Entry: PS51546

Forthcoming changes to the profile format
General information about the entry

Entry name [info] PI3K_RBD
Accession [info] PS51546
Entry type [info] MATRIX
Date [info] AUG-2011 (CREATED); OCT-2013 (DATA UPDATE); JUL-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC51546
Associated ProRule [info] PRU00879

Name and characterization of the entry

Description [info] Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=93;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=88;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0174348; R2=0.0095898; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=11016.48207; R2=21.62749; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=937; N_SCORE=11.0; H_SCORE=29011; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=468; N_SCORE=6.5; H_SCORE=21117; MODE=1; TEXT='?';
/DEFAULT: M0=-21; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='N'; M=-30,-37, 20,-14,-74,  6,  1,-23, 18,-27, -4, 46, 38, -9,-20,  1, 11,-43,-83,-32;
/M: SY='T'; M=  1,-72,-49,-13,-71, 27,-51, -6, -6,-38,-62, 21,-31, -7, -2, 21, 44, -5,-80,-21;
/M: SY='S'; M=-16,  8, -5,-22,-20,-36, 12,-33, 34,-72,-66, 31, -9, 11,  4, 38, 20,-35,-80,-16;
/M: SY='I'; M=-53,  5,-46,-24, 48,-86,-18, 53,-42, 37,-26,-76,-80,-74,-76,-53,-62, 28,-69,-22;
/M: SY='K'; M=-26,-11,-67,-18, 34,-75,-65,  9, 41, 13,-33, -3,-52,-43,-10,  1, 16, -2,-70,  3;
/M: SY='I'; M=-27, -3,-59,-79,-53,-86,-81, 67,-58, 12, -2,-49,-79,-75,-35,-71,-58, 61,-80,-25;
/M: SY='N'; M=-17,-19, 16,-14,-71,-67,-31,-15, 12,-48, 26, 43,-70,-24, 20, 17, 31, 15,-86,-67;
/M: SY='V'; M=-10, -2,-78,-74, -7,-42,-77, 49,-37,  3, -6,-32,-18,-25,-42,-36,  1, 56,-80,-61;
/M: SY='W'; M=-51, -6,-24, 11, 14,-59, 71,-71, 22,-25,-61,-11,-55, 29, -2,-56,-27,-57, 94, 35;
/M: SY='Y'; M=-53, 14,-25,-50, 43,-59,-65, 26,-34, 15,-51, -9,  4,-25,-11,-20, 11, -5,-13, 45;
/M: SY='E'; M=-16,-77, 25, 34,-36,-17,-40,  1,-30,-18,-62,-19,  7, 30, 14, 21, -2, -9,-82,-67;
/I:         I=-14; MD=-34;
/M: SY='W'; M=-21,-95, -3,-40, -8,-50,-33,-36,-14,-26,-79, -8, -7,-60,-86,-16,-17,  2, 13,-81; D=-14;
/I:         I=-14; MI=0; MD=-34; IM=0; DM=-34;
/M: SY='N'; M=-60,-89,  4,-15,-56, 18,-72,-21,  0,-60,-55, 57,-26,-19,-63,  2,-48,-65,-33,-83; D=-14;
/I:         I=-14; DM=-34;
/M: SY='S'; M=-14,  2, 40, -8,-25,-26,-64,-29,-31,-39,-28, 16,-46,-28,-27, 44,-16,-40,-83, 17; D=-14;
/I:         I=-14; DM=-34;
