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	Entry: PS50946

General information about the entry
Entry name	UDENN
Accession number	PS50946
Entry type	MATRIX
Date	DEC-2003 (CREATED); MAR-2010 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation	PDOC50211
Associated ProRule	PRU00305
Name and characterization of the entry
Description	uDENN domain profile.
Matrix / Profile	/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=73; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=68; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3775816; R2=0.0080749; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=783; N_SCORE=8.7; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=511; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-27; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='P'; M= -24, -99, -13, -51, -2, -19, 7, 6, 4, -11, -81, 18, 58, 25, 5, 1, 24, -42, 20, -43; /M: SY='L'; M= 12, -95, 13, 10, -36, 11, -34, -13, 6, 17, -7, -1, -51, -20, 5, 1, 13, -3,-100, -30; /M: SY='N'; M= 2, -97, 27, 18, -34, 18, 8, -27, 9, -47, -87, 31, -26, 11, 19, 22, 0, -37,-103, -88; /M: SY='N'; M= -13, -6, -2, 17, -92, 20, -42, -4, 8, -17, -83, 26, 25, 1, 15, -9, -10, 6,-101, -15; /M: SY='S'; M= -7, -96, 12, 23, -20, -13, -84, -12, 27, -18, -83, -3, 23, -17, -22, 28, 18, -7, -99, -3; /M: SY='Y'; M= -54,-100, 17, -50, 37, -38, -78, -30, 0, 3, 3, -19, 29, 3, -16, -15, -13, -37, 19, 78; /M: SY='E'; M= -31, -98, 19, 40, -94, -92, 17, -34, 37, -9, -40, 20, 18, 4, 5, -4, 12, 2,-105, -88; /M: SY='P'; M= 31, -4, -48, -50, -6, 12, -34, -54, -31, -47, -87, -7, 95, -87, -93, -19, -26, -21, -99, -47; /M: SY='E'; M= -1, 17, 8, 56, -33, -15, -6, -32, 32, -49, -86, -26, -88, 47, -30, -12, 0, -8,-101, -42; /M: SY='I'; M= -82, -6,-104,-100, -41, -61,-103, 75, -51, 13, -19, -96, -47, -96, -99, -17, -14, 62,-101, -82; /M: SY='L'; M= -37, -26, -63, -95, -72,-104, -92, 28, -64, 71, 20, -54, -38, -50, -9, -55, 18, -2, -6, -80; /M: SY='Y'; M= 2, -10, 40, -1, 39, -57, 5, -19, -51, -1, -79, -25, -96, 30, -23, 0, -7, -83, -4, 62; /M: SY='R'; M= -16, 15, -15, -17, -92, -60, 42, 13, 6, -45, 11, -78, -93, 49, 51, 27, -1, -14,-102, -32; /M: SY='Y'; M= -44, -24, -99, -97, 79,-101, 9, -53, -32, -9, -73, -94,-105, -91, -89, -52, -42, -48, 5, 106; /M: SY='P'; M= -55,-111, -88, -78,-108, -55, -23, -96, -52,-105, -92, -38, 124, 4, -94, -33, -45, -62,-103,-103; /M: SY='P'; M= -40, -99, 15, 31, -45, -89, -34, -50, -25, -35, -26, 22, 68, 8, -8, 31, -8, -8,-100, 10; /M: SY='D'; M= -35, 17, 38, 9, -89, -19, -2, -51, 2, -6, -83, 27, -3, 0, 3, 8, 20, 2,-101, 20; /I: I=-12; MD=-29; /M: SY='N'; M= -70, -33, 42, 7,-108, -3, 21, -68, -6, -49,-101, 45, 13, -47, -59, 4, -90, -42,-118, -22; D=-12; /I: I=-12; MI=0; MD=-29; IM=0; DM=-29; /M: SY='W'; M= -17,-118, -4, -6, -2, -54, 22,-111, -24,-109,-103, -4, 5, 30, 4, -40, -34, -67, 41, 22; D=-12; /I: I=-12; DM=-29; /M: SY='P'; M= -18,-108, 7, -1, -63, -25, 8, 6, 16, -52, -15, -2, 33, -41, 1, -7, -16, -28, -15, -16; D=-12; /I: I=-12; DM=-29; /M: SY='D'; M= -6, -2, 56, -23, -99, -26, 4, -53, -21, 3, -7, 19, 4, -86, -14, 1, -8, -23,-114, -95; D=-12; /I: I=-12; DM=-29; /M: SY='P'; M= 7, -36, 25, -16, 3, -27, 20, -36, -10, -23, -27, 19, 63, 24, -86, -20, 7, -57,-101, -16; D=-12; /I: I=-12; DM=-29; /M: SY='P'; M= -30,-100, 30, 14, 33, -64, 22, -20, -14, -10, -7, -2, 48, 32, -15, 2, -33, -20, -99, -81; D=-12; /I: I=-12; DM=-29; /M: SY='Y'; M= -41, -97, 21, -10, 12, -61, -22, -14, -53, 32, -36, 7, 22, -21, 1, -7, -18, 15, -18, 38; /M: SY='P'; M= -37, -43, -13, -8, -12, -97, 9, 33, -57, 18, -23, 5, 61, 7, -18, -42, -41, 0, -93, 37; /M: SY='K'; M= -24, -99, 27, 40, -29, -42, -4, -95, 47, -35, -41, 29, 38, -12, -25, 13, -6, -55,-102, -37; /M: SY='S'; M= -18, -95, 25, 10, -56, -10, 39, -14, -37, -48, 18, 34, -90, 43, -27, 49, 1, -36,-105, -47; /M: SY='I'; M= -25, 5,-105, -53, -15,-106, -99, 66, -98, 51, 21, -99,-101, -95, -99, -50, -45, 38, -98, -79; /M: SY='P'; M= 31, -9, -53, 23, -18, -22, -3, -10, 3, -51, -24, -26, 68, -42, -86, 12, -13, -12, 30, -88; /M: SY='M'; M= -17, -97, 26, -9, -41, -92, 23, -30, 18, 13, 56, 5, 11, 33, -2, 2, 5, -40, 10, -83; /M: SY='F'; M= -60, 10,-108,-102, 111,-104, -3, -72, -99, 6, -20, -99,-107, -37, -97, -95, -90, -37, 43, 26; /M: SY='C'; M= 28, 138,-100, -98, -20, -94,-100, -28, -96, -32, -85, -89,-106, -99,-101, -22, -16, -27,-113, -96; /M: SY='F'; M= -57, -96,-105, -99, 107,-104, -16, -26, -94, 11, 29, -97,-106, 3, -24, -94, -89, -54, -70, 32; /M: SY='P'; M= -43,-112, -90, -79,-106, -59, -92, -95, -86,-105, -92, -94, 127, -89, -98, -30, -24, -63,-102, -40; /M: SY='N'; M= -39, 37, 43, 33, -57, 7, 26, -95, -18, -21, -17, 45, -92, 27, -6, 0, -19, -67, -6, -4; /M: SY='G'; M= -43,-100, 11, -91, -21, 94, -36, -71, -25,-103, -95, -36, -92, -19, -93, -32, -88, -64, -95, 2; /M: SY='W'; M= 4, 37, 5, -10, 0, -20, -27, 24, -47, 12, 21, -89, -56, -33, -93, -54, 4, 43, 56, -80; /M: SY='K'; M= -15, -98, 16, 31, -89, -58, -25, -30, 41, -27, -84, 4, -23, 10, 22, 22, 11, -37, -96, 30; /M: SY='P'; M= 5, -2, -55, -57, 9, -50, -31, 24, -19, 13, -33, -9, 26, -45, -1, 22, 4, 15, -14, 7; /M: SY='Y'; M= -23, 1, -86, -2, -41, -94, -10, -2, 30, 0, -77, -27, -46, 0, 8, 22, 18, 17, 22, 48; /M: SY='R'; M= -17, -12, -41, 9, -92, -57, -82, -53, 29, -9, -38, 8, 1, 39, 40, 12, 26, 4,-101, -31; /I: I=-10; MD=-26; /M: SY='Q'; M= -33, -40, 20, 9, -28, -23, -23, -11, -5, -13, -34, -47, 2, 45, -15, 26, 13, 10, 40, -44; D=-10; /I: I=-10; MD=-26; /M: SY='P'; M= -46,-100, 