PROSITE entry PS51503
View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry
| Entry name [info] | HIG1 |
| Accession [info] | PS51503 |
| Entry type [info] | MATRIX |
| Date [info] |
01-AUG-2010 CREATED;
10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51503 |
| Associated ProRule [info] | PRU00836 |
Name and characterization of the entry
| Description [info] | HIG1 domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=92; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=87; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.2970145; R2=0.0079802; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=11597.2617188; R2=7.7663736; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=966; H_SCORE=19100; N_SCORE=11.0; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=402; H_SCORE=14719; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-23; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-255; BD=-255; /M: SY='P'; M= -9,-83, 24,-25,-75,-74,-10,-29,-43,-40, -3,-34, 29, 0,-16,-23,-38,-29,-14,-19; /M: SY='R'; M=-32,-82,-36, -9,-19,-78,-67,-24,-15,-15, -6,-68, 8, -8, 10,-11,-15,-32, -6, -1; /M: SY='P'; M=-16,-82, 20, 18,-40,-36,-66,-28, 1,-79,-73,-18, 23,-35,-63, -1,-23,-73,-85,-39; /M: SY='S'; M=-12,-78,-11, -1,-46,-33,-64,-45, 0,-43, -6, 6,-40, 13,-61, 22,-41,-50,-83,-33; /M: SY='M'; M=-47,-81,-28,-42, 6, 3,-66,-32,-30, 0, 11,-66,-39, 9, 5,-20,-43,-47,-72, 4; /M: SY='D'; M=-17,-78, 15, -8,-48,-29,-26, -2,-29,-32,-24,-37,-75,-38,-11,-17, 1, -1, -5,-68; /M: SY='E'; M=-22,-80, -5, 7,-10,-37,-68,-29,-15,-17,-26,-30,-13,-14,-10,-21, -6,-25, 3,-65; /M: SY='W'; M=-47,-80,-23, 1,-12,-74,-24,-18,-28,-40, 7, 2, 11,-15,-27, -3,-11,-31, 23, -2; /M: SY='Q'; M= -8,-77, 2, -7,-71,-36,-24,-19, -8,-14, 9,-41,-18, 11, -4,-16,-21,-15,-83,-67; /M: SY='E'; M=-13,-78, 18, 30,-37,-50,-60,-27,-15,-52, 12,-34,-10, -9,-38, -5,-18,-66, -7, 3; /M: SY='W'; M=-21,-77,-40, -8, 3, -5,-19,-30,-28,-20, 6,-21,-10,-32, -9, 9,-60,-23, 38,-36; /M: SY='E'; M=-19,-24, 5, 33,-38,-35,-26,-51, 3,-55,-31,-13,-12, 12, 12,-25,-13,-70,-77,-17; /M: SY='N'; M=-24,-75, 26, 2,-76,-21,-18,-51, -1,-73,-35, 32,-18, 10,-20, -4,-31,-14,-84,-34; /M: SY='E'; M=-26,-78,-34, 44,-66,-52,-21,-38,-36, 1, 17,-63, 20, 12,-37,-43,-27,-35,-76,-10; /M: SY='T'; M=-19,-71,-18,-36,-72, 9,-65,-45,-38,-30,-33,-15, -5,-32,-15, 27, 38,-42,-83,-69; /M: SY='P'; M=-16, 5,-67,-24, 14,-20,-17,-16, -7,-46, 12,-62, 27,-16,-38,-39, 20,-30, -3, -1; /M: SY='W'; M=-11,-72,-39,-13,-20,-18,-14,-20,-18, 0,-26,-60, -2,-29,-35, 8, 14,-20, 16, 1; /M: SY='Q'; M=-57,-76, 6, 39,-74,-23, 19,-74,-30,-54,-16, -4,-17, 52,-52, 15,-23,-72,-77,-16; /M: SY='K'; M=-11,-75,-12,-15,-45,-66,-56,-76, 64,-75,-65,-25,-21, 5, 26, -7,-36,-71,-74,-64; /I: I=-19; MI=0; MD=-47; IM=0; DM=-47; /M: SY='F'; M= 7,-70,-78,-53, 30,-74,-68, 22,-50, 27, 25,-72,-26,-68,-71,-29,-58, -7, -5,-20; /M: SY='W'; M= 4,-69,-68,-61,-32,-18,-64, -6, 11, 14, 32,-36,-69, -6,-10,-11,-26, -9, 53,-54; /M: SY='M'; M=-20,-70, 3, 17,-26,-63, 16,-58, -9,-38, 49, -6,-34, 4, 49, -8,-39,-42,-63, 28; /M: SY='W'; M=-45,-71,-40,-39, -1,-28, 16,-63, 45,-48,-33, 18,-64,-23, 17, 9,-53,-45, 94, 24; /M: SY='C'; M= 20, 40,-62,-40, 30,-13,-30,-20,-40, -5, 18,-55,-41,-12,-60,-12, 22, 11,-13, 13; /M: SY='K'; M= 0,-63,-32,-46,-22,-59,-25, -9, 51,-13, 31, -1,-29,-41, 34, -1,-28, -2,-63, 0; /M: SY='E'; M=-10,-65, 14, 66,-14,-26,-45,-32, -8,-15, 7, 8,-53, 10, 22,-10,-35,-48,-66,-35; /M: SY='H'; M=-43,-62, 23, 9,-61,-52, 71,-43,-16,-51,-25, 65,-57, 44,-43, 0, 2,-14,-75,-18; /M: SY='P'; M=-54,-72,-53, -7, -3,-48,-54, 5, 36,-33,-25,-53, 91,-31, 10,-51,-13,-53,-62,-23; /M: SY='Y'; M=-35,-63,-70,-65, 47,-49,-50, 1,-63, 54, -3,-67,-38,-59,-61,-61,-53,-23, 50, 65; /M: SY='V'; M=-18,-60,-63,-55, -2,-31,-33, 21, 27, 13, 5,-56, -3,-52, -4,-26,-27, 54,-65,-47; /M: SY='P'; M=-18,-18,-63,-56, -2,-40,-61, 38,-58, 8,-17,-61, 82,-58,-64,-10,-36, 10,-63,-23; /M: SY='I'; M= 5, 9,-71,-67,-21,-45,-68, 73,-65, 28,-27,-64,-65,-62,-67,-57,-47, 30,-64,-47; /M: SY='G'; M= 30,-60,-58,-61, 11, 73,-60,-51,-58, -8,-22,-47,-60,-56,-63,-33,-51, 6,-60,-53; /M: SY='C'; M= 23, 83,-62,-61,-17, 25,-59, 11,-58, -2, 56,-52,-62,-56,-62,-12, 2,-13,-67,-53; /I: I=-24; MI=0; MD=-61; IM=0; DM=-61; /M: SY='L'; M= 40,-10,-61,-58,-25, 17,-59, 1,-58, 41,-34,-54,-61,-55,-61,-12, 14, 9,-64,-50; /M: SY='W'; M= 56, 11,-66,-58,-26, 7,-64,-38,-57, 8, -1,-59,-61,-54,-60,-20,-51,-38,117,-40; /M: SY='T'; M= 20,-12,-57,-56,-16,-59,-61,-19,-54, -3, -6,-49,-57,-56,-59,-37, 72, 49,-71,-50; /M: SY='A'; M= 51, 24,-59,-55,-41, 2,-61,-36,-55, -5,-43,-51, -6,-54,-59, 2, 22, 40,-69,-55; /M: SY='G'; M= 26,-14,-56,-57,-12, 45,-57, 0,-55,-10,-45,-47,-59,-52,-59, 34, -2, 17,-61, 5; /M: SY='M'; M= 43, 7,-64,-58,-12,-56,-59, 9,-57, -7, 66,-57,-61,-54,-59,-17, 0, 47,-66,-48; /M: SY='L'; M= -2,-14,-67,-63, 9, 20,-58,-16,-63, 62,-27,-61,-67,-59,-63,-35,-49, 16,-58, -7; /M: SY='I'; M= 14,-59,-64,-62, -7, 27,-60, 39,-59, 21, 10,-55,-62,-57,-62,-18, 3, 22, 10, -4; /M: SY='S'; M= 28,-59,-56,-53, -8, 1,-50, 12,-46, 9, -3,-12,-60,-46, 26, 36,-21,-34, 6, 24; /I: I=-13; MD=-33; /M: SY='G'; M= 7,-63,-60,-63, 29, 72,-59,-22,-59,-27, 32,-48,-60,-56,-63,-11,-53,-39, 54,-46; D=-13; /I: I=-13; MI=0; MD=-33; IM=0; DM=-33; /M: SY='Y'; M= 17,-62,-62,-28, 34, -8,-15, 0,-24, 16, 32,-57,-38,-52,-11,-51,-32, -6, 48, 56; /M: SY='Y'; M= 14,-61,-38,-51, -6,-16,-47, 9, 15,-20, 27, 27,-61,-24, 20,-11,-45, 13, -6, 45; /M: SY='M'; M= 9,-10,-53,-35,-34,-11,-12, 9, 2,-24, 46, 10,-59,-18, 4, 28,-18, 20,-62, 15; /M: SY='M'; M=-20,-23,-34,-55, 37, 21,-49,-14,-26,-34, 61, 14,-60,-48, 22, 8, 14,-14, 6, 1; /M: SY='R'; M=-38,-66,-18,-41,-37, 11, 9,-63, 26,-48,-24,-24,-36, 3, 78, 12,-15,-35,-64,-26; /M: SY='N'; M= 0,-63, 32, -7,-64, 15,-43,-44, 2,-41,-54, 48,-57, 27, 47,-21, -6,-43,-69,-34; /M: SY='G'; M= -6,-65,-37,-14, 0, 63,-54,-62, 11,-46,-55,-32, 41, 13,-20,-19,-24,-27,-61,-37; /M: SY='N'; M=-22,-62, 38,-20,-28, -3, 10,-30,-22,-43,-22, 56, 4, 3,-34, 28,-27,-57,-60, 46; /M: SY='M'; M=-20,-62,-33,-45,-30,-30, 11,-15, 12, 5, 57,-46, 33, 29, 24, 23, -1,-39,-65,-48; /M: SY='T'; M= -3,-57,-11,-34,-57,-37,-48,-49, 29,-11, -2, 23,-56, 7, 15, 36, 37, -3,-14,-52; /M: SY='M'; M=-29,-11,-31,-15, -8, 0, -4,-50, 16, -1, 44, -2, 7, 7, 38,-29, 32,-49, -3, 5; /M: SY='S'; M= 23,-55,-47,-44,-62, 4,-49,-56,-30,-45, 7,-38, 8, 27,-49, 75, 13,-38,-67,-54; /M: SY='Q'; M=-47,-63,-38,-34,-64,-33,-38,-21,-34,-34,-45, 72,-58, 94, -8,-28,-43, 11,-68,-52; /M: SY='K'; M=-52,-65,-46,-35, -4,-59, 7,-60, 84,-35,-19,-17,-55,-10, 39,-46,-19,-58,-53, 29; /M: SY='M'; M=-17,-58,-71,-64, 20,-68,-54, 21,-61, 56, 76,-65,-66,-56,-60,-59,-49, 10, 34, -3; /M: SY='M'; M=-49,-58,-71,-63, 27,-67,-51, 29,-58, 1,114,-61,-62,-24,-57,-58,-46, 32,-58,-36; /M: SY='Q'; M=-52,-70,-47,-33,-12,-60, 70,-65, -3,-57, -7,-39,-59, 80, 76,-44,-37,-63,-64,-41; /M: SY='W'; M= 53,-56,-58,-54, 2, 0,-53,-45,-52, 14, 13,-20,-59,-50,-36, -5, 15,-43, 72, 27; /M: SY='R'; M=-54,-71,-51,-38,-64,-64,-40,-70,-11,-62,-51,-44,-63, -8,111,-48,-53,-64,-63,-50; /M: SY='V'; M=-44,-57,-71,-65,-39,-72,-66, 