/M: SY='Q'; M=-47,  5, 12, 13,-52, -7,-32,-23, 18,-56,  8, 38,  8, 48,  3, -9, 15,-38,-82,-47;
/M: SY='Q'; M=-51, 17, 12,  9,-43,-72, -1,  1, -6,-24, 19,  1,-16, 47,-17, -1, 34,  3,-81,-12;
/M: SY='S'; M=-17,  4, 13,-17,-32,-18,-64,-11, 22,-59,-13,-14, 37,-12,-18, 41, 23,-19,-81,-41;
/M: SY='F'; M=-24,-74,-70,-48, 42,-76,  0, 23, 25,  2, -3, 17,-38, -7,-34,-32,  2, 24,-69,  5;
/M: SY='T'; M=-22,-41,-43,-13,-71,-67,  1,-54,  5,-32,-18,-25,-21,-35, 16, 40, 75,-26,-85,-66;
/M: SY='F'; M=-33,-73,-84,-79, 74,-63,-72, 41,-59, 31, 17,-45,-81,-31,-37,-72,-38, 16,-62,-26;
/M: SY='Q'; M=-24,-75, -4,  4,-50,-52, -1,-15, 32,-55,  3, -1,-23, 46, 19,  4, 36, -7,-81,-45;
/M: SY='C'; M=-25, 94,-80,-76, 17,-81,-27, 41,-43, -4,-50,-29,-20,-15,-55,-67,-59, 46,-81,-61;
/M: SY='D'; M= -7, -2, 45,  0,-71,-32, 10,-67,-27,-22,  9, 38, 14,-16,-46, 36, -6,-22,-83, -2;
/M: SY='P'; M= -6, 28,-69,-36,  0,-53, 47, 22,-30,  1,-26,-11, 52,-65,-38,-28, 14, 12,-26,-15;
/M: SY='N'; M=-60,-73, 48, -8,-50,-23,-21,-68,  1,-21, -9, 60,-69, 23,-37, 14, 29,-24,-28,-17;
/M: SY='D'; M= -4, 24, 37,  1,-30,-24, -8,-11,-32,-17, 11,-37,-35, -4,-65, 35, 35,-29,-79, 11;
/M: SY='T'; M=-47,-34,-48,-48,-12,-31,-31,-23, -1,  5,-32, -8, -3,-61,-16, 19, 77, -8,-81,-33;
/M: SY='P'; M= 29,-10,-73,-65,-69,-70,-18, -5,-51,-59, 12,-48, 78,-44,-73,-27,-25, 50,  4,-69;
/M: SY='D'; M=-12,-76, 54, 36,-15,  0,-20,  3, -2,-22,-63,-25,-51,  8,-25,  6, -7,-23,-80,-23;
/M: SY='E'; M=-12,-40, 36, 47,-37,-57, 26,-19, 20,-15,-25, 10,-67, 35,-37, -2, -9,-41,-82,-44;
/M: SY='L'; M= 16,-71,-82,-76,  8,-80,-74, 38,-57, 48,-40,-77,-80,-72,-75,-54,-44, 43,-71, 10;
/M: SY='I'; M=-49,-10,-77,-56,-53,-82,-47, 73,-16, 29, 39,  2,-50,-48,-72,-50, -8, 10,-78,-59;
/M: SY='E'; M= 32,-25, -3, 37,-47,-50, -8,-61, 21,-36, -1,  2,-69,  8,  2,-15,-15, 18,-78, -6;
/M: SY='Q'; M=-41,  6,-24, 23,-67,-36, 18, -1,  4,  0, 35, 26,-69, 50,  5, 14, -8,-37,-79,-25;
/M: SY='I'; M= 39,-31,-23,-71, 21,-60,-74, 49,-71, 14,-15,-68,-73,-69,-74,-32, 21, 23,-74,-34;
/M: SY='L'; M=-44,-72,-79,-31, 52,-82,-69, 34,-55, 59,  6,-22,-80,-71,-74,-29,-48, -9,-23, -1;
/M: SY='C'; M= -9, 55,-48, 11,-41,-55, 19,-24, 29,-60,-39, 14,-70, 19, 46, 18, 14,-49,-80,-39;
/M: SY='K'; M= -1, 19,-58, 20,-19,-43,-61,-72, 72,-45,-28,-55,-45,-22, -5, 15, -4,-46, 29,  8;
/M: SY='M'; M=-20, 14,-70,-19, 34,-63,  8, 16, 24, 23, 45, -7,-75,-15, -1,-64,-19,  1, -8, -7;
