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| Entry: PS51323 |
General information about the entry
| Entry name [info] | IGFBP_N_2 |
| Accession [info] | PS51323 |
| Entry type [info] | MATRIX |
| Date [info] | 01-JUL-2007 CREATED; 10-MAY-2017 DATA UPDATE; 05-JUL-2017 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00194 |
| Associated ProRule [info] | PRU00653 |
Name and characterization of the entry
| Description [info] | Insulin-like growth factor-binding protein (IGFBP) N-terminal domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=82; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=77; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.9973607; R2=0.0059624; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=12126.1552734; R2=3.8296416; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=923; H_SCORE=15661; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=588; H_SCORE=14378; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-38; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-255; BD=-255; /M: SY='R'; M= 4, 8, -75, 3, -76, -15, -72, 0, -62, -22, -69, -70, -83, 32, 43, 31, -24, 3, -84, 18; /M: SY='G'; M= 28, -84, -16, 3, -25, 33, 28, -75, -7, 21, -68, -69, -11, -2, -74, 7, -26, -74, -88, -75; /M: SY='Q'; M= 23, -81, 32, -17, -24, -6, -71, -69, 2, 4, -67, -64, -17, 51, -68, 27, -20, 4, -87, -73; /M: SY='S'; M= -29, -80, 9, 18, -17, 28, 29, -75, 25, -21, -71, 6, -25, -60, 6, 29, 19, -11, -87, -71; /M: SY='C'; M= -66, 146, -84, -84, -77, -81, -85, -81, -81, -23, -73, -72, -94, -85, -87, 20, -9, -71,-104, -85; /M: SY='P'; M= 6, -84, -70, -27, -86, 33, 6, -81, -27, -43, -73, -65, 82, 23, -20, 20, 21, -78, -86, -79; /M: SY='P'; M= -68, -86, -2, 14, -77, -4, 32, -72, -16, 22, -66, -67, 75, 18, -71, 21, 1, -74, 31, -72; /I: I=-30; MD=-77; /M: SY='Q'; M= -6, 18, -91, -23,-107, -97, 0, -97, 19,-101, -93, -88, 24, 29, -20, -12, -87, -14,-110, -98; D=-30; /I: I=-30; MI=-77; IM=-77; DM=-77; /M: SY='C'; M= -69, 146, -79, -9, -81, -22, -83, -87, -79, -79, -77, 8, 8, -84, -86, -69, -68, -76,-105, -89; /M: SY='D'; M= -35, -82, 70, -17, -17, -23, -63, -76, -19, 2, -71, 41, -76, 31, 19, -16, 30, -75, -91, -72; /I: I=-24; MI=0; MD=-61; IM=0; DM=-61; /M: SY='P'; M= -79, -98, -76, 24, -80, -88, -76, -81, -14, 1, -75, -80, 60, 33, 21, -6, -76, -42, 52, 16; D=-24; /I: I=-24; DM=-61; /M: SY='C'; M= 31, 86, 37, 2, -85, -70, -70, -83, 26, -81, -76, -59, -77, -2, 3, 39, -3, -74, -92, -78; /M: SY='P'; M= 4, -82, -69, -18, -16, 26, -70, -79, 44, -18, -5, -64, 46, -60, 34, 36, -63, -76, -82, -73; /M: SY='C'; M= -29, 143, -84, -29, -77, -82, -84, -83, -76, -77, -76, -74, -93, -10, -5, -19, -69, -34, 55, -81; /M: SY='P'; M= 17, -87, -15, 14, 4, 3, -75, -2, -69, -42, -71, -71, 93, -7, -77, -24, -2, -72, -83, -76; /I: I=-19; MD=-47; /M: SY='P'; M= -33, -88, 