PROSITE entry PS51526
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General information about the entry
| Entry name [info] | RFX_DBD |
| Accession [info] | PS51526 |
| Entry type [info] | MATRIX |
| Date [info] |
01-MAR-2011 CREATED;
13-FEB-2019 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51526 |
| Associated ProRule [info] | PRU00858 |
Name and characterization of the entry
| Description [info] | RFX-type winged-helix DNA-binding domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=77; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=72; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0680783; R2=0.0061025; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=12314.2226562; R2=1.2322274; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=1136; H_SCORE=13714; N_SCORE=9.0; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=727; H_SCORE=13210; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-105; D=-200; I=-200; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='T'; M= 59, 60, -46,-241,-247, -17, 19, -14,-240, -63, 3, -3,-245,-239,-245, 14, 65, -43,-261,-244; /M: SY='Y'; M= -1, -15,-244, -11, 5, -35, 19, 20, -18, 24, 3, -46,-250, 20, 25, -21, -5, -15,-243, 52; /M: SY='Q'; M= 43, -49, -50, -10, -39,-243, 14, -4, 15, -90, -2, -45,-245, 53, 51, -14, 24, -45,-252, -18; /M: SY='W'; M=-249,-272,-267,-248, -20,-250,-265,-250, -55,-247,-248,-261, -51, 23, 4, -46, -52,-261, 177,-209; /I: I=-61; MI=0; MD=-115; IM=0; DM=-115; /M: SY='M'; M= -60,-248,-261,-254, -43,-261, -7, 57,-252, 69, 82,-254,-255,-246,-251,-250,-237, 5,-250,-230; /M: SY='R'; M= -20,-252,-236, -36,-249, -57, 26, -59, 42, -25, 3, -9, -44, 34, 73, 30, 5, -78,-255,-239; /M: SY='C'; M= 34, 82, 24, 2,-249, -72,-239, -31, -13, -22, 27, -5, -30, 41, -28, 10, 16,-237,-259,-245; /I: I=-61; MI=0; MD=-115; IM=0; DM=-115; /M: SY='N'; M= -26, 53, -43, -32, -31,-242, 71, -42,-235, -24, 47, 80,-249,-234, -25, -24, 34, 9,-264,-236; /M: SY='F'; M=-247, 61, -18, -50, 88,-257,-235, -32,-245, 14,-226, -35,-260,-248, -7,-246,-241, -40,-225, 86; /M: SY='E'; M= 4, -31, 6, 97,-253,-248,-235, -14, -26,-244, -12,-234,-238, 14,-232, -7, -63, 11,-258,-246; /M: SY='E'; M= 19, -14, -17, 64, 5, -59, -22, -36, -18, -16, -28,-238, 31,-229, 20,-234, 6, 2,-250, 8; /I: I=-33; MI=0; MD=-63; IM=0; DM=-63; /M: SY='D'; M= 22, 33, 74, -4, -37, -80, 57,-254, -21,-253,-247, 2, 23, -67, -46, 23, -21,-249,-261, -5; D=-33; /I: I=-33; DM=-63; /M: SY='P'; M= 12,-252, 2, 34,-254, -26,-239,-247, -12, -24, 1, -2, 72, 6,-239, 34, 22,-244,-258,-248; D=-33; /I: I=-33; DM=-63; /M: SY='D'; M= -22,-253, 67, 20,-255, 58, 35, -46, -44,-255,-248, 40,-245, -38,-241, -30, -19, -66,-261, -30; D=-33; /I: I=-33; MI=0; MD=-63; IM=0; DM=-63; /M: SY='G'; M= 31, 19, -36, -30, -60, 47,-247,-232,-244, -73, 2,-236,-248,-242,-249, 29, 22, 45,-255, -1; D=-33; /I: I=-33; MI=0; MD=-63; IM=0; DM=-63; /M: SY='C'; M= -4, 66, -64, 52, -9, -43,-238,-244, -50, -50,-240, -51, -35, 21, -12, 62, -22, -10,-254, -7; /M: