Entry: PS51134

General information about the entry

Entry name [info] ZF_TFIIB
Accession [info] PS51134
Entry type [info] MATRIX
Date [info] JUN-2005 (CREATED); JUN-2005 (DATA UPDATE); JUN-2015 (INFO UPDATE).
PROSITE Doc. [info] PDOC51134
Associated ProRule [info] PRU00469

Name and characterization of the entry

Description [info] Zinc finger TFIIB-type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=32;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=29;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.6841733; R2=0.0059513; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=1146; N_SCORE=7.7; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=810; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-13; D=-50; I=-50; B1=-200; E1=-200; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='E'; M=  -3, -22,   5,  20,   6,  -1,   3,  -9,   0, -12,  -6,   5,  11,   3,  -4,   6,   0,  -9, -20,   1;
/M: SY='P'; M=  -1, -23,   2,   7, -20,   0,  -6,  -4,  14, -12,  -8,  -3,  21,   7,   7,   3,   2,   0, -27, -15;
/M: SY='R'; M=  -6,  -1,  -3,   5,  -9, -23,  10,   3,   5,   6,   6,  -9, -20,  15,  20,  -8,  -7,   5, -22,   2;
/M: SY='R'; M=  -1,   1, -12,  -2,  -6,  -8, -12,   4,  13,  -6,  -1,  -6, -17,   6,  13,  -2,   9,   7,   9,   0;
/I:         I=-15; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='P'; M= -11, -33, -13,  -3, -26, -15, -13, -19,  12, -24, -11, -13,  87,  -9,  -8,  -3,  -3, -22, -24, -17;
/M: SY='E'; M=  -2, -23,  23,  27, -19, -10,   3,  -9,   4, -16,  -9,  25, -14,  11,   0,  -1,  -4, -10, -28,  -6;
/M: SY='C'; M= -10, 118, -25, -25, -19, -24,  25, -27, -22, -17, -15, -12, -37, -27, -27, -11, -10, -16, -49, -22;
/I:         I=-13; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='G'; M=  -5, -30,   7,   1, -25,  39, -10, -34,  -2, -32, -23,  -1,  24,  -4,  -4,  -3, -13, -30, -28, -23; D=-13;
/I:         I=-13; DM=-27;
/M: SY='S'; M=   2,  -6,  18,   4, -25,  10,  -3, -22,  -2, -25, -18,   9,  18,   1, -10,  26,  11, -16, -32, -17;
/M: SY='P'; M=   8, -19,   5,   4, -24,  14, -11, -18,   4, -21, -14,   5,  22,   2,   3,   9,  15, -11, -29, -18;
/M: SY='N'; M= -62, -16,  55,  35, -92, -82,  41,   5, -30, -48, -82,  66,   6,  11, -48,   8, -24, -38,-105, -83;
/M: SY='I'; M= -12, -19, -32, -26,  30, -34, -22,  40, -23,  31,  20, -26, -27, -21, -18, -21,  -8,  24, -18,   2;
/M: SY='V'; M=  -4, -20,  -6,   4,  -5, -30, -24,  31, -14,   9,   7, -17, -20, -12, -16, -11,   0,  32, -30, -10;
/M: SY='E'; M=  -7, -21,   2,  22,   1, -18,  -2,  -5,   5,  -6,  -6,  -4, -14,   2,   8,   0,  10,   1, -17,  13;
/M: SY='D'; M= -14, -28,  68,  23, -34, -12,   6, -33,  -1, -31, -29,  25, -14,   0,   6,  -2,  -5, -30, -48, -17;
/I:         I=-14; MD=-29;
/M: SY='Y'; M=  -9, -25,  -4,   1,  15, -16,  27,  -9,  -7,  -5,  -4,  -1,  10,  -5,  -4,  -3,  -3, -12,  -2,  40; D=-14;
/I:         I=-14; MD=-29;
/M: SY='E'; M=  10, -22,   6,  22, -28,  -6,  -6, -26,  12, -24, -17,   2, -13,  11,  18,  13,  -2, -18, -28, -18; D=-14;
/I:         I=-14; MI=-29; IM=-29; DM=-29;
/M: SY='R'; M=   9, -21,  -6,   1, -22,  -8,  35, -24,  15, -21, -10,   8, -17,   8,  35,   7,  -1, -17, -29,  -8;
/I:         I=-11; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='G'; M=   9, -23, -12, -22, -31,  70, -19, -36, -17, -32, -22,   3, -17, -14, -24,   4, -14, -28, -23, -26; D=-11;
/I:         I=-11; DM=-23;
/M: SY='D'; M= -12, -28,  50,  40, -26, -18,  -1, -30,  -3, -26, -23,  10, -11,  10,  -5,  -3,  -5, -26, -31,  -5; D=-11;
/I:         I=-11; DM=-23;
/M: SY='M'; M=   0, -17, -20, -18,   1, -22,   0,  15, -14,  16,  19, -10, -20, -12, -11,  -4,  11,  12, -22,   5; D=-11;
/I:         I=-11; DM=-23;
/M: SY='V'; M=  -6, -18, -30, -26,  13, -33, -27,  36, -23,  15,  11, -24, -25, -24, -25,  -6,   0,  45, -21,  -6;
/M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='G'; M=  10, -39,  -5,   6, -23,  17, -11, -15,   7, -19, -10,   2,  13,   4,   0,  11,  12, -10, -26, -17;
/M: SY='D'; M=  -1, -22,  33,  21, -27,  -4,  -3, -21,  10, -23, -17,  19, -13,   7,   8,   6,   0, -14, -33, -17;
/M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='G'; M=   8, -34,  -4, -21, -31,  75, -18, -38, -17, -33, -23,   2, -16, -14, -24,   3, -15, -31, -22, -25;
/M: SY='C'; M=  -4,  31, -22, -18,   8, -23, -13,  11, -15,  25,  10, -16, -25,  -8, -10,  -2,   3,   9, -17,  10;
/M: SY='V'; M=  -1, -15, -31, -26,  -1, -33, -34,  36, -23,   4,  11, -36, -26, -25, -25, -15,   1,  50, -34,  -9;
/M: SY='I'; M=  -8, -18, -40, -26,   4, -34, -26,  34, -24,  29,  17, -26, -26, -22, -25, -18,  -1,  32, -26,  -5;
/M: SY='E'; M=   1, -25,  23,  47, -30,  20,  -6, -30,   7, -25, -20,   1,  -9,  12,  -4,   1,  -3, -23, -28, -20;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2015_08 which contains 320'201 sequence entries.


