PROSITE entry PS51401

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General information about the entry

Entry name [info]	CHORD
Accession [info]	PS51401
Entry type [info]	MATRIX
Date [info]	01-AUG-2008 CREATED; 07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51401
Associated ProRule [info]	PRU00734

Name and characterization of the entry

Description [info]

CHORD domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=60;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=55;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7634766; R2=0.0060944; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=8861.1591797; R2=2.0322392; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=2008; H_SCORE=12942; N_SCORE=15.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=614; H_SCORE=10109; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-47; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='K';  M= -61, -76, -60, -49, -63, -61, -37, -66,  67, -60, -59, -53, -68,  44,  50, -30,  28,  -4, -67,  44;
/M: SY='N';  M= -65, -74, -45, -54, -75, -60,  68, -80, -39, -78, -65,  97, -73, -46,  71, -51, -55, -79, -89, -62;
/M: SY='K';  M= -37, -77, -61, -53,  14,  -4, -59,   0,  59, -24, -59,  19,  30,  28,  33, -37, -13, -64, -70, -16;
/M: SY='G';  M=   0,   9, -65, -74, -81,  97, -71, -87, -69, -83, -73, -51, -68, -67, -76, -29, -26, -79, -75, -77;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='G';  M= -24, -42,  13, -17, -79,  77, -62, -80,   4, -38, -41,  37, -68, -20, -43,  -6, -24, -76, -78, -73;
/M: SY='K';  M=  23, -74, -43,  -5, -71,  -4, -58, -68,  66, -14, -40, -35, -66,  61, -29, -34,  -5, -39, -71,   5;
/M: SY='T';  M= -15, -70, -24,  31, -27, -49, -18, -59,  22, -32,  -5, -38, -65, -52,  12,   6,  63,   6, -74,  25;
/M: SY='Y';  M= -74, -77, -79, -78,  95, -80, -11, -53, -72, -47, -51, -74, -84, -73, -69, -70, -67, -58,  29, 102;
/I:         I=-17; MD=-42;
/M: SY='T';  M= -16, -73,  45,  12, -74, -68, -60, -19,  41, -44, -63,   4, -66,  12,  11, -12,  49, -10, -83, -67; D=-17;
/I:         I=-17; MD=-42;
/M: SY='P';  M= -50, -82,  33,  53, -83,  39, -63, -77, -18, -64, -72, -24,  72, -28, -65, -37, -61, -22, -82, -76; D=-17;
/I:         I=-17; MD=-42;
/M: SY='D';  M=  -9, -81,  41,  34, -84,   9, -63, -81,  10, -47, -73,  15,  13, -19,  20, -30,  11, -77, -87, -75; D=-17;
/I:         I=-17; MI=0; MD=-42; IM=0; DM=-42;
/M: SY='D';  M= -31, -78,  68,  60, -85, -24, -37, -84, -12, -82, -77,  18, -65, -18, -59,  29, -15, -78, -90, -73; D=-17;
/I:         I=-17; DM=-42;
/M: SY='N';  M= -60, -71, -25, -31, -78, -19, -50, -77, -10, -82, -70, 101, -72, -51,  26,  28, -14, -48, -91, -71; D=-17;
/I:         I=-17; DM=-42;
/M: SY='H';  M=  -7, -74,  50,  33, -75, -55,  51, -71, -39, -28, -65,  46,  36, -25, -60,  -3,  27, -38, -88, -66;
/M: SY='D';  M= -11, -78,  71,  56, -51,  16, -56, -81,  -3, -80, -74,  13,  19,  -9, -58,  -2, -57, -77, -84, -71;
/M: SY='E';  M= -12, -74,  45,  68, -78,  24, -58, -76, -24, -37, -69,   8, -62, -10, -59, -19,  36, -70, -83, -71;
/M: SY='S';  M=  50, -19, -14,  -8, -73, -43, -64, -45, -20, -48, -37, -25,  16, -12,   5,  54, -14,   7, -80, -68;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='H';  M= -34, -31, -35, -36,  -6, -74,  43,   0,   2,  -3, -23, -12, -71,   9,  29, -18,  37,  42,  -1, -56;
