AC   PRU10130;
DC   Domain;
TR   PROSITE; PS00176; TOPO_IB_1; 1; level=0
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Names: Topoisomerase (Topo) IB-type active site
Function: The RKKRH/N "catalytic pentad", conserved in all members of the topo
 IB family, catalyzes the attack of the active site tyrosine nucleophile on
 the scissile phosphodiester.
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DE   + AltName: Full=DNA topoisomerase;
DE            EC=5.6.2.1;
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CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC         passage and rejoining.; EC=5.6.2.1;
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FT   From: PS00176
FT   ACT_SITE        6
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
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Chop: Nter=0; Cter=0;
Size: unlimited;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q76ZS7;
Scope:
 Eukaryota
 Viruses
Comments: None
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# Revision 1.8 2023/09/19
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