Entry: PS50946

Forthcoming changes to the profile format
General information about the entry

Entry name [info] UDENN
Accession [info] PS50946
Entry type [info] MATRIX
Date [info] DEC-2003 (CREATED); OCT-2013 (DATA UPDATE); MAR-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC50211
Associated ProRule [info] PRU00305

Name and characterization of the entry

Description [info] uDENN domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=73;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=68;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3775816; R2=0.0080749; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=8747.53768; R2=13.26842; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=783; N_SCORE=8.7; H_SCORE=17160; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=511; N_SCORE=6.5; H_SCORE=15528; MODE=1; TEXT='?';
/DEFAULT: M0=-27; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='P'; M= -24, -99, -13, -51,  -2, -19,   7,   6,   4, -11, -81,  18,  58,  25,   5,   1,  24, -42,  20, -43;
/M: SY='L'; M=  12, -95,  13,  10, -36,  11, -34, -13,   6,  17,  -7,  -1, -51, -20,   5,   1,  13,  -3,-100, -30;
/M: SY='N'; M=   2, -97,  27,  18, -34,  18,   8, -27,   9, -47, -87,  31, -26,  11,  19,  22,   0, -37,-103, -88;
/M: SY='N'; M= -13,  -6,  -2,  17, -92,  20, -42,  -4,   8, -17, -83,  26,  25,   1,  15,  -9, -10,   6,-101, -15;
/M: SY='S'; M=  -7, -96,  12,  23, -20, -13, -84, -12,  27, -18, -83,  -3,  23, -17, -22,  28,  18,  -7, -99,  -3;
/M: SY='Y'; M= -54,-100,  17, -50,  37, -38, -78, -30,   0,   3,   3, -19,  29,   3, -16, -15, -13, -37,  19,  78;
/M: SY='E'; M= -31, -98,  19,  40, -94, -92,  17, -34,  37,  -9, -40,  20,  18,   4,   5,  -4,  12,   2,-105, -88;
/M: SY='P'; M=  31,  -4, -48, -50,  -6,  12, -34, -54, -31, -47, -87,  -7,  95, -87, -93, -19, -26, -21, -99, -47;
/M: SY='E'; M=  -1,  17,   8,  56, -33, -15,  -6, -32,  32, -49, -86, -26, -88,  47, -30, -12,   0,  -8,-101, -42;
/M: SY='I'; M= -82,  -6,-104,-100, -41, -61,-103,  75, -51,  13, -19, -96, -47, -96, -99, -17, -14,  62,-101, -82;
/M: SY='L'; M= -37, -26, -63, -95, -72,-104, -92,  28, -64,  71,  20, -54, -38, -50,  -9, -55,  18,  -2,  -6, -80;
/M: SY='Y'; M=   2, -10,  40,  -1,  39, -57,   5, -19, -51,  -1, -79, -25, -96,  30, -23,   0,  -7, -83,  -4,  62;
/M: SY='R'; M= -16,  15, -15, -17, -92, -60,  42,  13,   6, -45,  11, -78, -93,  49,  51,  27,  -1, -14,-102, -32;
/M: SY='Y'; M= -44, -24, -99, -97,  79,-101,   9, -53, -32,  -9, -73, -94,-105, -91, -89, -52, -42, -48,   5, 106;
/M: SY='P'; M= -55,-111, -88, -78,-108, -55, -23, -96, -52,-105, -92, -38, 124,   4, -94, -33, -45, -62,-103,-103;
/M: SY='P'; M= -40, -99,  15,  31, -45, -89, -34, -50, -25, -35, -26,  22,  68,   8,  -8,  31,  -8,  -8,-100,  10;
/M: SY='D'; M= -35,  17,  38,   9, -89, -19,  -2, -51,   2,  -6, -83,  27,  -3,   0,   3,   8,  20,   2,-101,  20;
/I:         I=-12; MD=-29;
/M: SY='N'; M= -70, -33,  42,   7,-108,  -3,  21, -68,  -6, -49,-101,  45,  13, -47, -59,   4, -90, -42,-118, -22; D=-12;
/I:         I=-12; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='W'; M= -17,-118,  -4,  -6,  -2, -54,  22,-111, -24,-109,-103,  -4,   5,  30,   4, -40, -34, -67,  41,  22; D=-12;
/I:         I=-12; DM=-29;
/M: SY='P'; M= -18,-108,   7,  -1, -63, -25,   8,   6,  16, -52, -15,  -2,  33, -41,   1,  -7, -16, -28, -15, -16; D=-12;
/I:         I=-12; DM=-29;