/M: SY='H'; M= 19,-72,-21, 14,-21,-23, 38,-26,-11,-10,-16, 22,-34, 19, -9, 16, 11,-31,-74, 22;
/M: SY='N'; M=-46, 11, 27, -2,-72,-20, -5,-28, 28,-18,  9, 38,-51, 12, 16,  5, 32,-45,-83,-40;
/M: SY='Q'; M=-19,-74, 29,-14, -5,-24, 15, 12, 20,-12, -6,-31,-22, 29,-23, 17, 16, -3,-78,-37;
/M: SY='H'; M=-15,-74, -6,-61,  9,-37, 41, -8,  0, 36, 19, -9,-35, 33,-15,-36, -9,  3,-73, -1;
/M: SY='K'; M=-30, 12,  9,-11,-70, 13,  1,-39, 30,  2, 11, 29, -4,  9, 16,  6,-23,-16,-80,-65;
/M: SY='M'; M= -6,-72,  2,-13,  7,-26,  0, -3, -9, 14, 26,  4,  4, 23,-44, -1, 12, 10,-74,-10;
/M: SY='N'; M=-12,-40, 14, 13,-31,-26,-30, -2,-11,-21,  8, 34, 28, -5, 20, 15, -3, -3,-80,-45;
/M: SY='P'; M=-18,-22, 27, 27,-18,-21,-37,-15,  4, -7,-36, -4, 32,-22,-10,  0,  1, 13,-78,-12;
/I:         I=-18; MD=-45;
/M: SY='E'; M=-30,-83, 28, 37,-50,-61, -1, -1,  4,-20,-45,-20,-12, 21,-16, -6,-64,  8,-88,-71; D=-18;
/I:         I=-18; MD=-45;
/M: SY='Q'; M=-26,-92, 25, 10,-58,-45,-76,-33, -8, -9,-74,-39, 10, 29,-15,-38,-15,-35,-32,-80; D=-18;
/I:         I=-18; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='N'; M=-20,-56, 27,-30,-86,-77,-18,-67, -1,-65,-48, 31,  4,  5,-30, 13, -5,-36,-95, -9; D=-18;
/I:         I=-18; DM=-45;
/M: SY='P'; M=  0,-55,-16,-12,-88,-37,-74,-47,-27,-69,-76,-18, 78, 11,-41,  5,-45,-35,-89,-31; D=-18;
/I:         I=-18; DM=-45;
/M: SY='N'; M=-23, -6, -4, 27,-62, 12,-20,-42,  9,-45,-37, 38,-71, -2,-51, 35, 12,-72,-84,-14; D=-18;
/I:         I=-18; DM=-45;
/M: SY='D'; M=-52,-78, 80, 37,-79,-33,-30,-35, 13,-61,-19, 23,-66, 29,-17, -1,-33,-74,-14,-32;
/M: SY='Y'; M=-73,-29,-75,-74, 73,-79, 41,-43,-50,-30,-51,-71,-53,-33,-66,-69,-67,-61, 56,105;
/M: SY='V'; M= -2,-10,-50,-72,-34, -5,-76, 42,-41, 12,-30,-70,-76,-33,-13,-52, -4, 62,-79,-37;
/M: SY='L'; M=-52,-70,-85,-78, 32,-85,-70,  2,-78, 82,-19,-82,-84,-73,-76,-55,-63,-14,-68,-49;
/M: SY='K'; M=-61,-78,-58,-45,-76,-70,-57,-33, 82,-35,-61,-32,-67, 63, 32, -2,-45,-28,-13,-63;
/M: SY='V'; M=-36,-72,-82,-77,-54,-85,-28, 61,-75,  5,-23,-76,-15,-26,-77,-59,-32, 74,-82,-60;
/M: SY='C'; M= -8, 99,-49,-48,-27,-70,-39,-17,-18,-31, -6, -3,-20, 17, 11,  5, 30,-16, 14, -5;
/M: SY='G'; M=-50,-22,-51,-60,-83,100,-45,-90,-69,-86,-75,-34,-36,-67,-77,-33,-68,-84,-75,-78;
/M: SY='R'; M=-55, 22,-66,-25, 17,-73,-36,-21,-27, 13,-14,-59,-73, 20, 64, 21, 28,-59, -9, 10;
/M: SY='D'; M=-19,-76, 49, 47,-38,-46, 14,-73, -9,-28, -3, 31,-67, 19, 25, 11,-29,-52,-10,-31;