27, 29, -98, -42, -1, -55, 22, -49, -90, 20, 39, -30, 23, 31, 19, -94,-104, -6; D=-10; /I: I=-10; MD=-26; /M: SY='R'; M= -11,-100, 30, 25, -63, -94, -20, -18, 15, -23, -86, -7, 23, 1, 30, 12, -1, 1,-106, -91; D=-10; /I: I=-10; MD=-26; /M: SY='P'; M= -28, -6, -33, -9, -39, -29, -35, -94, -18, -39, -47, 32, 33, 31, 18, 26, 25, -23,-105, -13; D=-10; /I: I=-10; MD=-26; /M: SY='P'; M= -62, -42, -46, -18, -45, -60, -31,-104, -1, -42, -39, 23, 57, 16, 0, 1, -11, -36,-116, -58; D=-10; /I: I=-10; MD=-26; /M: SY='S'; M= -51,-113, 10, -10, 10, -35, -3, -33, -1, -35, -11, -7, -30, 5, -8, 20, -50, -41,-113, -41; D=-10; /I: I=-10; MD=-26; /M: SY='M'; M=-108,-122, -8, -23, -31, -80, -10, -54, 7, -27, 21, -8, -2, -44, -71, -2,-104, -19, -1, -7; D=-10; /I: I=-10; MD=-26; /M: SY='P'; M= -80,-129, 3, -5, -54,-119, -6, -46, -29, -39, -6, 6, 24, -39, -56, -5, -52,-118,-134,-117; D=-10; /I: I=-10; MI=0; MD=-26; IM=0; DM=-26; /M: SY='P'; M= -22, -23, 31, -35, -26, -42, 0, -37, -42, -31, -28, 7, 74, 11, -47, 35, -4, 9,-105, -90; /M: SY='Q'; M= -30, -5, -9, 53, -96, -92, -2, -22, 23, -25, -19, -19, -88, 67, -20, 17, 11, -25,-101, -33; /M: SY='F'; M= -33, -48, -92, -18, 52, -70, 6, 24, -3, 11, -22, -11, -41, -16, -14, 19, -7, 19, 16, 4; /M: SY='F'; M= -91, -97, -27, -54, 87, -95, 85, -84, -38, -78, -78, 28,-100, -86, -55, 4, -26, -57, -77, 60; /M: SY='T'; M= -40, -17, -58, -17, -22, -47, 26, -40, -82, -34, -24, -37, 21, 34, -86, 33, 66, 1, -13, 39; /M: SY='F'; M= -65, -95,-108,-103, 115,-105, -91, 0,-100, 7, -70, -52,-107, -37, -98, -95, -48, -39, -69, -6; /M: SY='V'; M= 1, -91, -98, -60, -28, -99, -24, 27, -52, -40, 30, -91, -97, 0, -35, -13, 16, 78,-103, -39; /M: SY='L'; M= -64, -93,-104, -99, 23,-106, -29, 23, -98, 76, 39, -46,-103, -94, -97, -95, -6, -9, -92, -26; /M: SY='T'; M= -27, -89, -82, -81, -93, -24, -88, -51, -14, -57, -25, -22, -4, 22, -33, 0, 102, -58,-107, -89; /M: SY='D'; M= -64, -34, 76, -10, -50, 19, -26, -33, -32, -19, -88, 32, -92, 28, -6, -8, 7, -30,-107, -39; /M: SY='E'; M= -10, -97, -19, 50, -26, 35, -85, 12, -6, -29, -14, 3, -41, 19, -83, 30, -79, -12, -99, -34; /M: SY='D'; M= -41, -28, 75, 24, -49, -24, -18, -62, 34, -99, -8, 13, -41, -8, -6, 32, -18, -96,-108, -90; /I: I=-29; MI=0; MD=-75; IM=0; DM=-75; /M: SY='G'; M= -29,-100, -86, -35,-103, 84, -29,-106, -19, -43, -95, -14, -93, 14, -92, 25, -36,-101,-101, -41; D=-29; /I: I=-29; DM=-75; /M: SY='T'; M= -20, 13, 22, -6, -96, -67, 1, -55, 34, -53, -36, 38, -43, 39, -33, 25, 41, -5,-106, -51; /M: SY='R'; M= -55, -40, -22, -1, -51, -96, -23, -52, 35, -4, -82, -39, -5, 2, 74, -41, 32, -65, 19, 21; /M: SY='R'; M= -85, -6, -42, -31, 23, -98, -39, 23, 12, 14, 19, -84, -95, -2, 49, 4, 33, -15, -93, 2; /M: SY='Y'; M= -94,-102, -94, -97, 