51,-62, -1, 61,-64,-64,-61,-63,-57,-42, 76,-69,-46; /M: SY='Y'; M= 19,-61,-62,-59, 10, 6, 15, 8,-20, 10, 28,-56,-63,-52,-54,-49,-49, 10, 56, 70; /M: SY='A'; M= 72,-53,-60,-54, 37, -8,-56,-30,-55, 19,-40,-54,-59,-52,-58,-25,-32,-38, -9,-21; /M: SY='Q'; M=-47,-72,-42,-21,-77,-55,-35,-63,-27,-58,-45,-37,-54,126,-27,-36,-49,-65,-60,-48; /M: SY='G'; M= 51,-56,-57,-58, 55, 60,-57,-55,-56,-40,-50,-47,-58,-55,-60,-12,-32,-50,-52,-42; /M: SY='F'; M= 28, 19,-66,-61, 42,-33,-59, 32,-60, 36, 8,-59,-64,-58,-61,-18,-17, 17,-56,-39; /M: SY='T'; M= 43,-49,-49,-49,-55,-51,-57,-42,-48,-49,-46,-40,-50,-50,-55,-27, 91, 11,-72,-54; /M: SY='V'; M=-47,-58,-72,-67,-36,-74,-68, 60,-65, 40,-23,-67,-66,-62,-65,-59,-44, 64,-66,-45; /M: SY='A'; M= 50,-55,-60,-58,-34, 32,-61, 28,-57, 1,-20,-52,-59,-54,-60,-11,-16, 32,-64,-52; /M: SY='A'; M= 48, 33,-64,-58, -7,-56,-60, 19,-59, 38,-15,-59,-63,-56,-60,-18,-30, 29,-63,-47; /M: SY='L'; M=-38,-29,-71,-65, 5,-50,-58, 38,-63, 64, 49,-66,-67,-59,-63,-60,-35, 18,-59,-40; /M: SY='M'; M= -2,-18,-66,-62,-11,-15,-61, 32,-60, 30, 52,-59,-63,-57,-61,-29, 2, 51,-64,-45; /M: SY='G'; M= 32,-58,-60,-60, 2, 53,-58, 11,-58, 23,-19,-51,-60,-55,-61,-12,-47, 12,-59,-21; /M: SY='G'; M= 19,-57,-53,-56,-14, 56,-54,-11,-53,-14,-23,-42,-56,-50,-58, 36, 27,-16,-60, 3; /M: SY='A'; M= 44,-55,-62,-58,-10, 14,-58, 6,-57, 18, 34,-54,-60,-54,-59, -7,-11, 34,-62,-28; /M: SY='W'; M= 33,-12,-62,-59, 31, 13,-51,-22,-56, 5, 41,-40,-63,-54,-58,-15,-31, 3, 58, 50; /M: SY='Y'; M= 3,-59,-36,-60, 47,-62,-49, 10,-57, 24, 45,-29,-65,-30,-57,-14,-16, 4, 32, 56; /M: SY='T'; M= -1,-59,-26, 34, 5,-55, 17,-22, -1,-30, 13,-11,-54,-11, -7, 28, 35,-48, 14, 34; /M: SY='M'; M= 7,-62,-16,-15,-53, 45,-11,-27,-24,-26, 68, -5,-58, 13, 15,-14,-31,-39, 1, 11; /M: SY='Y'; M= 14,-63,-15,-46, 3, 3, 8,-26, 8,-23, 0, 6,-31, 37, 7,-19,-10,-14,-54, 43; /M: SY='D'; M=-15,-68, 44, 19,-69, 19,-51,-34, 15,-44, 16,-41,-18, 27,-18, 10,-13,-61,-72,-60; /M: SY='R'; M= 4,-71, 11, -6,-69, -1,-55,-32, 19,-50,-60, -3, -9, 8, 32, -7,-37,-29, 4,-31; /M: SY='K'; M=-10,-76, 0,-13,-27,-22,-22,-68, 31,-31,-59,-28, -6, 19, 19,-26,-58,-50,-65, 30; /M: SY='K'; M=-63,-77, 16, 20,-66,-20,-26,-39, 20, 3,-57,-13,-30, 18,-17,-58,-19,-43, -5,-10; /M: SY='G'; M=-11,-78,-40, 2,-31, 21, -1,-74, 15,-53,-67, 3,-21, 6,-11,-31,-28,-40,-77,-29; /M: SY='R'; M=-24,-80,-23,-17,-77,-37,-31,-74, 22,-49,-67, 7, 22,-15, 30,-26,-20,-37,-81,-34; /M: SY='K'; M=-19,-78,-23, -1,-16,-13, 2,-49, 23,-40, 7, 6,-23,-32, 0, -7,-40,-70,-80,-65; /M: SY='Q'; M= -7,-80,-35, 9,-41,-38,-63, -9, 4,-18,-61,-17,-40, 23, 16,-60,-19,-63,-78,-28; /M: SY='W'; M=-39,-83,-10, 2,-21,-74,-65,-73, 8,-57,-68,-62, 25, 33,-23,-12, -6,-38, 34,-24; /I: E1=0; IE=-255; DE=-255;» more |
Numerical results [info]
| Total number of hits | 75 in 75 different sequences |
| Number of true positive hits | 75 in 75 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | HIG1 |
| Version [info] | 4 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
75 sequences
ATL48_ARATH (Q7X843), HIG1A_HUMAN (Q9Y241), HIG1A_MOUSE (Q9JLR9), HIG1A_PONAB (Q5NVQ1), HIG1A_RAT (Q8VH49), HIG1B_HUMAN (Q9P298), HIG1B_MOUSE (Q99JY6), HIG1C_HUMAN (A8MV81), HIG1C_MOUSE (Q76I25), HIG2A_HUMAN (Q9BW72), HIG2A_MOUSE (Q9CQJ1), HIG2B_HUMAN (Q4VC39), RCF1A_TALMQ (B6QHL9), RCF1B_TALMQ (B6QHL8), RCF1_AJECG (C0NUL6), RCF1_AJECH (C6H220), RCF1_AJECN (A6RBB3), RCF1_AJEDR (C5GDJ2), RCF1_ARTOC (C5FSQ7), RCF1_ASPCL (A1CHC5), RCF1_ASPFC (B0Y606), RCF1_ASPFN (B8N9M0), RCF1_ASPFU (Q4WP59), RCF1_ASPNC (A2QI79), RCF1_ASPOR (Q2UGQ3), RCF1_ASPTN (Q0CLP4), RCF1_BLAGS (C5JIT3), RCF1_BOTFB (A6SSX6), RCF1_CANAL (Q59N74), RCF1_CANAW (C4YRP9), RCF1_CANDC (B9WHT6), RCF1_CANGA (Q6FSW5), RCF1_CANTT (C5MAV2), RCF1_CHAGB (Q2GMG9), RCF1_CLAL4 (C4Y631), RCF1_COCP7 (C5P447), RCF1_COPC7 (A8P006), RCF1_DEBHA (Q6BIT1), RCF1_EMENI (Q5B6J9), RCF1_EREGS (Q756G1), RCF1_FUSV7 (C7YJ02), RCF1_KLULA (Q6CWT4), RCF1_KOMPG (C4QV79), RCF1_LACBS (B0D4J7), RCF1_LACTC (C5DLZ7), RCF1_LODEL (A5E2M7), RCF1_NEOFI (A1CXG2), RCF1_NEUCR (Q7S455), RCF1_PARBD (C1G794), RCF1_PARBP (C0RYW2), RCF1_PENRW (B6H465), RCF1_PHANO (Q0V4P1), RCF1_PICGU (A5DHC2), RCF1_PICST (A3LVL1), RCF1_PODAN (Q875C2), RCF1_PYRO7 (A4RI25), RCF1_PYRTR (B2WBP3), RCF1_SCHJY (B6K2Z6), RCF1_SCLS1 (A7F679), RCF1_TALSN (B8MJJ2), RCF1_TRIVH (D4DDK2), RCF1_UNCRE (C4JHR1), RCF1_USTMA (Q4PIK6), RCF1_VANPO (A7TFU8), RCF1_VERA1 (C9SF29), RCF1_YARLI (Q6CBQ8), RCF1_YEAS1 (B3LLM2), RCF1_YEAS2 (C7GT60), RCF1_YEAS7 (A6ZM32), RCF1_YEAS8 (C8ZEH4), RCF1_YEAST (Q03713), RCF1_ZYGRC (C5DWC4), RCF2_SCHPO (Q9P3B2), RCF2_YEAST (P53721), YL87_SCHPO (Q9UTB1)» more
|
| PDB [Detailed view] |
8 PDB
2LOM; 2LON; 5NF8; 6LUL; 6T0B; 6T15; 8C8Q; 8Q1B |