PROSITE documentation PDOC51738 [for PROSITE entry PS51738]Peptidase family C21 domain profile
The family Tymoviridae comprises the genus Tymovirus, from which it derives its name, the genus Marafivirus and the genus Maculavirus [1,E1]. Members of the family are plant viruses that have the following traits in common: icosahedral virion structure, a monopartite single-stranded RNA genome with a very high cytidine content and a similar genome organization. The replication strategy encompasses post-translational proteolytic cleavage of the polypeptide encoded by ORF1 by a peptidase family C21 domain [E2]. The peptidase family C21 domain is a papain-like proteinase with catalytic cysteine and histidine residues [2,3].
Some proteins known to contain a peptidase family C21 domain are listed below:
- Turnip yellow mosaic virus (TYMV) replication-associated polyprotein (RP).
- Grapevine fleck virus (GFkV) replication-associated polyprotein (RP).
- Oat blue dwarf virus (OBDV) replication-associated polyprotein (RP).
- Maize rayado fino virus (MRFV) replication-associated polyprotein (RP).
- Olive latent virus 3 (OLV-3) replication-associated polyprotein (RP).
- Eggplant mosaic virus (EMV) replication-associated polyprotein (RP).
- Ononis yellow mosaic virus (OYMV) replication-associated polyprotein (RP).
- Kennedya yellow mosaic virus (KYMV) replication-associated polyprotein (RP).
- Erysimum latent virus (ELV) replication-associated polyprotein (RP).
The profile we developed covers the entire peptidase family C21 domain.
Last update:November 2014 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Martelli G.P. Sabanadzovic S. Abou-Ghanem Sabanadzovic N. Edwards M.C. Dreher T. |
| Title | The family Tymoviridae. | |
| Source | Arch. Virol. 147:1837-1846(2002). | |
| PubMed ID | 12209322 | |
| DOI | 10.1007/s007050200045 |
| 2 | Authors | Bransom K.L. Dreher T.W. |
| Title | Identification of the essential cysteine and histidine residues of the turnip yellow mosaic virus protease. | |
| Source | Virology 198:148-154(1994). | |
| PubMed ID | 8037790 | |
| DOI | 10.1006/viro.1994.1017 |
| 3 | Authors | Alabdullah A. Minafra A. Elbeaino T. Saponari M. Savino V. Martelli G.P. |
| Title | Complete nucleotide sequence and genome organization of Olive latent virus 3, a new putative member of the family Tymoviridae. | |
| Source | Virus Res. 152:10-18(2010). | |
| PubMed ID | 20561953 | |
| DOI | 10.1016/j.virusres.2010.05.010 |
| E1 | Title | https://viralzone.expasy.org/54?outline=all_by_protein |
| E2 | Title | https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=c21 |
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