Entry: PS51542

Forthcoming changes to the profile format
General information about the entry

Entry name [info] FYRN
Accession [info] PS51542
Entry type [info] MATRIX
Date [info] JUL-2011 (CREATED); OCT-2013 (DATA UPDATE); JUN-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC51542
Associated ProRule [info] PRU00875

Name and characterization of the entry

Description [info] FYR domain FYRN motif profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=60;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=55;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2239439; R2=0.0097524; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=6266.32694; R2=14.06172; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=952; N_SCORE=11.5; H_SCORE=18205; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=439; N_SCORE=6.5; H_SCORE=12425; MODE=1; TEXT='?';
/DEFAULT: M0=-28; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='M'; M= -27, -12, -13, -16,  10, -14,  -7,  -6,   5,  16,  25,   2,  15, -17, -11, -15,   0,   2, -48, -42;
/M: SY='P'; M= -40, -26, -35, -36,  37, -70,  13, -10, -35,  12,  -1, -28,  66, -39, -42, -19, -27,  14, -90,   5;
/M: SY='P'; M= -17,  -2, -35, -30,   3, -39,  13,   3, -11,   6,  -4, -18,  66,   8,  -7, -42, -17, -19, -94,  -8;
/M: SY='F'; M= -19, -93, -37, -21,  30, -37, -19,  23,   5,  21,  28, -11, -44, -42,  11, -38, -16,   5, -89,  -1;
/M: SY='R'; M= -10, -94, -39,  -8,  -8, -39, -11, -14,  -5,  16,  33, -13,   1,   4,  41, -38,   2,   5, -35, -54;
/M: SY='I'; M= -17, -21, -16, -86, -17,  -3, -40,  34, -28,  -1,  -6,   3, -56, -38, -20,  32,  -1,  27, -97, -30;
/M: SY='G'; M= -28,   3,  -8,   1, -57,  64,  20, -32, -22, -37, -85, -14,  13, -20, -38, -13,   3, -52, -97, -14;
/M: SY='S'; M= -11,  -8,  24, -53, -70,  26, -15, -59,  -8, -66,  42,  30, -16, -11, -26,  55,   6, -59,-100, -55;
/M: SY='L'; M= -35, -42, -98, -92,   6, -53, -89,   0, -73,  61,  30, -66, -97, -36, -68, -35,  -6,  47, -92, -45;
/M: SY='T'; M= -39, -54, -23,  42, -24, -89, -29,   2,  -9, -25,  32,  -6, -84,  17,  18,  -9,  58, -11, -54, -47;
/M: SY='V'; M= -52, -90,-100, -63,  23,-102, -96,  60, -93,  29, -58, -96,  22, -71, -74, -68, -75,  60, -92, -73;
/M: SY='H'; M= -67, -92,   1,  17, -58, -95,  63,  20, -32,  26, -23, -14, -90, -37,  -9, -51,  14,  20, -11,  36;
/M: SY='S'; M=  -2,  31,  14,   9, -94, -75, -15, -93,   2, -70, -86,  57, -85,  -3,   3,  68, -34, -70,-103, -86;
/M: SY='L'; M= -58, -89,-100, -95,  23,-101, -39,  36, -94,  71,  17, -53, -56, -89, -93, -41, -32,   0, -86, -13;
/M: SY='G'; M= -68, -95, -83, -94, -53, 104, -89,-106, -88, -78, -92, -39, -49, -86, -95, -68, -86, -82, -39, -94;
/M: SY='Q'; M=  -6, -15, -55,  31, -37, -49,  17, -41,  36, -86, -23, -51, -84,  49,  28,  19,  31, -18, -96, -48;
/M: SY='I'; M= -80, -90,-102, -66, -17,-105, -96,  71, -94,  43, -33, -97, -97, -92, -61, -90, -76,  55, -11, -32;
/M: SY='V'; M= -35, -40,  18, -26, -34, -93,  29,  27, -52,   9,   9, -21,  -6, -27, -42, -10,   6,  53, -98, -17;
/I:         I=-17; MD=-42;
