{PDOC00049}
{PS00050; RIBOSOMAL_L23}
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* Ribosomal protein L23 signature *
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Ribosomal protein L23 is one of the proteins from the large ribosomal subunit.
In  Escherichia coli,  L23 is known to bind a specific region on the 23S rRNA;
in yeast, the corresponding protein binds to a homologous site on the 26S rRNA
[1]. It  belongs  to  a  family  of  ribosomal proteins which, on the basis of
sequence similarities [2,3,4], groups:

 - Eubacterial L23.
 - Algal and plant chloroplast L23.
 - Archaebacterial L23.
 - Mammalian L23A.
 - Caenorhabditis elegans L23A (F55D10.2).
 - Fungi L25.
 - Yeast mitochondrial YmL41 (gene MRPL41 or MRP20).

As a signature pattern, we selected a small conserved region in the C-terminal
section of these proteins, which is probably involved in rRNA-binding [2].

-Consensus pattern: [RK](2)-[AM]-[IVFYT]-[IV]-[RKT]-L-[STANEQK]-x(7)-[LIVMFT]
-Sequences known to belong to this class detected by the pattern: ALL,  except
 for yeast mitochondrial YmL41.
-Other sequence(s) detected in Swiss-Prot: 1.
-Last update: July 1999 / Pattern and text revised.

[ 1] El Baradi T.T.A.L., Raue H.A., van de Regt C.H.F., Verbree E.C.,
     Planta R.J.
     EMBO J. 4:210-2107(1985).
[ 2] Raue H.A., Otaka E., Suzuki K.
     "Structural comparison of 26S rRNA-binding ribosomal protein L25 from
     two different yeast strains and the equivalent proteins from three
     eubacteria and two chloroplasts."
     J. Mol. Evol. 28:418-426(1989).
     PubMed=2501503
[ 3] Fearon K., Mason T.L.
     "Structure and function of MRP20 and MRP49, the nuclear genes for two
     proteins of the 54 S subunit of the yeast mitochondrial ribosome."
     J. Biol. Chem. 267:5162-5170(1992).
     PubMed=1544898
[ 4] Otaka E., Hashimoto T., Mizuta K.
     Protein Seq. Data Anal. 5:285-300(1993).

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