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Entry: PS51337

General information about the entry

Entry name [info] B12_BINDING_NTER
Accession [info] PS51337
Entry type [info] MATRIX
Date [info] 01-NOV-2007 CREATED; 10-MAY-2017 DATA UPDATE; 22-NOV-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC51332
Associated ProRule [info] PRU00667

Name and characterization of the entry

Description [info] B12-binding N-terminal domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=95;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=92;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0990186; R2=0.0076604; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=12199.7734375; R2=8.7261305; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1032; H_SCORE=21205; N_SCORE=10.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=575; H_SCORE=17217; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-19; D=-90; I=-90; E0=-100; B1=-400; E1=-400; MI=-205; MD=-205; IM=-205; DM=-205;
...
                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-205; BD=-205;
/M: SY='K'; M= 21,-50, -4, 25,-51,-17, -4,-15, 30,-35,-39, -1, 21,-11, 12, -1, 10, -3,-57,-45;
/M: SY='D'; M= 22,-50, 35, 28,-52,  2,-18,-25, 19,-26,-20, 17, -8,-15, -3, -9, -1,-16,-59,-46;
/M: SY='E'; M=  5,-51, 20, 36,-28,-11,-38,-14, 11,  4,-25,-14,  4, 11, -9, 14,-11,-10,-56,-43;
/M: SY='E'; M= 16,-51,-21, 47,-25,-16,-40,  5,  0, -2,-10,-37, 14, 13,-18,  3, -5,-12, -9,-42;
/M: SY='W'; M=-12,-56,  7, 13,-11,-25,-16,  9,  4,  1,-12, -7,  7, -1,-16,-27, -8,-13, 91, 17;
/M: SY='R'; M= 22,-50,-24, 15,-28,-32,-29,-36, 15,-20,-12, -7, 21,-11, 43, 16, -9, -2,-55,-43;
/M: SY='P'; M= 21,-51, 17, 37,-47,-10,-30,-19,  1,-36,-43, 33, 40,  0,-36,  5, -7,-31,-59,-48;
/M: SY='E'; M=  8,-51, 20, 31,-21,-23,-39,-14, 10, 30, 25,-20,-25, 10,-35,-26,-23,-16, 19,-38;
/M: SY='P'; M=-15,-53, 13, 20,-52,-10,-39,-29, -3,-34,-30,  3, 62,-11, -3, 15, 27,-22,-58,-25;
/M: SY='P'; M=-20,-49,-33,-45,-34,-40, -9, 16,-31, 34,  3,-12, 36,-43, -8,-12, 12, 35,-57,-39;
/M: SY='E'; M=-10,-52, 13, 51, 15,-33,-38, -4,  7,  8,-12, -6,-26, -6,  0,-16,-23, -1,-29,-37;
/M: SY='E'; M=-17,-56, 23, 73,-53,-37, -9,-53, 26,-25,-43,-15,-39, 21,  8,-34,-26,-38,-54, -6;
/M: SY='R'; M=-25,-56,  4, 14,-54,-22,-34,-24, 28,-49, -7,-31, 10, 18, 68,  4, -6,-31,-55,-43;
/M: SY='L'; M=-43,-48,-31,-53, -7,-63,-49, 38,-34, 66, 22,-56,-58,-48,-51,-52,-38, 15,-50,-31;
/M: SY='A'; M= 32,-49,-34, 27,-19,-33, 17,-28, 28,-28,-38, -2,-45, -5, 24,  9,-15, -8,-51,  3;
/M: SY='H'; M=-17,-55, 23, 30,-36,-46, 61,-50, 25,-21,-38, 22,-45, 35, 22,-33,-17,-38,-54, 17;
