PROSITE documentation PDOC00083 [for PROSITE entry PS00088]

Manganese and iron superoxide dismutases signature




Description

Manganese superoxide dismutase (EC 1.15.1.1) (SODM) [1] is one of the three forms of an enzyme that catalyzes the dismutation of superoxide radicals. The four ligands of the manganese atom are conserved in all the known SODM sequences. These metal ligands are also conserved in the related iron form of superoxide dismutases [2,3]. We selected, as a signature, a short conserved region which includes two of the four ligands: an aspartate and a histidine.

Last update:

December 2004 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

SOD_MN, PS00088; Manganese and iron superoxide dismutases signature  (PATTERN)


References

1AuthorsBannister J.V., Bannister W.H., Rotilio G.
TitleAspects of the structure, function, and applications of superoxide dismutase.
SourceCRC Crit. Rev. Biochem. 22:111-180(1987).
PubMed ID3315461

2AuthorsParker M.W., Blake C.C.F.
TitleIron- and manganese-containing superoxide dismutases can be distinguished by analysis of their primary structures.
SourceFEBS Lett. 229:377-382(1988).
PubMed ID3345848

3AuthorsSmith M.W., Doolittle R.F.
TitleA comparison of evolutionary rates of the two major kinds of superoxide dismutase.
SourceJ. Mol. Evol. 34:175-184(1992).
PubMed ID1556751



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