PROSITE entry PS51433

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General information about the entry

Entry name [info]	PNT
Accession [info]	PS51433
Entry type [info]	MATRIX
Date [info]	01-JAN-2009 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51433
Associated ProRule [info]	PRU00762

Name and characterization of the entry

Description [info]

Pointed (PNT) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=86;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=81;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9862151; R2=0.0114276; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=13877.1757812; R2=2.7274234; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=921; H_SCORE=16389; N_SCORE=12.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=395; H_SCORE=14955; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-47; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='S';  M=  16,  -9, -37,  40,-120,-112,  47, -27,  -2,-117, -10, -38,  39,   4,-107,  54,-101,  -6,-128, -15;
/M: SY='P';  M=  -5,  -4,-112, -12, -34,-116,   1, -45,-110, -28,  28,   5,  53,  13,-114,  23,  32,  24,-122,  32;
/M: SY='P';  M=  -6,  16, -10,-109,  39, -41,-115,  22,   7, -17, -14,-110,  41,  35, -21,  -5,  14,  -5,-121,-105;
/M: SY='P';  M= -18,   3,   5,   3,  -4, -55, -15,-108, -11, -25,  22,  25,  41,  19, -16,  29,   2,  12,-128,-112;
/M: SY='S';  M=  -5,-122,  43,  25,-119,  11,  22, -47, -25, -60,-115,  45, -20, -32,-109,  46, -41, -51,-127,  19;
/M: SY='F';  M= -27,  11,  12, -51,  57, -23,  21,  20, -40, -17,  32,   3, -15, -35, -38,   8, -29, -11,  44, -31;
/M: SY='E';  M= -18,-125,  36,  44,-120,-117,-106,-116,   1, -14,  -9, -42,  31,  20,  37,   8,   9, -41,-127, -11;
/M: SY='K';  M=   7,   9, -35,  30, -24,  -2,   9, -12,  46, -67,-110, -25, -13,-101,  10, -19,  35, -12,-127,-113;
/M: SY='E';  M=   5,-121,  22,  42, -36, -49,  -6,  -2,  10, -44,-109,  -9, -45, -13,-107,  25,  25,   3,   5,  -4;
/M: SY='C';  M= -43,  81,  28,  11, -12,-118,  40,-116, -45, -51,  -7,  17, -20,  57,  -5,  -4, -42, -11,-128,   0;
/M: SY='Q';  M=  12,-124, -28,   5, -43,  -4,  24, -45,  30,  30,  37, -32,  15,  41,   7,-107,-109,-109,-124,-110;
/M: SY='R';  M=  27,-122, -18, -22, -24, -53,-110, -30,  19, -19, -15,-106,  12,  -8,  56,   5,  21, -53,  28, -23;
/M: SY='L';  M= -54,  22,  11,-109,-109, -30,-112, -31, -48,  39, -99,   4,  18,   3,  29,  29,-104,  20,-126, -14;
/M: SY='W';  M=-110,-127,-114, -21,  20,  38, -14,   0, -18, -35,-108,  23,-121,  35, -16, -20, -20, -41, 103,  32;
/M: SY='I';  M= -24,  32,-127,-121, -28,-129, -13,  62, -27,  39,  -4,-120,-125,-116,   4, -58, -30,  35,-123, -20;
/M: SY='P';  M= -16,  -7,-108,   7,-123,  -7,-111, -38,-106, -68,-113,   7,  97,   6, -20,  23, -35, -34,-125,  -5;
/M: SY='K';  M=   8,-119, -32, -10,-115, -59,-111,  15,  53, -19,-105,   5, -22,   2, -41,  20,  38,  -4,-126, -33;
