{PDOC00057}
{PS00058; DNA_MISMATCH_REPAIR_1}
{BEGIN}
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* DNA mismatch repair proteins mutL / hexB / PMS1 signature *
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Mismatch repair contributes to the overall fidelity of DNA replication [1]. It
involves the correction of mismatched base pairs that  have been missed by the
proofreading  element  of the DNA polymerase complex.     The sequence of some
proteins involved in mismatch repair in different organisms have been found to
be evolutionary related. These proteins are:

 - Escherichia coli and  Salmonella typhimurium  mutL  protein [2].   MutL  is
   required for dam-dependent methyl-directed DNA repair.
 - Streptococcus pneumoniae hexB protein [3]. The Hex system is nick directed.
 - Yeast proteins PMS1 and MLH1 [4].
 - Human protein MLH1 [5] which is  involved  in a form of familial hereditary
   nonpolyposis colon cancer (HNPCC).

As a signature pattern for  this class of mismatch repair proteins we selected
a  perfectly conserved heptapeptide which is located in the N-terminal section
of these proteins.

-Consensus pattern: G-F-R-G-E-[AG]-L
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Modrich P.
     "DNA mismatch correction."
     Annu. Rev. Biochem. 56:435-466(1987).
     PubMed=3304141; DOI=10.1146/annurev.bi.56.070187.002251
[ 2] Mankovich J.A., McIntyre C.A., Walker G.C.
     "Nucleotide sequence of the Salmonella typhimurium mutL gene required
     for mismatch repair: homology of MutL to HexB of Streptococcus
     pneumoniae and to PMS1 of the yeast Saccharomyces cerevisiae."
     J. Bacteriol. 171:5325-5331(1989).
     PubMed=2676972
[ 3] Prudhomme M., Martin B., Mejean V., Claverys J.-P.
     "Nucleotide sequence of the Streptococcus pneumoniae hexB mismatch
     repair gene: homology of HexB to MutL of Salmonella typhimurium and to
     PMS1 of Saccharomyces cerevisiae."
     J. Bacteriol. 171:5332-5338(1989).
     PubMed=2676973
[ 4] Prolla T.A., Christie D.M., Liskay R.M.
     "Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two
     homologs of the bacterial mutL gene."
     Mol. Cell. Biol. 14:407-415(1994).
     PubMed=8264608
[ 5] Bronner C.E., Baker S.M., Morrison P.T., Warren G., Smith L.G.,
     Lescoe M.K., Kane M., Earabino C., Lipford J., Lindblom A.
     "Mutation in the DNA mismatch repair gene homologue hMLH1 is
     associated with hereditary non-polyposis colon cancer."
     Nature 368:258-261(1994).
     PubMed=8145827; DOI=10.1038/368258a0

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