21, -23, -92, -24, -77, -83, 14, -89, -82, -67, 74, -69, -74, 42, 26, -29, -96, -85; D=-19; /I: I=-19; MD=-47; /M: SY='P'; M= -10, -96, -87, -31, 0, -27, -88, -74, -82, -9, -76, -87, 84, -83, -24, -10, -76, 10, -94, -84; D=-19; /I: I=-19; MD=-47; /M: SY='P'; M= -82, 50, -91, -84, -98, -92, -90, -23, -77, -93, -87, -87, 69, -83, 34, 24, -78, -10,-106, -95; D=-19; /I: I=-19; MD=-47; /M: SY='C'; M= -34, 61, -29, -84, -96, -92, -92, -87, -84, -45, -86, -81, 45, -14, -21, -5, 49, -26,-110, -95; D=-19; /I: I=-19; MI=-47; MD=-47; IM=-47; DM=-47; /M: SY='C'; M= -3, 96, 22, 15, -82, -28, -74, -82, 21, -20, 2, 14, -25, 0, -21, -67, -16, -77, 27, -79; D=-19; /I: I=-19; DM=-47; /M: SY='C'; M= -11, 94, 9, 16, -84, 2, -76, -85, -21, -47, -78, -70, 71, -70, -24, 3, -68, -80, -91, -11; D=-19; /I: I=-19; DM=-47; /M: SY='C'; M= 10, 96, -76, 2, -78, 9, -77, -79, -76, -8, -73, -7, 72, -76, -83, -69, -70, -77, -88, 11; D=-19; /I: I=-19; DM=-47; /M: SY='G'; M= 13, 38, 10, -74, -78, 54, -77, -75, -75, -39, -74, -68, 45, -75, -25, -4, -69, 10, -84, 19; D=-19; /I: I=-19; DM=-47; /M: SY='G'; M= -26, -83, -68, 42, 8, 50, -74, -18, -3, 1, -65, -69, -77, -64, 16, -31, -69, 24, 26, -69; /I: I=-28; MD=-71; /M: SY='G'; M= 18, -81, -73, 0, -76, 33, -74, -2, -67, 12, -65, -68, 8, 3, 18, 25, 5, -11, -86, -75; D=-28; /I: I=-28; MD=-71; /M: SY='V'; M= -28, -81, -79, -4, -68, -83, -77, -20, -71, 25, 29, -76, 20, -70, 15, 26, 4, 44, -88, -17; D=-28; /I: I=-28; MI=-71; IM=-71; DM=-71; /M: SY='V'; M= -32, -80, -78, -69, -69, -85, -74, 15, 24, 6, 11, -72, -6, 15, 47, -68, 20, 51, -86, -69; /M: SY='D'; M= -6, -84, 54, 12, -79, -78, -68, -71, 30, 14, 2, -62, 41, -8, 29, -65, 2, -29, -88, -74; /I: I=-30; MD=-77; /M: SY='D'; M= -79, -95, 88, 48, -95, -35, 44, -95, -67, -42, -86, -58, 23, -63, -74, -71, -73, -92,-106, -81; D=-30; /I: I=-30; MI=-77; IM=-77; DM=-77; /M: SY='G'; M= 29, -83, -19, 25, -81, 48, 12, -7, 5, -78, -71, -63, 6, 26, 12, -23, -68, -32, -82, -8; /M: SY='C'; M= -69, 148, -87, -87, -78, -12, -87, -83, -84, -23, -74, -75, 8, -89, -90, -71, -69, -73,-104, -88; /M: SY='G'; M= -21, -84, 22, -2, -91, 90, -72, -95, -70, -91, -82, 10, -75, 14, -77, -57, -72, -89, -85, -83; /M: SY='C'; M= -12, 148, -85, -20, -77, -83, -86, -81, -82, -19, -73, -75, -96, -87, -88, -70, -69, -71,-104, -87; /M: SY='C'; M= -24, 148, -87, -88, -77, -12, -87, -82, -84, -19, -73, -75, -96, -89, -90, -70, -69, -72,-104, -87; /M: SY='W'; M= -33, -85, 12, 38, -74, -75, -65, -75, 3, 2, 28, 10, 27, -7, 36, 28, -65, -75, 60, -8; /M: SY='V'; M= -63, -77, -78, -1, -67, 6, -81, 19, -71, -27, 30, -73, -79, -73, 2, -66, 41, 72, -90, -70; /M: SY='C'; M= -67, 150, -85, -86, -79, -82, -87, -85, -82, -77, -76, -72, -95, -88, -89, -5, 2, -73,-107, -88; /M: SY='A'; M= 77, -73, -77, -73, -75, 24, -77, 5, -73, 0, 28, -70, -76, -70, -77, -26, 