/M: SY='D';  M= -53,-126, 102,  12,-129,-112,  63,-126,-100,-125,-120,  37,-115,  28,-106, -38,-104, -33,-143,-112;
/M: SY='P';  M=-113,-136,-116,-105, -23,-117,-118,-112,-112, -63,-113,-121, 128,-115,-123,-112,-106,   1,-126,-125;
/M: SY='R';  M=-109,-123,-109,  -6,-107, -56,  21, -21, -36,  13,  32,  17,-120,  52,  55,  15, -38, -15,  42,  29;
/M: SY='Q';  M= -10,  19,  13,  42,  -2,-119,   1, -14,-105,  25,   5, -20,-118,  49,-108,   1, -15, -32,-117,  39;
/M: SY='W';  M=-123,-149,-151,-128, -88,-121,-151,-121,-120,-119,-121,-144,-127,-120,-123,-130,-136,-136, 185, -74;
/M: SY='T';  M= -97, -14,  13,-105,-118, -40,-110,-112,-105, -44,-111,  -1,-110,-104,-112,  68,  95,-106,-134,-114;
/M: SY='P';  M=  -3,  27,   1,  34, -37,-117, -16,-112,  39, -51,   2,   1,  41, -98,  33, -30,   9,  -2,-125, -12;
/M: SY='E';  M=  18, -11,  41,  71, -24,  -8,-105,-121, -98,-120,-116,  14, -26, -12,  -3, -43,  24, -57,  15, -25;
/M: SY='H';  M=-112,-128,  69,   9,-126, -47, 111,-130, -98,-122,-111,  28,-115,  75,-100,-101,-109,-129,-139,-102;
/M: SY='V';  M=-100,-114,-129,-124,-102, -41,-132,  -2,-122, -88, -91,-123,-125,-124,-124,-112, -19, 107,-134,-109;
/M: SY='W';  M=  25,-122,-115, -46, -10,-118, -11, -11,   2,   7,   7, -31,-120,  48,  52,-105,  -4,  -5,  80, -31;
/M: SY='Q';  M=  15,-122,  30,  34,-122, -41,  32, -44,  -2, -67,-109, -98,-113,  74,  -6,   7,  28, -40,-126, -23;
/M: SY='W';  M=-123,-147,-150,-128,   6,-122,-148,-119,-120,-116,-120,-143,-127,-120,-123,-130,-134,-133, 182, -74;
/M: SY='L';  M= -48,-117,-131,-125, -93,-132,-121,  37,-124,  74,  16,-128,-128,-120,-123,-120,-106,  51,-123,-103;
/M: SY='R';  M=-108,-122,   5,  25,-111,-119,   5, -40, -32,  16,  28,   5,-118,  44,  51,   9,  -7,   5,   5, -11;
/M: SY='W';  M=-119,   0,  24, -30,  20,-119,  53,-119,-113, -61,-115,  -3,-124, -13,-116, -46,-121,-127, 160,  -7;
/M: SY='A';  M=  57,  44,-119,-114,-109,-114,   6, -19,-114,   9,   4,-112,-119, -13,-117, -16,  32,  50,-129,-111;
/M: SY='V';  M=  52,  32,-117,   0,-109,-115,-118,  20,-112,  -6,  24,-114,-119,  16,-116,   0, -28,  53,-127,-111;
/M: SY='N';  M=   7,-122,  30,   9,-125,-111,  29,-123,  54,-121,   2,  54,-114,  45,  28, -24, -13,-119,-129,-112;
/M: SY='E';  M= -58,-125, -91,  88,-126,-118,  -7,-124,  19, -67,   0,-101,-108,  59,  17,  12, -11,-119,-126,-114;
/M: SY='F';  M=-119,   2,-116, -40,  92,-123,  61, -26,-115, -98,-100,  35,-128,-115,-114,-113,-111,-107, -92,  92;
/M: SY='Q';  M= -53, -11,  -2,  19,-129,  29,   1,-129,  17,-127,-118,  43,-116,  48,  15,  43, -35,-124,-130,-117;
/M: SY='L';  M=-116,   4,-134,-128, -93,-136,-121,  51,-127,  81,  21,-130,-131,-121,-126,-125,-111, -39,-122,-104;
/I:         I=-28; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='P';  M=-111,-130,  57,  -6,-131,  -3,  40,-126, -52,-127,-118,-101,  74,  47,  -1, -10,  16, -59,-134,-118;