/M: SY='D'; M=  -6,  -2,  56, -23, -99, -26,   4, -53, -21,   3,  -7,  19,   4, -86, -14,   1,  -8, -23,-114, -95; D=-12;
/I:         I=-12; DM=-29;
/M: SY='P'; M=   7, -36,  25, -16,   3, -27,  20, -36, -10, -23, -27,  19,  63,  24, -86, -20,   7, -57,-101, -16; D=-12;
/I:         I=-12; DM=-29;
/M: SY='P'; M= -30,-100,  30,  14,  33, -64,  22, -20, -14, -10,  -7,  -2,  48,  32, -15,   2, -33, -20, -99, -81; D=-12;
/I:         I=-12; DM=-29;
/M: SY='Y'; M= -41, -97,  21, -10,  12, -61, -22, -14, -53,  32, -36,   7,  22, -21,   1,  -7, -18,  15, -18,  38;
/M: SY='P'; M= -37, -43, -13,  -8, -12, -97,   9,  33, -57,  18, -23,   5,  61,   7, -18, -42, -41,   0, -93,  37;
/M: SY='K'; M= -24, -99,  27,  40, -29, -42,  -4, -95,  47, -35, -41,  29,  38, -12, -25,  13,  -6, -55,-102, -37;
/M: SY='S'; M= -18, -95,  25,  10, -56, -10,  39, -14, -37, -48,  18,  34, -90,  43, -27,  49,   1, -36,-105, -47;
/M: SY='I'; M= -25,   5,-105, -53, -15,-106, -99,  66, -98,  51,  21, -99,-101, -95, -99, -50, -45,  38, -98, -79;
/M: SY='P'; M=  31,  -9, -53,  23, -18, -22,  -3, -10,   3, -51, -24, -26,  68, -42, -86,  12, -13, -12,  30, -88;
/M: SY='M'; M= -17, -97,  26,  -9, -41, -92,  23, -30,  18,  13,  56,   5,  11,  33,  -2,   2,   5, -40,  10, -83;
/M: SY='F'; M= -60,  10,-108,-102, 111,-104,  -3, -72, -99,   6, -20, -99,-107, -37, -97, -95, -90, -37,  43,  26;
/M: SY='C'; M=  28, 138,-100, -98, -20, -94,-100, -28, -96, -32, -85, -89,-106, -99,-101, -22, -16, -27,-113, -96;
/M: SY='F'; M= -57, -96,-105, -99, 107,-104, -16, -26, -94,  11,  29, -97,-106,   3, -24, -94, -89, -54, -70,  32;
/M: SY='P'; M= -43,-112, -90, -79,-106, -59, -92, -95, -86,-105, -92, -94, 127, -89, -98, -30, -24, -63,-102, -40;
/M: SY='N'; M= -39,  37,  43,  33, -57,   7,  26, -95, -18, -21, -17,  45, -92,  27,  -6,   0, -19, -67,  -6,  -4;
/M: SY='G'; M= -43,-100,  11, -91, -21,  94, -36, -71, -25,-103, -95, -36, -92, -19, -93, -32, -88, -64, -95,   2;
/M: SY='W'; M=   4,  37,   5, -10,   0, -20, -27,  24, -47,  12,  21, -89, -56, -33, -93, -54,   4,  43,  56, -80;
/M: SY='K'; M= -15, -98,  16,  31, -89, -58, -25, -30,  41, -27, -84,   4, -23,  10,  22,  22,  11, -37, -96,  30;
/M: SY='P'; M=   5,  -2, -55, -57,   9, -50, -31,  24, -19,  13, -33,  -9,  26, -45,  -1,  22,   4,  15, -14,   7;
/M: SY='Y'; M= -23,   1, -86,  -2, -41, -94, -10,  -2,  30,   0, -77, -27, -46,   0,   8,  22,  18,  17,  22,  48;
/M: SY='R'; M= -17, -12, -41,   9, -92, -57, -82, -53,  29,  -9, -38,   8,   1,  39,  40,  12,  26,   4,-101, -31;
/I:         I=-10; MD=-26;
/M: SY='Q'; M= -33, -40,  20,   9, -28, -23, -23, -11,  -5, -13, -34, -47,   2,  45, -15,  26,  13,  10,  40, -44; D=-10;
/I:         I=-10; MD=-26;
/M: SY='P'; M= -46,-100,  27,  29, -98, -42,  -1, -55,  22, -49, -90,  20,  39, -30,  23,  31,  19, -94,-104,  -6; D=-10;
/I:         I=-10; MD=-26;
/M: SY='R'; M= -11,-100,  30,  25, -63, -94, -20, -18,  15, -23, -86,  -7,  23,   1,  30,  12,  -1,   1,-106, -91; D=-10;
/I:         I=-10; MD=-26;
/M: SY='P'; M= -28,  -6, -33,  -9, -39, -29, -35, -94, -18, -39, -47,  32,  33,  31,  18,  26,  25, -23,-105, -13; D=-10;
/I:         I=-10; MD=-26;
/M: SY='P'; M= -62, -42, -46, -18, -45, -60, -31,-104,  -1, -42, -39,  23,  57,  16,   0,   1, -11, -36,-116, -58; D=-10;
/I:         I=-10; MD=-26;
/M: SY='S'; M= -51,-113,  10, -10,  10, -35,  -3, -33,  -1, -35, -11,  -7, -30,   5,  -8,  20, -50, -41,-113, -41; D=-10;