/M: SY='P'; M= -26, -99, -22, -32, -16, -33,  -3, -37, -13, -46, -36, -25,  66,  -2, -12,  10,  24, -19,  49,  11; D=-17;
/I:         I=-17; MD=-42;
/M: SY='D'; M= -11,-101,  55,  -2, -63,  27,  29,-103,  -7, -67, -93,   2, -37, -18,  27, -30, -27, -59,-108, -91; D=-17;
/I:         I=-17; MD=-42;
/M: SY='R'; M= -55,-117, -57, -93,-114, -86, -59, -89, -62, -48, -54,   7,  -4,  37,  39,  27, -69,-111, -41, -48; D=-17;
/I:         I=-17; MI=0; MD=-42; IM=0; DM=-42;
/M: SY='P'; M=  -8, -33,  20,  24, -38,  -7, -50, -63,  36, -66, -21, -20,  60,   8,   4,  10, -20, -59, -96, -45; D=-17;
/I:         I=-17; DM=-42;
/M: SY='N'; M=  19, -28, -15, -49,   1,  26,  29, -83,  -6,  -1, -12,  35,  -6, -58,   4,  19,   2, -45, -35, -24;
/M: SY='F'; M= -65, -93, -95, -91,  92, -41, -80, -75, -59, -46,  -1, -25, -36, -38, -11,  20, -81, -60,  92,  55;
/M: SY='H'; M= -53,  68,  23, -74, -13,  -1, 117, -93, -22, -72, -78, -34, -90,  -9, -77, -16, -29, -33, -51,  13;
/M: SY='N'; M= -50,  31,  31, -51, -60, -30,  19, -66,  -4, -43, -83,  58, -19, -31, -51,  48,  49, -56,-104, -53;
/M: SY='E'; M=   1, -94,  36,  44, -34, -35, -11, -57,  40, -74, -68, -32,  17,  17,  -3,  23, -40, -32, -95, -21;
/M: SY='R'; M= -21, -37,  17, -13, -39, -16,  41, -55,  21, -73, -63,  13, -27,  34,  46,   7,  23, -38, -24,  -3;
/M: SY='Y'; M=  41,  -3, -63, -34,  11, -85,  56, -48,  -6, -47,  -3, -23, -91, -15, -24, -30, -18, -18,  11,  81;
/M: SY='I'; M= -36, -26, -98, -61, -70,-101, -96,  87, -93,  22,  -5, -63,  28, -90, -96, -49, -43,  15, -93, -53;
/M: SY='Y'; M= -71,   0, -97, -95,  74, -70, -73, -20, -89, -29, -70, -48,-101, -89, -88, -88, -51, -35,  94, 102;
/M: SY='P'; M= -84,  -6, -85, -75, -50, -87, -88, -89, -81, -50, -86, -60, 126, -84, -54, -53, -55, -68, -97, -98;
/M: SY='V'; M=  -4, -40,  13,   4, -79, -68, -91,  39,  10, -19, -67, -61,  12, -48, -83, -66, -21,  66,-100, -82;
/M: SY='G'; M= -69, -95,   1, -88,-100, 100, -86, -63, -70,-103, -93,   4, -45, -52, -92, -68, -84,-100, -94, -95;
/M: SY='Y'; M= -91, -95, -95, -95,  85, -98, -65, -70, -88, -50, -44, -92,-102, -88, -85, -87, -84, -52, -51, 116;
/M: SY='R'; M= -66,  26, -44,  12, -89, -89,   8, -56,  47, -51, -15, -38, -85,  22,  53, -15,  48,  -3, -45, -53;
/M: SY='C'; M=  50,  76, -48, -81, -86, -64, -86, -11, -81, -81, -21, -74, -87, -78, -86,  65,  14,  11,-100, -50;
/M: SY='S'; M= -50,  -5, -58,  27, -43, -57, -39, -14, -11, -34, -18, -58, -84, -10,  47,  50,  49,  -3, -43, -50;
/M: SY='R'; M= -56, -46, -84, -73, -86, -94, -27, -81,  12, -69, -78, -64, -92, -32, 101, -79, -20,  26,  67, -76;
/M: SY='I'; M=  -8, -90, -62, -27, -30, -56,  19,  32,  28,  27, -12, -46, -57,   3,   6, -27,  16,  13,  16, -25;
/I:         I=-16; MD=-40;
/M: SY='Y'; M= -77, -27, -98, -71,  69, -85,  -1, -75, -92, -38, -29, -94, -32, -91, -63, -34, -60, -14, -27, 102; D=-16;
/I:         I=-16; MD=-40;
/M: SY='W'; M=  -4,-102, -99, -43,  37, -50, -15, -35, -20, -31,   0, -46,   5, -61,  -4, -45, -17, -36, 121,  28; D=-16;
/I:         I=-16; MD=-40;
/M: SY='S'; M= -50, -35, -20, -80, -27, -66,  21, -53, -50, -97, -91,   9, -90, -46, -25,  91, -65, -37, -11, -85; D=-16;