/I:         I=-30; MD=-77;
/M: SY='P';  M=   1,-126,  19,  36, -23,  -9, -12, -43, -13,-122,-116,   4,  52,  10, -47,  17,  10, -40,-129, -24; D=-30;
/I:         I=-30; MI=-77; IM=-77; DM=-77;
/M: SY='V';  M= -42,-121,-120, -32, -23,-125,   0,  31,-118,  39, -15,  14,  18,-115,-121,  11,-105,  47,-124,  -3;
/M: SY='D';  M=-113,  24,  85,  24,-127,-114, -20, -27, -19,-125, -27,  57, -28, -31,   0, -12, -40,-122,-139, -29;
/M: SY='L';  M= -51, -11,-119,   0,  -4, -55,-117,  41, -42,  52,   0,   3,  11,-113, -21, -21, -15, -15,-124,-107;
/M: SY='S';  M=   8,   6,  24,  14,-124,   1,  25,-119, -15, -34,   7, -19,  23,  30,  -2,  33, -18, -38,-131,-116;
/M: SY='R';  M= -49, -15, -13, -18,  46, -12,  31,-111,   8,  14,  25,   0, -30,-104,  52,   0, -48,-112,-119, -27;
/I:         I=-22; MD=-57;
/M: SY='F';  M=-121,  50,-127,  -6, 105,-130,-116,-106,-118, -20,-104,-122, -43,  44, -40,-119,-117,-110,  46, -82; D=-22;
/I:         I=-22; MD=-57;
/M: SY='H';  M= -52,  22, -22,  18,-123, -54,  70, -45,   4, -39,-113,  45,  29,  39, -42,  26, -50,-121,-132, -14; D=-22;
/I:         I=-22; MI=0; MD=-57; IM=0; DM=-57;
/M: SY='M';  M= -57,   5,-127, -19,-103,-130,-119,  60, -36,   1, 100,-120,-122,-115,-119,-116,   9,  31,-127,-107;
/M: SY='N';  M=-106, -11,  58,-100,-126,-107,-103,-122, -53,-126,-119,  83,-116, -24,-110,  43,  59,-118,-142,-119;
/M: SY='G';  M= -99,-126,-114,-126,-133, 107,-121,-141,-119,-136,-125,-100,-118,-117,-127, -99,-118,-134,-123,-128;
/M: SY='K';  M=  23, -24,-112, -42,-115,-119,  20,  -2,  53, -21,   2,-107, -23,  29,  51, -39, -40, -53,-121,  14;
/M: SY='E';  M=  32,-124,  55,  56,-129, -20,  13,-124,   6,-121,  25,-100, -34,  34,-104, -27, -10,-118,-132,-117;
/M: SY='L';  M=-116,-119,-134,-126, -91,-135,-117, -35,-126,  91,  55,-132,-132,-119,-124,-126,-112, -89,-121,-103;
/M: SY='C';  M=   4, 140,-125,-123,-119,-122,-124, -13,-117, -30,-112, -41,-134, -23,   5, -22,-109,-110,-141,-125;
/M: SY='Q';  M= -62,-123, -32,   0,-115,  -2,-108,-107,  12,  26,  37,  12,-120,  49,  28,  27, -29, -19,-127,-112;
/M: SY='M';  M=-114,   4,-134,-125,   2,-129,-110, -85,-121,  55, 128,-125,-126,-113,-119,-123,-111, -92,-121, -99;
/M: SY='T';  M=  -3,-117,   8,-104,-124, -13,-110,-120, -25,-123,-116,   1, -33,  16,  -4,  67,  67,-113,-133,-117;
/M: SY='Q';  M=-112,-129, -27,  35,-122,-123,  40,-117,  52,  -8,  15,-104, -19,  65,  47,-108,-111, -27,-127,-111;
/M: SY='E';  M=   4,-127,  54,  73,-130,-118,-105, -35,  13,-122,-116, -19,-113,  51, -14,-103, -47, -26,-131,-118;
/M: SY='D';  M= -19,-128,  92,  58,-133,   4, -15,-130,-101,-126,  13, -94,-114,  12, -46, -39,-108,-126,-138,-119;
/M: SY='F';  M=-124,-121,-136,-132, 118,-133,-115, -96,-127,   6,   7,-127,-135,-134,-124,-124,-116,-102, -93,  16;
