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	Entry: PS51022

General information about the entry
Entry name	L27
Accession number	PS51022
Entry type	MATRIX
Date	SEP-2004 (CREATED); SEP-2004 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation	PDOC51022
Associated ProRule	PRU00365
Name and characterization of the entry
Description	L27 domain profile.
Matrix / Profile	/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=58; /DISJOINT: DEFINITION=PROTECT; N1=1; N2=58; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7863903; R2=0.0291390; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=197; N_SCORE=8.5; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=84; N_SCORE=5.2; MODE=1; TEXT='RR'; /DEFAULT: B1=; E1=; MM=; II=; A C D E F G H I K L M N P Q R S T V W Y /I: B1=-85; E0=; BD=-50; /M: SY='P'; M= -1, 0, -7, -1,-10, -8,-20,-37, 1, 12,-28,-12, 17,-15, -1, 9, -2,-33, 5, -7; M0=-6; /I: MM=0; MI=-101; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='D'; M= 1,-38, 13, 12,-13,-10, 3, -6, -6, -1,-29, -7,-34, 7, -8, 13, -2,-15,-40, -2; M0=-5; /I: MM=0; MI=-101; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='P'; M= 7,-38, -3, 6,-41,-17,-20, -6, -6, -9, 4, 4, 21, -3, 6, 2, 3,-18,-40,-33; M0=-6; /I: MM=0; MI=-101; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='D'; M= 12,-36, 19, 3,-38, 7,-21, -6, -7, 2,-27, -3,-35,-16,-22,-12,-23, 10,-38,-32; M0=-8; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='V'; M= 3, 2,-48,-42,-24,-41, 8, 11, -3, 13, 10,-37,-42, -8, 2,-12, -1, 17,-29,-26; M0=-12; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='H'; M=-14, 3, -2, 10,-42,-23, 23,-39, -1,-12, -8, -5, -7, 19,-21, 14,-17,-12,-40, 13; M0=-9; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='R'; M=-24,-38, 5, 10,-42,-10, -3,-15, 8,-16,-29, 15,-34, 16, 20, 1,-10,-35,-40,-33; M0=-10; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='A'; M= 20, -1,-50,-44,-25,-42,-31, 6,-40, 9,-17, 9,-43,-36,-38, -3, -3, 16,-30,-26; M0=-16; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M= -2,-25,-48,-42, -7,-21,-30, 9, -7, 23, 4,-16,-26, 8,-16,-19,-26, 4,-29, -7; M0=-11; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='E'; M= 5,-39, 14, 21,-42, -7, 2,-39, -7,-39, -4, -5, -2, 14, -6, 2, -5,-35,-40,-34; M0=-11; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M= 2, 2,-48,-42,-24,-42, -1, 0,-38, 20,-17, 4,-42, 1,-37, 10,-11, 9,-29,-26; M0=-14; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M= 6, 3,-51,-45,-25,-43,-32, 4,-41, 26, 7,-40,-44,-10,-39,-34,-16, 4,-31,-27; M0=-20; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='E'; M=-15,-39, 14, 23,-42,-16,-20,-39, 14,-17,-30,-10, 3, 6, -1, -9, -2,-35,-40, -7; M0=-11; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='D'; M= 4,-39, 21, 19,-42,-14, 7,-14, 3,-14,-30,-20,-35, 5, 3, -5,-23,-14,-40,-34; M0=-10; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='I'; M= -9, 