Entry: PS51323

Forthcoming changes to the profile format
General information about the entry

Entry name [info] IGFBP_N_2
Accession [info] PS51323
Entry type [info] MATRIX
Date [info] JUL-2007 (CREATED); OCT-2013 (DATA UPDATE); MAR-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00194
Associated ProRule [info] PRU00653

Name and characterization of the entry

Description [info] Insulin-like growth factor-binding protein (IGFBP) N-terminal domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=82;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=77;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.9973607; R2=0.0059624; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=11952.46528; R2=16.66435; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=923; N_SCORE=8.5; H_SCORE=24534; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=588; N_SCORE=6.5; H_SCORE=21734; MODE=1; TEXT='?';
/DEFAULT: M0=-38; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='R'; M=   4,   8, -75,   3, -76, -15, -72,   0, -62, -22, -69, -70, -83,  32,  43,  31, -24,   3, -84,  18;
/M: SY='G'; M=  28, -84, -16,   3, -25,  33,  28, -75,  -7,  21, -68, -69, -11,  -2, -74,   7, -26, -74, -88, -75;
/M: SY='Q'; M=  23, -81,  32, -17, -24,  -6, -71, -69,   2,   4, -67, -64, -17,  51, -68,  27, -20,   4, -87, -73;
/M: SY='S'; M= -29, -80,   9,  18, -17,  28,  29, -75,  25, -21, -71,   6, -25, -60,   6,  29,  19, -11, -87, -71;
/M: SY='C'; M= -66, 146, -84, -84, -77, -81, -85, -81, -81, -23, -73, -72, -94, -85, -87,  20,  -9, -71,-104, -85;
/M: SY='P'; M=   6, -84, -70, -27, -86,  33,   6, -81, -27, -43, -73, -65,  82,  23, -20,  20,  21, -78, -86, -79;
/M: SY='P'; M= -68, -86,  -2,  14, -77,  -4,  32, -72, -16,  22, -66, -67,  75,  18, -71,  21,   1, -74,  31, -72;
/I:         I=-30; MD=-77;
/M: SY='Q'; M=  -6,  18, -91, -23,-107, -97,   0, -97,  19,-101, -93, -88,  24,  29, -20, -12, -87, -14,-110, -98; D=-30;
/I:         I=-30; MI=-77; IM=-77; DM=-77;
/M: SY='C'; M= -69, 146, -79,  -9, -81, -22, -83, -87, -79, -79, -77,   8,   8, -84, -86, -69, -68, -76,-105, -89;
/M: SY='D'; M= -35, -82,  70, -17, -17, -23, -63, -76, -19,   2, -71,  41, -76,  31,  19, -16,  30, -75, -91, -72;
/I:         I=-24; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='P'; M= -79, -98, -76,  24, -80, -88, -76, -81, -14,   1, -75, -80,  60,  33,  21,  -6, -76, -42,  52,  16; D=-24;
/I:         I=-24; DM=-61;
/M: SY='C'; M=  31,  86,  37,   2, -85, -70, -70, -83,  26, -81, -76, -59, -77,  -2,   3,  39,  -3, -74, -92, -78;
/M: SY='P'; M=   4, -82, -69, -18, -16,  26, -70, -79,  44, -18,  -5, -64,  46, -60,  34,  36, -63, -76, -82, -73;
/M: SY='C'; M= -29, 143, -84, -29, -77, -82, -84, -83, -76, -77, -76, -74, -93, -10,  -5, -19, -69, -34,  55, -81;
/M: SY='P'; M=  17, -87, -15,  14,   4,   3, -75,  -2, -69, -42, -71, -71,  93,  -7, -77, -24,  -2, -72, -83, -76;
/I:         I=-19; MD=-47;
/M: SY='P'; M= -33, -88,  21, -23, -92, -24, -77, -83,  14, -89, -82, -67,  74, -69, -74,  42,  26, -29, -96, -85; D=-19;
/I:         I=-19; MD=-47;
