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	Entry: PS50896

General information about the entry
Entry name	LISH
Accession number	PS50896
Entry type	MATRIX
Date	FEB-2003 (CREATED); FEB-2003 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation	PDOC50896
Associated ProRule	PRU00126
Name and characterization of the entry
Description	LIS1 homology (LisH) motif profile.
Matrix / Profile	/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=33; /DISJOINT: DEFINITION=PROTECT; N1=1; N2=33; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=5.5517526; R2=0.0001392; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=13997; N_SCORE=7.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=6812; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: B0=; B1=; E0=; E1=; MM=; II=; A C D E F G H I K L M N P Q R S T V W Y /I: B1=-8455; BM=-16; BD=-6459; /M: SY='Q'; M= -485, -655, 565, 524, -489,-2325, 566,-2057, 522, -37, -108, 260, -475, 1123, 1061, 491, -371,-1660, 529,-1524; M0=-292; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='R'; M=-1258, -578, -168, 465,-5430, -719, -25,-1026, 1337,-1963,-4198, 524, 142, 1208, 1853, 307, -650,-1554, -499,-4610; M0=-713; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='R'; M= -172,-5109, -592, 941,-1863,-2339, 269,-2490, 1040,-1368,-1033, 1139,-1014, 984, 1264, 1045, -913, -777,-5292,-4610; M0=-670; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='E'; M= -373,-5102, 1663, 1945,-1859,-2532,-3271, -410, -260, 380, 592, -382,-2538, 259, -73, -876, -42,-2726,-5287,-1467; M0=-708; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='L'; M=-1571,-3751,-6271,-5635, -24,-2868,-4345, 1162,-5230, 2373, 1221,-1936,-5523,-4853,-5030, -881, -713, 1311,-4210,-3868; M0=-2170; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='N'; M= -722, 1180, 1035,-1927,-1903,-4870, 803, 1166,-1881, 298,-3608, 2710,-1832, 30,-3776,-1733,-1438, -634,-4793, 280; M0=-1058; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='R'; M= -471, 106,-3543, -398, 325, -948, -891,-2248, 796, -608,-1226, -639, -234, 1153, 2259, -94, -839, -596,-5217, 378; M0=-510; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='L'; M= 448, -770,-6268,-5632, -345,-5470, -953, 1389,-5227, 2323, 1458,-5116,-5520, -925,-5027,-1400,-3863,-2014,-4206, 1414; M0=-2319; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='I'; M=-6016, 183,-8682,-8336,-2061,-8542,-8358, 2997,-8294, -255, 1125,-8201,-8156,-8001,-8349,-7928,-5992, 2551,-7421,-7144; M0=-5211; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='Y'; M= 671, -585,-5996,-1969, -384,-2615, 991, -337, -200, 1392, 1503,-1025,-5481,-2455,-1273, -221,-1236, 366, 771, 1836; M0=-916; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='Q'; M=-2088,-5109, 