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| Entry: PS51027 |
General information about the entry
| Entry name [info] | INTEGRASE_DBD |
| Accession [info] | PS51027 |
| Entry type [info] | MATRIX |
| Date [info] | 01-OCT-2004 CREATED; 10-MAY-2017 DATA UPDATE; 05-JUL-2017 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51027 |
| Associated ProRule [info] | PRU00506 |
Name and characterization of the entry
| Description [info] | Integrase DNA binding domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=50; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=45; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8148787; R2=0.0159785; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2856.8085938; R2=1.9361702; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=419; H_SCORE=3668; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=294; H_SCORE=3426; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-9; D=-20; I=-20; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='K'; M= -7, -7,-29, -7, 8,-15,-20, -4,-21, 11,-19,-10, -6, 3, 7, 6, -7,-10,-20,-19, -8, 7; /M: SY='W'; M=-14,-25,-28,-28,-18, 13,-24,-15, -2,-14, 5, 9,-22,-17,-13, -9,-21,-11, -7, 17, 8,-15; /M: SY='V'; M= -6,-27, 18,-32,-30, 4,-31,-27, 13,-24, 3, 2,-25,-31,-29,-23,-13, -5, 25,-27, -6,-30; /M: SY='Y'; M=-16,-17,-29,-19,-14, 12,-26, 3, -6, 2, -4, 3,-17,-24, -7, 0,-19,-11,-11, 16, 38,-12; /M: SY='W'; M=-18,-29,-35,-31,-26, 23,-27, -7, -2,-17, -5, -5,-28,-29,-18,-16,-27,-17,-11, 65, 48,-22; /M: SY='R'; M=-14, -4,-30, -4, 6,-26,-20, -6,-30, 41,-26,-10, 0,-14, 10, 48,-10,-10,-20,-20,-10, 6; /M: SY='D'; M=-13, 14,-26, 17, 3,-19,-19, -9, -7,-10, -6, -9, 7,-15, -6,-13, -6, -5,-10,-32,-12, -2; /M: SY='P'; M= -9,-11,-29, -8, -1,-22,-11,-12,-16, -2,-18,-11, -7, 15, -3, 2, -6, -8,-16,-27,-19, -5; /M: SY='R'; M= -9,-13,-26,-13, -8,-15, -5,-14,-16, 5, -3, -3, -9,-20, -6, 10,-12, -8,-12,-21,-11, -8; /I: I=-5; MD=-25; /M: SY='D'; M=-12, 12,-22, 15, 6,-20,-15, 1,-20, 1,-13,-12, 7,-13, 3, 4, -1, 2,-16,-27,-10, 3; D=-5; /I: I=-5; MI=0; MD=-25; IM=0; DM=-25; /M: SY='N'; M= -9, 5,-28, 4, 6,-28, 0, 1,-28, 8,-27,-14, 10, -7, 7, 7, -1, -9,-27,-27,-17, 6; /M: SY='E'; M= -7, -4,-22, -2, 7,-17,-19,-10,-13, 2, -7, -7, -5,-14, 2, 3, -1, 1, -9,-27,-12, 4; /M: SY='W'; M=-18,-37,-48,-37,-29, 7,-12,-29,-22,-20,-21,-20,-37,-29,-20,-20,-37,-29,-30,135, 