/M: SY='W';  M= -43,  -8,-117,   9, -43,-125, -16,   6,   4,  22,  40,-114,-122,   0,  32,  -2,   1,  23,  56,-106;
/M: SY='R';  M= -17,   4,  -6,  25, -39, -52,  25,-114, -19, -24,   3, -32,-120,  45,  57,  -9,-109, -13,-119,  41;
/M: SY='R';  M=  -6,  32,-119,-109,-110,-126,-111,  12,  27,  32,-100,-113,-125,-102,  81,-112, -48, -32,-124, -25;
/M: SY='A';  M=  46,  40,  20,-113,  17,-115,-119, -19,-115, -14,   8,-110,-121,-115,-120,   8,  39,  32,-128,-110;
/M: SY='P';  M=  -3,-129,-112,-108,-132,  35,-116,-125,-111,-131,-120, -16, 102, -14,-120,  38, -39,-124,-129,-126;
/I:         I=-16; MD=-40;
/M: SY='P';  M=  -3,-128, -15,  10,-129, -20,   9,-116, -13,-124,-119,  -2,  39,-109,   0,  39, -14,  24,-138,-123; D=-16;
/I:         I=-16; MI=0; MD=-40; IM=0; DM=-40;
/M: SY='Y';  M= -10,-155, -11,-134,  25, -63,   7,-145,   2, -72,-137,-137,-152,  21, -32,-137,-141,-145,-138,  28; D=-16;
/I:         I=-16; DM=-40;
/M: SY='N';  M=   7,  42, -38,-114, -41,  23,-108, -27, -20, -21,-109,  58,  -3,-110, -49,  13, -35,  -5,-120,  49;
/M: SY='G';  M=  -3,-124,-114,-124,-131, 101,-120,-134,-118,-132,-123,-101,-118,-116,-125, -43, -38, -59,-124,-126;
/M: SY='D';  M=-110,-126,  90,  45,-131,-113,   0, -39, -38,-128,-123,  40,-115,  -1, -46,  29,-103,-125,-141,-118;
/M: SY='V';  M= -41,-121,-125,-122,-100,-130,   6,  60, -47,  11,  -5, -13,-125, -14,-121,-114,  -5,  63,-125,  15;
/M: SY='L';  M=-117,-120,-134,-127,  20,-136,-118,  12,-127,  87, -12,-132,-133,-121,-125,-126,-113, -88,-116, -10;
/M: SY='W';  M= -18,-130,-127,-123,  48,-125,  53, -50,-118, -19,   8,-122,-130,-115,-117,-118,-118, -50, 114,  98;
/M: SY='S';  M=  34,-120, -17,  41, -27, -52, -20,-120, -33, -29,-113,  32,-115,  29,  -4,  45,   3,-114,-129,-115;
/M: SY='H';  M=-114,-128,  20,  -1,-117,-121, 120, -20, -42,  -9,-104, -30,-119,  28,   4,  -5,-111, -15,-139, -99;
/M: SY='L';  M=-117,-120,-134,-127,  58,-134, -21, -29,-127,  79,  -4,-130,-133,-123,-124,-125,-113, -11,-112,  -8;
/M: SY='Q';  M=  -7,  19,  14,  41,-126, -41,  54,-126, -42, -73,-113,  -5,-116,  80,  16, -42, -10,-123,  56,-110;
/M: SY='Y';  M=-113, -19,  -4,  18,  16,-125,  38,   5,  12,  18,   0, -34,-122, -14,   6, -20, -21,   5,-117,  43;
/M: SY='W';  M=-116,-124,-131,-122, -15,-131,   6,   4,-114,  70,  13,-126,-130,-115,  30, -37,-114, -20,  90, -98;
/M: SY='R';  M=-112,-125,-115,-103, -24,-125,-109,-105,  64,  30, -19,-109,-122,  17,  64, -41, -27,   5,-123,-109;
/M: SY='W';  M= -21,-124,-106,  13, -33, -53,-108,  -5,  41,-116,  11,  12,-116,  45,  15,  30,  24,-112,  50, -13;
/M: SY='Q';  M= -15,  39,  18,  37, -42,  13, -15, -35, -27, -68, -14,  19,-117,  42, -34,  22,  -7, -41,-130, -34;
/M: SY='Y';  M=  39,  35,   5, -30, -22,  -3, -19, -37, -19, -64, -17,  13,   1,-108,  -2,  -4,  -7, -58,-118,  53;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.

