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Entry: PS50954

General information about the entry

Entry name [info] LEM
Accession [info] PS50954
Entry type [info] MATRIX
Date [info] 01-JAN-2004 CREATED; 10-MAY-2017 DATA UPDATE; 20-DEC-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC50954
Associated ProRule [info] PRU00313

Name and characterization of the entry

Description [info] LEM domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=45;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=41;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8992707; R2=0.0160747; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2242.4704590; R2=2.1274660; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=411; H_SCORE=3117; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=287; H_SCORE=2853; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='M'; M= -9,-13,-22,-17,-16,  0,-23,  5,  7,-12,  4, 19,-13,-21, -7,-12,-12, -5,  4,-14, 14,-13;
/M: SY='D'; M= -5,  9,-22, 14,  7,-24,-14, -7,-20, -2,-16,-13,  2,-13,  4, -2,  5,  1,-14,-31,-15,  5;
/M: SY='D'; M= -9, 21,-24, 27,  7,-27,-11, -5,-26,  2,-21,-18, 12,-13, -1, -1,  3, -4,-20,-34,-16,  3;
/M: SY='I'; M=-10,-27,-24,-29,-22,  8,-31,-20, 18,-23, 14,  8,-25,-10,-22,-21,-19, -8, 14,-16,  4,-24;
/M: SY='Q'; M= -6,  6,-26,  7,  7,-26,-16, -6,-20,  4,-16,-11,  2, -4,  8,  2, -2, -4,-19,-27,-15,  7;
/M: SY='R'; M= -9, -4,-25,  0,  5,-22,-18, -7,-17,  4,-15, -9, -4, -6,  7,  9,  0, -4,-13,-28,-14,  4;
/M: SY='L'; M=-11,-28,-21,-29,-20, 10,-29,-13, 18,-25, 41, 24,-28,-29,-16,-18,-28,-10,  8,-15,  7,-19;
/M: SY='S'; M=  5,  2,-15, -1,  3,-19, -7, -9,-19, -4,-23,-16,  9,-11,  0, -2, 23, 17,-12,-34,-17,  1;
/M: SY='D'; M=-15, 34,-27, 43, 16,-32,-11, -2,-31, -1,-27,-25, 20, -3,  0, -8,  3, -3,-27,-37,-20,  8;
/M: SY='D'; M=  5,  8,-22, 11,  6,-24, -5,-12,-22, -3,-14,-15,  0,-11, -4,-10,  1, -2,-15,-27,-17,  1;
/M: SY='E'; M= -6, 12,-28, 20, 39,-33,-17,  0,-28,  7,-21,-17,  2, -4, 22, -1,  1, -9,-27,-29,-18, 31;
/M: SY='L'; M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 50, 20,-30,-30,-20,-20,-30,-10, 10,-20,  0,-20;
/M: SY='R'; M= -7,-12,-24,-13, -5,-10,-18, -1,-17,  7, -8, -5, -5,-19, -1, 24, -6, -6,-12,-21, -6, -5;
/M: SY='A'; M=  7, -3,-19, -5, -1,-20,-12,-10,-17,  2,-14,-10, -2,-13,  2,  5,  6,  4,-10,-26,-14,  0;
/M: SY='E'; M= -4, -4,-25, -3, 17,-23,-19, -5,-15, 11,-13, -2, -6,-11, 13,  7, -5, -8,-12,-24,-13, 15;
/M: SY='L'; M= -9,-28, -4,-30,-22,  5,-29,-20, 15,-27, 36, 19,-28,-30,-20,-20,-25, -9, 11,-24, -4,-21;
/M: SY='R'; M=-10,-11,-23,-15, -9,-12,-23,-12, -4,  8, -4,  3, -7,-19, -4, 15, -9, -2,  1,-24, -8, -8;
/M: SY='Q'; M=  3, -4,-23, -6,  6,-28,-15, -5,-18, 13,-20, -6, -2,-12, 20,  9,  3, -4,-15,-23,-13, 13;
/M: SY='Y'; M=-10,-16,-24,-18,-12,  9,-23, 10, -5,-11,  2,  1,-13,-23, -4, -6,-12, -8, -9, -4, 26,-10;
/M: SY='G'; M= -1, -5,-29, -7,-18,-29, 63,-17,-38,-18,-30,-20,  6,-20,-18,-18,  1,-18,-30,-22,-29,-18;
/M: SY='L'; M= -3,-26,-21,-31,-23, 15,-27,-19, 17,-25, 22, 10,-23,-25,-21,-21,-18, -8, 12,-12,  8,-23;
/M: SY='P'; M= -5, -7,-28, -6, -3,-23,-15,-14,-13, -6,-24,-15, -1, 32, -6,-12,  3, -2,-18,-32,-21, -7;
/M: SY='P'; M= -8, -9,-14,-10, -9,-17,-18, -4,-10,-14,-13, -9, -3, 11,-11,-15, -5, -6,-11,-33,-16,-12;
/I:         I=-15; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='G'; M= -2,-13,-28,-14,-20,-22, 45,-21,-25,-21,-17,-12, -4,-20,-19,-20, -3,-13,-19,-21,-23,-20;
/M: SY='P'; M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='I'; M= -6,-30,-20,-35,-29,  1,-35,-29, 38,-26, 18, 16,-25,-25,-24,-25,-16, -6, 37,-24, -4,-29;
/M: SY='T'; M= -2, -1,-12, -6,-11,-11,-21,-20, -6,-11, -8, -8, -3,-13,-13,-12, 13, 36,  6,-31,-11,-12;
/M: SY='G'; M= -2, -2,-25, -1,  1,-15,  4,-14,-25, -5,-21,-16, -2, -4, -8,-10,  2, -4,-19,-23,-16, -4;
/M: SY='T'; M= -2, -4,-15, -9, -5, -9,-16,-12,-15, -6,-15,-11,  1,-13, -1, -1, 17, 25, -8,-27, -9, -3;
/M: SY='T'; M=  0,  4,-11, -6, -8,-12,-16,-16,-12, -9,-14,-12,  8,-11, -8, -9, 21, 42, -4,-32,-12, -8;
/M: SY='R'; M=-19, -9,-30, -9,  1,-21,-20, -1,-30, 32,-21,-10,  0,-19, 10, 66,-10,-10,-20,-20,-10,  1;
/M: SY='R'; M= -7, -8,-27, -9, -1,-17,-10,-10,-26, 20,-22,-11, -3,-10,  0, 25, -6, -8,-18,-19,-11, -2;
/M: SY='L'; M= -9,-26,-20,-29,-22,  2,-30,-11, 23,-24, 27, 20,-24,-26,-17,-19,-21, -9, 19,-23,  0,-21;
/M: SY='Y'; M=-10,-22,-25,-24,-20, 24,-27,  3,  4,-17, 12,  4,-21,-28,-15,-14,-19, -9, -3, 11, 45,-20;
/M: SY='E'; M= -9, -9,-27, -7, 18,-14,-27,-13,  3, -8,  3, -2,-12,-12,  0,-12,-10, -9, -2,-26,-11,  7;
/M: SY='K'; M=-12, -1,-30, -1, 12,-28,-20, -7,-30, 43,-27,-11,  0,-11, 11, 36, -9,-10,-21,-21,-11, 10;
/M: SY='K'; M=-12, -2,-30, -2,  9,-29,-20, -6,-29, 43,-27, -9,  0,-12, 15, 35, -9,-10,-21,-20,-10, 11;
/M: SY='L'; M=-10,-30,-21,-31,-21,  9,-31,-21, 23,-30, 47, 20,-29,-29,-20,-21,-29,-10, 12,-20,  0,-21;
/M: SY='R'; M=-10,-14,-26,-17, -7, -6,-23,  1, -9,  1, -2,  1, -9,-20,  0, 12,-13,-10, -9,-18, -1, -5;
/M: SY='K'; M= -5, -5,-28, -6, 10,-23,-22, -2,-11, 12,-14, -4, -4,-11,  8,  3, -7,-10,-11,-23, -8,  7;
/M: SY='H'; M=  5,-11,-21,-13, -5, -6,-16,  9, -8,-12, -1, -3,-10,-18, -5,-12, -5, -6, -8,-15,  9, -7;
/M: SY='R'; M=-11,-13,-26,-15, -2,-13,-25, -9, -1,  2,  1,  7,-10,-17,  4,  9,-12, -6, -4,-22, -7, -1;
/M: SY='R'; M= -5, -5,-24, -5,  1,-18,-11,-11,-15, -1,-10, -9, -3,-15, -2,  7, -2, -2,-11,-25,-14, -3;
/M: SY='S'; M=  0,  3,-22,  1,  8,-26,  0, -7,-23,  1,-23,-14,  7,-11,  9, -3, 10,  2,-20,-28,-18,  9;
/M: SY='E'; M=-10,  0,-28,  2, 14,-26,-10, -6,-21,  4,-17,-11,  0,-12, 12,  8, -2, -6,-20,-25,-15, 11;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_12 which contains 556'388 sequence entries.