/M: SY='E'; M=-18,-16, 17, 98,-81,-73,-56,-35,-45,-51,-35,-55,-59, 15,-54,-27,-19,-71,-81,-72;
/M: SY='Y'; M=-50,-34,-75,-75, 68,-79, 32,-18,-70,-37,-50,-72,-83,-68,-67,-68,-65, -4, 16,108;
/M: SY='L'; M=-36,-70,-84,-78, -5,-85,-72, 39,-77, 72, 19,-80,-81,-72,-76,-49,-61, 21,-72,-54;
/M: SY='Q'; M=  8,-27,-30,-27, 35,-72, -8, 11,-53, 13,-50,-46,-73, 46,-29,  1, 18,  4,-65, 37;
/I:         I=-16; MI=0; MD=-40; IM=0; DM=-40;
/M: SY='G'; M=-33,-76,-10,  1,-78, 68,-37,-76,-16,-43,-19, 42, 37,-58,-20,-13,-18,-41,-80,-73;
/M: SY='D'; M=-54,-77, 76, 13,-81,-45,  7,-80, 19,-79,-15, 49,  5,  0, -2,  9,-19,-77,-90,-69;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='H'; M=-40,-31,-20,-15, 20,-73, 80, 18,-32,-33,-53,-33,-73, 13,-32,  7,  9, -4, -8, 61;
/M: SY='P'; M=-14, 24,-35,-23,-52,-57,-64,-42,  7,-15,-62,-46, 83,  7, 20, 12,-10,-28,-76, -1;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='L'; M=-58,-71,-85,-77,-44,-86,-70, 33,-77, 78, 47,-81,-82,-35,-75,-76,-62,-11,-73,-55;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='I'; M=-28, 38,-47,-67,-64, 31,-20, 40, -2,  1,-22,  1,-72,-20,-10, 28,  4,-16,-79,-48;
/M: SY='Q'; M=-48,-33, 47, 15,-54,-52,  9,-77,-49,-76,-68, 37,-67, 71,-17, 52,-15,-56,-85,-66;
/M: SY='Y'; M=-55,-21,-73,-73, 74,-78, 58,-24,-69, -4,-50,-11,-61,-42,-67,-49,-45,-24,-45, 90;
/M: SY='E'; M=-40,-22, 46, 49,-47,-54,-20,-29, 26,-16,  0,-30,-35, 46, -6,-31,-26, -7,-80,-29;
/M: SY='Y'; M=-52, 36,-72,-70,  2,-45, 31, -5,-62,-42,-11,-68,-80,-19,  9,-14,-50,-19, 51,105;
/M: SY='I'; M=-60,-73,-83,-79,  1,-87,-28, 75,-56,-32,-41,-76,-77,-28,-77,-69,-25, 70,-78,-57;
/M: SY='R'; M=-50, -6,-60,-37,-47,-28, 38,-77,-26,-57,-62,  5,-74, 63, 91,-48,-64,-37,-78,-61;
/M: SY='Q'; M=-42,-75, 11, 24,-75,-66, 38,-43, 19,-38,-14, 36,-45, 61,  2, 24, -1,-27,-81,-35;
/M: SY='C'; M=-19,124,-20,-27, -8,-70,-16,-35,-17,-61, -2, -2,-80,-28, -3, 23,-40,-65,-29,-69;
/M: SY='L'; M=-44,-47,-79,-60,  3,-82,-23, 39,-13, 61,-21,-74,-79,-67, -4,-18,-39, 17,-73,-39;
/M: SY='K'; M=-15,-41,-42,  3,-69,-60,  6,-30, 48,  2, 21,-55,-55, 10, 45, 32, -9,-43,-77,-39;
/M: SY='R'; M=-53,-75,-16,-52, 24,-20, -3,-47, 19,  1,-30, 35,-39, 25, 43, 14,-12, -8, 13,-56;
/M: SY='G'; M=-28,-59, 29, 21,-71, 38,  4, -8,  8,-55, -9,  5,-45, 21,  7,  1,-28,-35,-76, 14;
/M: SY='Q'; M=-23,-34,-16, 35,-74,-29, -4,-26, 50,-25,-15,-46,-44, 52, 25,-44, 12,-40, 12,-44;