11,-50,-12,-24,-42,-31, 22,-39, 15,-17,-38,-28, 7,-37,-16,-13, 13,-29, 9; M0=-14; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Q'; M= -5, 1,-24, 0,-38,-34, 8, 3, 1, 7, -5, -6, 4, 24, -6, -4, -5, -7,-39, -7; M0=-6; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Q'; M= 0, -1, -7, 10,-42, -2, 11,-39, -2,-21, -1, -3, -4, 14, 6, 14, 4,-18,-40,-34; M0=-7; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M= -9,-39, 0, -1,-42,-15,-20,-39, 8, 10, -6,-10, 8, 1, 3, 10, 8,-12,-40, -9; M0=-6; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M=-13, 13,-15,-42, 3, 4, 11, 2,-38, 18, -5,-37, -3, -1,-37, 4, 3, -4,-29,-26; M0=-9; /I: MM=-1; MI=-102; MD=-42; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='D'; M=-12,-38, 17, 9,-41, -3, 0,-39, 0,-38,-29, 4,-34, 14,-13, 13, -3, 3,-40, -2; M0=-10; /I: MM=-1; MI=-101; MD=-41; IM=-9; II=-11; DM=-18; DD=-5; /M: SY='Q'; M= 6, 12, 8, 12,-19, -9,-10,-14,-15,-12,-28, 4, 6, 14, -7, 0, -8, 1,-39,-32; M0=-4; /I: MM=0; MI=-101; MD=-60; IM=-9; II=-11; DM=-25; DD=-3; /M: SY='H'; M= -4,-37,-21, -7,-15,-14, 21,-37, 4,-12, 0, 7, 7,-14, 5, 20, -6,-16,-39,-22; M0=-7; /I: MM=-4; MI=-100; MD=-20; IM=-9; II=-11; DM=-26; DD=-3; /M: SY='C'; M=-13, 19, 4, 4, -7, 7, 8,-17,-11,-23,-25, -3,-16, 15, 11, 9,-19, -1,-36,-15; M0=-5; /I: MM=-7; MI=-97; MD=-14; IM=-9; II=-11; DM=-38; DD=-1; /M: SY='D'; M= -6, 7, 21, 0,-28,-25, 9,-10, -8,-10,-17, 2, 7, -7,-13, 10,-14, -1,-28, 6; M0=-5; /I: MM=-14; MI=-7; MD=-100; IM=-16; II=-6; DM=-4; DD=-19; /M: SY='Q'; M=-11,-37, 8, 8,-40,-32, 10,-38, 1,-37,-28, 15, 6, 17, 12, 4, -5, -8,-39,-32; M0=-10; /I: MM=0; MI=-100; MD=-111; IM=-9; II=-11; DM=-8; DD=-12; /M: SY='E'; M= -4,-38, 10, 15,-41,-33, 9, -5, 8,-10,-29, 3, 10, 7,-16, 4, 3,-34,-40,-16; M0=-7; /I: MM=0; MI=-101; MD=-112; IM=-9; II=-11; DM=-2; DD=-27; /M: SY='D'; M= -3,-39, 24, 16,-42, -5, 9,-40, 12,-21,-30, 1,-35,-16, -9, 0, -5,-35,-41,-34; M0=-12; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M= 12, 11,-49,-19, -8,-11,-31, 15,-19, 16, 0,-38,-14,-35, -8, -4,-12, 3,-29,-26; M0=-9; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Q'; M= 5, 5, 5, 8,-42, -5, 0, 3, 5,-13,-30, -8,-35, 13, 8, 7, 1,-35,-41,-34; M0=-7; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='E'; M= 0,-27,-40, 24, 22,-40,-28,-22,-32, 4, 5,-33,-41,-30, 6,-10, -2,-10,-31,-27; M0=-13; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M=-19,-48,-78,-73, 3,-75,-64, -9,-71, 30,-21,-72,-68,-61,-67,-69,-52, 9,-51,-52; M0=-42; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='W'; M= 1, 2,-38,-15, 3,-17, 11, 7, 6, 5, -8,-32,-40, 14, 12, -5,-13, -8, 14, 6; M0=-6; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Q'; M= -1, -5, 13, -6,-42, 5, 10,-40, 10,-39,-30, 7,-35, 18, 12, 0, -4,-21,-41,-34; M0=-10; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='I'; M=-42,-38,-34,-62,-38,-62,-54, 