{PDOC00045} {PS00046; HISTONE_H2A} {BEGIN} ************************* * Histone H2A signature * ************************* Histone H2A is one of the four histones, along with H2B, H3 and H4, which forms the eukaryotic nucleosome core. Using alignments of histone H2A sequences [1,2,E1] we selected, as a signature pattern, a conserved region in the N-terminal part of H2A. This region is conserved both in classical S- phase regulated H2A's and in variant histone H2A's which are synthesized throughout the cell cycle. -Consensus pattern: [AC]-G-L-x-F-P-V -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: 2. -Last update: November 1995 / Pattern and text revised. [ 1] Wells D.E., Brown D. "Histone and histone gene compilation and alignment update." Nucleic Acids Res. 19:2173-2188(1991). PubMed=2041803 [ 2] Thatcher T.H., Gorovsky M.A. "Phylogenetic analysis of the core histones H2A, H2B, H3, and H4." Nucleic Acids Res. 22:174-179(1994). PubMed=8121801 [E1] https://www.ncbi.nlm.nih.gov/projects/HistoneDB2.0/index.fcgi/browse/ -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}