/I:         I=-10; MD=-26;
/M: SY='M'; M=-108,-122,  -8, -23, -31, -80, -10, -54,   7, -27,  21,  -8,  -2, -44, -71,  -2,-104, -19,  -1,  -7; D=-10;
/I:         I=-10; MD=-26;
/M: SY='P'; M= -80,-129,   3,  -5, -54,-119,  -6, -46, -29, -39,  -6,   6,  24, -39, -56,  -5, -52,-118,-134,-117; D=-10;
/I:         I=-10; MI=0; MD=-26; IM=0; DM=-26;
/M: SY='P'; M= -22, -23,  31, -35, -26, -42,   0, -37, -42, -31, -28,   7,  74,  11, -47,  35,  -4,   9,-105, -90;
/M: SY='Q'; M= -30,  -5,  -9,  53, -96, -92,  -2, -22,  23, -25, -19, -19, -88,  67, -20,  17,  11, -25,-101, -33;
/M: SY='F'; M= -33, -48, -92, -18,  52, -70,   6,  24,  -3,  11, -22, -11, -41, -16, -14,  19,  -7,  19,  16,   4;
/M: SY='F'; M= -91, -97, -27, -54,  87, -95,  85, -84, -38, -78, -78,  28,-100, -86, -55,   4, -26, -57, -77,  60;
/M: SY='T'; M= -40, -17, -58, -17, -22, -47,  26, -40, -82, -34, -24, -37,  21,  34, -86,  33,  66,   1, -13,  39;
/M: SY='F'; M= -65, -95,-108,-103, 115,-105, -91,   0,-100,   7, -70, -52,-107, -37, -98, -95, -48, -39, -69,  -6;
/M: SY='V'; M=   1, -91, -98, -60, -28, -99, -24,  27, -52, -40,  30, -91, -97,   0, -35, -13,  16,  78,-103, -39;
/M: SY='L'; M= -64, -93,-104, -99,  23,-106, -29,  23, -98,  76,  39, -46,-103, -94, -97, -95,  -6,  -9, -92, -26;
/M: SY='T'; M= -27, -89, -82, -81, -93, -24, -88, -51, -14, -57, -25, -22,  -4,  22, -33,   0, 102, -58,-107, -89;
/M: SY='D'; M= -64, -34,  76, -10, -50,  19, -26, -33, -32, -19, -88,  32, -92,  28,  -6,  -8,   7, -30,-107, -39;
/M: SY='E'; M= -10, -97, -19,  50, -26,  35, -85,  12,  -6, -29, -14,   3, -41,  19, -83,  30, -79, -12, -99, -34;
/M: SY='D'; M= -41, -28,  75,  24, -49, -24, -18, -62,  34, -99,  -8,  13, -41,  -8,  -6,  32, -18, -96,-108, -90;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='G'; M= -29,-100, -86, -35,-103,  84, -29,-106, -19, -43, -95, -14, -93,  14, -92,  25, -36,-101,-101, -41; D=-29;
/I:         I=-29; DM=-75;
/M: SY='T'; M= -20,  13,  22,  -6, -96, -67,   1, -55,  34, -53, -36,  38, -43,  39, -33,  25,  41,  -5,-106, -51;
/M: SY='R'; M= -55, -40, -22,  -1, -51, -96, -23, -52,  35,  -4, -82, -39,  -5,   2,  74, -41,  32, -65,  19,  21;
/M: SY='R'; M= -85,  -6, -42, -31,  23, -98, -39,  23,  12,  14,  19, -84, -95,  -2,  49,   4,  33, -15, -93,   2;
/M: SY='Y'; M= -94,-102, -94, -97,  60,-100,  21, -44, -90, -75, -74, -21,-105, -87, -88, -48, -51, -83, -56, 125;
/M: SY='C'; M=  29,  88, -92, -96, -98,  78,   1, -37, -93, -68, -26, -80, -96, -91, -98, -26, -85, -22,-103, -97;
/M: SY='F'; M=   5,  48, -95, -93,  56, -43,  27,  10, -91, -30,   6, -86, -97, -41, -93,   1,  42,  11, -86,  47;
/M: SY='C'; M=   9, 134, -99, -98, -32, -61,-100, -46, -95, -86, -85, -87,-104, -98,-100,   4,  13,  24,-114, -96;
/M: SY='L'; M=  -5, -10,-101, -94,   2,-103, -25,  24, -58,  61,  15, -95,-101, -88,  34, -90,  -8,   7, -94,  -7;
/M: SY='R'; M= -17,  -5, -48, -82, -50, -94,  42,  14, -10, -11, -77, -23, -43,  14,  49,  19,  33,  16, -99,   8;
/M: SY='F'; M= -60, -95, -57, -62,  88, -40, -22,   7, -26, -25, -12, -93, -27, -94,  -1, -46, -10,  34, -78,  33;
/M: SY='Y'; M= -88,  -4, -31, -11,  -9, -72,  23, -39,   8,   5, -37, -30,  21, -82, -31,  -3, -18, -17,  80,  86;
/I:         E1=0; IE=-380; DE=-380;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_04 which contains 544'996 sequence entries.


