PROSITE entry PS51777
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General information about the entry
| Entry name [info] | RH2 |
| Accession [info] | PS51777 |
| Entry type [info] | MATRIX |
| Date [info] |
01-OCT-2015 CREATED;
13-FEB-2019 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51777 |
| Associated ProRule [info] | PRU01113 |
Name and characterization of the entry
| Description [info] | RH2 domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=77; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=72; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.5714810; R2=0.0063112; TEXT='-LogE'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=10833.6210938; R2=2.9783344; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=1494; H_SCORE=15283; N_SCORE=12.0; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=623; H_SCORE=12689; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-39; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='R'; M= -44,-111, -91, 6,-106,-105, 13,-106, 25, -62, 12, -21, -33, -4, 95, -30, -28, -56,-109, -94; /M: SY='P'; M= -35, 15, -95, -84, -48, -54, -96,-108, 59,-111,-100, -93, 99, -86, 20, -6, -90,-107,-109,-105; /M: SY='R'; M= -96, 57, -96, -88, -39, -41, -21,-110, -33,-105, -96, -16, -34, -42, 103, -13, -94, -56, -3, -31; /M: SY='F'; M=-107,-105,-118,-114, 120,-115, -95, -45,-109, -74, -82,-108,-118,-117,-106,-105, -99, -86, -71, 47; /M: SY='T'; M= -82, -94, -89, -91,-101, -95, -98, -94, -29, -99, -94, -78, -92, -90, -95, 50, 107, -86,-118, -98; /M: SY='R'; M= -52,-107,-101, -91, -20,-110, -92, -51, 37, 44, 30, -95,-107, -83, 78, -96, -8, -51,-105, -90; /M: SY='Q'; M= 27,-105, -4, 37,-103, -44, -90, -34, -2, -46, -2, -37, -99, 60, 11, 20, -87, 9,-108, -16; /M: SY='E'; M= -92,-113, -18, 114,-115,-108, -85,-115, -74,-107, -16, -88, -88, -67, -84, -89, -93,-108,-113,-105; /M: SY='M'; M= -93, -99,-114,-105, -75,-111, -92, -62,-102, 68, 118,-107,-107, -95,-100,-104, -91, 0,-103, -82; /M: SY='R'; M= 50,-104, -90, -12,-107, -94, -87,-104, 38,-101, -1, -85, -98, 47, 77, -4, -87, -96,-105, -95; /M: SY='R'; M= -41,-111, 44, 59,-108,-102, 22,-109, -9,-104, -96, -36, -97, 43, 77, -86, -60, -51,-109, -31; /M: SY='V'; M= -39, -99,-113,-108, -82,-114,-112, 56,-105, 4, 1,-108,-108,-105,-107, -98, -84, 89,-112, -89; /M: SY='L'; M= -95,-100,-115,-108, -73,-117,-102, 40,-108, 86, -60,-112,-112,-102,-106,-106, -91, 10,-103, -84; /M: SY='M'; M= -20, -24, -96, -88, 8, -20, 58, 5, -17, 5, 89, 7,-101, 67, -88, -53, -2, -84,-104, -82; /M: SY='E'; M= -91,-111, 38, 112,-114,-104, -83,-115, -73,-107,-104, -83, -86, -66, -83, -86, -90,-107,-112,-103; /M: SY='R'; M= -95,-111, -91, -79,-106,-105, -83,-112, 47,-106, -94, -84,-102, -70, 112, -29, -93,-106,-105, -93; /M: SY='N'; M= -92, -98, -33, -37,-105, -82, -74, -32, -33,-108, 1, 127,-102, -80, -86, -76, -78,-104,-124,-101; /M: SY='Q'; M= -23,-109, -19, 72,-103, -51, 14, -22, 27, -56, 14, -84, -93, 77, -21, -30, -90, -98,-103, 8; /M: SY='Y'; M= -98,-103,-108,-104, -28,-112, -84, -70, -39, 75, -15,-108,-113, -96, -98,-102, -94, -77, -79, 97; /M: SY='K'; M= -93,-107, -85, -22,-108,-100, -20,-108, 111, -57, -94, -79, -93, -7, -14, -87, -88,-104,-103, -95; /M: SY='E'; M= 39, -18, -78, 78, -26, -26, -91, -45, -82, -62, -15, -86, -92, -23, -90, 30, 27, -39,-108, -97; /M: SY='R'; M= -93,-108, -20, -44,-108, -99, -82,-109, 61,-106, -95, 39, -99, 43, 86, -20, -34,-105,-107, -94; /M: SY='L'; M= -93, 18,-113,-107, -1,-115,-100, 12,-106, 71, -65,-109,-112,-103,-105,-102, -37, 49, -99, 21; /M: SY='M'; M= -37,-101, -37,-101, 71,-104, -93, 22, -99, 16, 95, -22,-105, -13, -99, 13, -38, -46, 20, -72; /M: SY='E'; M= -32,-106, 26, 84, -27,-104, -87, -90, -27, 24, -6, -27, -95, 24, -26, -89, -90, -2,-108, -94; /M: SY='L'; M= 0, 6,-113,-105, -23,-111,-101, -13,-106, 83, -6,-110,-111,-101,-105,-101, -90, 20,-103, -85; /M: SY='Q'; M= -90,-112, -75, 75, -32,-101, -81,-106, -20,-102, -93, -31, -93, 106, 12, -82, -35, -62,-105, -94; /M: SY='E'; M= -91,-111, 66, 103,-115,-102, -83,-114, -74,-108,-105, -80, -88, -10, -84, -36, -89,-108,-115,-102; /M: SY='E'; M= 41,-103, -74, 86,-109, -94, -3,-107, -30,-103, -97, -85, -91, -11, 15, 25, -9, -98,-109, -99; /M: SY='L'; M= -94,-100,-114,-107, -73,-115,-100, 38,-106, 76, 41,-110,-111,-101,-105,-104, -90, 30,-102, -7; /M: SY='R'; M= 29,-105, -15, 36, -31, -96, -21,-105, 29,-101, -2, -8, -97, 39, 67, 5, -58, -99,-106, -94; /M: SY='W'; M= -16, 34, -29, -35, 0,-101, 3, -87, -93, 19, -84, -17,-106, -28, -6, 10, -12, -20, 108, 73; /M: SY='Y'; M= -27, 31,-101, -99, 27,-103, -22, -80, -96, 18, 41, -94,-105, -32, -97, 6, 48, -11, -85, 87; /M: SY='Q'; M= -91,-110, -34, 61,-109, -61, -21, -33, 55,-101, -5, -82, -94, 77, 39, -35, -29,-101,-106, -95; /M: SY='M'; M= 8, 5, -93, -89, -99, -28, -89, -14, -31, -45, 72, 30, 37, -4, 52, 18, 20, -89,-109, -95; /M: SY='E'; M= -24, -41, -11, 47, -21, 13, -92, 21, 10, 9, -23, -88, -98, 34, 17, 3, -89, -21, -12, -92; /M: SY='R'; M= -26, -17, -16, 4, -98, 4, -89, -4, 5, 2, -89, -1, 3, -20, 66, 22, -14, -62,-106, -25; /M: SY='A'; M= 45,-100, 0, -24, -17, -21, -94, 0, -21, 18, -32, 20, -18, 9, -6, -18, -38, 15,-106, -36; /M: SY='N'; M= -30, -17, 14, -3, -50, -19, -25, -50, 18, -15, 8, 38, 31, 6, 13, 35, 4, -40, 0, -95; /M: SY='Q'; M= -21,-106, 33, 27, -48, -47, -31,-101, 48, -32, -93, -18, -29, 51, 36, -1, -5, -39,-106, -16; /M: SY='P'; M= -3, -8, -4, 51,-100, -57, -92, -12, 23, -15, 29, -47, 52, -81, 7, 7, -27, -38, 22, -96; /M: SY='E'; M= -8,-106, -1, 42, -56, -3, -21, -49, -51, -52, -9, 22, 32, 41, 23, 15, -53, -10,-105, 13; /M: SY='H'; M= 4, 27, 11, -15,-102, 1, 49, -49, 3, -61, -16, -9, 17, 18, 16, 38, -45, 2,-111, -36; /M: SY='P'; M= 7,-105, 6, 14,-101, -38, -92, -26, 18, 2, -26, 7, 60, 32, -42, -7, -12, 8,-109, -97; /M: SY='S'; M= -17, -25, 20, 29,-104, 3, -8, -39, 13, -33, 9, -14, 1, 35, -20, 39, 19, -34,-110, -96; /M: SY='E'; M= 16,-102, 7, 36, -43, -45, -92, -7, -16, 7, -86, -24, -1, 35, -13, 23, 7, 7,-108, -94; /I: I=-10; MD=-24; /M: SY='D'; M= -2,-106, 33, 25, 13,-101, -23, -17, -3, 21, 3, -6, 9, -88, -26, 22, -12, -91, 1, -91; D=-10; /I: I=-10; MD=-24; /M: SY='P'; M= -98,-114, 24, 2,-107, -4,-102, -20, 2, -2, -21, -20, 36, -95, -12, 11, -3, -7, -14,-105; D=-10; /I: I=-10; MD=-24; /M: SY='E'; M= -72,-120, 0, 39, -41, -44,-101,-114, 24, -39, -4, 18,-111, -32, 18, -9, -16, -53, -11,-108; D=-10; /I: I=-10; MD=-24; /M: SY='K'; M= -2,-120, 13, -12,-123, 12,-106,-118, 30, -43,-111, 2, -23, 4, -21, -3,-102, -48,-125,-115; D=-10; /I: I=-10; MD=-24; /M: SY='M'; M= -22,-122, -16, 15,-120, -42,-112, -24, 14,-112, 30, -45, -18,-102, -25, 3, 4, -13,-130,-116; D=-10; /I: I=-10; MD=-24; /M: SY='K'; M= -46,-129, -54, -27, -23, -27,-117,-117, 27,-122,-117, -50, 14, -41, -12, -10, -21, -6, 3, -21; D=-10; /I: I=-10; MI=0; MD=-24; IM=0; DM=-24; /M: SY='V'; M= -15,-118, -19, -37,-111, -70,-119, -43, -50, 1, -24, -43, 8,-113,-118, -30, 20, 36,-131,-114; D=-10; /I: I=-10; DM=-24; /M: SY='Q'; M=-109,-124,-112,-106, 13, -23,-109, -27,-107, -21, 11, 9, 43, 53,-111, -69, 0, -23,-120,-106; D=-10; /I: I=-10; DM=-24; /M: SY='Q'; M= -98,-117,-107,-103, -41, 41,-109, -27, 4,-110,-105, -97,-112, 44,-103, 2, 33, 0,-120, -50; D=-10; /I: I=-10; DM=-24; /M: SY='P'; M= -25, 37, -7, -95, -56, -14,-105, -55, -5, -74,-105, -98, 60, 11, 33, -34, 16,-109, 51,-105; D=-10; /I: I=-10; DM=-24; /M: SY='P'; M= -66,-110, 29, -18,-104, -1, -6, 10, 6, -16, 28, -7, 47, 24, -94, 31, -42, -95, -7, -99; D=-10; /I: I=-10; DM=-24; /M: SY='P'; M= -35,-106, -94, -57, -17, -54, -94, 14, -49, -23, -87, 16, 77, 24, 28, 36, -84, 13,-107, -95; /M: SY='R'; M= -6,-105, -29, 15, 2, -40, -89, -52, 21, -21, 13, 3, 35, -18, 44, -21, 15, -30, 34, 16; /M: SY='P'; M= 6, -21, -85, 48, -54, -96, -21,-103, 36, -63, -96, -89, 77, 1, -7, 18, -53, -67, 26, -26; /M: SY='P'; M= 21,-106, -18, 2, 13, -23, -3, -25, 25, -29, -92, -22, 68, 5, 5, -1, -15, -95, 