PROSITE documentation PDOC50173 [for PROSITE entry PS50173]UmuC domain profile
Description
In Escherichia coli, UV and many chemicals appear to cause mutagenesis by a process of translesion synthesis that requires DNA polymerase III and the SOS-regulated proteins umuC, umuD and recA. This machinery allow the replication to continue through DNA lesion, and therefore avoid lethal interruption of DNA replication after DNA damage [1].
Proteins known to contain an UmuC domain are listed below:
- Bacterial umuC protein.
- Escherichia coli mucB and Salmonella typhimurium impB proteins. Plasmid- born analogues of the UmuC protein.
- Salmonella typhimurium samB, a plasmid associated homologue of UmuC .
- Bacterial DNA polymerase IV.
- Yeast REV1 protein, required for normal induction of mutations by physical and chemical agents.
The profile we developed spans the complete UmuC domain.
Last update:September 2002 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Smith B.T. Walker G.C. |
| Title | Mutagenesis and more: umuDC and the Escherichia coli SOS response. | |
| Source | Genetics 148:1599-1610(1998). | |
| PubMed ID | 9560379 |
| 2 | Authors | Walker G.C. |
| Title | SOS-regulated proteins in translesion DNA synthesis and mutagenesis. | |
| Source | Trends Biochem. Sci. 20:416-420(1995). | |
| PubMed ID | 8533155 |
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