25,-20; /M: SY='K'; M=-12, -3,-29, -1, 12,-21,-22, 0,-23, 29,-20, -8, -4,-13, 10, 16,-10,-10,-20,-16, 1, 10; /I: I=-6; MD=-32; /M: SY='G'; M= -2, -3,-28, -2,-13,-29, 52,-16,-37,-12,-28,-19, 2,-17,-15,-14, -1,-17,-27,-20,-26,-14; D=-6; /I: I=-6; MI=-32; IM=-32; DM=-32; /M: SY='P'; M=-10,-17,-37,-11, -2,-28,-15,-13,-17,-10,-25,-15,-16, 62, -4,-17, -9,-11,-26,-28,-24, -7; /M: SY='D'; M= -7, 3,-27, 8, -4,-19, -5,-10,-20,-10,-14,-11, -4, -7, -6,-14, -5, -5,-18,-14, -9, -5; /M: SY='P'; M=-12, -7,-31, -5, 6,-26,-20, -8,-20, 11,-22,-11, -4, 16, 6, 14, -7, -9,-20,-26,-17, 3; /M: SY='V'; M= 0,-26,-16,-28,-24, 2,-27,-22, 22,-21, 14, 9,-24,-26,-22,-20,-12, -3, 28,-21, -1,-24; /M: SY='L'; M=-10,-27,-10,-29,-18, 4,-31,-21, 18,-28, 36, 14,-26,-28,-19,-21,-25,-10, 9,-23, -4,-19; /M: SY='W'; M=-10,-25,-31,-28,-22, -3,-19,-22, 3,-18, -6, -3,-21,-23,-12,-18,-17, -9, -2, 31, 7,-17; /M: SY='W'; M=-11,-11,-35, -9, 1,-17,-13,-14,-27, 11,-23,-16,-12,-16, -1, 8,-16,-16,-24, 29, -1, 1; /M: SY='G'; M= 8, -9,-25,-10,-16,-27, 52,-19,-33,-17,-27,-19, 0,-17,-16,-19, 6,-12,-23,-22,-27,-16; /M: SY='R'; M=-10, 4,-27, 8, 12,-26,-16, -3,-29, 18,-22,-15, 3,-13, 10, 29, -2, -8,-21,-26,-14, 9; /M: SY='G'; M= -1, -8,-30, -7,-13,-30, 62,-18,-39,-17,-29,-20, 0,-18,-17,-18, 0,-19,-30,-21,-29,-15; /M: SY='A'; M= 21,-12,-17,-17,-10, -9, -5, -9,-13,-12,-13,-10, -9, -6,-10,-17, 5, -2, -8,-16, -5,-11; /M: SY='V'; M= 19,-22,-14,-28,-22, -8,-19,-26, 17,-18, 3, 3,-20,-20,-20,-22, -3, -2, 26,-24,-12,-22; /M: SY='C'; M= -2,-25, 34,-30,-27, -7,-28,-27, 5,-25, 6, 0,-25,-32,-26,-24,-13, -6, 17,-34,-16,-27; /M: SY='V'; M= -4,-30,-16,-32,-28, 2,-32,-28, 31,-24, 20, 14,-28,-28,-26,-22,-16, -4, 38,-26, -6,-28; /M: SY='K'; M= -8, -7,-25, -9, -1, 0,-19, -8,-18, 10,-17, -9, -3,-11, -3, 3, -4, -6,-15,-14, 2, -2; /M: SY='D'; M=-12, 11,-28, 19, 7,-25,-17, -3,-20, -6,-21,-17, 3, 10, -4,-12, -2, -5,-18,-32,-15, 0; /I: I=-4; MD=-18; /M: SY='Q'; M= -9, 0,-27, 1, 11,-27, -7, -2,-20, 4,-18, -9, 2,-12, 17, 9, -1, -9,-21,-23,-14, 13; D=-4; /I: I=-4; MD=-18; /M: SY='E'; M= -5, 9,-19, 13, 14,-20, -1, -4,-20, 1,-15,-11, 4, -7, 2, -4, 0, -5,-17,-21,-14, 8; D=-4; /I: I=-4; MD=-18; /M: SY='S'; M= 2, 3,-10, 1, 5,-12, -7, -1,-11, 0,-11, -8, 4, -6, 1, -2, 7, 5, -8,-17, -8, 3; D=-4; /I: I=-4; MI=0; MD=-18; IM=0; DM=-18; /M: SY='E'; M= -9, 16,-27, 22, 23,-32, -6, -3,-30, 6,-25,-19, 9, -9, 11, -1, 3, -6,-26,-31,-18, 17; /M: SY='K'; M= -3, 1,-25, 1, 2,-24, -2,-11,-24, 7,-21,-14, 3, -8, -2, 3, 0, -4,-19,-26,-17, 0; /M: SY='P'; M= -6,-17,-29,-16,-12, -9,-24,-14, 0,-14, -8, -6,-17, 19,-13,-19,-10, -5, -6,-16, 1,-16; /M: SY='V'; M= -7,-19,-23,-22,-13, -2,-25,-16, 4, -4, 4, 4,-14,-21, -9, 2,-12, -7, 5,-20, -4,-12; /M: SY='W'; M= -9,-34,-34,-34,-26, 4,-23,-28, -1,-20, -4, -7,-33,-23,-21,-20,-27,-17, -3, 65, 10,-22; /M: SY='I'; M= -7,-28,-21,-31,-24, 1,-34,-25, 33,-23, 16, 13,-24,-24,-22,-23,-16, -6, 31,-22, -1,-25; /M: SY='P'; M= -7,-18,-38,-10, 0,-29,-19,-20,-20, -7,-29,-19,-18, 80, -9,-18, -9, -9,-28,-29,-28, -9; /M: SY='R'; M=-12, -4,-28, -3, 5,-12,-17, 0,-21, 0,-16,-13, -3,-17, 1, 6, -5, -5,-20, 0, 1, 2; /M: SY='R'; M=-17, -8,-29, -9, 1,-21,-20, -3,-29, 31,-21,-10, 0,-18, 9, 60, -8, -7,-19,-21,-10, 1; /M: SY='H'; M=-15, -6,-26, -4, -5, -5,-23, 6,-12, -3, 3, 0, -7,-21, -6, 0,-16,-12,-11,-22, 1, -6; /M: SY='V'; M= 6,-20,-10,-26,-20, -4,-23,-23, 13,-19, 11, 7,-19,-22,-18,-19, -7, 5, 18,-25, -9,-20; /M: SY='K'; M=-13, -3,-30, -3, 7,-27,-20, -7,-30, 44,-27,-10, 0,-13, 10, 42,-10,-10,-20,-20,-10, 7; /M: SY='F'; M= -9,-19,-26,-22,-13, 7,-20,-12, -6, -9, -4, -3,-12, -8,-12, -4,-12,-10, -7,-14, -1,-14; /M: SY='I'; M= -2,-21,-23,-27,-22, 5,-28,-21, 22,-22, 10, 7,-17,-21,-19,-23,-13, -7, 16,-16, 3,-23; /M: SY='P'; M= -4, -7,-29, -8, -1,-23,-18,-13,-12, 0,-20,-11, -3, 20, -2, -4, -3, -4,-16,-27,-18, -4; /M: SY='D'; M=-10, 8, -8, 11, 11,-27,-17,-10,-27, -3,-25,-20, 2, 7, -2,-10, 0, -2,-23,-35,-22, 4; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 106 in 106 different sequences |
| Number of true positive hits | 106 in 106 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 1 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 99.07 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | N_Hulo |
| Taxonomic range [info] | Eukaryotes, Eukaryotic viruses |
| Maximum number of repetitions [info] | 1 |
| Feature key [info] | DNA_BIND |
| Feature description [info] | Integrase-type |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
106 sequences
