PROSITE documentation PDOC51820 [for PROSITE entry PS51820]PA14 domain profile
The ~150-amino acid PA14 domain, named after its location in the protective antigen of anthrax toxin, is found in a variety of bacterial and eukaryotic proteins such as glycosidases, glycosyltransferases, proteases, amidases, toxins, adhesins and signaling molecules. The PA14 domain is combined in a mosaic manner with various catalytic or non-catalytic domains directly or indirectly implicated in binding carbohydrate or peptidoglycan. It could be a carbohydrate-binding module [1,2,3].
The PA14 domain is a β-barrel structure comprising two β-sheets (see <PDB:1ACC>). The N and C termini of the domain are close together in space, presumably, thereby facilitating the insertion of the PA14 domain into other recognized domains without structural disruption [1,2,3].
The profile we developed covers the entire PA14 domain.
Last update:November 2016 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Rigden D.J. Mello L.V. Galperin M.Y. |
| Title | The PA14 domain, a conserved all-beta domain in bacterial toxins, enzymes, adhesins and signaling molecules. | |
| Source | Trends Biochem. Sci. 29:335-339(2004). | |
| PubMed ID | 15236739 | |
| DOI | 10.1016/j.tibs.2004.05.002 |
| 2 | Authors | Yoshida E. Hidaka M. Fushinobu S. Koyanagi T. Minami H. Tamaki H. Kitaoka M. Katayama T. Kumagai H. |
| Title | Role of a PA14 domain in determining substrate specificity of a glycoside hydrolase family 3 beta-glucosidase from Kluyveromyces marxianus. | |
| Source | Biochem. J. 431:39-49(2010). | |
| PubMed ID | 20662765 | |
| DOI | 10.1042/BJ20100351 |
| 3 | Authors | Petosa C. Collier R.J. Klimpel K.R. Leppla S.H. Liddington R.C. |
| Title | Crystal structure of the anthrax toxin protective antigen. | |
| Source | Nature 385:833-838(1997). | |
| PubMed ID | 9039918 | |
| DOI | 10.1038/385833a0 |
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