Total number of hits 25 in 25 different sequences
Number of true positive hits 25 in 25 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 2
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 92.59 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] LEM
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
25 sequences

ANKL1_CAEEL (G5EGA3    ), ANKL1_HUMAN (Q8NAG6    ), ANKL1_MOUSE (A8VU90    ), 
ANKL2_HUMAN (Q86XL3    ), ANKL2_MOUSE (Q6P1H6    ), ANKL2_RAT   (Q7TP65    ), 
BOCKS_DROME (Q709R6    ), EMD_HUMAN   (P50402    ), EMD_MOUSE   (O08579    ), 
EMD_RAT     (Q63190    ), EMR1_CAEEL  (O01971    ), LAP2A_HUMAN (P42166    ), 
LAP2A_MOUSE (Q61033    ), LAP2B_HUMAN (P42167    ), LAP2B_MOUSE (Q61029    ), 
LAP2_RAT    (Q62733    ), LEM2_CAEEL  (Q9XTB5    ), LEMD1_HUMAN (Q68G75    ), 
LEMD1_MOUSE (Q14C37    ), LEMD2_HUMAN (Q8NC56    ), LEMD2_MOUSE (Q6DVA0    ), 
MAN1_DROME  (Q7JRE4    ), MAN1_HUMAN  (Q9Y2U8    ), MAN1_MOUSE  (Q9WU40    ), 
OTE_DROME   (P20240    )
» more

UniProtKB/Swiss-Prot
False negative sequences
2 sequences

VCR_ARATH   (Q9LTT9    ), VCS_ARATH   (Q9LTT8    )

		
PDB
[Detailed view]
5 PDB

1GJJ; 1H9F; 1JEI; 2ODC; 2ODG

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