|PROSITE documentation PDOC51183 [for PROSITE entry PS51184]|
The JmjN and JmjC domains are two non-adjacent domains which have been identified in the jumonji family of transcription factors. Although it was originally suggested that the JmjN and JmjC domains always co-occur and might form a single functional unit within the folded protein, the JmjC domain was latter found without the JmjN domain in organisms from bacteria to human [1,2].
JmJC domains are predicted to be metalloenzymes that adopt the cupin fold (see <PDB:1H2K>), and are candidates for enzymes that regulate chromatin remodelling. The cupin fold is a flattened β-barrel structure containing two sheets of five antiparallel β strands that form the walls of a zinc-binding cleft. JmjC domains were identified in numerous eukaryotic proteins containing domains typical of transcription factors, such as PHD (see <PDOC50016>), C2H2 (see <PDOC00028>), ARID/BRIGHT and zinc fingers [2,3]. The JmjC has been shown to function in a histone demethylation mechanism that is conserved from yeast to human .
In addition to eukaryotic transcription factors of the jumonji family, a JmjC domain is also found in the following proteins:
The profiles we developed cover the entire JmjN and JmjC domains.Last update:
February 2006 / First entry.
PROSITE methods (with tools and information) covered by this documentation:
|1||Authors||Balciunas D., Ronne H.|
|Title||Evidence of domain swapping within the jumonji family of transcription factors.|
|Source||Trends. Biochem. Sci. 25:274-276(2000).|
|2||Authors||Clissold P.M., Ponting C.P.|
|Title||JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta.|
|Source||Trends. Biochem. Sci. 26:7-9(2001).|
|3||Authors||Elkins J.M., Hewitson K.S., McNeill L.A., Seibel J.F., Schlemminger I., Pugh C.W., Ratcliffe P.J., Schofield C.J.|
|Title||Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.|
|Source||J. Biol. Chem. 278:1802-1806(2003).|
|4||Authors||Tsukada Y., Fang J., Erdjument-Bromage H., Warren M.E., Borchers C.H., Tempst P., Zhang Y.|
|Title||Histone demethylation by a family of JmjC domain-containing proteins.|