1816, 1651,-5431, -736, 1240,-5181, -702,-2750,-4198, 1446,-4703, 1913, 574, -336,-1161,-4731, -243,-4610; M0=-1592; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='Y'; M=-2838, -702,-8617,-8976, 2713,-8493, 3063,-7131,-8530,-3567,-6532,-7106,-8350,-7248,-7891,-7742,-8088,-7286,-3927, 4009; M0=-5908; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='L'; M=-7253, 1004,-9409,-8929, 1469,-9210,-7001,-4195,-8698, 3082, 877,-8684,-4220,-7378,-8117,-8566,-7077,-5073,-5823,-1468; M0=-5564; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='Q'; M=-2596, -650, 260, -104, -562,-1632, -944, 109, 191, 932, -218, -67,-4762, 1595, 274,-1367,-1182, 914,-5150, 954; M0=-556; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='H'; M=-1270,-5108, -682, 1358, -316,-4610, 1984,-1500, 1000,-2910,-4197, -91,-4703, 980, 1640, 371, -184,-1196, 1693,-4609; M0=-1114; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='N'; M= -261, 1671,-3562, 945, -878,-4651, 1126,-1087, 654,-2056, 849, 2088,-4742, 1418, -886, 228,-1132,-1753,-5195, 315; M0=-991; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='G'; M=-2058, -536, -625,-1742,-5461, 3145,-3295,-5212, 488,-5156,-4230, 1268,-4728, -352,-1936, -686,-3605,-4762,-5323,-1197; M0=-2202; /I: MM=-18; MI=-11609; MD=-6391; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='Y'; M= -628,-4528,-1233,-6359, 1720,-6209, -965,-4034,-2061, 1572, 1297,-5707,-6237,-5497,-5731,-5308,-4684,-3978,-4079, 3706; M0=-3072; /I: MM=-1; MI=-11592; MD=-12634; IM=-894; II=-1115; DM=-371; DD=-2142; /M: SY='H'; M=-2459, 714, 267, 1029, -536,-1779, 1692,-1430, 1238, -659, -450, -491,-1860, 249, -705, 494, 88, -78, -238, 629; M0=-368; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='E'; M= -541,-5109, 1462, 1989,-1852,-2390, 1614,-1574, 521,-1251,-4198, 831,-4703, 562, 150, -192,-1718,-2392,-5292, -491; M0=-917; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='T'; M= 1253, -437,-6789,-6279,-4442,-5538,-5023,-2290,-5880,-1750,-3675,-5548,-2100,-5488,-5665, 1340, 2960, 837,-4948,-4617; M0=-2829; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='A'; M= 2725, -659,-5870, -219, 730, -915,-1317,-1817,-1375, 598, 340,-4923,-5462,-1923,-1817,-1499,-3845, -565,-4248,-1444; M0=-1444; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='H'; M= 647,-5107, -144, 1454, -257,-2533, 1866,-1010, 1258,-1265,-1095,-1708,-4704, 1506, 233, -179, -888,-2286,-5291,-1048; M0=-772; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='T'; M= 1363, 1066,-4775, 357,-4051,-2419,-3919,-2506, 1014, -690, 1163,-4253,-5216,-3879, -810, -518, 1972, 857,-4463,-4056; M0=-1350; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='F'; M=-7028,-6438,-9182,-8696, 3452,-8885, -729,-2128,-8431, 2324, 