/M: SY='A'; M= 61,-46,-20,-19,-43,-37, 11,-12, 10,-18, -7,-37,-25, 10,  6, -9,-20,-33,-48, 18;
/M: SY='I'; M=-39,-49,-61,-55,-25,-64,-55, 58,-30, 44, 17,-56,-56,-50,-53,-50,-35, 47,-54,-34;
/M: SY='V'; M=-28,-49,-56,-14,  5,-62,-24, 50,-51, 19, 14,-53,-54,-49,-52,-47,-34, 59,-50, 12;
/M: SY='D'; M=-20,-56, 60, 53,-57,-46, 17,-58, 41,-52,-48,-12,-40, 18,-13,-12,-22,-54,-60,-20;
/M: SY='G'; M= -5,-15,-17,-26,-57, 87,-46,-40,-44,-59,-50,-29,-46,-16,-36,-15,-43,-55,-51,-25;
/M: SY='D'; M=-41,-54, 56, 33,-42,-36,-41, 46, -8,  5,-27,-12,-46,-33,-10,-19, -6,-22,-59,-41;
/M: SY='K'; M=-34,-53, 11, 12,-46,-15,-35,-40, 51,-13, -2,-18,-27, -6, 42, -5, 11,-23,-52,  0;
/M: SY='E'; M=-11,-54, 59, 68,-58,-30,-33,-33, -9,-46,-49,  9,-39, -5,-15,-10,  1,-45,-63,-48;
/M: SY='G'; M=-18,-54,  7, 20, 21, 51,-10,-23,-24,-25,-11, 11,-12,-35,-11,-10,-39,-46,-43, 32;
/M: SY='I'; M=  2, -3,-13,-34,-25,-56,-51, 57,-29, 30, 13,-24,-52,-46,-50,-29, -9, 30,-55,-37;
/M: SY='E'; M=-22,-52,  7, 49,-45,-13,-27, 19, 11,-20,-22, -9,-44,  6, -8,-20,  3, 24,-56,-20;
/M: SY='E'; M= 30,-51, 35, 57,-56, -7,-36,-54, -5,-51,-47, -8,  8,  3,-35, 10, -8,-42,-58,-26;
/M: SY='D'; M=  1,-52, 61, -4,-41,  7,-28,-27, -5, 26,-33,-25,-48,  2,-40,-21,-24,-13, 31, -8;
/M: SY='T'; M=  0,-44,-52,-49,-31,-54,-51, 19,-47, 36, -6,-45,-50,-47,-50,-34, 51, 46,-58,-38;
/M: SY='E'; M=-23,-56, 33, 69,-55,-33,-32,-20, 18,-46,-44,  6,-27, 32,  0,-27,-27,-26,-57,-21;
/I:         I=-14; MD=-31;
/M: SY='E'; M=-10,-31, 21, 67,-54,-38,-36,-22, 37,-20,-43,-28,-41,  5,  1,-20,-30,-27,-57,-47; D=-14;
/I:         I=-14; MD=-31;
/M: SY='A'; M= 68,-21,-48,-22,-42,  8,-48,-21,-35, 12,-25,-44,-48,-40,-47,-28,-35,-14, 36,-12; D=-14;
/I:         I=-14; MD=-31;
/M: SY='L'; M=-43,-50,-56,-48,-17,-55,-45, 16,-16, 57, 18,-51,-57,-41, 32,-47,  1,  6,-14,-18; D=-14;
/I:         I=-14; MD=-31;
/M: SY='Q'; M= 17,-54, 10, 33,-56,-24,-36,-45, 36,-29, -5,  2,-36, 48, -1,-13, -9,-37,-57,-46; D=-14;
/I:         I=-14; MD=-31;
/M: SY='E'; M= 20,-38, -5, 37,-50,-41,  4,-13, 27,-10,-38,  1,-45, 21,  8,-17,  3,-41,-56,-21; D=-14;
/I:         I=-14; MD=-31;
/M: SY='G'; M= -3,-48,-41,  7, -3, 54,-25,-12, -7,-16,-28, -7,-50,-33,-10,-31,-35,-33,-42, 45; D=-14;
/I:         I=-14; MD=-31;
/M: SY='W'; M=  4,-52,  0, 11,-28,-23,-31, -3, 20, 10,  0,-21, 12,-35,-16, -2,  9,  2, 21,-42; D=-14;
/I:         I=-14; MD=-31;
/M: SY='D'; M=-17,-68, 42, 13,-69,-58,-20,-41, 13,-52,-51,-20,-58,-11,  0, -4,-10,-61,-75,-39; D=-14;
/I:         I=-14; MI=0; MD=-31; IM=0; DM=-31;
/M: SY='P'; M= 13,-32,-41,  2,-62,-43,-46,-51,-39,-58,-47,-48,110,-40,-50,-33,-27,-51,-57,-58;
/M: SY='L'; M=-35,-50,-40,-31, 18,-59,-41, 32,-47, 52, 30,-51,-56, 20,-32,-36,-39, -1,-41, 31;
