization of the entry

Description [info] GoLoco/GPR motif profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=23;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=21;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.5159345; R2=0.0172079; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=904.4058838; R2=0.6058823; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=447; H_SCORE=1175; N_SCORE=8.2; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=348; H_SCORE=1115; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-7; D=-20; I=-20; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='D'; M=-10,  5,-27,  7,  3,-24, -6, -7,-18, -4,-18,-10,  4, -5,  1, -4, -1, -5,-18,-29,-17,  1;
/M: SY='E'; M=-12, 15,-27, 24, 26,-28,-19, -6,-20,  0,-17,-16,  2, -9,  7, -7, -1, -5,-17,-32,-16, 16;
/M: SY='D'; M=-13, 26,-29, 37, 28,-34, -6,  0,-34,  2,-26,-23, 13, -8, 10, -5,  1,-10,-30,-33,-20, 19;
/M: SY='F'; M=-11,-28,-20,-32,-24, 27,-22,-19, 11,-27, 26, 14,-24,-28,-25,-19,-22,-10,  8,-12,  6,-23;
/M: SY='L'; M=-11,-25,-19,-30,-22, 22,-28,-14, 12,-22, 24, 17,-23,-27,-20,-17,-19, -4,  9,-11, 12,-21;
/M: SY='D'; M= -5, 21,-24, 27, 27,-29,-10, -2,-28,  1,-25,-22, 14, -8,  7, -6,  8, -3,-24,-35,-20, 17;
/M: SY='M'; M= -8,-23,-21,-28,-20,  1,-20,-14, 16,-21, 27, 28,-21,-23,-13,-17,-19, -5,  8,-21, -3,-17;
/M: SY='L'; M= -9,-30,-23,-34,-25,  5,-34,-25, 32,-29, 35, 19,-26,-26,-21,-24,-25, -9, 21,-21, -1,-25;
/M: SY='M'; M= -7, -8,-22,-14, -5, -2,-20, -9,  2, -8,  4, 10, -4,-19, -7, -9,-11, -7, -1,-23, -6, -6;
/M: SY='R'; M=-10, -2,-25, -4,  2,-22,-14, -4,-27, 23,-25,-13,  6,-16,  7, 39,  3, -2,-18,-26,-13,  2;
/M: SY='M'; M= -3,-18, -9,-23,-19, -4,-22, -3,  8,-14,  3, 18,-17,-23,-11,-14, -8, -2, 13,-24,  0,-16;
/I:         I=-6; MD=-29;
/M: SY='Q'; M= -9,  0,-27,  0, 18,-37,-18,  9,-18,  9,-18,  0,  0, -9, 55,  9,  0, -9,-27,-18, -9, 37; D=-6;
/I:         I=-6; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='S'; M=  8, -7, -5, -9,-10,-21, 13,-16,-22,-16,-22,-16,  0,-17,-10,-16, 18,  3,-13,-33,-22,-10;
/M: SY='S'; M=  4, -2,-19, -3, -3,-24, 10, -9,-25, -5,-27,-16,  8,-14,  2, -1, 18,  3,-18,-30,-20, -1;
/M: SY='R'; M=-17,-10,-30,-10, -3,-22, -5, -3,-32, 22,-22,-12,  0,-20,  5, 55, -8,-12,-22,-20,-13, -3;
/M: SY='M'; M=  0,-22,-19,-29,-19,  0,-21,-12, 17,-18, 25, 33,-22,-22, -9,-16,-18, -8, 10,-20, -3,-15;
/M: SY='D'; M=-16, 25,-30, 38, 34,-33,-16, 16,-34,  3,-24,-21, 10, -7, 10, -4, -2,-12,-30,-34,-13, 21;
/M: SY='D'; M=-12, 37,-28, 53, 25,-36,-11, -2,-35,  1,-26,-26, 14, -8,  3, -9,  1, -9,-27,-36,-20, 14;
/M: SY='Q'; M=-10,  0,-30,  0, 20,-40,-20, 10,-20, 10,-20,  0,  0,-10, 60, 10,  0,-10,-30,-20,-10, 40;
/M: SY='R'; M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='C'; M= 10,-11, 12,-16,-16,-20,  6,-21,-20,-17,-19,-15, -6,-20,-16,-19,  9,  2, -8,-32,-23,-16;
/M: SY='E'; M= -6, -4,-22, -2, 13,-17,-18, -1,-16, -5,-10,-10, -4, -5,  2, -4,  3,  3,-15,-30,-12,  6;
/M: SY='L'; M=-11,-24,-25,-24,-13,  6,-27,-19,  8,-21, 16,  8,-23, -1,-17,-19,-20, -9,  1,-20, -5,-16;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_10 which contains 556'006 sequence entries.


Total number of hits 41 in 21 different sequences
Number of true positive hits 41 in 21 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] N_Hulo
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 4
Feature key [info] DOMAIN
Feature description [info] GoLoco
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
21 sequences

GPR1_CAEEL  (Q95QJ7    ), GPR2_CAEEL  (Q03569    ), GPSM1_HUMAN (Q86YR5    ), 
GPSM1_MOUSE (Q6IR34    ), GPSM1_RAT   (Q9R080    ), GPSM2_HUMAN (P81274    ), 
GPSM2_MOUSE (Q8VDU0    ), GPSM3_HUMAN (Q9Y4H4    ), GPSM3_MOUSE (Q3U1Z5    ), 
GPSM3_RAT   (Q6MG88    ), PCP2_HUMAN  (Q8IVA1    ), PCP2_MOUSE  (P12660    ), 
RGS12_HUMAN (O14924    ), RGS12_MOUSE (Q8CGE9    ), RGS12_RAT   (O08774    ), 
RGS14_HUMAN (O43566    ), RGS14_MOUSE (P97492    ), RGS14_RAT   (O08773    ), 
RGS_DROME   (Q9VCX1    ), RPGP1_HUMAN (P47736    ), RPGP1_MOUSE (A2ALS5    )
» more

PDB
[Detailed view]
10 PDB

1KJY; 2OM2; 2XNS; 3ONW; 3QI2; 4G5O; 4G5Q; 4G5R; 4G5S; 4JHR

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission