Entry: PS51134

Forthcoming changes to the profile format
General information about the entry

Entry name [info] ZF_TFIIB
Accession [info] PS51134
Entry type [info] MATRIX
Date [info] JUN-2005 (CREATED); JUN-2005 (DATA UPDATE); JUL-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC51134
Associated ProRule [info] PRU00469

Name and characterization of the entry

Description [info] Zinc finger TFIIB-type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=32;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=29;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.6841733; R2=0.0059513; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=1146; N_SCORE=7.7; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=810; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-13; D=-50; I=-50; B1=-200; E1=-200; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='E'; M=  -3, -22,   5,  20,   6,  -1,   3,  -9,   0, -12,  -6,   5,  11,   3,  -4,   6,   0,  -9, -20,   1;
/M: SY='P'; M=  -1, -23,   2,   7, -20,   0,  -6,  -4,  14, -12,  -8,  -3,  21,   7,   7,   3,   2,   0, -27, -15;
/M: SY='R'; M=  -6,  -1,  -3,   5,  -9, -23,  10,   3,   5,   6,   6,  -9, -20,  15,  20,  -8,  -7,   5, -22,   2;
/M: SY='R'; M=  -1,   1, -12,  -2,  -6,  -8, -12,   4,  13,  -6,  -1,  -6, -17,   6,  13,  -2,   9,   7,   9,   0;
/I:         I=-15; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='P'; M= -11, -33, -13,  -3, -26, -15, -13, -19,  12, -24, -11, -13,  87,  -9,  -8,  -3,  -3, -22, -24, -17;
/M: SY='E'; M=  -2, -23,  23,  27, -19, -10,   3,  -9,   4, -16,  -9,  25, -14,  11,   0,  -1,  -4, -10, -28,  -6;
/M: SY='C'; M= -10, 118, -25, -25, -19, -24,  25, -27, -22, -17, -15, -12, -37, -27, -27, -11, -10, -16, -49, -22;
/I:         I=-13; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='G'; M=  -5, -30,   7,   1, -25,  39, -10, -34,  -2, -32, -23,  -1,  24,  -4,  -4,  -3, -13, -30, -28, -23; D=-13;
/I:         I=-13; DM=-27;
/M: SY='S'; M=   2,  -6,  18,   4, -25,  10,  -3, -22,  -2, -25, -18,   9,  18,   1, -10,  26,  11, -16, -32, -17;
/M: SY='P'; M=   8, -19,   5,   4, -24,  14, -11, -18,   4, -21, -14,   5,  22,   2,   3,   9,  15, -11, -29, -18;
/M: SY='N'; M= -62, -16,  55,  35, -92, -82,  41,   5, -30, -48, -82,  66,   6,  11, -48,   8, -24, -38,-105, -83;
/M: SY='I'; M= -12, -19, -32, -26,  30, -34, -22,  40, -23,  31,  20, -26, -27, -21, -18, -21,  -8,  24, -18,   2;
/M: SY='V'; M=  -4, -20,  -6,   4,  -5, -30, -24,  31, -14,   9,   7, -17, -20, -12, -16, -11,   0,  32, -30, -10;
/M: SY='E'; M=  -7, -21,   2,  22,   1, -18,  -2,  -5,   5,  -6,  -6,  -4, -14,   2,   8,   0,  10,   1, -17,  13;
/M: SY='D'; M= -14, -28,  68,  23, -34, -12,   6, -33,  -1, -31, -29,  25, -14,   0,   6,  -2,  -5, -30, -48, -17;
/I:         I=-14; MD=-29;
/M: SY='Y'; M=  -9, -25,  -4,   1,  15, -16,  27,  -9,  -7,  -5,  -4,  -1,  10,  -5,  -4,  -3,  -3, -12,  -2,  40; D=-14;
/I:         I=-14; MD=-29;
/M: SY='E'; M=  10, -22,   6,  22, -28,  -6,  -6, -26,  12, -24, -17,   2, -13,  11,  18,  13,  -2, -18, -28, -18; D=-14;
/I:         I=-14; MI=-29; IM=-29; DM=-29;
/M: SY='R'; M=   9, -21,  -6,   1, -22,  -8,  35, -24,  15, -21, -10,   8, -17,   8,  35,   7,  -1, -17, -29,  -8;
/I:         I=-11; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='G'; M=   9, -23, -12, -22, -31,  70, -19, -36, -17, -32, -22,   3, -17, -14, -24,   4, -14, -28, -23, -26; D=-11;
/I:         I=-11; DM=-23;
/M: SY='D'; M= -12, -28,  50,  40, -26, -18,  -1, -30,  -3, -26, -23,  10, -11,  10,  -5,  -3,  -5, -26, -31,  -5; D=-11;
/I:         I=-11; DM=-23;
/M: SY='M'; M=   0, -17, -20, -18,   1, -22,   0,  15, -14,  16,  19, -10, -20, -12, -11,  -4,  11,  12, -22,   5; D=-11;
/I:         I=-11; DM=-23;
/M: SY='V'; M=  -6, -18, -30, -26,  13, -33, -27,  36, -23,  15,  11, -24, -25, -24, -25,  -6,   0,  45, -21,  -6;
/M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='G'; M=  10, -39,  -5,   6, -23,  17, -11, -15,   7, -19, -10,   2,  13,   4,   0,  11,  12, -10, -26, -17;
/M: SY='D'; M=  -1, -22,  33,  21, -27,  -4,  -3, -21,  10, -23, -17,  19, -13,   7,   8,   6,   0, -14, -33, -17;
/M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='G'; M=   8, -34,  -4, -21, -31,  75, -18, -38, -17, -33, -23,   2, -16, -14, -24,   3, -15, -31, -22, -25;
/M: SY='C'; M=  -4,  31, -22, -18,   8, -23, -13,  11, -15,  25,  10, -16, -25,  -8, -10,  -2,   3,   9, -17,  10;
/M: SY='V'; M=  -1, -15, -31, -26,  -1, -33, -34,  36, -23,   4,  11, -36, -26, -25, -25, -15,   1,  50, -34,  -9;
/M: SY='I'; M=  -8, -18, -40, -26,   4, -34, -26,  34, -24,  29,  17, -26, -26, -22, -25, -18,  -1,  32, -26,  -5;
/M: SY='E'; M=   1, -25,  23,  47, -30,  20,  -6, -30,   7, -25, -20,   1,  -9,  12,  -4,   1,  -3, -23, -28, -20;
/I:         E1=0; IE=-105; DE=-105;
» More