PO113_HUMAN (P63132 ), POK10_HUMAN (P10266 ), POK11_HUMAN (Q9UQG0 ), POK19_HUMAN (Q9WJR5 ), POK25_HUMAN (P63136 ), POK6_HUMAN (Q9BXR3 ), POK7_HUMAN (P63135 ), POK8_HUMAN (P63133 ), POL_ALV (Q7SQ98 ), POL_BIV29 (P19560 ), POL_BLVAU (P25059 ), POL_BLVJ (P03361 ), POL_CAEVC (P33459 ), POL_EIAV9 (P11204 ), POL_EIAVC (P32542 ), POL_EIAVY (P03371 ), POL_FIVPE (P16088 ), POL_FIVSD (P19028 ), POL_FIVT2 (P31822 ), POL_HTL1A (P03362 ), POL_HTL1C (P14078 ), POL_HTL1L (P0C211 ), POL_HTL32 (Q0R5R2 ), POL_HTL3P (Q4U0X6 ), POL_HTLV2 (P03363 ), POL_HV190 (O93215 ), POL_HV192 (O12158 ), POL_HV193 (O89290 ), POL_HV196 (Q9QBY3 ), POL_HV197 (Q9QBZ9 ), POL_HV19N (O41798 ), POL_HV1A2 (P03369 ), POL_HV1AN (Q77373 ), POL_HV1B1 (P03366 ), POL_HV1B5 (P04587 ), POL_HV1B9 (Q73368 ), POL_HV1BR (P03367 ), POL_HV1EL (P04589 ), POL_HV1ET (Q75002 ), POL_HV1H2 (P04585 ), POL_HV1JR (P20875 ), POL_HV1LW (P0C6F2 ), POL_HV1M2 (Q9QBZ1 ), POL_HV1MA (P04588 ), POL_HV1MN (P05961 ), POL_HV1MP (Q9QBZ5 ), POL_HV1MV (Q79666 ), POL_HV1N5 (P12497 ), POL_HV1ND (P18802 ), POL_HV1OY (P20892 ), POL_HV1RH (P05959 ), POL_HV1S2 (Q9WC54 ), POL_HV1S9 (Q9WC63 ), POL_HV1SE (O89940 ), POL_HV1U4 (P24740 ), POL_HV1V9 (Q9Q720 ), POL_HV1VI (Q9QSR3 ), POL_HV1Y2 (P35963 ), POL_HV1YB (Q9IDV9 ), POL_HV1YF (O91080 ), POL_HV1Z2 (P12499 ), POL_HV1Z6 (P04586 ), POL_HV2BE (P18096 ), POL_HV2CA (P24107 ), POL_HV2D1 (P17757 ), POL_HV2D2 (P15833 ), POL_HV2EH (Q89928 ), POL_HV2G1 (P18042 ), POL_HV2KR (Q74120 ), POL_HV2NZ (P05962 ), POL_HV2RO (P04584 ), POL_HV2SB (P12451 ), POL_HV2ST (P20876 ), POL_HV2UC (Q76634 ), POL_IPHA (P04026 ), POL_IPMA (P11368 ), POL_IPMAI (P12894 ), POL_JEMBR (Q82851 ), POL_JSRV (P31623 ), POL_MMTVB (P03365 ), POL_MMTVC (P11283 ), POL_MPMV (P07572 ), POL_OMVVS (P16901 ), POL_RSVP (P03354 ), POL_RSVSA (Q04095 ), POL_RSVSB (O92956 ), POL_SIVCZ (P17283 ), POL_SIVEK (Q1A249 ), POL_SIVG1 (Q02836 ), POL_SIVGB (P22382 ), POL_SIVM1 (P05896 ), POL_SIVMB (Q1A267 ), POL_SIVMK (P05897 ), POL_SIVS4 (P12502 ), POL_SIVSP (P19505 ), POL_SIVTN (Q8AII1 ), POL_SIVV1 (P27973 ), POL_SIVVG (P27980 ), POL_SIVVT (P05895 ), POL_SMRVH (P03364 ), POL_SRV1 (P04025 ), POL_SRV2 (P51517 ), POL_VILV (P03370 ), POL_VILV1 (P23426 ), POL_VILV2 (P23427 ), POL_VILVK (P35956 )» more
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| UniProtKB/Swiss-Prot False negative sequences |
1 sequence
POL1_CHICK (P10399 ) |
| PDB [Detailed view] |
12 PDB
1C0M; 1C1A; 1C6V; 1EX4; 1IHV; 1IHW; 1QMC; 3JCA; 4FW1; 4FW2; 5D7U; 5EJK |
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