/M: SY='Y';  M= -71, -81, -66, -67,  22, -76,  87, -62, -14, -56, -51, -62, -79, -57, -58, -64, -66, -66, -39, 117;
/I:         I=-4; MD=-11;
/M: SY='H';  M=-119,-130,-102,-103,-117,-120, 155,-136,-107,-118,-103, -92,-119, -96,-101,-108,-117,-135,-153, -86; D=-4;
/I:         I=-4; MD=-11;
/M: SY='P';  M= -19, -85, -40, -42, -84, -66, -68, -75, -11, -83, -71, -52, 111, -62, -19,  25, -26, -76, -81, -79; D=-4;
/I:         I=-4; MD=-11;
/M: SY='G';  M= -19, -78, -62,   0, -84,  91, -69, -89,  -8, -85, -75, -52, -68, -13, -69,  -5, -66, -82, -76, -77; D=-4;
/I:         I=-4; MD=-11;
/M: SY='P';  M=  27, -76, -49, -10, -74,  20, -69, -56, -28, -66, -12, -65,  65,  35, -30, -56, -32,  38, -80, -40; D=-4;
/I:         I=-4; MI=0; MD=-11; IM=0; DM=-11;
/M: SY='P';  M=  20, -87, -69, -58, -84, -67, -72, -26, -65, -80, -69, -73, 117, -67, -76, -61, -60, -72, -80, -82; D=-4;
/I:         I=-4; DM=-11;
/M: SY='I';  M= -60,  21, -84, -80,   2, -86, -81,  67, -75, -20, -17, -76, -79, -76, -34, -25, -57,  66, -77,  -5; D=-4;
/I:         I=-4; DM=-11;
/M: SY='F';  M=-125,-121,-137,-133, 128,-132,-117, -98,-128, -90,-100,-126,-135,-138,-125, -80,-116,-103, -90, -68; D=-4;
/I:         I=-4; DM=-11;
/M: SY='H';  M= -69, -82, -57, -56, -69, -72, 139, -86, -57, -71, -58, -47, -72, -49,   9,  -5, -68, -85,  43, -41; D=-4;
/I:         I=-4; DM=-11;
/M: SY='D';  M= -66, -83,  90,  81, -88, -71, -55, -87, -49, -82, -80, -46, -63, -45, -59, -58, -61, -82, -92, -74; D=-4;
/I:         I=-4; DM=-11;
/M: SY='G';  M=  16,  -9, -68, -71, -76,  78, -70, -39, -62, -11, -66, -56, -71, -64,  24, -52,   2, -69, -77, -73; D=-4;
/I:         I=-4; DM=-11;
/M: SY='M';  M= -59, -73, -67,  -6, -53, -41, -32, -37,   4,  12,  86, -38, -72,  21, -60,  38, -44, -17, -67,  51; D=-4;
/I:         I=-4; DM=-11;
/M: SY='K';  M= -63, -77, -56, -43, -79, -71, -58, -79, 104, -78, -66, -49, -64, -40,  22, -56, -11, -74, -73, -66;
/I:         I=-19; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='G';  M= -56, -77, -62,   7,  19,  72, -12, -28, -38, -68, -64, -56, -71, -27, -32,   5, -63, -70, -57,  68;
/I:         I=-26; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='W';  M=-123,-147,-147,-127, -86,-122,-141,-119,-119,-117,-119,-142,-127,-119,-122,-129,-134,-133, 181,  33;
/M: SY='S';  M= -11, -67, -58, -55, -72, -24, -61, -66,  39, -28, -63, -19,  -3, -34, -24,  76,  31, -17, -80, -66;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/I:         I=-24; MD=-61;
/M: SY='C';  M=-111, 157,-131,-131,-121,-126,-131,-128,-127,-119,-119,-117,-142,-134,-133,-114,-111,-116,-151,-132; D=-24;
/I:         I=-24; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='K';  M= -62, -30,  51,  31, -81, -13, -54, -80,  66, -78, -24,  41, -33,  19,  -1, -28, -57, -77, -81, -68;
/I:         I=-30; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='K';  M=  -5, -77, -62, -49, -74, -71, -60,   6,  74, -67, -59, -55,  15,  27,  55, -58, -43,  -3, -75, -65;
/M: SY='R';  M= -63, -78, -58,  -8, -72, -72,  42, -35,  67, -18, -60, -53, -36, -11,  74,  -2, -60, -70, -76, -41;
/I:         I=-12; MD=-30;
/M: SY='V';  M=  -9,  22, -70, -68, -36, -71, -75, -42, -31, -56, -56, -61, -71, -67, -70,  36,  62,  63, -87, -66; D=-12;