/M: SY='D'; M=  7,-53, 54, 48,-57,-38, 17,-40,  3,-47,-46,  9,-41, 27, -8,  6,  2,-43,-62,-45;
/M: SY='I'; M=-19,-50,-61,-57,-27,-63,-59, 73,-54, 25, -3,-54,-54,-52,-56,-47,-19, 45,-54,-35;
/M: SY='I'; M=-38,-51,-60,-57, -9,-62,-58, 77,-54, 20,-15,-52,-53,-51,-56, -4,-33, 39,-53,-34;
/M: SY='N'; M=-40,-50, 31, 49,  0,-40,-28,-30,-27,-35,-44, 79,-45,  3,-35,-28, -2,-23,-62,-43;
/M: SY='D'; M=-36,-54, 50, 45,-59, 43,-35,-48,  0,-57,-50, 30,-42,  6,-22,-26, -1,-44,-61,-49;
/M: SY='P'; M= 20,-54,-19,-27,-17, 33, 11,  7,-30,-23,-37,-30, 59,-14,-32,-26,-28,-27,-45, 32;
/M: SY='L'; M=-45,-47,-62,-54,  1,-63,-45, -1,-55, 79, 27,-60,-61,-48,-52,-55,-41,-17,-48,-29;
/M: SY='M'; M=-11,-48,-57,-51,-29,-54,-44, 49,-46, 24, 86,-47,-50,-42,-27,  2, -7, 10,-53,-33;
/M: SY='P'; M=  8,-55, 41, -1,-54,-19,-41,-31,  7,-24,-20, -5, 72, -7,-23,-16,-19, -5,-59,-49;
/M: SY='G'; M= 41,-49,-43,-47,-58, 81,-48,-59,-25,-57,-48,-31,-45,-41,-49,-17,-40,-50,-52,-53;
/M: SY='M'; M=-40,-48,-62,-52,-26,-56,-36, 29,-47, 23,120,-50,-50,-39,-45,-50,-38,-16,-51,-29;
/M: SY='N'; M=-19,-52, 34, 30,-57,  5,-32,-55, 46,-56,-47, 48,-43, -9,  8, -1, -2,-40,-60,-47;
/M: SY='E'; M=-30,-53,-23, 51,-40,-38, 11, 34,-17,-21, -9,-41,-45, -1, 11,-39,-15, 39,-56,-11;
/M: SY='V'; M= -9,-44,-60,-54,-32,-60,-62, 24,-52,-10,-20,-55,-56,-54,-54,-43,-29, 87,-64,-39;
/M: SY='G'; M=-26,-52,-41,-51,-59, 90,-47,-50,-45,-61,-51,-27,-45,-42,-52, 17,-17,-57,-52,-53;
/M: SY='D'; M=-23,-57, 71, 50,-59,-47,-32,-42,  6,-53,-49,-15,-42, 14, 37,-33,-20,-29,-64,-46;
/M: SY='L'; M=-44,-50, -8,-24,-27,-59,-40,-20,  4, 65, 27,-48,-56,-16, 33,-48,-40,-26,-51,-34;
/M: SY='Y'; M=-51,-54,-57,-57, 90,-58,-30,-30,-50,-23,-28,-53,-62,-52,-47,-48,-44,-35, 21, 91;
/M: SY='G'; M=-21,-55, 34, 52,-60, 56,-36,-62,-29,-58,-50,  6,-42, 13, -4,-13,-23,-56,-58,-50;
/M: SY='Q'; M= 18,-51, 32, 19,-57,-40,-33,-52, 35,-52,-44, 12,-43, 35, 28, 24,-31,-28,-58,-45;
/M: SY='G'; M=-30,-53,-35,-45,-59, 84,-41,-65, -5,-62,-51, 41,-46, -8,-13,-27,-41,-60,-54,-53;
/M: SY='E'; M=-39,-56, -9, 55,-49,-53,-38, 27, 54,-35,-36,-34,-41, 29,-12,-36,-25,  0,-54,-43;
/M: SY='M'; M= -2,-49,-56,-49, -3,-55,-37, 26,-25, 27, 85,-49,-53,-40, -2,-45,-38,  8,-41, 42;
/M: SY='F'; M=-50,-52,-58,-50,100,-58,-40,  4,-48,-16,-27,-50,-60, 34,-46,-47,-43,-31,-22, 32;
/M: SY='L'; M=-41,-46,-62,-55,-21,-64,-50, 11,-55, 71, -9,-60,-60,-50,-53,-52,-37, 40,-52,-33;
/M: SY='P'; M=-11,-65,-44,-33,-62,-44,-47,-50,-40,-59,-47,-48,115,-43,-52,-38,  0,-53,-57,-59;
/M: SY='Q'; M=-40,-57, 15, 27, 34,-46, 25,-50,-24,-44,-38, 23,-46, 93,-26,-31,-38,-51,-48,-30;