Total number of hits 37 in 37 different sequences
Number of true positive hits 37 in 37 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] uDENN
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
37 sequences

DEN1A_HUMAN (Q8TEH3), DEN1A_MOUSE (Q8K382), DEN1A_XENLA (Q68F67), 
DEN1B_HUMAN (Q6P3S1), DEN1B_MOUSE (Q3U1T9), DEN1C_HUMAN (Q8IV53), 
DEN1C_MOUSE (Q8CFK6), DEN2A_HUMAN (Q9ULE3), DEN2A_MOUSE (Q8C4S8), 
DEN2C_HUMAN (Q68D51), DEN2C_MOUSE (Q6P9P8), DEN2D_HUMAN (Q9H6A0), 
DEN2D_MOUSE (Q91VV4), DEN4B_HUMAN (O75064), DEN4B_MOUSE (Q3U1Y4), 
DEN4C_HUMAN (Q5VZ89), DEN4C_MOUSE (A6H8H2), DEN5A_HUMAN (Q6IQ26), 
DEN5A_MOUSE (Q6PAL8), DEN5B_DANRE (Q6NXD8), DEN5B_HUMAN (Q6ZUT9), 
DEN5B_MOUSE (A2RSQ0), DEND3_HUMAN (A2RUS2), DEND3_MOUSE (A2RT67), 
DENN_SCHPO  (Q9Y7Q7), MADD_CAEEL  (O02626), MADD_DROME  (Q9VXY2), 
MADD_HUMAN  (Q8WXG6), MADD_MOUSE  (Q80U28), MADD_RAT    (O08873), 
MTMR5_HUMAN (O95248), MTMR5_MOUSE (Q6ZPE2), MTMRD_HUMAN (Q86WG5), 
MTMRD_XENLA (Q6NTN5), MYCPP_HUMAN (Q7Z401), ST5_HUMAN   (P78524), 
ST5_MOUSE   (Q924W7)
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PDB
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1 PDB

3TW8

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