/M: SY='P'; M=-54,-12, 38, 27,-30,-58, 22, -4,  4, -5,  9,  5, 40,-56,-36,-20, 29,-16,-82,-41;
/M: SY='P'; M=-52,-79,-76,-60,  2,-61, 15, 62,-45,  2,-40,-51, 72,-70,-50,-55,-34, 26,-76,-60;
/M: SY='H'; M=-40,-10, 23, 11,-70,-41, 67,-32, 18,-14, 16, 23,-50, 32, 23,-14, -9,-47,-21,-19;
/M: SY='L'; M=-66,-71,-59,-72, 32,-82,-34,-12,-54, 69,-37, -7,-82,  7,-33,-56,-47, 22,-70,-51;
/M: SY='T'; M=-30,-23,-34,  5, -7,-30,-67, 13, -3,-18, 21,-42,-50,  3,-20, 17, 43, 38,-79,-40;
/M: SY='L'; M=-57,-70,-77,-52,-12,-81,-68, -4,-58, 66, 33,-16,-10,-68,-34,-30,  3, 22,-75,-41;
/M: SY='V'; M=-41, 21,  3, -4,-21,-18,-69, 36,-33,  1, 26,-64,-58,-14,  8,-48, 21, 40,-79,-28;
/M: SY='H'; M= -5,-59, 24, 28,-42,-68, 52,-22, -5,-18,-28, 18, 31,  7,  7,  6, -8,-27,-82,-38;
/I:         E1=0; IE=-380; DE=-380;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_09 which contains 546'439 sequence entries.


Total number of hits 23 in 23 different sequences
Number of true positive hits 23 in 23 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] PI3K-RBD
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
23 sequences

AGE1_CAEBR  (P0C5E7), AGE1_CAEEL  (Q94125), P3C2A_HUMAN (O00443), 
P3C2A_MOUSE (Q61194), P3C2A_PONAB (Q5RAY1), P3C2B_HUMAN (O00750), 
P3C2G_HUMAN (O75747), P3C2G_MOUSE (O70167), P3C2G_RAT   (O70173), 
PI3K1_DICDI (P54673), PI3K2_DICDI (P54674), PI3K3_DICDI (P54675), 
PK3CA_BOVIN (P32871), PK3CA_HUMAN (P42336), PK3CA_MOUSE (P42337), 
PK3CB_HUMAN (P42338), PK3CB_MOUSE (Q8BTI9), PK3CB_RAT   (Q9Z1L0), 
PK3CD_HUMAN (O00329), PK3CD_MOUSE (O35904), PK3CG_HUMAN (P48736), 
PK3CG_MOUSE (Q9JHG7), PK3CG_PIG   (O02697)
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PDB
[Detailed view]
106 PDB

1E7U; 1E7V; 1E8W; 1E8X; 1E8Y; 1E8Z; 1E90; 1HE8; 2A4Z; 2A5U; 2CHW; 2CHX; 2CHZ; 2RD0; 2V4L; 2WXF; 2WXG; 2WXH; 2WXI; 2WXJ; 2WXK; 2WXL; 2WXM; 2WXN; 2WXO; 2WXP; 2WXQ; 2WXR; 2X38; 2Y3A; 3APC; 3APD; 3APF; 3CSF; 3CST; 3DBS; 3DPD; 3ENE; 3HHM; 3HIZ; 3IBE; 3L08; 3L13; 3L16; 3L17; 3L54; 3LJ3; 3MJW; 3ML8; 3ML9; 3NZS; 3NZU; 3OAW; 3P2B; 3PRE; 3PRZ; 3PS6; 3QAQ; 3QAR; 3QJZ; 3QK0; 3R7Q; 3R7R; 3S2A; 3SD5; 3T8M; 3TJP; 3TL5; 3ZIM; 3ZVV; 3ZW3; 4A55; 4AJW; 4ANU; 4ANV; 4ANW; 4ANX; 4AOF; 4BFR; 4DK5; 4EZJ; 4EZK; 4EZL; 4F1S; 4FA6; 4FAD; 4FHJ; 4FHK; 4FJY; 4FJZ; 4FLH; 4FUL; 4G11; 4GB9; 4HLE; 4HVB; 4J6I; 4JPS; 4KZ0; 4KZC; 4L1B; 4L23; 4L2Y; 4PS3; 4PS7; 4PS8
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