/M: SY='V'; M=-35,-45,-61,-54,-26,-62,-54, -2,-53, 48, 27,-58,-58,-51,-53,-48,-33, 71,-58,-35;
/M: SY='M'; M=-40,-48,-62,-55,-24,-62,-48, 45,-53, 53, 67,-56,-56,-47,-52,-51,-37, 29,-52,-32;
/M: SY='Q'; M=-19,-53,-42,-27,-43,-50,-34, -9, 43, 20, 50,-36,-47, 70, 10,-22,-37,-24,-50,-37;
/M: SY='S'; M= 44,-41,-37,-36,-51,-15,-40,-24,-37,-50,-44,-27,-42,-30,-41, 80, -9,-37,-58,-45;
/M: SY='A'; M= 83,-40,-44,-38,-54,  1,-46,-44,-40,-46,-40,-37,-44,-36,-45, 13,-29,-32,-54,-49;
/M: SY='E'; M=-27,-58, 37, 67,-60,-21,-31,-60,  7,-55,-48,  4,-41, 30, 44,-21,-37,-55,-59,-47;
/M: SY='T'; M= 43,-40,-44,-42,-43,-42,-50,-16,-41,-34,-32,-36,-44,-42,-46, -5, 65, 44,-61,-44;
/M: SY='M'; M=-37,-46,-61,-51,-29,-54,-34,-10,-45, -7,127,-49,-49,-37,-43,-48,-36, 23,-53,-29;
/M: SY='K'; M=-40,-54,  4,-23,-43,-48,-15,-28, 78,-15,  5,-14,-44, 27, -6,-24, -8,-44,-46, 24;
/M: SY='K'; M= 41,-49, -9,  8,-47,  0,-26,-34, 44,-49,-24,  3,  0, 21,-12, -3, -5,-42,-53,-28;
/M: SY='A'; M= 67, -8,-44,-42,-54, 49,-47,-28,-42,-49,-42,-34,-45,-39,-47, 12,-24,-37,-54,-50;
/M: SY='V'; M=-38,-47,-62,-56, 56,-61,-51, 22,-53, 12, 54,-55,-57,-53,-52,-48,-35, 61,-45,-22;
/M: SY='A'; M= 50,-48, 36, 42,-25, -4,-39,-51,-17,-51,-45,-22,  9,-29,-26, -1, -2,-42,-57,-47;
/M: SY='Y'; M=-32,-35,-52,-48, 14,-58, 45, 40,-26, 11, -4,-46,-55,-41, 14,-45,-39, 16,  2, 67;
/M: SY='L'; M=-44, 51,-62,-55,-21,-63,-49, 21,-56, 74, -9,-59,-61,-50,-54,-53,-40, -9,-51,-33;
/M: SY='K'; M=-26,-53,-22, 46,-51,-48,-34,-15, 52,-20,  0, 12,-41, 22, 16,-11, 11,-34,-55,-43;
/M: SY='P'; M=-22,-62, -5, 24,-62,-44,-41,-52,-21,-58,-47,-40,100, 22,-42,  0,-11,-53,-57,-55;
/M: SY='Y'; M=-39,-53,-41, 15, 35,-54, 42,-28,  6, 21, -4,-13,-52, -9,  7,-25,-27,-15,-34, 61;
/M: SY='M'; M=-32,-47,-59,-52,-24,-57,-43, 33,-50, 55, 82,-51,-54,-43,-49, -6,-16,-15,-51,-31;
/M: SY='E'; M= -4,-54,  8, 69,-27, -9,-36,-25, 12,-49,-44, -8, 10,  4,-19, -8,  1,-19,-57,-46;
/M: SY='K'; M= 21,-51,-26, 38,-56,  6, -8,-49, 50,-42,-43,-24,-41, 22,  2, 21,-25,-47,-54,-45;
/M: SY='E'; M=  3,-49, 27, 42,-54, -3,-36,-42, 20,-49,-11, 18,-19, -5,-32, 19, 21, -8,-60,-46;
/M: SY='K'; M= 13,-52, 24, 18,-56, 22, -5,-52, 31,-53,-12,  9, 29,-19,  2,  8,-17,-34,-58,-47;
/M: SY='E'; M= 19,-50, -4, 26,-53, 18,  6,-31, 19,-31,-41, -3,  0, 11,  2, 15, -9, -7,-57,-45;
/M: SY='P'; M= 21,-51, 13, 27,-52, 13,-38,-44, 12,-35,-36, -8, 28, 10,-30, 19,  2,-18,-55,-17;
/M: SY='K'; M=-22,-38, -5, 23,-51, 20,  6,-38, 45,-25, -1,  6,-38,  2, -8, 15, 23,-43,-56,-40;
/M: SY='G'; M= -4,-42, -4,-14,-49, 37,-29,  9, 26,-17,-33,-19,-19, 14,  8,  9,  4,-10,-55,-44;
/I:         E1=0; IE=-205; DE=-205;
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Post-processing [info]