/I:         I=-16; MD=-40;
/M: SY='M'; M= -38,   8, -60, -91, -18, -29, -33,  -8, -52,  -2,  43, -87,  29, -89, -28,   4,  41,  23, -23, -37; D=-16;
/I:         I=-16; MD=-40;
/M: SY='K'; M= -25, -20, -10, -50,  -2, -47, -16, -29,  34,   3, -80, -55, -97, -12,  29, -14,   9,  10,-102, -85; D=-16;
/I:         I=-16; MI=0; MD=-40; IM=0; DM=-40;
/M: SY='D'; M= -21,  -4,  81,   0,-101, -46,  25,-102, -23, -92, -95,  46, -49, -60,  -5,   0, -27, -92,-112, -29; D=-16;
/I:         I=-16; DM=-40;
/M: SY='P'; M=   8,-101, -23, -47, -49, -14, -31, -24, -13,  -9, -60,  -9,  95,  -7, -53, -48, -29, -63, -99, -92; D=-16;
/I:         I=-16; DM=-40;
/M: SY='W'; M= -45, -93,  41,  -5, -27,   9,  27, -36,   8, -41, -42,  39, -22, -37,  36,  -8,  17, -45,  43, -20;
/M: SY='K'; M= -31, -24,  -9,  16, -26, -12, -24, -79,  45, -50, -81,  17, -15,  38,  42,  11,  11, -29, -95, -82;
/M: SY='R'; M= -43, -41, -32, -24, -60,  14, -20,  -4,  31,  -6,  12, -61, -25, -28,  67,  -1,   3, -35, -33, -21;
/M: SY='C'; M=   5, 102, -89, -25, -14, -75, -91,   7, -85, -61,   3, -41, -93, -19, -64,   6,  22,  47, -51, -83;
/M: SY='W'; M= -60, -16, -71,  -3,  -6, -92, -17,  -4,   4,  12,  -2,   0, -25, -28,  34, -14,  23,  14,  75,  18;
/M: SY='Y'; M= -71, -11, -91, -92,  33, -62,  13, -44, -60, -59,  -8, -89,-100, -81, -82, -62, -83, -26,  55, 123;
/M: SY='T'; M= -44, -90, -22,  13, -64, -92,   8,  36,  27, -23, -17, -33, -85, -13,  22, -48,  58,  11, -96, -17;
/M: SY='C'; M=  -9, 119, -89, -88, -15, -84, -86, -19, -85, -37,  65, -16, -95, -31, -89,  50, -71, -45,-102, -84;
/M: SY='E'; M= -53, -94, -38,  75, -94, -87,  -9, -56,  25, -67, -18, -50,  -8,   9,  35,  28,   9, -66, -96, -45;
/M: SY='I'; M= -77, -91, -99, -96, -41, -61,-101,  90, -63, -55, -58, -90, -92, -91, -52, -44,   8,  57, -96, -76;
/M: SY='L'; M= -30,  -7, -14,  24, -35, -46,   8,  -6,   7,  40, -27, -28, -89, -34,  -8,   4,  19,  10, -94, -21;
/M: SY='D'; M= -39,  -6,  76,  59, -95, -37, -47,  -9, -27, -49, -85,  -4, -45,  -8,  10, -34, -25, -15,-104, -86;
/M: SY='G'; M=  14,  34,  15, -15, -50,  45, -35, -71, -15, -78, -83,  31, -59,  18,  -8,   2,   7,  -7,  -8, -25;
/I:         E1=0; IE=-380; DE=-380;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_07 which contains 546'000 sequence entries.


Total number of hits 19 in 19 different sequences
Number of true positive hits 19 in 19 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] FYR N-terminal
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
19 sequences

ATX1_ARATH  (Q9C5X4), ATX2_ARATH  (P0CB22), JMJ14_ARATH (Q8GUI6), 
KMT2A_HUMAN (Q03164), KMT2A_MOUSE (P55200), KMT2B_HUMAN (Q9UMN6), 
KMT2B_MOUSE (O08550), KMT2C_HUMAN (Q8NEZ4), KMT2C_MOUSE (Q8BRH4), 
KMT2D_HUMAN (O14686), KMT2D_MOUSE (Q6PDK2), MBD9_ARATH  (Q9SGH2), 
TBRG1_HUMAN (Q3YBR2), TBRG1_MOUSE (Q3UB74), TBRG1_RAT   (Q5PQK8), 
TBRG1_XENTR (Q66IH2), TRR_DROME   (Q8IRW8), TRX_DROME   (P20659), 
TRX_DROVI   (Q24742)
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PDB
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1 PDB

2WZO

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