{PDOC00033} {PS00033; ENGRAILED} {BEGIN} *********************************************** * 'Homeobox' engrailed-type protein signature * *********************************************** Most proteins which contain a 'homeobox' domain can be classified [1,2], on the basis of their sequence characteristics, in three subfamilies: engrailed, antennapedia and paired. Proteins currently known to belong to the engrailed subfamily are: - Drosophila segmentation polarity protein engrailed (en) which specifies the body segmentation pattern and is required for the development of the central nervous system. - Drosophila invected protein (inv). - Silk moth proteins engrailed and invected, which may be involved in the compartmentalization of the silk gland. - Honeybee E30 and E60. - Grasshopper (Schistocerca americana) G-En. - Mammalian and birds En-1 and En-2. - Zebrafish Eng-1, -2 and -3. - Sea urchin (Tripneusteas gratilla) SU-HB-en. - Leech (Helobdella triserialis) Ht-En. - Caenorhabditis elegans ceh-16. Engrailed homeobox proteins are characterized by the presence of a conserved region of some 20 amino-acid residues located at the C-terminal of the 'homeobox' domain. As a signature pattern for this subfamily of proteins, we have used a stretch of eight perfectly conserved residues in this region. -Consensus pattern: L-M-A-[EQ]-G-L-Y-N -Sequences known to belong to this class detected by the pattern: ALL, except for ceh-16. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: July 1999 / Pattern and text revised. [ 1] Scott M.P., Tamkun J.W., Hartzell G.W. III "The structure and function of the homeodomain." Biochim. Biophys. Acta 989:25-48(1989). PubMed=2568852 [ 2] Gehring W.J. "Homeo boxes in the study of development." Science 236:1245-1252(1987). PubMed=2884726 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}