Total number of hits 77 in 77 different sequences
Number of true positive hits 77 in 77 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 6
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 92.77 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] N_Hulo
Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Feature key [info] ZN_FING
Feature description [info] TFIIB-type
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
77 sequences

BRF2_BOVIN  (Q29S07), BRF2_DANRE  (A8KBY2), BRF2_HUMAN  (Q9HAW0), 
BRF2_MACFA  (Q4R318), BRF2_MOUSE  (Q3UAW9), BRF2_RAT    (Q4V8D6), 
BRF2_XENLA  (Q66IW8), BRF2_XENTR  (A4QNR3), TF2B1_ARATH (P48512), 
TF2B1_HALSA (Q9HNA2), TF2B1_THEAC (Q9HJM7), TF2B1_THEKO (Q5JGN1), 
TF2B1_THEVO (Q979Q3), TF2B2_ARATH (Q9SS44), TF2B2_HALSA (Q9HRE6), 
TF2B2_HALVD (Q9YGA5), TF2B2_SULSO (P58110), TF2B2_THEAC (Q9HJM2), 
TF2B2_THEKO (P58109), TF2B2_THEVO (Q979P7), TF2B3_HALSA (Q9HHK5), 
TF2B4_HALSA (Q9HR45), TF2B6_HALSA (Q9HSB3), TF2B7_HALSA (Q9HSF7), 
TF2B_ARCFU  (O28970), TF2B_BOVIN  (Q2KIN8), TF2B_CAEEL  (O16991), 
TF2B_CALMQ  (A8MCX6), TF2B_DICDI  (Q54FD6), TF2B_DROME  (P29052), 
TF2B_DROVI  (Q9NHP7), TF2B_ENCCU  (Q8SRP3), TF2B_HUMAN  (Q00403), 
TF2B_IGNH4  (A8AC96), TF2B_KLULA  (Q05959), TF2B_MACFA  (Q4R3J5), 
TF2B_META3  (A6UW60), TF2B_METAC  (Q8TT29), TF2B_METB6  (A7IAR4), 
TF2B_METJA  (Q58192), TF2B_METKA  (Q8TX21), TF2B_METM5  (A4G0F2), 
TF2B_METM6  (A9A8Q0), TF2B_METM7  (A6VI28), TF2B_METMA  (P0CW15), 
TF2B_METMJ  (A3CSQ6), TF2B_METMP  (Q6M176), TF2B_METMZ  (P0CW14), 
TF2B_METPE  (B8GJQ9), TF2B_METS3  (A5UKA1), TF2B_METST  (Q2NEL6), 
TF2B_METTH  (O26971), TF2B_METTL  (Q9P9I7), TF2B_METTP  (A0B5T8), 
TF2B_MOUSE  (P62915), TF2B_ORYSJ  (Q8W0W3), TF2B_PONAB  (Q5R886), 
TF2B_PYRAB  (Q9V0V5), TF2B_PYRAE  (Q8ZWS3), TF2B_PYRAR  (A4WMA6), 
TF2B_PYRFU  (P61998), TF2B_PYRHO  (O59151), TF2B_PYRIL  (A1RV37), 
TF2B_PYRNV  (B1YCX0), TF2B_PYRWO  (P61999), TF2B_RAT    (P62916), 
TF2B_SCHPO  (O13749), TF2B_SOYBN  (P48513), TF2B_XENLA  (P29054), 
TF2B_YEAST  (P29055), TF3B_CANAL  (P43072), TF3B_HUMAN  (Q92994), 
TF3B_KLULA  (P46070), TF3B_MOUSE  (Q8CFK2), TF3B_SCHPO  (Q9P6R0), 
TF3B_YEAST  (P29056), YTF2_SULSH  (P46221)
» More

UniProtKB/Swiss-Prot
False negative sequences
6 sequences

LYSW_SULAC  (Q4JAQ0), LYSW_SULSO  (Q980W8), LYSW_SULTO  (Q976J8), 
LYSW_THET8  (Q5SH22), TF2B5_HALSA (Q9HHH8), TF2B_MIMIV  (Q5UPT1)
» More

PDB
[Detailed view]
10 PDB

1DL6; 1PFT; 1RLY; 1RO4; 3K1F; 3K7A; 4BBR; 4BBS; 4V1N; 4V1O

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