|PROSITE documentation PDOC50919 [for PROSITE entry PS50919]|
The protein mannosyltransferase, inositol 1,4,5-trisphosphate receptor (IP3R) and ryanodine receptor (RyR) (MIR) domain is an ~50-residue motif found generally in multiple copies in:
As single MIR domains are found in the chlamydial proteins and in a splice variant of mouse tape-2 IP3R, it is proposed that MIR domains represent independent structural units, rather than being tandem repeats arranged within a single structural domain. The MIR domain can be found associated with other domains such as MAC/Perforin domain, SPRY, RyR repeated domain, EF-hand domain (see <PDOC00018>) or RIH. The function of the MIR domain is not yet known .
The profile we developed covers the entire MIR domain.Last update:
August 2003 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|Title||Novel repeats in ryanodine and IP3 receptors and protein O-mannosyltransferases.|
|Source||Trends Biochem. Sci. 25:48-50(2000).|