23,-59, 19, 21,-58,-60,-56,-58,-54, -4, 16,-49,-46; M0=-32; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M=-56,-51,-79,-73, 25,-76, 0,-27,-71, 28, 10,-72,-68,-59,-66,-69,-55, -3,-48,-46; M0=-44; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Q'; M=-10,-39, -8, 2,-42, 0, 3,-40, 11,-39,-30, 5,-35, 31, 3, 5, -1,-35,-41,-34; M0=-13; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='S'; M= -5,-39, 15, 13,-42,-34,-21,-40, 0,-39,-30, 2,-35, 2,-22, 22, 6,-35,-41, -4; M0=-14; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='P'; M=-24,-39, 2, -3,-42,-14, 2,-40, 9,-39,-30, 3, 31, -5, 4, -3,-14,-11,-41, -8; M0=-12; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='H'; M=-25,-35, -1, 3, 10,-35, 37, -5, -3, 4,-26, -3,-36,-18,-10, 6,-24, -6, 9,-32; M0=-10; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='F'; M=-51, 20,-75,-69, 31,-71,-59, -5,-67, 18, 21,-68,-65,-57,-63,-63,-50, 6,-48,-49; M0=-40; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Q'; M=-12,-39,-12, -3,-42,-15, 25,-40, 6,-39, -5, 9,-35, 28, 15, -4, -8,-16,-41,-34; M0=-13; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='A'; M= 22,-39,-23, -9,-42, -8, -1,-39, -8,-39, -6, 7,-35, 8,-21, 18, -3,-35,-41, -8; M0=-14; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M= -6, 4,-68,-62,-10,-62,-53, 15,-60, 28,-24,-59,-60,-55,-58,-54,-42, 1,-48,-46; M0=-34; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M= -4,-33,-59,-53, 3,-51,-40,-12,-49, 26, 7,-48,-51,-44, 7,-42,-35, 14,-37,-34; M0=-24; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='K'; M=-24,-39, 9, 15, -2,-34, 7,-40, 16, -6, 3, 5,-35, 14, -1, 4, -8,-35,-41,-34; M0=-10; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='A'; M= 19,-25,-51,-44,-25,-43, -8, 18,-40, 7,-18,-39,-43,-37,-38,-14, 0, 17,-30,-27; M0=-18; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='H'; M=-67,-57,-71,-74, 5,-70, 46,-56,-69,-18,-51,-57,-69, 19,-64,-27,-66,-58,-26, 26; M0=-46; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='D'; M=-38,-55, 34, 18,-57,-41,-20,-55,-31,-54,-46, 2,-45, 5,-38,-16, -4,-51,-56,-15; M0=-27; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='K'; M= 0, 5,-28, 0, 2,-36, 10, -9, 16,-18, -8,-24,-37,-10, 11, 10, 8, 1,-35, -1; M0=-7; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='V'; M=-30,-28,-23,-48,-28,-46,-35, 23,-44, 10, -2,-43,-46,-40,-20,-37,-30, 25,-34, 13; M0=-22; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='A'; M= 23,-39,-22, 10,-42,-10, 5,-39, 0,-39,-30, 0,-35, 8, -5, -6,-10, -5,-40, 11; M0=-11; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Q'; M= -2, 12, -2, 15,-42,-34, 10,-39, 1,-10,-30, -7,-35, 20, -1, 8, 0, -2,-40, -3; M0=-8; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='T'; M=-17,-37,-16, 2, -3,-34, 11,-15, 18, 4,-28,-21,-35, 3, -9, -2, 18, -9,-39, 9; M0=-8; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='V'; M=-24, 