{PDOC00067}
{PS00069; G6P_DEHYDROGENASE}
{BEGIN}
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* Glucose-6-phosphate dehydrogenase active site *
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Glucose-6-phosphate dehydrogenase (EC 1.1.1.49) (G6PD) [1] catalyzes the first
step  in  the  pentose  pathway,  the   reduction  of  glucose-6-phosphate  to
gluconolactone 6-phosphate.   A  lysine  residue  has  been  identified  as  a
reactive nucleophile associated with the activity of the enzyme.  The sequence
around this lysine is totally conserved from bacterial to mammalian G6PD's and
can be used as a signature pattern.

-Consensus pattern: D-H-[YF]-L-G-K-[EQK]
                    [K is the active site residue]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2006 / Pattern revised.

[ 1] Jeffery J., Persson B., Wood I., Bergman T., Jeffery R., Joernvall H.
     "Glucose-6-phosphate dehydrogenase. Structure-function relationships
     and the Pichia jadinii enzyme structure."
     Eur. J. Biochem. 212:41-49(1993).
     PubMed=8444164

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{END}