/M: SY='P'; M= -10, -96, -87, -31,   0, -27, -88, -74, -82,  -9, -76, -87,  84, -83, -24, -10, -76,  10, -94, -84; D=-19;
/I:         I=-19; MD=-47;
/M: SY='P'; M= -82,  50, -91, -84, -98, -92, -90, -23, -77, -93, -87, -87,  69, -83,  34,  24, -78, -10,-106, -95; D=-19;
/I:         I=-19; MD=-47;
/M: SY='C'; M= -34,  61, -29, -84, -96, -92, -92, -87, -84, -45, -86, -81,  45, -14, -21,  -5,  49, -26,-110, -95; D=-19;
/I:         I=-19; MI=-47; MD=-47; IM=-47; DM=-47;
/M: SY='C'; M=  -3,  96,  22,  15, -82, -28, -74, -82,  21, -20,   2,  14, -25,   0, -21, -67, -16, -77,  27, -79; D=-19;
/I:         I=-19; DM=-47;
/M: SY='C'; M= -11,  94,   9,  16, -84,   2, -76, -85, -21, -47, -78, -70,  71, -70, -24,   3, -68, -80, -91, -11; D=-19;
/I:         I=-19; DM=-47;
/M: SY='C'; M=  10,  96, -76,   2, -78,   9, -77, -79, -76,  -8, -73,  -7,  72, -76, -83, -69, -70, -77, -88,  11; D=-19;
/I:         I=-19; DM=-47;
/M: SY='G'; M=  13,  38,  10, -74, -78,  54, -77, -75, -75, -39, -74, -68,  45, -75, -25,  -4, -69,  10, -84,  19; D=-19;
/I:         I=-19; DM=-47;
/M: SY='G'; M= -26, -83, -68,  42,   8,  50, -74, -18,  -3,   1, -65, -69, -77, -64,  16, -31, -69,  24,  26, -69;
/I:         I=-28; MD=-71;
/M: SY='G'; M=  18, -81, -73,   0, -76,  33, -74,  -2, -67,  12, -65, -68,   8,   3,  18,  25,   5, -11, -86, -75; D=-28;
/I:         I=-28; MD=-71;
/M: SY='V'; M= -28, -81, -79,  -4, -68, -83, -77, -20, -71,  25,  29, -76,  20, -70,  15,  26,   4,  44, -88, -17; D=-28;
/I:         I=-28; MI=-71; IM=-71; DM=-71;
/M: SY='V'; M= -32, -80, -78, -69, -69, -85, -74,  15,  24,   6,  11, -72,  -6,  15,  47, -68,  20,  51, -86, -69;
/M: SY='D'; M=  -6, -84,  54,  12, -79, -78, -68, -71,  30,  14,   2, -62,  41,  -8,  29, -65,   2, -29, -88, -74;
/I:         I=-30; MD=-77;
/M: SY='D'; M= -79, -95,  88,  48, -95, -35,  44, -95, -67, -42, -86, -58,  23, -63, -74, -71, -73, -92,-106, -81; D=-30;
/I:         I=-30; MI=-77; IM=-77; DM=-77;
/M: SY='G'; M=  29, -83, -19,  25, -81,  48,  12,  -7,   5, -78, -71, -63,   6,  26,  12, -23, -68, -32, -82,  -8;
/M: SY='C'; M= -69, 148, -87, -87, -78, -12, -87, -83, -84, -23, -74, -75,   8, -89, -90, -71, -69, -73,-104, -88;
/M: SY='G'; M= -21, -84,  22,  -2, -91,  90, -72, -95, -70, -91, -82,  10, -75,  14, -77, -57, -72, -89, -85, -83;
/M: SY='C'; M= -12, 148, -85, -20, -77, -83, -86, -81, -82, -19, -73, -75, -96, -87, -88, -70, -69, -71,-104, -87;
/M: SY='C'; M= -24, 148, -87, -88, -77, -12, -87, -82, -84, -19, -73, -75, -96, -89, -90, -70, -69, -72,-104, -87;
/M: SY='W'; M= -33, -85,  12,  38, -74, -75, -65, -75,   3,   2,  28,  10,  27,  -7,  36,  28, -65, -75,  60,  -8;
/M: SY='V'; M= -63, -77, -78,  -1, -67,   6, -81,  19, -71, -27,  30, -73, -79, -73,   2, -66,  41,  72, -90, -70;
/M: SY='C'; M= -67, 150, -85, -86, -79, -82, -87, -85, -82, -77, -76, -72, -95, -88, -89,  -5,   2, -73,-107, -88;
/M: SY='A'; M=  77, -73, -77, -73, -75,  24, -77,   5, -73,   0,  28, -70, -76, -70, -77, -26,   2, -58, -83, -75;
/M: SY='R'; M=  18, -83, -72, -65, -75, -34, -66, -72,   4,  26, -63,  12,   9, -57,  84, -21, -68, -71, -84, -71;
