{PDOC00004}
{PS00004; CAMP_PHOSPHO_SITE}
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* cAMP- and cGMP-dependent protein kinase phosphorylation site *
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There has been a  number of studies  relative to the  specificity of cAMP- and
cGMP-dependent protein kinases [1,2,3].  Both types of kinases appear to share
a preference  for  the  phosphorylation  of serine or threonine residues found
close to at least  two consecutive N-terminal  basic residues. It is important
to note that there are quite a number of exceptions to this rule.

-Consensus pattern: [RK](2)-x-[ST]
                    [S or T is the phosphorylation site]
-Last update: June 1988 / First entry.

[ 1] Fremisco J.R., Glass D.B., Krebs E.G.
     J. Biol. Chem. 255:4240-4245(1980).
[ 2] Glass D.B., Smith S.B.
     "Phosphorylation by cyclic GMP-dependent protein kinase of a synthetic
     peptide corresponding to the autophosphorylation site in the enzyme."
     J. Biol. Chem. 258:14797-14803(1983).
     PubMed=6317673
[ 3] Glass D.B., el-Maghrabi M.R., Pilkis S.J.
     "Synthetic peptides corresponding to the site phosphorylated in
     6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as substrates of
     cyclic nucleotide-dependent protein kinases."
     J. Biol. Chem. 261:2987-2993(1986).
     PubMed=3005275

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