|PROSITE documentation PDOC50145 [for PROSITE entry PS50145]|
TRAF proteins were isolated first by their ability to interact with TNF receptor . They are involved in different cytoplasmic signal transduction pathways. TRAF proteins are composed of 3 structural domains: a RING finger (see <PDOC00449>) in the N terminal part of the protein, TRAF zinc fingers in the middle part and the TRAF domain in the C terminal part. TRAF zinc fingers contain 8 possible ligands for one or two zinc atoms. This domain is found only in TRAF and TRAF-related proteins and its function is not yet known.
The profile we developed covers the whole domain.Last update:
January 2002 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Rothe M., Wong S.C., Henzel W.J., Goeddel D.V.|
|Title||A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.|