2, -58, -83, -75; /M: SY='R'; M= 18, -83, -72, -65, -75, -34, -66, -72, 4, 26, -63, 12, 9, -57, 84, -21, -68, -71, -84, -71; /M: SY='Q'; M= 25, -83, -67, 5, -79, 29, 7, -72, -18, -2, -65, -9, -77, 77, 22, -60, -68, -8, -82, -12; /M: SY='E'; M= -70, -87, -51, 88, -11, -83, -64, 13, -53, -5, -67, 5, -11, 32, 18, -67, -68, -70, -84, -72; /M: SY='G'; M= -20, -84, -14, -79, -88, 97, -76, -96, -75, -92, -82, 15, -77, -73, -82, -57, -74, -90, 33, -82; /M: SY='E'; M= -2, -88, 24, 84, -92, -11, 6, -89, -53, -83, -75, -60, -69, 78, -59, -60, -68, -83, -87, -76; /M: SY='P'; M= -14, -83, -11, 0, -74, -76, 3, -1, 8, 10, -64, -66, 52, 16, 21, 28, 12, -25, -84, -8; /M: SY='C'; M= -69, 155, -89, -89, -79, -85, -89, -86, -85, -77, -77, -75,-100, -93, -91, -72, -69, -74,-109, -90; /M: SY='G'; M= -61, -82, 49, -68, -15, 78, -69, -90, -70, -88, -81, 31, -76, -68, -77, 22, -18, -86, -85, -10; /I: I=-26; MD=-65; /M: SY='V'; M= -65, -83, -71, 25, -77, 41, 29, -59, -69, -32, 26, -9, -7, -14, -4, -66, 7, 51, -91, -74; D=-26; /I: I=-26; MI=-65; MD=-65; IM=-65; DM=-65; /M: SY='Y'; M= 2, -85, 6, -69, -59, 2, -65, -22, 9, 18, -62, -70, 22, -4, 19, -67, 5, -68, -68, 73; D=-26; /I: I=-26; DM=-65; /M: SY='T'; M= -15, -83, 37, 22, -77, -3, -1, -33, -63, -78, -73, 25, 15, 15, -21, -59, 56, -32, 28, 17; D=-26; /I: I=-26; DM=-65; /M: SY='P'; M= -9, -84, 6, 41, -73, -33, -71, -66, -67, 30, 28, -71, 66, -8, -32, 10, -66, -33, 35, -72; /I: I=-12; MD=-31; /M: SY='C'; M= -26, 91, -17, -75, -10, 28, -76, -23, -69, -19, -70, -5, -20, -71, 26, 39, -64, -3, -90, -75; D=-12; /I: I=-12; MD=-31; /M: SY='H'; M= -91,-106, 52, -19, -98, -39, 56,-104, 3, -99, -3, -10, -14, -13, 14, -83, -86,-103,-108, -6; D=-12; /I: I=-12; MD=-31; /M: SY='H'; M= -16,-105, 8, -4, -19, 16, 33,-106, -86,-103, -96, 3, 11, 14, -91, -31, -27,-103,-109, -92; D=-12; /I: I=-12; MI=0; MD=-31; IM=0; DM=-31; /M: SY='C'; M= -80, 144,-100,-100, -90, -96,-100, -97, -96, -88, -88, -86,-111,-103,-102, -83, -80, -85,-120,-101; D=-12; /I: I=-12; DM=-31; /M: SY='G'; M= 52, -78, 23, -68, -85, 60, 32, -23, -22, -81, -74, -59, -75, -67, -74, 20, -16, -73, -87, -77; /M: SY='P'; M= -31, -85, 18, 27, -83, -76, -68, -76, 52, -20, -71, -62, 54, 25, 4, 19, -11, -14, -87, -76; /M: SY='G'; M= -25, -84, -10, -23, -89, 91, 17, -94, -70, -90, -80, 14, -76, -4, -34, -57, -26, -88, -85, -81; /M: SY='L'; M= -75, -77, -92, -84, -48, -93, -73, -41, -84, 89, 49, -90, -91, -77, -81, -84, -71, -48, -77, 1; /M: SY='R'; M= -69, -85, -63, 48, 7, -82, 46, -70, -51, -35, -66, -65, -77, 22, 67, 5, -21, 16, -80, 18; /M: SY='C'; M= -69, 155, -89, -89, -79, -85, -89, -86, -85, -77, -77, -75,-100, -93, -91, -72, -69, -74,-109, -90; /M: SY='H'; M= -32, -82, 32, -1, -75, -42, 68, -64, -3, -41, -65, -60, -77, 29, 33, -19, 25, 38, -90, -11; /I: I=-10; MD=-27; /M: SY='P'; M= -20, -86, -78, -25, 