SY='V'; M=-236, -18,-259,-254,-227, -43,-254, 52,-252, 47, 23,-254, -26,-250,-254,-246, -29, 73,-256,-236; /M: SY='P'; M= 6,-254, -38, 1,-254, -91,-243,-245, -33, -36,-241,-238, 103, -12, -38, -32, 60,-243,-257,-251; /M: SY='Q'; M= -45,-259,-236,-221,-257,-248,-229,-254, 25,-250,-238,-230,-247, 101, 94, -55,-239, -56,-251,-240; /M: SY='Q'; M= -55, 31,-240, -20,-243, 17, -28, 46,-236, -27,-230, 28,-248, 66, -43, 26, -38, 29,-257,-241; /M: SY='D'; M= 20,-251, 47, 46, -57, -10, -7, -8, -33, -54, -5,-229, -22, 28, -15, 31, 1, -45,-258,-243; /M: SY='L'; M= -54,-247,-260,-254, 6,-261,-252, 54,-253, 59, 30,-255, -26,-250,-253,-248, -48, 54,-251,-231; /M: SY='W'; M= -52,-262,-255,-250, 4,-253,-229,-239, -33,-235,-234,-253,-258,-241, -44,-246, -49,-245, 134, 122; /I: I=-61; MI=0; MD=-115; IM=0; DM=-115; /M: SY='Q'; M= 32,-249, 27, -28, -55, -29, -10, -51, 35, -42,-240, 48,-244, 53, -7, -3, 26,-242,-257,-242; /M: SY='H'; M= 50,-247, 12, 35,-246,-240, 63, -30, -58, 2, -7, -24,-244, -47, -20, 26, 13, -40,-259,-239; /M: SY='Y'; M=-248,-259, -32,-247, -37,-254,-216,-235, -13,-232,-228,-246,-259,-236, -44,-243,-242,-240,-207, 141; /M: SY='R'; M= -52, -4,-240, -9, -47,-251, -7, -41, 16, 24,-228, 16,-250, 51, 57,-236, -10, 36,-253, -27; /M: SY='D'; M= 31,-249, 50, 29,-251, -59,-237, 8, 13,-244, -7,-228,-242, 6, 24, 31, 27, -67,-258,-244; /I: I=-61; MI=0; MD=-115; IM=0; DM=-115; /M: SY='F'; M= -43,-249,-251,-249, 91,-253, 58, -18,-246, 11, -7, -42, -35,-246, -65, 0, -3, -30,-231, 54; /M: SY='C'; M= -16, 130,-243, 12, -39,-248,-246,-246,-239, -28,-240, -31, -18, -4, 0, 5, 29, -49,-265,-248; /M: SY='Q'; M= -3,-255, -13, 63, -37, -37, 22, -41, 7,-250,-242, 33, 33, 74, -59, -1,-234,-249,-256,-243; /M: SY='K'; M= -54,-253, -46, 21, 7,-245, 25, -46, 61, -54,-239, 14, 15, 4, 36, 26, -40, -60,-249, 11; /M: SY='H'; M= 6, 18,-243, -10, -5,-249, 69,-228,-239, 51, 45, 22,-252, 34, -48, -72,-238, -42, 12, 28; /M: SY='K'; M= 21, -8, -21, -41,-253, 31, 35, -27, 68,-250,-242, 38,-244, -1, -65, 22,-232, -51,-256,-243; /I: I=-18; MD=-33; /M: SY='C'; M= 3, 36,-256, -21,-267,-260,-256, -56, -23, -78, 6, -19, -4, 1, 35, 22, -12, -55,-275,-262; D=-18; /I: I=-18; MD=-33; /M: SY='M'; M= -54, 36, -11, -18, -28, -24,-243, 35, -1, 17, 44, -44,-249, -25,-243, 25, 28, -7,-252, 6; D=-18; /I: I=-18; MD=-33; /M: SY='S'; M= -25,-253, 3, 3,-250, 28, 35,-247, -1, -72,-243, -56, 38, 5, 11, 42, -1, -6,-256, -1; D=-18; /I: I=-18; MI=0; MD=-33; IM=0; DM=-33; /M: SY='P'; M= -30,-259,-255,-247,-243, -54, -28, 12,-249, 31, 50,-253, 90, -49,-255, -60, -24, 1,-259,-247; D=-18; /I: I=-18; MI=0; MD=-33; IM=0; DM=-33; /M: SY='L'; M= -2,-249,-260,-255, -33, -15,-251, 52,-254, 70, 14,-255,-257,-249,-254,-248,-238, 19,-251,-234; D=-18; /I: I=-18; DM=-33; /M: SY='S'; M= -15, 46, -2,-238,-254, 21,-239,-249,-237,-254,-247, 62, 36,-235,-244, 69, 12, -28,-264,-250; D=-18; /I: I=-18; DM=-33; /M: SY='A'; M= 71,-245,-242,-235,-250, -59,-244, -35,-236, -54,-237, -42, 53, 31, -42, 12, 