9, -92; /M: SY='E'; M= -6,-106, 41, 46, -3, -65, -93, 17, -60, -61, -13, -13, 30, 6, -9, -9, 16, -12, 24, -93; /M: SY='S'; M= -6,-103, 36, 24, 4, -94, -90,-101, 33, -68, -97, -6, 29, -43, -45, 50, 28, -55,-109, -49; /M: SY='K'; M= 34, -13, 39, -22,-106, -22, -3,-101, 47, -34, -95, 0, 5, -82, 20, 16, -33, -30,-112, -98; /M: SY='P'; M= -1,-104, -10, -1, -35, 6, -24, -9, 16, 10, 1, -2, 27, -86, 24, 13, -52, 4,-107, -50; /M: SY='W'; M= -29,-105, -27, -58, 1, 5, -93, -55, -50, -28, 34, -40, 42, -14, -28, 50, 2, -26, 76, 33; /M: SY='W'; M= -52,-104, -94, -94, 23, 15, -34, -92, -3, 12, -89, 39, 46, -91, -38, 37, -7, -22, 72, -87; /M: SY='W'; M= -42,-105, -12, -30, -98, 7, 10, -13, 22, -22, -92, -19, 7, -85, 36, 26, 40, -44, 77, -91; /M: SY='P'; M= -50,-105, 14, -84, -45, -23, -39, -43, 47, -8, -92, 8, 50, 1, -6, 11, 38, -36,-111, -97; /M: SY='P'; M= 2,-107, -43, 11, -13, -29, 25,-105, 24,-105, -97, 36, 52, 10, 16, 36, -85, -52,-108, -23; /M: SY='E'; M= -19,-108, -17, 63, -19, -39, -87,-105, -3, -31, -96, 17, 15, 54, 13, 4, 1,-102,-109, -97; /M: SY='S'; M= -57,-101, -89, -1,-101, -25, -91, -95, -10, 7, -92, -17, -32, 6, 23, 80, -5, -25,-111, -96; /M: SY='G'; M= -10,-107, -94, -91, -45, 53, 11, -38, 7, -41, -37, -45, 37, 19, 30, -23, 29, -99,-107, -39; /M: SY='I'; M= -92, 24,-101, -2, -91, -26, -1, 69, -29, -9, -79, -96, -2, -36, 22, 4, -17, 17,-110, -93; /M: SY='R'; M= -89,-107, 7, -16, -8, -99, 0, -35, 40,-100, -94, -84, 16, 20, 53, 44, -6, -2,-109, -93; /M: SY='K'; M= -5,-106, -6, -84,-104, 3, 14, -32, 65, -97, 58, -84, 19, -12, 5, 16, -9, -49,-109, -95; /M: SY='F'; M= -33,-104, -4, -29, 55, -61, -97, 13, -31, 43, 15, -24, 13, 2, -45, -15, -9, -31, -99, -81; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 25 in 25 different sequences |
| Number of true positive hits | 25 in 25 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | RH2 |
| Version [info] | 4 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
25 sequences
JIP3_DROME (Q9GQF1), JIP3_DROPS (Q29EP6), JIP3_HUMAN (Q9UPT6), JIP3_MOUSE (Q9ESN9), JIP3_RAT(E9PSK7), JIP4_HUMAN (O60271), JIP4_MOUSE (Q58A65), JIP_CAEEL (P34609), RILP_HUMAN (Q96NA2), RILP_MOUSE (Q5ND29), RIPL1_BOVIN (Q17QG3), RIPL1_DANRE (A0PJT0), RIPL1_HUMAN (Q5EBL4), RIPL1_MOUSE (Q9JJC6), RIPL1_RAT (D3ZUQ0), RIPL1_XENLA (Q0IHE5), RIPL1_XENTR (A0PJP4), RIPL2_BOVIN (A4IFK7), RIPL2_DANRE (A4IGC3), RIPL2_HUMAN (Q969X0), RIPL2_MOUSE (Q99LE1), RIPL2_RAT (Q6AYA0), RIPL2_XENLA (Q6IP02), RIPL2_XENTR (Q0P4J3), RIPL_DROME (O76878)» more
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| PDB [Detailed view] |
8 PDB
1YHN; 6RIR; 6SQ2; 7LWB; 8PR2; 8PR3; 8PR4; 8PTK |