Total number of hits	45 in 45 different sequences
Number of true positive hits	45 in 45 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	PNT
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

45 sequences

EHF_BOVIN   (Q32LN0), EHF_HUMAN   (Q9NZC4), EHF_MOUSE   (O70273),

EHF_PANPA   (A1YG61), EHF_PANTR   (A2T737), ELF3_HUMAN  (P78545), 
ELF3_MOUSE  (Q3UPW2), ELF3_RAT(Q4V7E1), ELF5_BOVIN  (Q58DT0), 
ELF5_HUMAN  (Q9UKW6), ELF5_MOUSE  (Q8VDK3), ELG_DROME   (Q04688), 
ERG_CHICK   (Q90837), ERG_HUMAN   (P11308), ERG_MOUSE   (P81270), 
ETS1A_CHICK (P13474), ETS1A_XENLA (P18755), ETS1B_CHICK (P15062), 
ETS1_HUMAN  (P14921), ETS1_MOUSE  (P27577), ETS1_RAT(P41156), 
ETS2A_XENLA (P19102), ETS2B_XENLA (Q91712), ETS2_BOVIN  (A1A4L6), 
ETS2_CHICK  (P10157), ETS2_HUMAN  (P15036), ETS2_MOUSE  (P15037), 
ETS4_CAEEL  (A8WFJ9), ETS4_DROME  (P29775), ETS6_DROME  (P29776), 
ETV6_BOVIN  (Q0VC65), ETV6_HUMAN  (P41212), ETV6_MOUSE  (P97360), 
ETV7_HUMAN  (Q9Y603), FLI1_BOVIN  (Q29RS8), FLI1_HUMAN  (Q01543), 
FLI1_MOUSE  (P26323), FLI1_XENLA  (P41157), GABPA_HUMAN (Q06546), 
GABPA_MOUSE (Q00422), MYBE_AVILE  (P01105), PNT_DROME   (P51023), 
POK_DROME   (Q01842), SPDEF_HUMAN (O95238), SPDEF_MOUSE (Q9WTP3)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

38 PDB

1JI7; 1LKY; 1SV0; 1SV4; 1SXD; 1SXE; 1X66; 2DKX; 2E8P; 2JV3; 2KMD; 2QAR; 2QB0; 2QB1; 2YTU; 4MHV; 5L0P; 7JU2; 7N1O; 7N2B; 7T8J; 7TDY; 7TW7; 7TW8; 7TW9; 7U4W; 7U4Z; 8BWU; 8E1F; 8FRJ; 8FRK; 8FT6; 8FT8; 8FZ3; 8FZU; 8FZV; 8THA; 9FEH
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