30, -82, -74, -24, -1, 18, -63, -77, 74, 2, -75, -4, -12, -3, -77, 20; D=-10; /I: I=-10; MD=-27; /M: SY='R'; M= -72, -89, -13, -12, -82, 6, -67, -84, -16, -22, -74, 37, 58, -61, 66, -2, -24, -83, -87, -10; D=-10; /I: I=-10; MD=-27; /M: SY='P'; M= 29, -83, -72, -68, -2, -8, 8, -77, 1, -80, -74, -2, 70, -16, -20, -1, 38, -29, -87, -76; D=-10; /I: I=-10; MD=-27; /M: SY='D'; M= -31, -88, 72, -13, -94, 58, -71, -94, -23, -92, -85, -56, 28, 14, -74, 8, -69, -89, -93, -83; D=-10; /I: I=-10; MD=-27; /M: SY='E'; M= -74, -91, -10, 55, 9, 16, -76, -20, -31, -13, 7, -73, 5, -66, 13, -7, -74, -11, -89, -76; D=-10; /I: I=-10; MD=-27; /M: SY='D'; M= -33, -96, 57, 25, -98, -12, 29, -98, -66, -97, -89, 10, 37, -67, 24, -1, -74, -95,-104, -85; D=-10; /I: I=-10; MD=-27; /M: SY='R'; M= -10, -97, 4, -81, -94, 16, -85, -90, -7, -7, -3, -14, 7, -78, 28, -7, -21, -89,-102, -90; D=-10; /I: I=-10; MD=-27; /M: SY='P'; M= -77, -99, 7, -4, -92, 7, -79, -97, -22, -98, -89, -75, 65, -73, 15, 33, -75, -95, -93, 16; D=-10; /I: I=-10; MD=-27; /M: SY='L'; M= -12, -92, -17, -2, -83, 9, -81, -79, 15, 31, -72, -12, -90, -74, 8, 1, -25, -79, -96, -84; D=-10; /I: I=-10; MD=-27; /M: SY='R'; M= -19,-108, -98, -91, -98, -11, -7, -9, -33, -42, -89, -90,-103, 12, 33, -86, 14, -91,-106, -8; D=-10; /I: I=-10; MI=0; MD=-27; IM=0; DM=-27; /M: SY='L'; M= -42,-104,-103, -27, -17, -12, 0, -79, -98, 31, 6, -99,-108, -95, -30, -33, -29, -26,-107, -88; D=-10; /I: I=-10; DM=-27; /M: SY='L'; M= -92,-105, -94, 13, -90, -52, 0, -22, -92, 25, -79, -96, 7, -88, -29, -4, -23, -39,-110, -93; D=-10; /I: I=-10; DM=-27; /M: SY='D'; M= -22,-101, 20, 10, -94, 6, -6, -88, -24, -22, -85, -80, -94, 13, -21, -80, -1, -10,-103, -12; D=-10; /I: I=-10; DM=-27; /M: SY='G'; M= -76, -99, -80, 10,-101, 51, -87,-100, -24,-101, -93, -16, 15, -13, -19, 18, -81, -37, 13, -94; D=-10; /I: I=-10; DM=-27; /M: SY='R'; M= -17, -96, -78, 26, -90, -91, -79, -27, -30, -52, -80, -78, -89, 22, 51, 7, 1, -10, -96, -12; D=-10; /I: I=-10; DM=-27; /M: SY='G'; M= -6, -90, -77, -85, -97, 84, -83,-100, -81, -99, -88, 8, 12, -79, -88, 1, -76, -94, -91, -91; D=-10; /I: I=-10; DM=-27; /M: SY='V'; M= -70, -82, -85, -79, -66, -92, -83, 47, -21, 23, -54, -78, -85, -11, 22, -72, 38, 48, -90, -71; D=-10; /I: I=-10; DM=-27; /M: SY='C'; M= -69, 155, -89, -89, -79, -85, -89, -86, -85, -77, -77, -75,-100, -93, -91, -72, -69, -74,-109, -90; /M: SY='Q'; M= -28, -79, -70, 13, -66, -43, -68, -54, 4, 8, 30, -12, -78, 47, -12, -3, 17, 44, -81, 26; /M: SY='C'; M= 5, 124, 19, -13, -80, -76, -74, -84, 8, -80, -76, 22, 26, -73, -74, -65, -16, -76, -95, -8; /M: SY='K'; M= 34, 5, -17, 35, -79, -75, -68, -30, 38, 4, -66, 11, -10, 16, 23, -62, -19, -21, -86, -74; /I: E1=0; IE=-255; DE=-255;» more |
Numerical results [info]
| Total number of hits | 98 in 98 different sequences |