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_08 which contains 546'238 sequence entries.


Total number of hits 77 in 77 different sequences
Number of true positive hits 77 in 77 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 6
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 92.77 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] N_Hulo
Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Feature key [info] ZN_FING
Feature description [info] TFIIB-type
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
77 sequences

BRF2_BOVIN  (Q29S07), BRF2_DANRE  (A8KBY2), BRF2_HUMAN  (Q9HAW0), 
BRF2_MACFA  (Q4R318), BRF2_MOUSE  (Q3UAW9), BRF2_RAT    (Q4V8D6), 
BRF2_XENLA  (Q66IW8), BRF2_XENTR  (A4QNR3), TF2B1_ARATH (P48512), 
TF2B1_HALSA (Q9HNA2), TF2B1_THEAC (Q9HJM7), TF2B1_THEKO (Q5JGN1), 
TF2B1_THEVO (Q979Q3), TF2B2_ARATH (Q9SS44), TF2B2_HALSA (Q9HRE6), 
TF2B2_HALVD (Q9YGA5), TF2B2_SULSO (P58110), TF2B2_THEAC (Q9HJM2), 
TF2B2_THEKO (P58109), TF2B2_THEVO (Q979P7), TF2B3_HALSA (Q9HHK5), 
TF2B4_HALSA (Q9HR45), TF2B6_HALSA (Q9HSB3), TF2B7_HALSA (Q9HSF7), 
TF2B_ARCFU  (O28970), TF2B_BOVIN  (Q2KIN8), TF2B_CAEEL  (O16991), 
TF2B_CALMQ  (A8MCX6), TF2B_DICDI  (Q54FD6), TF2B_DROME  (P29052), 
TF2B_DROVI  (Q9NHP7), TF2B_ENCCU  (Q8SRP3), TF2B_HUMAN  (Q00403), 
TF2B_IGNH4  (A8AC96), TF2B_KLULA  (Q05959), TF2B_MACFA  (Q4R3J5), 
TF2B_META3  (A6UW60), TF2B_METAC  (Q8TT29), TF2B_METB6  (A7IAR4), 
TF2B_METJA  (Q58192), TF2B_METKA  (Q8TX21), TF2B_METM5  (A4G0F2), 
TF2B_METM6  (A9A8Q0), TF2B_METM7  (A6VI28), TF2B_METMA  (P0CW15), 
TF2B_METMJ  (A3CSQ6), TF2B_METMP  (Q6M176), TF2B_METMZ  (P0CW14), 
TF2B_METPE  (B8GJQ9), TF2B_METS3  (A5UKA1), TF2B_METST  (Q2NEL6), 
TF2B_METTH  (O26971), TF2B_METTL  (Q9P9I7), TF2B_METTP  (A0B5T8), 
TF2B_MOUSE  (P62915), TF2B_ORYSJ  (Q8W0W3), TF2B_PONAB  (Q5R886), 
TF2B_PYRAB  (Q9V0V5), TF2B_PYRAE  (Q8ZWS3), TF2B_PYRAR  (A4WMA6), 
TF2B_PYRFU  (P61998), TF2B_PYRHO  (O59151), TF2B_PYRIL  (A1RV37), 
TF2B_PYRNV  (B1YCX0), TF2B_PYRWO  (P61999), TF2B_RAT    (P62916), 
TF2B_SCHPO  (O13749), TF2B_SOYBN  (P48513), TF2B_XENLA  (P29054), 
TF2B_YEAST  (P29055), TF3B_CANAL  (P43072), TF3B_HUMAN  (Q92994), 
TF3B_KLULA  (P46070), TF3B_MOUSE  (Q8CFK2), TF3B_SCHPO  (Q9P6R0), 
TF3B_YEAST  (P29056), YTF2_SULSH  (P46221)
» More

UniProtKB/Swiss-Prot
False negative sequences
6 sequences

LYSW_SULAC  (Q4JAQ0), LYSW_SULSO  (Q980W8), LYSW_SULTO  (Q976J8), 
LYSW_THET8  (Q5SH22), TF2B5_HALSA (Q9HHH8), TF2B_MIMIV  (Q5UPT1)
» More

PDB
[Detailed view]
8 PDB

1DL6; 1PFT; 1RLY; 1RO4; 3K1F; 3K7A; 4BBR; 4BBS

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission