PROSITE documentation PDOC00584 [for PROSITE entry PS00702]Granulocyte-macrophage colony-stimulating factor signature
Granulocyte-macrophage colony-stimulating factor (GM-CSF) [1,2] is a cytokine that acts in hematopoiesis by stimulating the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
GM-CSF is a glycoprotein of about 120 amino acid residues that contains four conserved cysteine residues involved in two disulfide bonds, as shown in the following schematic representation.
+---------------+
| |
xxxxxxxxxxxxxxxxxxxxxxxxxxCxxxxxxxxxxxxxxxxCxxxCxxxxxxxxxxxCxxx
| *****
+--------------------+
'C': conserved cysteine involved in a disulfide bond. '*': position of the pattern.
As a signature pattern, we selected the region that includes the second and third conserved cysteines.
Last update:May 2004 / Text revised.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Morstyn G. Burgess A.W. |
| Title | Hemopoietic growth factors: a review. | |
| Source | Cancer Res. 48:5624-5637(1988). | |
| PubMed ID | 2458827 |
| 2 | Authors | Walter M.R. Cook W.J. Ealick S.E. Nagabhushan T.L. Trotta P.P. Bugg C.E. |
| Title | Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor. | |
| Source | J. Mol. Biol. 224:1075-1085(1992). | |
| PubMed ID | 1569568 |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
View entry in original PROSITE document format
View entry in raw text format (no links)