39, -10,-256,-246; /M: SY='A'; M= 78,-241,-241, -43,-249, -62,-244,-237, -59, -38,-237,-234, -12, -14,-242, 49, 31, 2,-256,-245; /M: SY='D'; M= -69,-250, 73, 39,-252, -41, 35,-248, -25,-249, 2, 28,-242, 3,-235, 43, 19, -22,-263, -28; /M: SY='F'; M= -60,-247,-263,-258, 122,-259,-246,-221,-254, -7, -26,-253,-261,-262,-252,-249, -44, 14,-224,-202; /M: SY='G'; M= -58,-253,-246,-251,-243, 79, 4, 70,-247,-236,-234,-235, 14,-244,-253, -15, 2,-227,-251, -30; /M: SY='K'; M=-239,-253,-232,-223,-255, -45,-233,-256, 102,-255,-243, 29,-243,-219, 55, -35, -15,-251,-252,-243; /M: SY='N'; M= -41, 38,-244,-247, -17, -48,-241, 29,-244, 52, -3, 65,-255, -13,-247,-239, -21, 26,-253, -18; /M: SY='M'; M= -54,-247,-258,-254,-230,-258,-253, 69,-250, -44, 79,-250,-252,-248,-252, -13, -42, 77,-257,-235; /I: I=-9; MD=-17; /M: SY='R'; M=-236,-252,-235, -43,-252,-245, 15,-253, 61,-251, -7, -15,-245,-222, 84, 43, 28,-248,-256,-241; D=-9; /I: I=-9; MD=-17; /M: SY='H'; M= 23, -26, -40, 38,-245,-243, 61, 15, -53, 2,-233, 19,-245, 25, -12, 31, 5, -48,-259,-239; D=-9; /I: I=-9; MD=-17; /M: SY='V'; M= 18, 16,-256, -67, -46,-256,-257, 49, -21, -10, -26,-250,-253,-249,-250,-240, 1, 76,-259,-239; D=-9; /I: I=-9; MD=-17; /M: SY='F'; M=-253,-252,-262,-259, 119,-260, -20,-229,-254, -77,-229,-254,-264,-259,-251,-251,-246,-235,-217, 79; D=-9; /I: I=-9; MI=0; MD=-17; IM=0; DM=-17; /M: SY='P'; M=-240,-262,-243,-235,-260, -28, -6,-250, -43,-256, 23, -13, 120,-241,-248, 18, -19,-253,-259,-255; D=-9; /I: I=-9; DM=-17; /M: SY='N'; M= -32,-251, 49, -41,-254, 52, 12, -51, -68,-255,-247, 67,-246, 15, -28, 20, 8,-251,-260, -29; D=-9; /I: I=-9; DM=-17; /M: SY='A'; M= 53,-244, -31, -13,-238,-244,-248, 26,-243, 19, -3,-241,-247,-240,-247, 10, 38, 36,-257,-241; D=-9; /I: I=-9; MI=0; MD=-17; IM=0; DM=-17; /M: SY='Q'; M= -36,-253,-237, -22,-248, 19, 23, -38, 55, -16,-237, -20,-246, 56, 41, 11, -60, -19,-252, -20; D=-9; /I: I=-9; MI=0; MD=-17; IM=0; DM=-17; /M: SY='A'; M= 66, -4, -31,-240, -24,-241,-248, 22,-242, -55,-237, -44, 9, 12,-247, -1, 57,-230,-258,-245; D=-9; /I: I=-9; DM=-17; /M: SY='R'; M=-242,-258,-242, -10,-250,-254, -12,-244, 32, -42, 53,-237,-251, 28, 92, -17,-240, -1,-256,-241; D=-9; /I: I=-9; DM=-17; /M: SY='R'; M=-241, -4, -6, -38,-248,-257,-242, -50, -10,-239, 2,-240, -35,-231, 92,-241, -8, 55,-261,-243; D=-9; /I: I=-9; MI=0; MD=-17; IM=0; DM=-17; /M: SY='L'; M= -64,-249,-262,-254, -33, -54,-252, -4,-254, 70, 24,-257,-259, -14,-253,-250, -42, 53, 17,-234; D=-9; /I: I=-9; DM=-17; /M: SY='G'; M= -26,-255, 6, -16,-258, 73,-243,-254, -48, -50, -1, -6, 32, 25, -37, -18, -1, -65,-258,-252; D=-9; /I: I=-9; DM=-17; /M: SY='T'; M= 14,-248, 6, -18,-243, 24, 11, -28,-240, -47, 23, 7,-247, -1,-244, -1, 49, 32,-257, 9; D=-9; /I: I=-9; DM=-17; /M: SY='R'; M= 0,-255, 1, -24,-255, -31,-234,-254, -18, -63,-242, -13, 34, 28, 88, 6, 1,-249,-256,-244; D=-9; /I: I=-9; DM=-17; /M: SY='G'; M= -70,-252, 3,-242,-258, 88,-242,-259, -44,-260,-250, 40, 1, -31,-246, 25, -33, -65,-257,-252; D=-9; /I: I=-9; DM=-17; /M: SY='Q'; M= -14,-255,-231, 29,-256, 32, 47, -48, -23, -38,-241, 50,-246, 70, -4, -35, 3,-250,-259,-244; D=-9; /I: I=-9; DM=-17; /M: SY='S'; M= -40, 1,-239, -16,-255, -17, 2, -37, -17, -59, -10, 21, -1,-235, -43, 82, -16, -61,-265,-249; D=-9; /I: I=-9; MI=0; MD=-17; IM=0; DM=-17; /M: SY='K'; M=-243,-258,-239, -8,-255, -8,-239, -41, 89, -69, 32,-234,-248, -32, 54, -48,-240, -61,-255,-245; D=-9; /I: I=-9; DM=-17; /M: SY='Y'; M=-251,-258,-255,-253, 78,-259,-229, 8,-247,-229,-230,-252, -21, -9, -34,-247, -42,-235,-217, 115; D=-9; /I: I=-9; DM=-17; /M: SY='H'; M=-242, 54,-244, -38, -43,-254, 105, 36,-245, -63,-230, 18,-255,-241,-245, -16, -53, 42,-260, 25; D=-9; /I: I=-9; DM=-17; /M: SY='Y'; M= -47,-262,-259,-259, 8,-263, -9, 63,-253,-228,-228,-256,-262,-249,-252,-250,-245, -26, 26, 112; D=-9; /I: I=-9; DM=-17; /M: SY='Y'; M= -1, 31, -20, 5,-245,-249,-239,-243, 12, -44, -7, 17,-252, 27, 23, 23, -13, 10,-255, 36; D=-9; /I: I=-9; MI=0; MD=-17; IM=0; DM=-17; /M: SY='G'; M= -33,-255, -25,-252,-262, 103,-248,-268,-247,-265,-254, 18,-248,-245,-254,-229,-245,-262,-256,-257; D=-9; /I: I=-9; DM=-17; /M: SY='I'; M= -77, -4, -51,-258, -59,-265,-257, 92,-255, 29, 39,-254,-255,-252,-257,-250, -44, 18,-254,-235; /M: SY='R'; M= -64, -28, -13, -1,-255, -58, 7,-256, 36,-252, -14,-232,-249, 40, 94, -9,-240, -65,-255, -47; /M: SY='W'; M= -54,-256,-251, -48, -3,-255, 4, -14, 6, 36, 47,-248, 52,-238, 44, -45,-240, 1, 62,-234; /M: SY='R'; M= -77, 4,-240, -48,-252,-253,-237, -5, 60, -73,-240, 6, -25,-225, 91,-238, -16, -25,-256,-244; /M: SY='E'; M= 17,-254, 3, 48,-256, -98,-238, -50, 29, -66,-244, 18, 37, -31, 40, -35, 28,-246,-259,-248; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 41 in 41 different sequences |
| Number of true positive hits | 41 in 41 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DNA_BIND |
| Feature description [info] | RFX-type winged-helix |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
41 sequences
ARID2_HUMAN (Q68CP9), ARID2_MOUSE (E9Q7E2), DAF19_CAEEL (Q09555), RFX1_CANAL (Q59V88), RFX1_HUMAN (P22670), RFX1_MOUSE (P48377), RFX1_YEAST (P48743), RFX2_BOVIN (A6QLW9), RFX2_CANAL (Q5AMQ6), RFX2_DANRE (Q5EAP5), RFX2_HUMAN (P48378), RFX2_MACFA (Q4R3Z4), RFX2_MOUSE (P48379), RFX2_PONAB (Q5RDR2), RFX2_RAT(B2GV50), RFX2_XENLA (Q32NR3), RFX2_XENTR (B1WAV2), RFX3_DANRE (A0JMF8), RFX3_HUMAN (P48380), RFX3_MACFA (Q4R3I8), RFX3_MOUSE (P48381), RFX3_XENTR (Q0V9K5), RFX4_DANRE (A2BGA0), RFX4_HUMAN (Q33E94), RFX4_MOUSE (Q7TNK1), RFX4_XENLA (A0A1L8GWK2), RFX5_HUMAN (P48382), RFX5_MOUSE (Q9JL61), RFX6_AILME (D2HNW6), RFX6_DANRE (Q5RJA1), RFX6_HUMAN (Q8HWS3), RFX6_MOUSE (Q8C7R7), RFX7_HUMAN (Q2KHR2), RFX7_MOUSE (F8VPJ6), RFX7_XENLA (A0A1L8H0H2), RFX8_HUMAN (Q6ZV50), RFX8_MOUSE (D3YU81), RSC9_SCHPO (Q9P7W8), RSC9_YEAST (Q03124), SAK1_SCHPO (P48383), SWSN7_CAEEL (Q09441)» more
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| PDB [Detailed view] |
10 PDB
1DP7; 6K15; 6KW3; 6KW4; 6KW5; 6TDA; 6V8O; 6V92; 7VDV; 7Y8R |