/M: SY='Q'; M=  25, -83, -67,   5, -79,  29,   7, -72, -18,  -2, -65,  -9, -77,  77,  22, -60, -68,  -8, -82, -12;
/M: SY='E'; M= -70, -87, -51,  88, -11, -83, -64,  13, -53,  -5, -67,   5, -11,  32,  18, -67, -68, -70, -84, -72;
/M: SY='G'; M= -20, -84, -14, -79, -88,  97, -76, -96, -75, -92, -82,  15, -77, -73, -82, -57, -74, -90,  33, -82;
/M: SY='E'; M=  -2, -88,  24,  84, -92, -11,   6, -89, -53, -83, -75, -60, -69,  78, -59, -60, -68, -83, -87, -76;
/M: SY='P'; M= -14, -83, -11,   0, -74, -76,   3,  -1,   8,  10, -64, -66,  52,  16,  21,  28,  12, -25, -84,  -8;
/M: SY='C'; M= -69, 155, -89, -89, -79, -85, -89, -86, -85, -77, -77, -75,-100, -93, -91, -72, -69, -74,-109, -90;
/M: SY='G'; M= -61, -82,  49, -68, -15,  78, -69, -90, -70, -88, -81,  31, -76, -68, -77,  22, -18, -86, -85, -10;
/I:         I=-26; MD=-65;
/M: SY='V'; M= -65, -83, -71,  25, -77,  41,  29, -59, -69, -32,  26,  -9,  -7, -14,  -4, -66,   7,  51, -91, -74; D=-26;
/I:         I=-26; MI=-65; MD=-65; IM=-65; DM=-65;
/M: SY='Y'; M=   2, -85,   6, -69, -59,   2, -65, -22,   9,  18, -62, -70,  22,  -4,  19, -67,   5, -68, -68,  73; D=-26;
/I:         I=-26; DM=-65;
/M: SY='T'; M= -15, -83,  37,  22, -77,  -3,  -1, -33, -63, -78, -73,  25,  15,  15, -21, -59,  56, -32,  28,  17; D=-26;
/I:         I=-26; DM=-65;
/M: SY='P'; M=  -9, -84,   6,  41, -73, -33, -71, -66, -67,  30,  28, -71,  66,  -8, -32,  10, -66, -33,  35, -72;
/I:         I=-12; MD=-31;
/M: SY='C'; M= -26,  91, -17, -75, -10,  28, -76, -23, -69, -19, -70,  -5, -20, -71,  26,  39, -64,  -3, -90, -75; D=-12;
/I:         I=-12; MD=-31;
/M: SY='H'; M= -91,-106,  52, -19, -98, -39,  56,-104,   3, -99,  -3, -10, -14, -13,  14, -83, -86,-103,-108,  -6; D=-12;
/I:         I=-12; MD=-31;
/M: SY='H'; M= -16,-105,   8,  -4, -19,  16,  33,-106, -86,-103, -96,   3,  11,  14, -91, -31, -27,-103,-109, -92; D=-12;
/I:         I=-12; MI=0; MD=-31; IM=0; DM=-31;
/M: SY='C'; M= -80, 144,-100,-100, -90, -96,-100, -97, -96, -88, -88, -86,-111,-103,-102, -83, -80, -85,-120,-101; D=-12;
/I:         I=-12; DM=-31;
/M: SY='G'; M=  52, -78,  23, -68, -85,  60,  32, -23, -22, -81, -74, -59, -75, -67, -74,  20, -16, -73, -87, -77;
/M: SY='P'; M= -31, -85,  18,  27, -83, -76, -68, -76,  52, -20, -71, -62,  54,  25,   4,  19, -11, -14, -87, -76;
/M: SY='G'; M= -25, -84, -10, -23, -89,  91,  17, -94, -70, -90, -80,  14, -76,  -4, -34, -57, -26, -88, -85, -81;
/M: SY='L'; M= -75, -77, -92, -84, -48, -93, -73, -41, -84,  89,  49, -90, -91, -77, -81, -84, -71, -48, -77,   1;
/M: SY='R'; M= -69, -85, -63,  48,   7, -82,  46, -70, -51, -35, -66, -65, -77,  22,  67,   5, -21,  16, -80,  18;
/M: SY='C'; M= -69, 155, -89, -89, -79, -85, -89, -86, -85, -77, -77, -75,-100, -93, -91, -72, -69, -74,-109, -90;
/M: SY='H'; M= -32, -82,  32,  -1, -75, -42,  68, -64,  -3, -41, -65, -60, -77,  29,  33, -19,  25,  38, -90, -11;
/I:         I=-10; MD=-27;
/M: SY='P'; M= -20, -86, -78, -25,  30, -82, -74, -24,  -1,  18, -63, -77,  74,   2, -75,  -4, -12,  -3, -77,  20; D=-10;
/I:         I=-10; MD=-27;
/M: SY='R'; M= -72, -89, -13, -12, -82,   6, -67, -84, -16, -22, -74,  37,  58, -61,  66,  -2, -24, -83, -87, -10; D=-10;
/I:         I=-10; MD=-27;
/M: SY='P'; M=  29, -83, -72, -68,  -2,  -8,   8, -77,   1, -80, -74,  -2,  70, -16, -20,  -1,  38, -29, -87, -76; D=-10;
/I:         I=-10; MD=-27;
/M: SY='D'; M= -31, -88,  72, -13, -94,  58, -71, -94, -23, -92, -85, -56,  28,  14, -74,   8, -69, -89, -93, -83; D=-10;
/I:         I=-10; MD=-27;
/M: SY='E'; M= -74, -91, -10,  55,   9,  16, -76, -20, -31, -13,   7, -73,   5, -66,  13,  -7, -74, -11, -89, -76; D=-10;
/I:         I=-10; MD=-27;
/M: SY='D'; M= -33, -96,  57,  25, -98, -12,  29, -98, -66, -97, -89,  10,  37, -67,  24,  -1, -74, -95,-104, -85; D=-10;
/I:         I=-10; MD=-27;
/M: SY='R'; M= -10, -97,   4, -81, -94,  16, -85, -90,  -7,  -7,  -3, -14,   7, -78,  28,  -7, -21, -89,-102, -90; D=-10;
/I:         I=-10; MD=-27;
/M: SY='P'; M= -77, -99,   7,  -4, -92,   7, -79, -97, -22, -98, -89, -75,  65, -73,  15,  33, -75, -95, -93,  16; D=-10;
/I:         I=-10; MD=-27;
/M: SY='L'; M= -12, -92, -17,  -2, -83,   9, -81, -79,  15,  31, -72, -12, -90, -74,   8,   1, -25, -79, -96, -84; D=-10;
/I:         I=-10; MD=-27;
/M: SY='R'; M= -19,-108, -98, -91, -98, -11,  -7,  -9, -33, -42, -89, -90,-103,  12,  33, -86,  14, -91,-106,  -8; D=-10;
/I:         I=-10; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='L'; M= -42,-104,-103, -27, -17, -12,   0, -79, -98,  31,   6, -99,-108, -95, -30, -33, -29, -26,-107, -88; D=-10;
/I:         I=-10; DM=-27;
/M: SY='L'; M= -92,-105, -94,  13, -90, -52,   0, -22, -92,  25, -79, -96,   7, -88, -29,  -4, -23, -39,-110, -93; D=-10;
/I:         I=-10; DM=-27;
/M: SY='D'; M= -22,-101,  20,  10, -94,   6,  -6, -88, -24, -22, -85, -80, -94,  13, -21, -80,  -1, -10,-103, -12; D=-10;
/I:         I=-10; DM=-27;
/M: SY='G'; M= -76, -99, -80,  10,-101,  51, -87,-100, -24,-101, -93, -16,  15, -13, -19,  18, -81, -37,  13, -94; D=-10;
/I:         I=-10; DM=-27;
/M: SY='R'; M= -17, -96, -78,  26, -90, -91, -79, -27, -30, -52, -80, -78, -89,  22,  51,   7,   1, -10, -96, -12; D=-10;
/I:         I=-10; DM=-27;
/M: SY='G'; M=  -6, -90, -77, -85, -97,  84, -83,-100, -81, -99, -88,   8,  12, -79, -88,   1, -76, -94, -91, -91; D=-10;
/I:         I=-10; DM=-27;
/M: SY='V'; M= -70, -82, -85, -79, -66, -92, -83,  47, -21,  23, -54, -78, -85, -11,  22, -72,  38,  48, -90, -71; D=-10;
/I:         I=-10; DM=-27;
/M: SY='C'; M= -69, 155, -89, -89, -79, -85, -89, -86, -85, -77, -77, -75,-100, -93, -91, -72, -69, -74,-109, -90;
/M: SY='Q'; M= -28, -79, -70,  13, -66, -43, -68, -54,   4,   8,  30, -12, -78,  47, -12,  -3,  17,  44, -81,  26;
/M: SY='C'; M=   5, 124,  19, -13, -80, -76, -74, -84,   8, -80, -76,  22,  26, -73, -74, -65, -16, -76, -95,  -8;
/M: SY='K'; M=  34,   5, -17,  35, -79, -75, -68, -30,  38,   4, -66,  11, -10,  16,  23, -62, -19, -21, -86, -74;
/I:         E1=0; IE=-255; DE=-255;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_04 which contains 544'996 sequence entries.