162,-8356,-8126,-7245,-7913,-8176,-6870,-2184,-5689, -788; M0=-5266; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='Q'; M= 524, 1799,-2109, 895,-1794,-1135,-3295, -201, 134, 328, 46, -827,-2118, 1835, 670, -131,-1268, -720,-5236,-1528; M0=-459; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='K'; M= -469,-5109,-1116, 1285,-1934,-4610, -434,-2156, 1948, -567, -410,-2021, 22, 1433, 1365, 209,-1645,-4731,-5292,-1858; M0=-1051; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='E'; M= -528,-5361, -113, 3511,-5676,-4766,-3480,-5434, -637,-5375,-1466,-1569,-4897, -124,-3614, -944,-1180,-4981,-5543,-4846; M0=-2626; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='T'; M= 1436, 1489,-6257,-5621,-3704,-1050,-4339,-1277,-5219, -631, -805, -467,-5518,-4844,-5023, 1788, 2193, -454,-4208,-1085; M0=-1944; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='G'; M=-1323, -768, 309, -94,-5430, 2115, 667,-2841, 1144,-2157,-4198, 703,-1156, 919, 101, 12, -563,-4731,-5292,-4610; M0=-1096; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='I'; M=-1546, 230, -64, -342, 236,-2964, -51, 1395,-1899, 1212, -922,-2055,-1045, 246, -614, -630, -209, 1265, -142,-4210; M0=-551; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='S'; M= -853,-5099, 270, 687, -963,-2036, -531, -438, 405, -369, -392, -131, 707, 665,-1919, 903, 877, 283,-5285,-1576; M0=-354; /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378; /M: SY='D'; M=-2169,-1710, 889, 280, -962, -344,-1035,-1011, 645, 628, -691, 464, 49, 426, 86, -241, -225, 553,-5279,-1535; M0=-256; /I: E1=-1000;
Numerical results
UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052. Total number of hits in UniProtKB/Swiss-Prot: 247 hits in 247 different sequences Number of hits on proteins that are known to belong to the set under consideration: 247 hits in 247 different sequences Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences Number of false hits (on unrelated proteins): 0 hits in 0 different sequences Number of known missed hits: 12 Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0 Precision (true hits / (true hits + false positives)): 100.00 % Recall (true hits / (true hits + false negatives)): 95.37 %
Comments
MATRIX_TYPE: protein_domain Scaling database: UniProtKB/Swiss-Prot: reversed Matrix author: CJA_Sigrist Taxonomic range: Eukaryotes Maximum known number of repetitions of the pattern in a single protein: 1 FT_KEY: DOMAIN FT_DESC: LisH VERSION: 1
Cross-references