| Number of true positive hits | 98 in 98 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 1 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | window20 |
| Author [info] | CJA_Sigrist |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Feature key [info] | DOMAIN |
| Feature description [info] | IGFBP N-terminal |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
98 sequences
CRIM1_CHICK (Q8AWW5 ), CRIM1_DANRE (Q7T3Q2 ), CRIM1_HUMAN (Q9NZV1 ), CRIM1_MOUSE (Q9JLL0 ), CTGF_BOVIN (O18739 ), CTGF_HUMAN (P29279 ), CTGF_MOUSE (P29268 ), CTGF_PIG (O19113 ), CTGF_RAT (Q9R1E9 ), CYR61_CHICK (P19336 ), CYR61_HUMAN (O00622 ), CYR61_MOUSE (P18406 ), CYR61_PANTR (A5A6L1 ), CYR61_RAT (Q9ES72 ), ESM1_HUMAN (Q9NQ30 ), ESM1_MOUSE (Q9QYY7 ), ESM1_RAT (P97682 ), HTR1A_DANRE (Q6GMI0 ), HTR1B_DANRE (A9JRB3 ), HTRA1_BOVIN (F1N152 ), HTRA1_HUMAN (Q92743 ), HTRA1_MOUSE (Q9R118 ), HTRA1_RAT (Q9QZK5 ), HTRA1_XENLA (A6YFB5 ), HTRA1_XENTR (A4IHA1 ), HTRA3_HUMAN (P83110 ), HTRA3_MOUSE (Q9D236 ), HTRA3_RAT (D3ZA76 ), HTRA4_BOVIN (E1BJW1 ), HTRA4_HUMAN (P83105 ), HTRA4_MOUSE (A2RT60 ), HTRA4_RAT (D3ZKF5 ), IBP1_BOVIN (P24591 ), IBP1_HUMAN (P08833 ), IBP1_ICTTR (Q6Q484 ), IBP1_MOUSE (P47876 ), IBP1_PIG (Q75ZP3 ), IBP1_RAT (P21743 ), IBP2A_DANRE (Q9PTH3 ), IBP2B_DANRE (B3F211 ), IBP2_BOVIN (P13384 ), IBP2_CHICK (P49705 ), IBP2_HUMAN (P18065 ), IBP2_MOUSE (P47877 ), IBP2_PIG (P24853 ), IBP2_RAT (P12843 ), IBP2_SHEEP (Q29400 ), IBP2_XENLA (Q5XHC5 ), IBP2_XENTR (A4IIA2 ), IBP3_BOVIN (P20959 ), IBP3_HUMAN (P17936 ), IBP3_MOUSE (P47878 ), IBP3_PIG (P16611 ), IBP3_RAT (P15473 ), IBP4_BOVIN (Q05716 ), IBP4_HUMAN (P22692 ), IBP4_MOUSE (P47879 ), IBP4_PIG (P24854 ), IBP4_RAT (P21744 ), IBP4_SHEEP (Q28893 ), IBP5_BOVIN (Q05717 ), IBP5_HUMAN (P24593 ), IBP5_MOUSE (Q07079 ), IBP5_PIG (Q28985 ), IBP5_RAT (P24594 ), IBP5_XENLA (Q90WV8 ), IBP6_BOVIN (Q05718 ), IBP6_HUMAN (P24592 ), IBP6_MOUSE (P47880 ), IBP6_RAT (P35572 ), IBP7_HUMAN (Q16270 ), IBP7_MOUSE (Q61581 ), IBPL1_BOVIN (A5PKD8 ), IBPL1_HUMAN (Q8WX77 ), IBPL1_MOUSE (Q80W15 ), IGFBP_CUPSA (G4V4G1 ), KAZD1_HUMAN (Q96I82 ), KAZD1_MOUSE (Q8BJ66 ), NOV_CHICK (P28686 ), NOV_COTJA (P42642 ), NOV_HUMAN (P48745 ), NOV_MOUSE (Q64299 ), NOV_RAT (Q9QZQ5 ), NOV_XENLA (P51609 ), PLSLP_LOTGI (B3A0Q9 ), PLS_HALLA (P82595 ), SIBD1_CUPSA (G4V4F9 ), SIBD2_CUPSA (G4V4G0 ), VP302_LYCMC (P0CJ14 ), VP59_LYCMC (P0CJ12 ), WISP1_HUMAN (O95388 ), WISP1_MOUSE (O54775 ), WISP1_RAT (Q99PP0 ), WISP2_HUMAN (O76076 ), WISP2_MOUSE (Q9Z0G4 ), WISP2_RAT (Q9JHC6 ), WISP3_HUMAN (O95389 ), WISP3_MOUSE (D3Z5L9 )» more
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| UniProtKB/Swiss-Prot 'Partial' sequences |
1 sequence
IBP2_ONCTS (P83628 ) |
| PDB [Detailed view] |
9 PDB
1BOE; 1H59; 1WQJ; 2DSP; 2DSQ; 2DSR; 3TJQ; 3ZXB; 3ZXC |
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