9, 4, 6,-39,-16,-21, -1, 10, -2, 9, 9,-10, -8,-22, 2, 5, 11,-39, -6; M0=-5; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Y'; M=-12, 3, 14, -1, 11,-13, 0,-15, -3, 2, 8, 0,-35, -7, 7, -8, -5,-15,-39, 21; M0=-5; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Q'; M=-14, -4, 16, 14,-42, -9,-20, -1, 2,-39, -9, -7, -7, 21, 0, 0,-11,-17,-40, 2; M0=-8; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='P'; M= 5,-39, 6, 1,-42,-27,-20,-14, 1, -4,-30, 7, 21, 3, -8, 5, 3, -9,-40,-34; M0=-6; /I: MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='P'; M= -4,-39, -9, 8,-42, -1, 11,-13, -6, -2,-30, 3, 16, -4, 2, 6, -4, 5,-40,-34; M0=-5; /I: B0=; E1=-10;
Numerical results
UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052. Total number of hits in UniProtKB/Swiss-Prot: 75 hits in 51 different sequences Number of hits on proteins that are known to belong to the set under consideration: 75 hits in 51 different sequences Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences Number of false hits (on unrelated proteins): 0 hits in 0 different sequences Number of known missed hits: 0 Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0 Precision (true hits / (true hits + false positives)): 100.00 % Recall (true hits / (true hits + false negatives)): 100.00 %
Comments
MATRIX_TYPE: protein_domain Scaling database: UniProtKB/Swiss-Prot: reversed Matrix author: CJA_Sigrist Taxonomic range: Eukaryotes Maximum known number of repetitions of the pattern in a single protein: 2 FT_KEY: DOMAIN FT_DESC: L27 VERSION: 1
Cross-references
UniProtKB/Swiss-Prot	True positive hits: CSKP_DROME (Q24210), CSKP_HUMAN (O14936), CSKP_MOUSE (O70589), CSKP_RAT (Q62915), DLG1_DANRE (Q5PYH6), DLG1_DROME (P31007), DLG1_HUMAN (Q12959), DLG1_MOUSE (Q811D0), DLG1_RAT (Q62696), DLG1_XENTR (Q28C55), DLG4_DANRE (Q6R005), INADL_HUMAN (Q8NI35), INADL_MOUSE (Q63ZW7), LIN2_CAEEL (P54936), LIN7A_BOVIN (Q32LM6), LIN7A_HUMAN (O14910), LIN7A_MOUSE (Q8JZS0), LIN7A_RAT (Q9Z250), LIN7B_BOVIN (Q2KIB6), LIN7B_HUMAN (Q9HAP6), LIN7B_MOUSE (O88951), LIN7B_RAT (Q9Z252), LIN7C_BOVIN (Q0P5F3), LIN7C_CHICK (Q5F425), LIN7C_HUMAN (Q9NUP9), LIN7C_MOUSE (O88952), LIN7C_PONAB (Q5RAA5), LIN7C_RAT (Q792I0), MPDZ_HUMAN (O75970), MPDZ_MOUSE (Q8VBX6), MPDZ_RAT (O55164), MPP2_HUMAN (Q14168), MPP2_MOUSE (Q9WV34), MPP3_HUMAN (Q13368), MPP3_MOUSE (O88910), MPP3_RAT (O88954), MPP4_HUMAN (Q96JB8), MPP4_MOUSE (Q6P7F1), MPP5A_DANRE (Q8JHF4), MPP5_HUMAN (Q8N3R9), MPP5_MOUSE (Q9JLB2), MPP5_PONAB (Q5RDQ2), MPP6_HUMAN (Q9NZW5), MPP6_MOUSE (Q9JLB0), MPP7_BOVIN (A6QQZ7), MPP7_DANRE (Q6P0D7), MPP7_HUMAN (Q5T2T1), MPP7_MOUSE (Q8BVD5), MPP7_RAT (Q5U2Y3), MPP7_XENTR (A8KBF6), PATJ_DROME (Q9NB04) Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
PDB [Detailed view]	1RSO; 1VF6; 1Y74; 1Y76; 1ZL8; 3LRA; 3UIT;

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