UniProtKB/Swiss-Prot	True positive hits: ADN2_SCHPO (O94619), ADN3_SCHPO (O74522), ARMC9_BOVIN (Q2KI89), ARMC9_HUMAN (Q7Z3E5), ARMC9_MOUSE (Q9D2I5), ARMC9_PONAB (Q5R629), ARMC9_RAT (A1A5P5), ARMC9_XENLA (Q5U245), ARMC9_XENTR (A0JMA8), DCAF1_ARATH (Q9M086), DCAF1_CAEEL (Q21106), DCAF1_DROME (Q9W2F2), EBI_DROME (Q95RJ9), FLO8_CANAL (Q59QW5), FLO8_YEAS1 (B3LRM5), FLO8_YEAS2 (C7GS77), FLO8_YEAS6 (B5VHN4), FLO8_YEAS7 (A6ZR64), FLO8_YEAS8 (C8Z7C7), FLO8_YEAST (P40068), FOPNL_CHICK (Q5ZJ24), FOPNL_HUMAN (Q96NB1), FOPNL_MOUSE (Q9CZS3), FOPNL_XENLA (Q4V7R8), FR1OP_BOVIN (Q2YDD1), FR1OP_HUMAN (O95684), FR1OP_MACFA (Q4R7V3), FR1OP_MOUSE (Q66JX5), FR1OP_RAT (Q4V7C1), FYV10_ASPCL (A1C9R2), FYV10_ASPFU (Q4WTQ4), FYV10_ASPNC (A2R9P6), FYV10_ASPTN (Q0CA25), FYV10_CHAGB (Q2H991), FYV10_COCIM (Q1DTI6), FYV10_EMENI (Q5AS80), FYV10_MAGO7 (A4RK04), FYV10_NEOFI (A1CZJ5), FYV10_NEUCR (Q7S2X0), FYV10_PHANO (Q0TYW1), FYV10_SCHPO (Q9URU9), FYV10_YARLI (Q6C435), GEFA_DICDI (Q54PQ4), GEFF_DICDI (Q54C94), GEFH_DICDI (Q8IS16), GEFI_DICDI (Q8IS15), GEFJ_DICDI (Q8IS14), GID8_BOVIN (Q32L52), GID8_CHICK (Q5ZKQ7), GID8_DANRE (Q6PC55), GID8_DICDI (Q54X16), GID8_HUMAN (Q9NWU2), GID8_MOUSE (Q9D7M1), GID8_NEMVE (A7SWD3), HIF2_SCHPO (O74845), K1468_DANRE (Q6P6Y1), K1468_HUMAN (Q9P260), K1468_MOUSE (Q148V7), K1468_XENTR (Q08BT5), KATL2_HUMAN (Q8IYT4), KATL2_MOUSE (Q9D3R6), KATL2_XENLA (Q3B8D5), KATL2_XENTR (A0JMA9), LEUNG_ARATH (Q9FUY2), LIS11_ASPCL (A1CUD6), LIS11_CHAGB (Q2HBX6), LIS11_NEUCR (Q7RY30), LIS11_PARTE (A0DB19), LIS11_PENMQ (B6QC56), LIS11_PODAN (B2AEZ5), LIS11_POSPM (B8P4B0), LIS11_SORMK (D1ZEB4), LIS12_ASPCL (A1CF18), LIS12_CHAGB (Q2GT28), LIS12_NEUCR (Q7S7L4), LIS12_PARTE (A0CH87), LIS12_PENCW (B6GZD3), LIS12_POSPM (B8PD53), LIS12_SORMK (D1ZEM6), LIS1A_DANRE (Q7T394), LIS1A_SALSA (B5X3Z6), LIS1B_DANRE (Q803D2), LIS1B_SALSA (B5X3C4), LIS1_AEDAE (Q17N69), LIS1_AJECG (C0NRC6), LIS1_AJECH (C6HTE8), LIS1_AJEDR (C5GVJ9), LIS1_AJEDS (C5JD40), LIS1_ARTBC (D4AZ50), LIS1_ARTOC (C5FWH1), LIS1_ASPFC (B0XM00), LIS1_ASPFN (B8N9H4), LIS1_ASPFU (Q4WLM7), LIS1_ASPNC (A2QP30), LIS1_ASPOR (Q2UGU1), LIS1_BOVIN (P43033), LIS1_BRAFL (C3XVT5), LIS1_CAEBR (A8XZJ9), LIS1_CAEEL (Q9NDC9), LIS1_CHICK (Q9PTR5), LIS1_COCP7 (C5PFX0), LIS1_COPC7 (A8NEG8), LIS1_CRYNB (P0CS43), LIS1_CRYNJ (P0CS42), LIS1_DICDI (Q8I0F4), LIS1_DROAN (B3MEY6), LIS1_DROER (B3NPW0), LIS1_DROGR (B4JWA1), LIS1_DROME (Q7KNS3), LIS1_DROMO (B4KT48), LIS1_DROPE (B4GAJ1), LIS1_DROPS (Q291L9), LIS1_DROSE (B4HSL3), LIS1_DROSI (B4QHG6), LIS1_DROVI (B4LQ21), LIS1_DROWI (B4MY65), LIS1_DROYA (B4P6P9), LIS1_EMENI (Q00664), LIS1_FELCA (B0LSW3), LIS1_GLOMM (D3TLL6), LIS1_HUMAN (P43034), LIS1_IXOSC (B7PS00), LIS1_MACFA (Q8HXX0), LIS1_MAGO7 (A4R3M4), LIS1_MONBE (A9V790), LIS1_MOUSE (P63005), LIS1_NEMVE (A7S338), LIS1_NEOFI (A1DP19), LIS1_PANTR (Q5IS43), LIS1_PARBD (C1GB49), LIS1_PARBP (C0S902), LIS1_PHANO (Q0U1B1), LIS1_PIG (Q9GL51), LIS1_POLPA (D3BUN1), LIS1_PONAB (Q5REG7), LIS1_PYRTR (B2VWG7), LIS1_RAT (P63004), LIS1_SCHMA (C4Q0P6), LIS1_SCLS1 (A7EKM8), LIS1_TALSN (B8M0Q1), LIS1_TETNG (Q4RJN5), LIS1_TRIAD (B3S4I5), LIS1_TRIVH (D4DG66), LIS1_TUBMM (D5GBI7), LIS1_USTMA (Q4P9P9), LIS1_XENLA (Q90ZL4), LIS1_XENTR (Q6NZH4), MAEA_BOVIN (Q3MHJ2), MAEA_CHICK (Q5F398), MAEA_DANRE (Q7SXR3), MAEA_HUMAN (Q7L5Y9), MAEA_MACFA (Q4R9A8), MAEA_MOUSE (Q4VC33), MAEA_PONAB (Q5R532), MAEA_RAT (Q5RKJ1), MAEA_XENLA (Q6GR10), MKLN1_HUMAN (Q9UL63), MKLN1_MOUSE (O89050), MKLN1_PONAB (Q5RB35), MKLN1_RAT (Q99PV3), MSS11_CANAL (Q59N20), MSS11_CANGA (Q6FTZ3), MSS11_KLULA (Q6CPW4), MSS11_VANPO (A7TIN6), MSS11_YEAS7 (A6ZMM3), MSS11_YEAST (Q03825), NOLC1_HUMAN (Q14978), NOLC1_RAT (P41777), NPAT_HUMAN (Q14207), NPAT_MOUSE (Q8BMA5), NPAT_XENLA (A2RRX6), OFD1_DANRE (Q7SZK7), OFD1_HUMAN (O75665), OFD1_MOUSE (Q80Z25), RANB9_DANRE (A1L252), RANB9_HUMAN (Q96S59), RANB9_MOUSE (P69566), RANB9_XENLA (Q9PTY5), RANB9_XENTR (Q28FM1), RBP10_BOVIN (A3KMV8), RBP10_DANRE (Q1LUS8), RBP10_HUMAN (Q6VN20), RBP10_MOUSE (Q6VN19), RBP9X_DROME (Q4Z8K6), RMD5A_HUMAN (Q9H871), RMD5A_MOUSE (Q80YQ8), RMD5A_XENLA (Q6GLP4), RMD5A_XENTR (Q640V2), RMD5B_HUMAN (Q96G75), RMD5B_MOUSE (Q91YQ7), SIF2_YEAST (P38262), SMU1_BOVIN (Q2TBS9), SMU1_CHICK (Q5ZME8), SMU1_CRIGR (Q76B40), SMU1_DANRE (Q7ZVA0), SMU1_DICDI (Q54Y96), SMU1_HUMAN (Q2TAY7), SMU1_MOUSE (Q3UKJ7), SMU1_RAT (Q99M63), SMU1_XENLA (Q6NRT3), SMU1_XENTR (Q6P4J8), SSBP2_HUMAN (P81877), SSBP2_MOUSE (Q9CYZ8), SSBP3_CHICK (Q98948), SSBP3_HUMAN (Q9BWW4), SSBP3_MOUSE (Q9D032), SSBP3_RAT (Q9R050), SSBP4_HUMAN (Q9BWG4), TAF5_HUMAN (Q15542), TAF5_MOUSE (Q8C092), TAF5_SCHPO (O13282), TAF5_YEAST (P38129), TAF73_SCHPO (O74319), TB1RA_XENLA (Q7SZM9), TB1RB_XENLA (Q6GPC6), TBL1R_HUMAN (Q9BZK7), TBL1R_MOUSE (Q8BHJ5), TBL1X_HUMAN (O60907), TBL1X_MACFA (Q4R8H1), TBL1X_MOUSE (Q9QXE7), TBL1Y_HUMAN (Q9BQ87), TCOF_HUMAN (Q13428), TCOF_MOUSE (O08784), TON1A_ARATH (Q9FQ25), TON1B_ARATH (Q9FQ24), TPL_ARATH (Q94AI7), TPR1_ARATH (Q0WV90), TPR2_ARATH (Q9LRZ0), TPR3_ARATH (Q84JM4), TPR4_ARATH (Q27GK7), VID30_YEAST (P53076), VPRBP_HUMAN (Q9Y4B6), VPRBP_MOUSE (Q80TR8), WDR26_DANRE (Q5SP67), WDR26_DROME (Q7K0L4), WDR26_HUMAN (Q9H7D7), WDR26_MOUSE (Q8C6G8), WDR26_XENTR (Q28D01), WDR47_HUMAN (O94967), WDR47_MOUSE (Q8CGF6), Y4E9_ENCCU (Q8SVQ8), YB83_SCHPO (O59668), YC5C_SCHPO (O94712), YDED_SCHPO (Q10446), YG32_YEAST (P53270), YIPC_SCHPO (Q9UT85), YNY5_SCHPO (Q9P785) False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile): GID8_YEAST (P40208), LIS11_PENCW (B6HP56), LIS11_UNCRE (C4JZS6), LIS12_PODAN (B2B766), LIS1_ASPTN (Q0D0X6), LIS1_GIBZE (Q4ICM0), LIS1_NECH7 (C7Z6H2), LIS1_YEAS1 (B3LJT5), LIS1_YEAS2 (C7GWC1), LIS1_YEAS7 (A6ZPA6), LIS1_YEAS8 (C8ZH19), LIS1_YEAST (P39946) Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
PDB [Detailed view]	1UUJ; 2D68; 2XTC; 2XTD; 2XTE;

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