60,-100, 21, -44, -90, -75, -74, -21,-105, -87, -88, -48, -51, -83, -56, 125; /M: SY='C'; M= 29, 88, -92, -96, -98, 78, 1, -37, -93, -68, -26, -80, -96, -91, -98, -26, -85, -22,-103, -97; /M: SY='F'; M= 5, 48, -95, -93, 56, -43, 27, 10, -91, -30, 6, -86, -97, -41, -93, 1, 42, 11, -86, 47; /M: SY='C'; M= 9, 134, -99, -98, -32, -61,-100, -46, -95, -86, -85, -87,-104, -98,-100, 4, 13, 24,-114, -96; /M: SY='L'; M= -5, -10,-101, -94, 2,-103, -25, 24, -58, 61, 15, -95,-101, -88, 34, -90, -8, 7, -94, -7; /M: SY='R'; M= -17, -5, -48, -82, -50, -94, 42, 14, -10, -11, -77, -23, -43, 14, 49, 19, 33, 16, -99, 8; /M: SY='F'; M= -60, -95, -57, -62, 88, -40, -22, 7, -26, -25, -12, -93, -27, -94, -1, -46, -10, 34, -78, 33; /M: SY='Y'; M= -88, -4, -31, -11, -9, -72, 23, -39, 8, 5, -37, -30, 21, -82, -31, -3, -18, -17, 80, 86; /I: E1=0; IE=-380; DE=-380;
Numerical results
UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052. Total number of hits in UniProtKB/Swiss-Prot: 37 hits in 37 different sequences Number of hits on proteins that are known to belong to the set under consideration: 37 hits in 37 different sequences Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences Number of false hits (on unrelated proteins): 0 hits in 0 different sequences Number of known missed hits: 0 Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0 Precision (true hits / (true hits + false positives)): 100.00 % Recall (true hits / (true hits + false negatives)): 100.00 %
Comments
MATRIX_TYPE: protein_domain Scaling database: UniProtKB/Swiss-Prot: reversed Matrix author: CJA_Sigrist Taxonomic range: Eukaryotes Maximum known number of repetitions of the pattern in a single protein: 1 FT_KEY: DOMAIN FT_DESC: uDENN VERSION: 2
Cross-references
UniProtKB/Swiss-Prot	True positive hits: DEN1A_HUMAN (Q8TEH3), DEN1A_MOUSE (Q8K382), DEN1A_XENLA (Q68F67), DEN1B_HUMAN (Q6P3S1), DEN1B_MOUSE (Q3U1T9), DEN1C_HUMAN (Q8IV53), DEN1C_MOUSE (Q8CFK6), DEN2A_HUMAN (Q9ULE3), DEN2A_MOUSE (Q8C4S8), DEN2C_HUMAN (Q68D51), DEN2C_MOUSE (Q6P9P8), DEN2D_HUMAN (Q9H6A0), DEN2D_MOUSE (Q91VV4), DEN4B_HUMAN (O75064), DEN4B_MOUSE (Q3U1Y4), DEN4C_HUMAN (Q5VZ89), DEN4C_MOUSE (A6H8H2), DEN5A_HUMAN (Q6IQ26), DEN5A_MOUSE (Q6PAL8), DEN5B_DANRE (Q6NXD8), DEN5B_HUMAN (Q6ZUT9), DEN5B_MOUSE (A2RSQ0), DEND3_HUMAN (A2RUS2), DEND3_MOUSE (A2RT67), DENN_SCHPO (Q9Y7Q7), MADD_CAEEL (O02626), MADD_DROME (Q9VXY2), MADD_HUMAN (Q8WXG6), MADD_MOUSE (Q80U28), MADD_RAT (O08873), MTMR5_HUMAN (O95248), MTMR5_MOUSE (Q6ZPE2), MTMRD_HUMAN (Q86WG5), MTMRD_XENLA (Q6NTN5), MYCPP_HUMAN (Q7Z401), ST5_HUMAN (P78524), ST5_MOUSE (Q924W7) Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
PDB [Detailed view]	3TW8;

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