PROSITE documentation PDOC51053 [for PROSITE entry PS51053]

SERTA domain profile

The SERTA (for SEI-1, RBT-1, and TARA) domain is a motif of ~47 residues corresponding to the largest conserved region among TRIP-Br (transcriptional regulator interacting with the PHD-bromodomain) proteins, an evolutionarily conserved family restricted to higher eukaryotes. In proteins of the TRIP-Br family, the SERTA domain is found in association with a cyclin A-binding domain and a PHD-bromo binding domain. The SERTA domain is also found in some other proteins with no conservation with TRIP-Br proteins outside of the SERTA motif. The cyclin-dependent kinase CDK4-interacting segment of TRIP-Br1 includes most of the SERTA domain [1,2].

Some proteins known to contain a SERTA domain are listed below:

• Mammalian cell division cycle associated protein 4 (CDCA4) or hematopoietic progenitor protein (HEPP), a protein expressed preferentially in hematopoietic progenitors and mature blood cells.
• Human TRIP-Br1/p34SEI-1, a cyclin-dependent kinase regulator interacting with PHD (see <PDOC50016>) and bromodomains (see <PDOC00550>), two modules widely found in chromosomal proteins.
• Mammalian RBT1, a potent transcriptional coactivator that interacts with the second subunit of replication protein A.
• Human Y127, an hypothetical 34-kD protein.
• Drosophila TARANIS, a trithorax group (trxG) protein that might participate in a cell memory process coupling chromatin structure to cell cycle progression.
• Drosophila CG2865.

The profile we developed covers the entire SERTA domain.