AC   PRU01063;
DC   Domain;
TR   PROSITE; PS51726; MYST_HAT; 1; level=0
XX
Names: MYST-type histone acetyltransferase (HAT) domain
Function: The MYST-type HAT domain contains three regions: a central region
 associated with acetyl-CoA cofactor binding and catalysis in addition to
 flanking N- and C-terminal regions harboring respectively a C2HC-type zinc
 finger and a helix-turn-helix DNA-binding motif.
XX
case <FTGroup:1>
DE   + RecName: EC=2.3.1.48;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-
CC         lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752,
CC         Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
end case
XX
case <FTGroup:1>
GO   GO:0004402; F:histone acetyltransferase activity
end case
case <FT:2> or <FT:3>
GO   GO:0046872; F:metal ion binding
XX
KW   Zinc
KW   Metal-binding
end case
case <FTGroup:1>
KW   Zinc-finger
KW   Acetylation
KW   Transferase
end case
XX
FT   From: PS51726
FT   DOMAIN          from..to
FT                   /note="MYST-type HAT #"
case <Feature:PS51726:37=[C]> and <Feature:PS51726:40=[C]> and <Feature:PS51726:53=[H]> and <Feature:PS51726:57=[C]>
FT   ZN_FING         34..59
FT                   /note="C2HC MYST-type #"
else case <Feature:PS51726:37=[CH]> and <Feature:PS51726:40=[CH]> and <Feature:PS51726:53=[CH]> and <Feature:PS51726:57=[CH]>
FT   ZN_FING         34..59
FT                   /note="C2HC MYST-type #; atypical"
else
FT   ZN_FING         34..59
FT                   /note="C2HC MYST-type #; degenerate"
end case
case <Feature:PS51726:151-157=[MQ]-[KR]-[AHKLMQR]-G-[FLY]-G-[KLQRSV]>
FT   BINDING         151..157
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT   Group: 1
end case
case <Feature:PS51726:142-146=[AS]-C-I-[LM]-[TIV]>
FT   BINDING         142..146
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT   Group: 1
end case
FT   ACT_SITE        177
FT                   /note="Proton donor/acceptor"
FT   Group: 1; Condition: E
FT   BINDING         181
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT   Group: 1; Condition: S
case <FTGroup:1>
FT   BINDING         190
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT   Condition: S
FT   BINDING         260
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT   Condition: K
end case
FT   MOD_RES         101
FT                   /note="N6-acetyllysine; by autocatalysis"
FT   Group: 1; Condition: K
XX
Chop: Nter=0; Cter=0;
Size: 260-344;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q9LXD7;
Scope:
 Eukaryota
Comments: None;
XX
# Revision 1.12 2022/11/19
//