/I:         I=-12; MD=-30;
/M: SY='Y';  M= -61, -73, -68, -66,   4, -73,  47, -55,   7,  32, -51, -61, -75, -60, -28,  37,  28, -17,  12,  52; D=-12;
/I:         I=-12; MD=-30;
/M: SY='D';  M= -65, -80,  97,  55, -86, -68, -56, -85, -53, -82, -80, -11, -65, -50, -62, -19,   7, -80, -96, -73; D=-12;
/I:         I=-12; MD=-30;
/M: SY='F';  M= -78, -77, -92, -85, 114, -84, -73, -54, -80, -46, -55, -81, -87, -89, -78, -77, -72, -60,  93, -22; D=-12;
/I:         I=-12; MD=-30;
/M: SY='D';  M= -60, -76,  81,  32, -83,   4, -58, -82, -56, -82, -77,  28, -66, -53, -64,  32,  20, -77, -93, -72; D=-12;
/I:         I=-12; MD=-30;
/M: SY='E';  M=   3, -78,  47,  78, -80, -71, -59, -75, -51, -20, -68, -54, -63,  22, -59, -19,  17, -55, -85, -71; D=-12;
/I:         I=-12; MD=-30;
/M: SY='F';  M= -78, -74, -90, -85, 117, -85, -71, -51, -81, -21, -52, -80, -88, -90, -78, -77, -70, -56,  33, -22; D=-12;
/I:         I=-12; MD=-30;
/M: SY='M';  M= -29, -71, -82, -25, -49, -82, -65, -37, -36,  62, 101, -77, -78, -65, -70, -73, -63,  -2, -76, -56; D=-12;
/I:         I=-12; MD=-30;
/M: SY='K';  M=  26, -72,  -3,  26, -80, -28, -59, -77,  53, -78, -69,  39, -66, -18, -49,  32,   5, -70, -82, -71; D=-12;
/I:         I=-12; MD=-30;
/M: SY='I';  M= -66, -80, -79, -70, -26, -86, -74,  88, -70, -10, -41, -72, -76,  59, -71, -69, -61,   1, -73,  -4; D=-12;
/I:         I=-12; MD=-30;
/M: SY='P';  M=   5, -83, -58,  40, -82, -70, -66, -72,  40, -78, -69, -64,  89, -28, -21, -49, -40, -16, -80, -76; D=-12;
/I:         I=-12; MD=-30;
/M: SY='G';  M= -27, -82, -67, -69, -85,  81, -72, -85, -24, -86, -75, -58,  74, -68, -75, -55, -28, -82, -78, -81; D=-12;
/I:         I=-12; MD=-30;
/M: SY='C';  M=-111, 157,-131,-131,-121,-126,-131,-128,-127,-119,-119,-117,-142,-134,-133,-114,-111,-116,-151,-132; D=-12;
/I:         I=-12; MI=0; MD=-30; IM=0; DM=-30;
/M: SY='T';  M=  27,  44, -61, -27, -74, -66, -68, -66,  18, -69, -64, -39, -66, -20, -27,   2,  84, -46, -86, -70; D=-12;
/I:         I=-12; MI=0; MD=-30; IM=0; DM=-30;
/M: SY='K';  M= -59, -73, -61,   0, -31, -73, -63, -46,  55, -48, -19, -37, -68, -18,  36,  12,  46,  20, -79, -35; D=-12;
/I:         I=-12; DM=-30;
/M: SY='G';  M= -29, -78, -22, -75, -85,  98, -72, -91, -71, -87, -77, -31, -70, -68, -78, -42, -44, -84, -77, -79; D=-12;
/I:         I=-12; DM=-30;
/M: SY='W';  M= -24, -79, -60, -19, -54, -70, -59, -76,  66, -51, -65, -36,  19,   9,  66, -21,  -1, -72,  70, -61;
/M: SY='H';  M=-117,-129,-101,-101,-115,-119, 157,-134,-106,-116,-101, -90,-117, -95,-100,-106,-115,-133,-151, -84;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.

Total number of hits	34 in 17 different sequences
Number of true positive hits	34 in 17 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	CHORD
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

17 sequences

CHRD1_BOVIN (Q29RL2), CHRD1_CAEEL (G5EEI8), CHRD1_CHICK (Q5ZML4),

CHRD1_DANRE (Q7T3F7), CHRD1_DROME (Q9VCC0), CHRD1_HUMAN (Q9UHD1), 
CHRD1_MACFA (Q4R7U2), CHRD1_MOUSE (Q9D1P4), CHRD1_PIG   (A9YUB1), 
CHRD1_PONAB (Q5RD91), CHRD1_RAT   (D4A4T9), CHRD1_XENLA (Q6NUA0), 
ITBP2_HUMAN (Q9UKP3), ITBP2_MOUSE (Q9R000), ITBP2_PIG   (Q462R2), 
RAR1_ARATH  (Q9SE33), RAR1_ORYSJ  (Q6EPW7)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

2 PDB

2XCM; 2YRT