PROMOTED_BY PS51332

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_11 which contains 556'196 sequence entries.


Total number of hits 43 in 43 different sequences
Number of true positive hits 43 in 43 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] N_Hulo
Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] B12-binding N-terminal
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
43 sequences

CARH_MYXXA  (Q50900    ), METH_ALIFS  (Q9AJQ8    ), METH_BOVIN  (Q4JIJ3    ), 
METH_CAEBR  (A8XY95    ), METH_CAEEL  (Q09582    ), METH_DICDI  (Q54P92    ), 
METH_ECOLI  (P13009    ), METH_HUMAN  (Q99707    ), METH_MOUSE  (A6H5Y3    ), 
METH_MYCLE  (Q49775    ), METH_MYCTU  (O33259    ), METH_PSEAE  (Q9I2Q2    ), 
METH_RAT    (Q9Z2Q4    ), METH_SALTY  (P37586    ), METH_SYNY3  (Q55786    ), 
METH_VIBCH  (Q9KUW9    ), METH_VIBF1  (Q5E814    ), METH_VIBPA  (Q87L95    ), 
METH_VIBVU  (Q8DCJ7    ), METH_VIBVY  (Q7MHB1    ), MTAC_METBF  (Q46EH4    ), 
MTBC1_METAC (Q8TTB0    ), MTBC1_METMA (P58979    ), MTBC2_METAC (Q8TS71    ), 
MTBC2_METMA (P58980    ), MTBC3_METAC (Q8TN69    ), MTBC3_METMA (P58981    ), 
MTBC_METBA  (O93657    ), MTGC_DESHY  (Q24SP8    ), MTMC1_METAC (P58867    ), 
MTMC1_METBA (O30641    ), MTMC1_METMA (P58977    ), MTMC2_METAC (P58868    ), 
MTMC2_METBA (Q9P9L5    ), MTMC2_METMA (P58978    ), MTSB_METBA  (Q48925    ), 
MTSB_METMA  (Q8PUA7    ), MTTC1_METAC (Q8TTA8    ), MTTC1_METMA (P58982    ), 
MTTC2_METAC (Q8TS74    ), MTTC2_METMA (P58983    ), MTTC_METBA  (O93659    ), 
Y1042_HAEIN (Q57195    )
» more

PDB
[Detailed view]
8 PDB

1BMT; 1K7Y; 1K98; 2I2X; 3BUL; 3EZX; 3IV9; 3IVA

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