Total number of hits 98 in 98 different sequences
Number of true positive hits 98 in 98 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 0
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] IGFBP N-terminal
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
98 sequences

CRIM1_CHICK (Q8AWW5), CRIM1_DANRE (Q7T3Q2), CRIM1_HUMAN (Q9NZV1), 
CRIM1_MOUSE (Q9JLL0), CTGF_BOVIN  (O18739), CTGF_HUMAN  (P29279), 
CTGF_MOUSE  (P29268), CTGF_PIG    (O19113), CTGF_RAT    (Q9R1E9), 
CYR61_CHICK (P19336), CYR61_HUMAN (O00622), CYR61_MOUSE (P18406), 
CYR61_PANTR (A5A6L1), CYR61_RAT   (Q9ES72), ESM1_HUMAN  (Q9NQ30), 
ESM1_MOUSE  (Q9QYY7), ESM1_RAT    (P97682), HTR1A_DANRE (Q6GMI0), 
HTR1B_DANRE (A9JRB3), HTRA1_BOVIN (F1N152), HTRA1_HUMAN (Q92743), 
HTRA1_MOUSE (Q9R118), HTRA1_RAT   (Q9QZK5), HTRA1_XENLA (A6YFB5), 
HTRA1_XENTR (A4IHA1), HTRA3_HUMAN (P83110), HTRA3_MOUSE (Q9D236), 
HTRA3_RAT   (D3ZA76), HTRA4_BOVIN (E1BJW1), HTRA4_HUMAN (P83105), 
HTRA4_MOUSE (A2RT60), HTRA4_RAT   (D3ZKF5), IBP1_BOVIN  (P24591), 
IBP1_HUMAN  (P08833), IBP1_MOUSE  (P47876), IBP1_PIG    (Q75ZP3), 
IBP1_RAT    (P21743), IBP1_SPETR  (Q6Q484), IBP2A_DANRE (Q9PTH3), 
IBP2B_DANRE (B3F211), IBP2_BOVIN  (P13384), IBP2_CHICK  (P49705), 
IBP2_HUMAN  (P18065), IBP2_MOUSE  (P47877), IBP2_PIG    (P24853), 
IBP2_RAT    (P12843), IBP2_SHEEP  (Q29400), IBP2_XENLA  (Q5XHC5), 
IBP2_XENTR  (A4IIA2), IBP3_BOVIN  (P20959), IBP3_HUMAN  (P17936), 
IBP3_MOUSE  (P47878), IBP3_PIG    (P16611), IBP3_RAT    (P15473), 
IBP4_BOVIN  (Q05716), IBP4_HUMAN  (P22692), IBP4_MOUSE  (P47879), 
IBP4_PIG    (P24854), IBP4_RAT    (P21744), IBP4_SHEEP  (Q28893), 
IBP5_BOVIN  (Q05717), IBP5_HUMAN  (P24593), IBP5_MOUSE  (Q07079), 
IBP5_PIG    (Q28985), IBP5_RAT    (P24594), IBP5_XENLA  (Q90WV8), 
IBP6_BOVIN  (Q05718), IBP6_HUMAN  (P24592), IBP6_MOUSE  (P47880), 
IBP6_RAT    (P35572), IBP7_HUMAN  (Q16270), IBP7_MOUSE  (Q61581), 
IBPL1_BOVIN (A5PKD8), IBPL1_HUMAN (Q8WX77), IBPL1_MOUSE (Q80W15), 
IGFBP_CUPSA (G4V4G1), KAZD1_HUMAN (Q96I82), KAZD1_MOUSE (Q8BJ66), 
NOV_CHICK   (P28686), NOV_COTJA   (P42642), NOV_HUMAN   (P48745), 
NOV_MOUSE   (Q64299), NOV_RAT     (Q9QZQ5), NOV_XENLA   (P51609), 
PLSLP_LOTGI (B3A0Q9), PLS_HALLA   (P82595), SIBD1_CUPSA (G4V4F9), 
SIBD2_CUPSA (G4V4G0), VP302_LYCMC (P0CJ14), VP59_LYCMC  (P0CJ12), 
WISP1_HUMAN (O95388), WISP1_MOUSE (O54775), WISP1_RAT   (Q99PP0), 
WISP2_HUMAN (O76076), WISP2_MOUSE (Q9Z0G4), WISP2_RAT   (Q9JHC6), 
WISP3_HUMAN (O95389), WISP3_MOUSE (D3Z5L9)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

IBP2_ONCTS  (P83628)

		
PDB
[Detailed view]
9 PDB

1BOE; 1H59; 1WQJ; 2DSP; 2DSQ; 2DSR; 3TJQ; 3ZXB; 3ZXC

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