PROSITE documentation PDOC00689 [for PROSITE entry PS00884]Osteopontin signature
Osteopontin is an acidic phosphorylated glycoprotein of about 40 Kd which is abundant in the mineral matrix of bones and which binds tightly to hydroxyapatite [1,2,3]. It is suggested that osteopontin might function as a cell attachment factor and could play a key role in the adhesion of osteoclasts to the mineral matrix of bone.
Osteopontin-K is a kidney protein which is highly similar to osteopontin and probably also involved in cell-adhesion.
As a signature pattern we selected a highly conserved region located at the N-terminal extremity of the mature protein.
Last update:June 1994 / Text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Butler W.T. |
| Title | The nature and significance of osteopontin. | |
| Source | Connect. Tissue Res. 23:123-136(1989). | |
| PubMed ID | 2698313 |
| 2 | Authors | Gorski J.P. |
| Title | Acidic phosphoproteins from bone matrix: a structural rationalization of their role in biomineralization. | |
| Source | Calcif. Tissue Int. 50:391-396(1992). | |
| PubMed ID | 1596774 |
| 3 | Authors | Denhardt D.T. Guo X. |
| Title | Osteopontin: a protein with diverse functions. | |
| Source | FASEB J. 7:1475-1482(1993). | |
| PubMed ID | 8262332 |
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